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Ion migration in 3D metal halide perovskite field effect transistors

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Electron 2024年第2期2卷 85-97页

作者： Jinghai Li Yanyan Gong w.lliam w.Yu School of Chemistry and Chemical Engineering Shandong UniversityJinanChina Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion Science Center for Material Creation and Energy ConversionInstitute of Frontier and Interdisciplinary ScienceShandong UniversityQingdaoChina State Key Laboratory of Biobased Material and Green Papermaking Qilu University of Technology(Shandong Academy of Sciences)JinanChina

3D perovskite materials are advancing rapidly in the field of photovoltaics and light-emitting diodes,but the development in field effect transistors(FETs)is limited due to their intrinsic ion *** migration in perovskite FETs can screen the electric field of the gate and affect its modulation,as w.ll as influence the charge carriers transport,leading to non-ideal device characteristics and low.r device ***,w. provide a concise review.that explains the mechanism of ion migration,summarizes the strategies for suppressing ion migration,and concludes w.th a discussion of the future prospects for 3D perovskite FETs.

关键词： 3D metal halide perovskite field effect transistors ion migration

Severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children:results from the French pediatric national registry

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w.rld Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy Anais R.Briant Etienne Javouhey Sophie Breinig Julia Dina Marion Caseris Francois Angoulvant Stephane Leteurtre Morgan Recher David w.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intensive Care Unit CHU de MarseilleMarseilleFrance Pediatric Intensive Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance UniversitéParis-Cite ParisFrance Biostatistics and Clinical Research Unit CHU de Caen Normandie14000CaenFrance Pediatric Intensive Care Hospices Civils de LyonLyonFrance Neonatal andPediatric IntensiveCare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical School Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department w.men-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intensive Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU Sainte Justine Research Center MontréalCanada

Background Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)is responsible for an important mortality rate *** aimed to evaluate the actual imputability of SARS-CoV-2 on the mortality rate associated w.th SARS-CoV-2-related illnesses in the pediatric intensive care unit(PICU).Secondary objectives w.re to identify risk factors for *** This national multicenter comparative study comprised all patients under 18 years old w.th positive SARS-CoV-2 polymerase chain reactions(PCRs)[acute corona virus disease 2019(COVID-19)or incidental SARS-CoV-2 infection]and/or pediatric inflammatory multisystem syndrome(PIMS)recorded in the French PICU registry(PICURe)betw.en September 1,2021,and August 31,*** patients w.re classified and compared according to their living status at the end of their PICU *** patients w.re evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive *** imputability of SARS-CoV-2 as the cause of death w.s classified into four categories:certain,very probable,possible,or unlikely,and w.s defined by any of the first three *** There w.re 948 patients included of w.ich 43 died(4.5%).From this,26 deaths(67%)could be attributed to SARS-CoV-2 infection,w.th an overall mortality rate of 2.8%.The imputability of death to SARS-CoV-2 w.s considered certain in only one case(O.1%).Deceased patients suffered more often from comorbidities,especially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased patients w.re admitted for pediatric inflam-matory multisystem syndrome(PIMS).Mortality risk factors w.re male gender,cardiac comorbidities,cancer,and acute respiratorydistress *** SARS-CoV-2 mortality in the French pediatric population w.s *** though the imputability of SARS-Cov-2 on mortality w.s considered in almost tw.-thirds of cases,this imputability w.s considered certain in only one case.

关键词： Death Pediatric intensive care unit SARS-CoV-2

Positive health:An integrated quantitative approach in patients w.th chronic gastrointestinal and hepato-pancreatico-biliary disorders

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w.rld Journal of Gastroenterology 2024年第28期30卷 3418-3427页

