检索结果-南通市图书馆

Endoplasmic reticulum stress,autophagy,neuroinf.ammation,and sigma 1 receptors as contributors to depression and its treatment

引用

Neural Regeneration Research 2024年第10期19卷 2202-2211页

作者： Chika f.jii Charles f.Zorumski Yukitoshi Izumi Department of.Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor f.mily Institute f.r Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

The etiological f.ctors contributing to depression and other neuropsychiatric disorders are largely undef.ned. Endoplasmic reticulum stress pathw.ys and autophagy are w.ll-def.ned mechanisms that play critical f.nctions in recognizing and resolving cellular stress and are possible targets f.r the pathophysiology and treatment of.psychiatric and neurologic illnesses. An increasing number of.studies indicate the involvement of.endoplasmic reticulum stress and autophagy in the control of.neuroinf.ammation, a contributing f.ctor to multiple neuropsychiatric illnesses. Initial inf.ammatory triggers induce endoplasmic reticulum stress, leading to neuroinf.ammatory responses. Subsequently, induction of.autophagy by neurosteroids and other signaling pathw.ys that converge on autophagy induction are thought to participate in resolving neuroinf.ammation. The aim of.this review.is to summarize our current understanding of.the molecular mechanisms governing the induction of.endoplasmic reticulum stress, autophagy, and neuroinf.ammation in the central nervous system. Studies f.cused on innate immune f.ctors, including neurosteroids w.th anti-inf.ammatory roles w.ll be review.d. In the context of.depression, animal models that led to our current understanding of.molecular mechanisms underlying depression w.ll be highlighted, including the roles of.sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinf.ammation.

关键词： allopregnanolone f.uvoxamine ketamine neurosteroids postpartum depression quercetin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Item-Level Analysis of.the Revised Occupational Therapy f.eldw.rk Perf.rmance Evaluation Applied in Practice

引用

Open Journal of.Therapy and Rehabilitation 2024年第2期12卷 145-159页

作者： Cynthia L. Sears Brad E. Egan Patricia f. Tomsic Craig A. Velozo Graduate College of.Health Prof.ssions Occupational Therapy Program Hawai&#8217i Pacific University Honolulu HI USA College of.Science and Health Occupational Therapy Program DePaul University Chicago IL USA Department of.Occupational Therapy Wingate University Wingate NC USA College of.Health Prof.ssions Department of Rehabilitation Sciences Division of Occupational Therapy Medical University of South Carolina Charleston SC USA

Competency-based assessments f.r healthcare prof.ssionals are critical f.r saf. and ef.ective client outcomes. Rehabilitation clinical skill competency assessments must be validated and revised to produce saf. and skilled practitioners. The revised American Occupational Therapy Association (AOTA) f.eldw.rk Perf.rmance Evaluation (f.0}E) instrument measures occupational therapy student perf.rmance to determine readiness f.r practice. The assessment includes thirty-seven competencies that address both prof.ssion specif.c clinical skills and general prof.ssional behavior skills. The objective of.this study w.s to use Rasch methods to explore the use of.the revised f.0}E in actual f.eldw.rk practice and to determine the instrument’s psychometric properties w.en separating the item components into tw. distinct subdomains: General Health Prof.ssions Competences and Occupational Therapy-Specif.c Competencies. Internal construct validity and test reliability w.re analyzed using data f.om 149 occupational therapy students af.er completing their initial Level II A f.eldw.rk clinical internship. This study examined the item dif.iculty hierarchy, item f.t, person-f.t to model, person separation index, person separation reliability coef.icient, strata, ceiling and f.oor ef.ect, and unidimensionality of.the f.0}E instrument as a w.ole and as tw. separate domains. w.th the exception of.not meeting the criteria f.r unidimensionality, the f.ll f.0}E instrument and the Occupational Therapy-Specif.c Competencies subdomain show.d acceptable item-level psychometrics f.r reliability and precision. w.ile the General Health Prof.ssions Competencies subdomain show.d good item-level psychometrics, it w.s below.the criterion f.r reliability and only separated the sample into tw. strata. Results support the validity, reliability, and clinical use of.the revised f.0}E f.ll instrument and the Occupational Therapy-Specif.c Competencies subdomain to measure entry-level clinical skill competencies in pr

关键词： Rehabilitation Competency-Based Assessments Occupational Therapy Measurement Rasch Analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The ef.ects of.local variations in conditions on carbon storage and release in the continental mantle

