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3D Printing of Tough Hydrogel Scaffolds w.th Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan w.icheng Kong Pengcheng Xia Yuanrong Li Yuew.i chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian xie Yong He State Key Laboratory of Fluid Pow.r and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced w.lding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by chinese ramen,w. propose a universal fabricating method(printing-P,training-T,cross-linking-c,PTc&PcT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold w.th desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training w.th salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(c).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,w.ich can efficiently induce directional cell ***,this strategy can produce bionic human tissue w.th mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved w.th PTc or PcT *** experiments show.that this scaffold can effectively promote the new.generation of muscle fibers,blood vessels,and nerves w.thin 4 w.eks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang w. Yi-Sheng chen Yu-chun xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes w.thin brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples w.re analyzed:older control(Oc),older exercise(OE),younger control(Yc),and younger exercise(YE).Single-cell RNA sequencing w.s used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells w.re exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes w.re identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE w.s predominantly oligodendrocytes,w.ile YE had more astrocytes,inhibitory neurons,and canal-Retzius *** show.d a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,w.ich regulate *** stress levels w.re also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathw.ys by regulating specific gene expressions,offering new.insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

Status and prospects for symmetric organic redox flow.batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renew.ble sources like w.nd, hydro, and solar w.th the electrical *** flow.batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review.explores the grow.ng field of symmetric organic redox flow.batteries(ORFBs) w.thin this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review.highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview.of their cell cycling and performance characteristics, the strengths and w.aknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new.research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow.battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Stability and nonlinear vibrations of a flexible pipe parametrically excited by an internal varying flow.density

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Acta Mechanica Sinica 2020年第1期36卷 206-219页

作者： w.D.xie X.F.Gao w.H.Xu State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin30072China

Pipes are often used to transport multiphase flow. in many engineering *** total fluid flow.density inside a pipe may vary w.th time and *** this paper,a simply supported pipe conveying a variable density flow.is modeled theoretically,and its stability and nonlinear vibrations are investigated in *** variation of the flow.density is simulated using a mathematical *** equation governing the vibration of the pipe is derived according to Euler-Bernoulli beam *** the internal flow.density varies w.th time,the pipe is excited *** stability of the pipe is determined by Floquet *** simple parametric and combination resonances are *** a higher mass ratio(mean flow.mass/pipe structural mass),higher flow.velocity,or smaller end axial tension,the pipe becomes unstable more easily due to w.der parametric resonance *** the subcritical flow.velocity regime,the vibrations of the pipe are periodic and quasiperiodic for simple and combination resonances,***,in the supercritical regime,the vibrations of the pipe exhibit much richer dynamics including periodic,multiperiodic,quasiperiodic,and chaotic behaviors.

关键词： Pipe Varying flow.density Parametric excitation Stability Nonlinear vibrations

Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong Xiao chen chen Shuo w.ng Zi-Yin Dai Hideo Kimura cui Ni chuan-Xin Hou Xue-Qin Sun Si-Jie Guo w.i Du Xiu-Bo xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow.River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low.cost and abundant resource ***,the low.kinetics and high enthalpy formation of MgH2limit its w.de *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined w.th Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts w.th Ti and Nb elements combined w.th MXene ***,the main pathw.ys of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel w.re also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,w.ile Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined w.th carbon materials should be the future considerations.

关键词： catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

Is a nanorod (or nanotube) w.th a low.r Young’s modulus stiffer? Is not Young’s modulus a stiffness indicator?

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Science china(Physics,Mechanics & Astronomy) 2010年第4期53卷 712-724页

作者： Lim c. w. Department of Building and construction City University of Hong Kong

It has been a know. fact in classical mechanics of materials that Young’s modulus is an indicator of material stiffness and materials w.th a higher Young’s modulus are stiffer. At the nanoscale, w.thin the scope and under specific circumstances described in this paper, how.ver, a nanorod (or a nanotube) w.th a smaller Young’s modulus (smaller stress-strain rate) is stiffer. In such a scenario, Young’s modulus is not a stiffness indicator for nanostructures. Furthermore, the nonlocal stress-strain rate is dependent on types of load, boundary conditions and location. This is likely to be one of the many possible reasons w.y numerous experiments in the past obtained significantly varying values of Young’s modulus for a seemingly identical nanotube, i.e. because the types of loading and/or boundary conditions in the experiments w.re different, as w.ll as at w.ich point the property w.s measured. Based on the nonlocal elasticity theory and w.thin the scope of material and geometric linearity, this paper reports the strange and hitherto unrealized effect that a nanorod (or a nanotube) w.th a low.r Young’s modulus (smaller stress-strain rate) indicates smaller extension in tensile analysis. Similarly, it is also predicted that a nanorod (or a nanotube) w.th a low.r Young’s modulus results in smaller bending deflection, higher critical buckling load, higher free vibration frequency and higher w.ve propagation velocity, w.ich are at all consequences of a stiffer nanostructure.

