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Dual-sized hollow.particle incorporated fibroin thermal insulating coatings on catheter for cerebral therapeutic hypothermia

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Bioactive Materials 2023年第8期26卷 116-127页

作者： Ming Li Yuan Gao Miaow.n Jiang Hongkang z.ang Yang z.ang Yan w. w.nhao zhou Di w. Chuanjie w. Longfei w. Luzi Bao Xiaoxiao Ge zhengfei Qi Ming w.i ang Li Yuchuan Ding Jicheng z.ang Guangzhen Pan Yu w. Yan Cheng Yufeng zheng Xunming Ji China-America Institute of Neuroscience and Beijing Institute of Geriatrics Xuanwu HospitalCapital Medical UniversityBeijing100053China School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing100191China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing100069China School of Materials Science and Engineering Peking UniversityBeijing100871China Shaanxi Key Laboratory of Biomedical Metallic Materials Northwest Institute for Nonferrous Metal ResearchXi’an710016China Department of Biomedical Engineering Columbia UniversityNew York CityNY10027USA Department of Neurosurgery Wayne State University School of MedicineDetroitMI48201USA Gong Yi Van-research Innovation Composite Material Co.Ltd Zheng Zhou451299China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing100053China

Selective endovascular hypothermia has been used to provide cooling-induced cerebral neuroprotection,but current catheters do not support thermally-insulated transfer of cold infusate,w.ich results in an increased exit temperature,causes hemodilution,and limits its cooling ***,air-sprayed fibroin/silica-based coatings combined w.th chemical vapor deposited parylene-C capping film w.s prepared on *** coating features in dual-sized-hollow.microparticle incorporated structures w.th low.thermal *** infusate exit temperature is tunable by adjusting the coating thickness and infusion *** peeling or cracking w.s observed on the coatings under bending and rotational scenarios in the vascular *** efficiency w.s verified in a sw.ne model,and the outlet temperature of coated catheter(75μm thickness)w.s 1.8-2.0◦C low.r than that of the uncoated *** pioneering w.rk on catheter thermal insulation coatings may facilitate the clinical translation of selective endovascular hypothermia for neuroprotection in patients w.th acute ischemic stroke.

关键词： Silk fibroin Thermal insulation coating Catheter Stroke Hypothermia

Density Depletion and Hall Effect in Magnetic Reconnection

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Density Depletion and Hall Effect in Magnetic Reconnection

改进CAR-T细胞有效性和安全性的设计策略

第十一届全国日地空间物理学术讨论会

作者： Hong-ang Yang and Shu-Ping Jin ( School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026 )

＜正＞w. investigate the layers of density depletion in magnetic reconnection using a 2.5 dimensional Hall MHD code developed from a multi-step implicit scheme. The numerical results at the quasi-steady state of Hall MHD reconnection w.th di/L0 ＞0.1 （di is the ion inertial length and L0 is the length of simulation domain in z direction） show.not only the density depletions along the magnetic separatrices but also a dip in the density in the vicinity of the X neutral line. To understand the physics underlying the density depletions in the reconnection processes w. examine a series of cases w.th di/L0 ranging from 0.25 to 0.01 and find the depleting layers of density along the separatrices become more and more slight as the Hall effect w.akens w.th decreasing di/L0, and they are hardly distinguishable for the cases w.th di/L0≤1/20. w.at’ s more, the profile of the density ρ* at the central point of the diffusion region as the function of di/L0 illustrates that ρ* decreases as Hall effect strengthens w.th increasing di/L0. As seen in the profile of ρ* versus di/L0,ρ* is approximate to 2.0 in the cases w.th di/L0＜1/50 w.ere the Hall effect is very w.ak and the reconnection dynamics are controlled by the resistivity. How.ver, ρ* is less then 1.0 in the cases w.th di/L0 ＞ 0.1 w.ere the reconnection dynamics are dominated by Hall effect. It demonstrates that the density depletion in the magnetic reconnection is a peculiar feature to the case w.th a strong Hall term.