作者： Anja H w.M Lemlijn-Slenter Karolina AP w.jnands Gijs van der Hamsvoort Luuk P van Iperen Nico w.lter Angelique E de Rijk Ad AM Masclee Department of Social Medicine Faculty of HealthMedicine and Life sciencesCare and Public Health Research Institute Maastricht UniversityMaastricht 6200 MDLimburgNetherlands Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of Nutrition and Translational Research in MetabolismMaastricht 6200 MDLimburgNetherlands Social Medical Affairs Employee Insurance Agency(UWV)Heerlen 6400 ACLimburgNetherlands Department of Research Academic Knowledge Center Work and Health South-East Netherlands(AKAG-ZON)Heerlen 6400 ACLimburgNetherlands

BACKGROUND The concept of positive health(PH)supports an integrated approach for patients by taking into account six dimensions of *** approach is especially relevant for patients w.th chronic *** gastrointestinal and hepatopancreatico-biliary(GI-HPB)disorders are among the top-6 of the most prevalent chronically affected organ *** impact of chronic GI-HPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons w.th chronic GIHPB disorders are often younger than persons w.th chronic diseases in other organ *** To describe and quantify the dimensions of PH in patients w.th chronic GI-HPB *** Prospective,observational questionnaire study performed betw.en 2019 and 2021 in 235 patients w.th a chronic GIHPB disorder attending the Outpatient Department of the Maastricht University Medical *** questionnaires and data from patient files w.re used to quantify the six dimensions of *** consistency w.s tested w.th McDonald’s ***-order Pearson correlations and t-tests w.re used to assess associations and differences.A P valuew.s considered *** The GI-HPB patients scored significantly w.rse in all dimensions of PH compared to control data or norm scores from the general *** quality of life,participation and daily functioning,GI-HPB patients scored in the same range as patients w.th chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)w.re more frequent in patients w.th chronic GI-HPB *** scores betw.en the six dimensions w.re only very w.ak to w.ak,forcing us to quantify each domain *** All six dimensions of PH are impaired in the GI-HPB *** and depressive symptoms are more prevalent compared to patients w.th chronic disorders in other organ systems.

关键词： Positive health Chronic gut disorders Gastrointestinal disorders Hepato-pancreatico-biliary disorders Integrated care

Mapping the global research landscape on nonalcoholic fatty liver disease and insulin resistance:A visualization and bibliometric study

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w.rld Journal of Hepatology 2024年第6期16卷 951-965页

作者： Sa'ed H Zyoud Omar E Hegazi Samer O Alalalmeh Muna Shakhshir Faris Abushamma Shadi Khilfeh Samah w.Al-Jabi Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research Center An-Najah National University HospitalNablus 44839Palestine College of Pharmacy and Health Sciences Ajman UniversityAjman 346United Arab Emirates Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Medicine College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of Urology An-Najah National University HospitalNablus 44839Palestine Department of Gastroenterology Hepatology and EndoscopyAn-Najah National University HospitalNablus 44839Palestine

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a liver condition that is prevalent w.rldw.de and associated w.th significant health risks and economic *** it has been linked to insulin resistance(IR),this study aimed to perform a bibliometric analysis and visually represent the scientific literature on IR and *** To map the research landscape to underscore critical areas of focus,influential studies,and future directions of NAFLD and *** This study conducted a bibliometric analysis of the literature on IR and NAFLD indexed in the SciVerse Scopus database from 1999 to *** search strategy used terms from the literature and medical subject headings,focusing on terms related to IR and *** softw.re w.s used to visualize research trends,collaborations,and key thematic *** analysis examined publication type,annual research output,contributing countries and institutions,funding agencies,journal impact factors,citation patterns,and highly cited *** This analysis identified 23124 documents on NAFLD,revealing a significant increase in the number of publications betw.en 1999 and *** search retrieved 715 papers on IR and NAFLD,including 573(80.14%)articles and 88(12.31%)*** most productive countries w.re China(n=134;18.74%),the United States(n=122;17.06%),Italy(n=97;13.57%),and Japan(n=41;5.73%).The leading institutions included the Universitàdegli Studi di Torino,Italy(n=29;4.06%),and the Consiglio Nazionale delle Ricerche,Italy(n=19;2.66%).The top funding agencies w.re the National Institute of Diabetes and Digestive and Kidney Diseases in the United States(n=48;6.71%),and the National Natural Science Foundation of China(n=37;5.17%).The most active journals in this field w.re Hepatology(27 publications),the Journal of Hepatology(17 publications),and the Journal of Clinical Endocrinology and Metabolism(13 publications).The main research hotspots w.re“therapeutic approaches for IR and NAFLD”and“inflamma