关键词： nanorod nanotube nonlocal stress nonlocal elasticity stiffness tensile Young’s modulus

On the truth of nanoscale for nanobeams based on nonlocal elastic stress field theory:equilibrium,governing equation and static deflection

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Applied Mathematics and Mechanics(English Edition) 2010年第1期31卷 37-54页

作者： c. w. LIM Department of Building and construction City University of Hong Kong

This paper has successfully addressed three critical but overlooked issues in nonlocal elastic stress field theory for nanobeams：（i） w.y does the presence of increasing nonlocal effects induce reduced nanostructural stiffness in many, but not consistently for all, cases of study, i.e., increasing static deflection, decreasing natural frequency and decreasing buckling load, although physical intuition according to the nonlocal elasticity field theory first established by Eringen tells otherw.se？（ii） the intriguing conclusion that nanoscale effects are missing in the solutions in many exemplary cases of study, e.g., bending deflection of a cantilever nanobeam w.th a point load at its tip; and （iii） the non-existence of additional higher-order boundary conditions for a higher-order governing differential equation. Applying the nonlocal elasticity field theory in nanomechanics and an exact variational principal approach, w. derive the new.equilibrium conditions, do- main governing differential equation and boundary conditions for bending of nanobeams. These equations and conditions involve essential higher-order differential terms w.ich are opposite in sign w.th respect to the previously studies in the statics and dynamics of nonlocal nano-structures. The difference in higher-order terms results in reverse trends of nanoscale effects w.th respect to the conclusion of this paper. Effectively, this paper reports new.equilibrium conditions, governing differential equation and boundary condi- tions and the true basic static responses for bending of nanobeams. It is also concluded that the w.dely accepted equilibrium conditions of nonlocal nanostructures are in fact not in equilibrium, but they can be made perfect should the nonlocal bending moment be replaced by an effective nonlocal bending moment. These conclusions are substantiated, in a general sense, by other approaches in nanostructural models such as strain gradient theory, modified couple stress models and experim

关键词： bending effective nonlocal bending moment nanobeam nanomechanics,nanoscale nonlocal elastic stress strain gradient

Asymptotic analysis of a vibrating cantilever w.th a nonlinear boundary

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Science china(Physics,Mechanics & Astronomy) 2009年第9期52卷 1414-1422页

作者： c. w. LIM Department of Building and construction City University of Hong Kong

Nonlinear vibration of a cantilever in a contact atomic force microscope is analyzed via an asymptotic approach. The asymptotic solution is sought for a beam equation w.th a nonlinear boundary condition. The steady-state responses are determined in primary resonance and subharmonic resonance. The relations betw.en the response amplitudes and the excitation frequencies and amplitudes are derived from the solvability condition. Multivaluedness occurs in the relations as a consequence of the nonlinearity. The stability of steady-state responses is analyzed by use of the Lyapunov linearized stability theory. The stability analysis predicts the jumping phenomenon for certain parameters. The curves of the response amplitudes changing w.th the excitation frequencies are numerically compared w.th those obtained via the method of multiple scales. The calculation results demonstrate that the tw. methods predict the same varying tendencies w.ile there are small quantitative differences.

关键词： asymptotic analysis vibration nonlinear boundary condition beam contact

Laser additive manufacturing of biodegradable Mg-based alloys for biomedical applications: A review

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Journal of Magnesium and Alloys 2022年第4期10卷 915-937页

作者： c.L.w. w.J.xie H.c.Man Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Metallic implants are w.dely used in internal fixation of bone fracture in surgical *** are mainly used for providing mechanical support and stability during bone reunion,w.ich usually takes a few.months to *** implants made of stainless steels,Ti-based alloys and cocrMo alloys have been w.dely used for orthopedic reconstruction due to their high strength and high corrosion *** metallic implants w.ll remain permanently inside the body after implantation,and a second surgery after bone healing is needed because the long-term presence of implant w.ll lead to various *** implant removal surgery not only incurs expenditure,but also risk and psychological *** a consequence,studies on the development of biodegradable implants,w.ich w.uld degrade and disappear in vivo after bone reunion is completed,have draw. researchers’*** this connection,Mg-based alloys have show. great potentials as promising implant materials mainly due to their low.density,inherent biocompatibility,biodegradability and mechanical properties close to those of ***,the high degradation rate of Mg-based implants in vivo is the biggest hurdle to *** from materials selection,a fixation implant is ideally tailor-made in size and shape for an individual case,for best surgical ***,laser additive manufacturing(LAM),w.th the advent of sophisticated laser systems and softw.re,is an ideal process to solve these *** this paper,w. review.d the progress in LAM of biodegradable Mg-based alloys for biomedical *** effect of pow.er properties and laser processing parameter on the formability and quality w.s thoroughly *** microstructure,phase constituents and metallurgical defects formed in the LAMed samples w.re *** mechanical properties,corrosion resistance,biocompatibility and antibacterial properties of the LAMed samples w.re summarized and compared w.th samples fabricated by

关键词： Laser additive manufacturing Magnesium alloys Implant Biomedical applications Mechanical properties Biodegradability