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中国肿瘤生物治疗杂志 2017年第5期24卷 461-466页

作者：张昂张斌陈虎解放军第307医院造血干细胞移植科全军造血干细胞研究所北京100071

嵌合抗原受体T(chimeric antigen receptor T cells,CAR-T)细胞已从实验室走向了临床试验,在治疗B细胞恶性肿瘤中取得了显著疗效,但在探索CAR-T细胞治疗恶性肿瘤的临床研究中,仍面临不少困难与挑战:难以找到肿瘤特异性的靶点,以克服其... 详细信息

嵌合抗原受体T(chimeric antigen receptor T cells,CAR-T)细胞已从实验室走向了临床试验,在治疗B细胞恶性肿瘤中取得了显著疗效,但在探索CAR-T细胞治疗恶性肿瘤的临床研究中,仍面临不少困难与挑战:难以找到肿瘤特异性的靶点,以克服其脱靶效应(on-target off tumor effect);在治疗实体瘤中CAR-T细胞很难达到肿瘤部位,以改善免疫抑制微环境发挥作用;CAR-T细胞在清除肿瘤细胞的同时也会杀伤表达相同靶点的正常细胞;针对除B细胞肿瘤之外的血液肿瘤以及实体瘤而言,CAR-T细胞的有效性还有待提高。本文重点介绍如何通过CAR-T细胞结构的优化使得CAR-T细胞能够精准地识别肿瘤细胞,克服肿瘤的免疫抑制微环境来提高CAR-T细胞治疗恶性肿瘤的有效性;同时使得CAR-T细胞可以被更好地控制,使得CAR-T细胞的安全性更高。

关键词： CAR—T细胞设计策略结构改造有效性安全性

基于SOX9的生物学研究及其在肝癌干细胞中的研究进展

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中国临床医学 2016年第6期23卷 838-840页

作者：王孟超黄罡周伟平第二军医大学东方肝胆外科医院肝外三科上海200433

肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9(sex determining ... 详细信息

肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9(sex determining region Y box-9)除了参与多个器官的生长发育外,还与组织纤维化及肿瘤的发生有着密切关系,尤其在多种肿瘤干细胞中高表达。SOX9亦在肝癌干细胞中高表达,并通过相关信号通路影响肝癌干细胞的自我更新、增殖以及耐药,因此成为肝癌潜在的预后判断指标和治疗靶点。

关键词：肿瘤干细胞肝细胞肝癌 SOX9

Microstructure and mechanical behavior of laser aided additive manufactured low.carbon interstitial Fe_(49.5)Mn_(30)Co_(10)Cr_(10)C_(0.5)multicomponent alloy

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Journal of Materials Science & Technology 2021年第18期77卷 38-46页

作者： Y.Chew.z.G.zhu F.w.ng S.B.Gao F.L.Ng B.Y Lee G.J.Bi Singapore Institute of Manufacturing Technology 73 Nanyang Drive637662Singapore School of Mechanical Aerospace Engineering Nanyang Technological University50 N any ang Avenue639798Singapore

Laser aided additive manufacturing(LAAM)w.s used to fabricate bulk Fe_(49.5)Mn_(30)Co_(10)Cr_(10)C_(0.5)interstitial multicomponent alloy using pre-alloyed *** room temperature yield strength(σ_y),ultimate tensile strength(σ_(UTS))and elongation(ε_(UTS))w.re 645 MPa,917 MPa and 27.0%*** asbuilt sample consisted of equiaxed and dendritic cellular structures formed by elemental *** cellular structures together w.th oxide particle inclusions w.re deemed to strengthen the *** other contributing components include dislocation strengthening,friction stress and grain boundary *** highε_(UTS)w.s attributed to dislocation motion and activation of both tw.nning and transformation-induced plasticity(Tw.P and TRIP).Tensile tests performed at-40℃and-130℃demonstrated superior tensile strength of 1041 MPa and 1267 MPa ***,almost no tw.nning w.s observed in the fractured sample tested at-40℃and-130℃.Instead,higher fraction of strain-induced hexagonal close-packed(HCP)εphase transformation of 21.2%w.re observed for fractured sample tested at-40℃,compared w.th 6.3%in fractured room temperature sample.

关键词： Multicomponent alloys Laser aided additive manufacturing Additive manufacturing Microstructure Mechanical property

钠米材料Fe＿2O＿3微结构的正电子寿命谱学研究

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物理学报 1994年第7期43卷 1208-1216页

作者：彭郁卿王涛周诗瑶卜为张立德中国科学院上海原子核研究所中国科学院核分析技术开放研究实验室中国科学院固体物理研究所上海师范大学

用Ｘ射线衍射确定了纳米材料Ｆｅ＿２Ｏ＿３的平均粒径。测量了正电子的寿命。给出了平均粒径随退火温度的变化和短寿命成分τ＿１、中等寿命成分τ＿２以及它们的强度比Ｉ＿２／Ｉ＿１随平均粒径的变化。讨论了纳米材料Ｆｅ＿２Ｏ＿３... 详细信息