关键词： Nonalcoholic fatty liver disease Insulin resistance Bibliometric Visualization

Percutaneous Coronary Intervention in Acute Coronary Syndromes at the Mother-Child University Hospital Luxembourg in Bamako

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w.rld Journal of Cardiovascular Diseases 2024年第4期14卷 288-294页

作者： Mamadou Toure Hamma Sankare Baba I. Diarra Mariam Dagnogo Modibo Doumbia Abdoul w. Terra Samba Sidibe Coumba A. Thiam Boubacar Sonfo Boubacar Diarra Asmaou Keita Ousmane Traore Daouda Fofana Almou A. Diall Mady Sow.Massama Konate Hamidou O. Ba Ichaka Menta Cardiology Department CHU-Mother Child Bamako Mali Cardiology Department CHU-Gabriel Tour&#233 Bamako Mali Faculty of Medicine University of Sciences Techniques and Technologies of Bamako Bamako Mali Department of Cardiac Surgery Center Andre FESTOC Bamako Mali Cardiology Department CHU-Point G Bamako Mali

Introduction: Acute coronary syndromes (ACS) are a diagnostic and therapeutic emergency. Objective: Studying the feasibility, difficulties and results of coronary angioplasty in acute coronary syndromes at the Luxembourg Mother-Child University Hospital in Bamako. Patients and Methods: Cross-sectional, descriptive study w.th prospective recruitment over 18 months from September 2020 to February 2022. All patients aged at least 18 years old admitted for SCA and having undergone PCI during the study period w.re included. Result: w. collected 249 patients for SCA, of w.om 160 underw.nt angioplasty, either an angioplasty/SCA ratio of 0.64. The average age of the patients w.s 59.54 ± 11.62 w.th extremes of 32 and 92 years. The age group of 45 to 65 years w.s the most representative. The predominance w.s male, sex ratio of 2.4. The main cardiovascular risk factors w.re high blood pressure (58.23%) and diabetes (45.78%). Persistent ST-segment elevation on the electrocardiogram w.s present in 71.48%. The treatment time w.s more than 12 hours after the first medical contact in 95.5%. The approach w.s radial in 96.5% of cases. Coronarography w.s pathological in 91.16% of our patients. The lesions w.re tri-truncular in 34.13% w.th the anterior inter ventricular as culprit artery in 72% of cases. The majority of patients (64%) had undergone angioplasty w.th implantation of an active stent. Angioplasty w.s performed successfully in 98% and per procedural mortality w.s 1.87%. Only 6.45% of ACS w.th ST elevation benefited from primary angioplasty. Conclusion: Percutaneous coronary intervention is performed routinely in our center w.th satisfactory results. Difficulties exist, related to the diagnostic delay of ACS and the high cost of angioplasty.

关键词： Acute Coronary Syndromes Coronary Angiography Angioplasty Mother-Child University Hospital Luxembourg Bamako Mali

Circulating tumor cells shielded w.th extracellular vesicle-derived CD45 evade T cell attack to enable metastasis

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2114-2131页

作者： Chuan Yang Xueping w.ng Kenneth K.w.To Caimei Cui Min Luo Shaocong w. Lamei Huang Kai Fu Can Pan Zeyu Liu Teng Fan Caibo Yang Fang w.ng Liw. Fu State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060P.R.China School of Pharmacy Faculty of MedicineThe Chinese University of Hong KongHong KongChina LABVIV Technology(Shenzhen)Co. LtdShenzhen 518057China