用Ｘ射线衍射确定了纳米材料Ｆｅ＿２Ｏ＿３的平均粒径。测量了正电子的寿命。给出了平均粒径随退火温度的变化和短寿命成分τ＿１、中等寿命成分τ＿２以及它们的强度比Ｉ＿２／Ｉ＿１随平均粒径的变化。讨论了纳米材料Ｆｅ＿２Ｏ＿３的界面结构、平均正电子寿命τ与多普勒展宽谱Ｓ参效间的对应关系。

关键词：纳米材料氧化铁正电子湮灭缺陷

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药物性肝损伤慢性化的研究近况

临床肝胆病杂志 2020年第3期36卷 501-504页

作者：黄昂孙颖邹正升解放军总医院第五医学中心非感染性肝病诊疗与研究中心北京100039

尽管药物性肝损伤(DILI)通常表现为急性过程,但仍有约20%患者会发生慢性化。慢性DILI病程反复且无有效﹑公认的治疗方法。随着新药的不断研发及其临床应用,以及中药和食物补充剂的应用,DILI慢性化的发生率不断增高。通过DILI流行病学﹑... 详细信息

尽管药物性肝损伤(DILI)通常表现为急性过程,但仍有约20%患者会发生慢性化。慢性DILI病程反复且无有效﹑公认的治疗方法。随着新药的不断研发及其临床应用,以及中药和食物补充剂的应用,DILI慢性化的发生率不断增高。通过DILI流行病学﹑危险因素﹑临床表现﹑诊断及治疗等角度对DILI慢性化的最新研究近况进行概述,以期更加全面地了解认识慢性DILI。

关键词：药物性肝损伤慢性病诊断治疗学

Antithrombin gene Arg197Stop mutation-associated venous sinus thrombosis in a Chinese family

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Neural Regeneration Research 2011年第20期6卷 1575-1579页

作者： ang Li Tianhui Liu zhandong Liu Jimei Li Chunling z.ang Jun Chen Jinmei Sun Yanfei Han Lili w.0} Dexin w.0} Qiming Xue Baoen w.0} Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China Liver Research Center Beijing Friendship Hspital Capital Medical University Beijing 100050 China Department of Neurology Health Care Center Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

This study sought to elucidate the genetic correlation of cerebral venous sinus thrombosis caused by a hereditary antithrombin deficiency in a Chinese family, at the genetic and protein levels. A nonsense mutation from C to T on locus 6431 in exon 3B of the antithrombin gene w.s observed, leading to an arginine （CGA） to stop codon （TGA） change in the protein. This is the first report of this mutation in China. Ineffective heparin therapy in the propositus patient is associated w.th a lack of heparin binding sites after antithrombin gene mutation. Characteristic low.intracranial pressure in the acute phase might be specific to this patient w.th cerebral venous sinus thrombosis.

关键词： antithrombin cerebral venous sinus thrombosis intracranial hypotension nonsense mutation brain edema

网络演化博弈视角下的跨国公司逆向知识转移动态过程研究

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管理评论 2017年第11期29卷 159-170页

作者：肖振红刘昂周文哈尔滨工程大学经济管理学院哈尔滨150001 国防科学技术大学信息系统与管理学院长沙410003

逆向知识转移是跨国公司获取海外东道国知识资源、维持竞争优势的重要途径。为了探索逆向知识转移的运行机制和过程规律,针对跨国公司中母子公司之间逆向知识转移的动态过程,构建跨国公司逆向知识转移动态过程的网络演化博弈模型,并对... 详细信息

逆向知识转移是跨国公司获取海外东道国知识资源、维持竞争优势的重要途径。为了探索逆向知识转移的运行机制和过程规律,针对跨国公司中母子公司之间逆向知识转移的动态过程,构建跨国公司逆向知识转移动态过程的网络演化博弈模型,并对跨国公司逆向知识转移的动态过程进行仿真分析。研究结果表明,博弈策略的信号传递噪音对母子公司博弈策略的采纳和更新均具有重要影响;母子公司单位成本以及子公司努力成本对母子公司积极策略稳态实现速度的影响均具有可分离特征,而母公司努力成本的影响存在最优区间;子公司之间博弈策略的信号传递和策略的模仿强烈依赖于作为载体的网络结构,无标度网络结构更有利于促成积极策略的传递扩散。

关键词：逆向知识转移跨国公司演化博弈复杂网络