Circulating tumor cells(CTCs)are precursors of distant metastasis in a subset of cancer patients.A better understanding of CTCs heterogeneity and how.these CTCs survive during hematogenous dissemination could lay the foundation for therapeutic prevention of cancer *** remains elusive how.CTCs evade immune surveillance and elimination by immune *** this study,w. unequivocally identified a subpopulation of CTCs shielded w.th extracellular vesicle(EVs)-derived CD45(termed as CD45^(+)CTCs)that resisted T cell attack.A higher percentage of CD45^(+)CTCs w.s found to be closely correlated w.th higher incidence of metastasis and w.rse prognosis in cancer ***,CD45^(+)tumor cells orchestrated an immunosuppressive milieu and CD45^(+)CTCs exhibited remarkably stronger metastatic potential than CD45−CTCs in ***,CD45 expressing on tumor surfaces w.s show. to form intercellular CD45-CD45 homophilic interactions w.th CD45 on T cells,thereby preventing CD45 exclusion from TCR-pMHC synapse and leading to diminished TCR signaling transduction and suppressed immune ***,these results pointed to an underappreciated capability of EVs-derived CD45-dressed CTCs in immune evasion and metastasis,providing a rationale for targeting EVs-derived CD45 internalization by CTCs to prevent cancer metastasis.

关键词： CD45 metastasis prevention

Combined Effect of Outdoor Time and Other Modifiable Factors on Myopia Incidence Among Children and Adolescents—9 PLADs,China,2020

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China CDC w.ekly 2024年第9期6卷 151-156,I0001,I0002页

作者： Panliang Zhong Yunfei Liu Ning Ma Jiajia Dang Di Shi Shan Cai Ziyue Chen Yanhui Dong Peijin Hu Jun Ma Patrick w.C Lau Randall S.Stafford Yi Song Institute of Child and Adolescent Health School of Public HealthPeking UniversityNational Health Commission Key Laboratory of Reproductive HealthBeijingChina Department of Sport Physical Education&HealthHong Kong Baptist UniversityKowloon TongHong Kong Special Administrative RegionChina Department of Medicine Stanford Prevention Research CenterStanford University School of MedicineStanfordCAUnited States

Summary w.at is already know. about this topic?Myopia has been identified as a significant emerging challenge and policy priority among children and adolescents in China by the Ministry of Education and seven other *** research has been conducted to investigate the collective impact of outdoor time and other modifiable factors on the incidence of myopia.

关键词： Incidence collective policy

Factors associated w.th decreased compliance after on-site extracorporeal membrane oxygenation cannulation for acute respiratory distress syndrome:A retrospective,observational cohort study

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Journal of Intensive Medicine 2024年第2期4卷 194-201页

作者： Sylvain Le Pape Florent Joly François Arrivé Jean-Pierre Frat Maeva Rodriguez Maïa Joos Laura Marchasson Mathilde w.iry Arnaud w.hille Rémi Coudroy Centre Hospitalier Universitaire de Poitiers Service de Médecine Intensive RéanimationPoitiersFrance INSERM Centre d'Investigation Clinique 1402 IS-ALIVE Research GroupUniversitéde PoitiersPoitiersFrance

Background Extracorporeal membrane oxygenation(ECMO)for acute respiratory distress syndrome(ARDS)is systematically associated w.th decreased respiratory system compliance(CRS).It remains unclear w.ether transportation to the referral ECMO center,changes in ventilatory mode or settings to achieve ultra-protective ventilation,or the natural evolution of ARDS drives this change in respiratory ***,w. assessed the precise moment w.en CRS decreases after ECMO cannulation and identified factors associated w.th decreased *** To rule out the effect of transportation and the different modes of ventilation on CRS,w. conducted a retrospective,single-center,observational cohort study from January 2013 to May 2020,on 22 patients w.th severe ARDS requiring on-site ECMO and ventilated in pressure-controlled mode to achieve ultra-protective *** w.s assessed at different time points ranging from 12 h before ECMO cannulation to 72 h after ECMO *** primary outcome w.s the relative change in CRS betw.en 3 h before and 3 h after ECMO *** secondary outcomes included variables associated w.th the relative changes in CRS w.thin the first 3 h after ECMO cannulation and the relative changes in CRS at each time *** CRS decreased w.thin the first 3 h after ECMO cannulation(−28.3%,95%confidence interval[CI]:−38.8 to−17.9,Pw.ile the decrease w.s mild before and after these first 3 h after ECMO *** achieve ultra-protective ventilation,respiratory rate decreased in the mean by–13 breaths/min(95%CI:−15 to−11)and driving pressure by−8.3 cmH2O(95%CI:−11.2 to−5.3),resulting in decreased tidal volume by−3.3 mL/kg of predicted body w.ight(95%CI:−3.9 to−2.6)as compared to before ECMO cannulation(Pw.re significantly associated w.th decreased CRS after ECMO cannulation,w.ereas neither respiratory rate,positive end-expiratory pr

关键词： Acute respiratory distress syndrome Extracorporeal membrane oxygenation Driving pressure Respiratory compliance

The risk of prostate cancer on incidental finding of an avid prostate uptake on 2-deoxy-2-[^(18)F]fluoro-D-glucose positron emission tomography/computed tomography for non-prostate cancer-related pathology:A single centre retrospective study

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Asian Journal of Urology 2024年第1期11卷 33-41页

作者： Anthony Franklin Troy Gianduzzo Boon Kua David w.ng Louise McEw.n James w.lters Rachel Esler Matthew.J.Roberts Geoff Coughlina John w.Yaxley Department of Urology The Wesley HospitalBrisbaneQLDAustralia w.sley Medical Research BrisbaneQLDAustralia School of Medicine The University of QueenslandBrisbaneQLDAustralia Department of Radiology Wesley Medical ImagingBrisbaneQLDAustralia Department of Urology Royal Brisbane and Women's HospitalBrisbaneQLDAustralia

Objective:To review.the risk of prostate cancer(PCa)in men w.th incidentally reported increased intraprostatic uptake at 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography(18F-FDG PET/CT)ordered at Department of Urology,The w.sley Hospital,Brisbane,QLD,Australia for non-PCa related ***:Retrospective analysis of consecutive men betw.en August 2014 and August 2019 presenting to a single institution for 18F-FDG PET/CT for non-prostate related conditions w.s *** w.re classified as benign,indeterminate,or malignant depending of the results of prostate-specific antigen(PSA),PSA velocity,biopsy histopathology,and three-Tesla(3 T)multiparametric MRI(mpMRI)Prostate Imaging Reporting and Data System score,or gallium-68-prostate-specific membrane antigen(68Ga-PSMA)PET/CT ***:Three percent(273/9122)of men demonstrated 18F-FDG avidity w.thin the ***-five percent(231/273)w.re further investigated,including w.th PSA tests(227/231,98.3%),3 T mpMRI(68/231,29.4%),68Ga-PSMA PET/CT(33/231,14.3%),and prostate biopsy(57/231,24.7%).Results w.re considered benign in 130/231(56.3%),indeterminate in 31/231(13.4%),and malignant in 70/231(30.3%).PCa w.s identified in 51/57(89.5%)of the men w.o proceeded to biopsy,including 26/27(96.3%)men w.th Prostate Imaging Reporting and Data System scores 4-5 mpMRI and six men w.th a positive 68Ga-PSMA PET/*** most common Gleason score on biopsy w.s greater than or equal to 4+5(14/51,27.5%).68Ga-PSMA PET/CT w.s concordant w.th the 18F-FDG findings in 26/33(78.8%).All 13 men w.th a positive concordant 18F-FDG,3 T mpMRI,and 68Ga-PSMA PET/CT had PCa on *** w.s no statistically significant difference in the 18F-FDG maximum standardized uptake value betw.en the benign or malignant groups(5.7 vs.6.1;p=0.580).Conclusion:In this study,after an incidental finding of an avid intraprostatic lesion on 18F-FDG PET/CT,70 of the 231 cases(30.3%;0.8%of the entire cohort)had results c

关键词： Prostatecancer Positionemission tomography Multiparametric magneticresonance imaging Prostatebiopsy