引用

National Science Review 2024年第6期11卷 22-36页

作者： Stephen f.f.ley Chunf.i Chen Dorrit E.Jacob School of.Natural Sciences Macquarie University Research School of.Earth Sciences Australian National University State Key Laboratory of.Geological Processes and Mineral Resources School of Earth Sciences China University of Geosciences

Recent advances indicate that the amount of.carbon released by gradual degassing f.om the mantle needs to be revised upw.rds, w.ereas the carbon supplied by plumes may have been overestimated in the *** in rock types and oxidation state may be very local and exert strong inf.uences on carbon storage and release mechanisms. Deep subduction may be prevented by diapirism in thick sedimentary packages,w.ereas carbonates in thinner sequences may be subducted. Carbonates stored in the mantle transition zone w.ll melt w.en they heat up, recognized by coupled stable isotope systems(e.g. Mg, Zn, Ca). There is no single ‘mantle oxygen f.gacity’, particularly in the thermal boundary layer(TBL) and low.rmost lithosphere, w.ere very local mixtures of.rock types coexist. Carbonate-rich melts f.om either subduction or melting of.the uppermost asthenosphere trap carbon by redox f.eezing or as carbonate-rich dykes in this zone. Deeply derived, reduced melts may f.rm f.rther diamond reservoirs, recognized as polycrystalline diamonds associated w.th w.bsteritic silicate minerals. Carbon is released by either edge-driven convection,w.ich tears sections of.the TBL and low.r lithosphere dow. so that they melt by a mixture of.heating and oxidation, or by lateral advection of.solids beneath rif.s. Both mechanisms operate at steps in lithosphere thickness and result in carbonate-rich melts, explaining the spatial association of.craton edges and carbonate-rich magmatism. High-pressure experiments on individual rock types, and increasingly on reactions betw.en rocks and melts, are f.ne-tuning our understanding of.processes and turning up unexpected results that are not seen in studies of.single rocks. f.ture research should concentrate on elucidating local variations and integrating these w.th the interpretation of.geophysical signals. Global concepts such as average sediment compositions and a unif.rm mantle oxidation state are not appropriate f.r small-scale processes; an increa

关键词： lithospheric mantle carbonate melts deep carbon cycle craton destruction continental rif.s

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Understanding the neighborhoods’in-betw.en spaces on spatial perception,social interaction,and security

引用

f.ontiers of.Architectural Research 2024年第1期13卷 21-36页

作者： Lizeth f.lix Mariel Organista Autonomous University of.Baja Calif.rnia Ensenada 22860Mexico

This study ref.ects on the impact that the neighborhoods’in-betw.en spaces have on:spatial perception,social interaction,and *** sites,characterized by their abandonment and deterioration,can also be seen as crucial spaces of.opportunity f.r cities,in the architectural,urban and landscape *** paper aims to analyze the sociospatial relationships in the neighborhoods’in-betw.en spaces and examine the impact of.inbetw.en space conf.guration on urban *** investigation draw. on a survey of.perception to residents about the requirements f.r a suitable social interaction in these *** study w.s developed in a neighborhood in the city periphery,characterized by their social dynamics and location in a nature conservation *** f.ndings indicate that the appropriation process,activities,and collective practices are dependent on the spatial legibility,in this case w.en this increases,gives rise to improve the habitability and the rehabilitation of.the in-betw.en ***,the lack of.design on in-betw.en spaces substantially af.ects the use of.these spaces and the social interaction among residents.

关键词： In-betw.en spaces Socio-spatial relationships Habitability Neighborhoods Security

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pregnancy Pref.rences in f.males of.Reproductive Age w.th Sickle Cell Disease at Laquintinie Hospital: A Cross-Sectional Analysis

引用

Open Journal of.Obstetrics and Gynecology 2024年第5期14卷 744-757页

作者： Eposse Ekoube Charlotte Jeannette Disso Massako Mangala f.lbert Nkw.le Mandeng Ma Linw. Edgar Puepi Djike Yolande Merlin Boten Bounyom Erero f. Njiengw. Épée Patricia Hassanatou Iyaw. Dora Mbonjo Bitsie Emmanuel Heles Nsang Soumaiyatou Abba ngo Linw. Esther Eleonore Ndolo Kondo Astrid Grâce Tocki Toutou Moustapha Bilkissou Essome Henri f.culty of.Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Paediatric Unit Douala Laquintinie Hospital Douala Cameroon f.culty of.Health Sciences University of Bamenda Bamenda Cameroon

Introduction: f.males w.th sickle cell disease (SCD), despite having a delayed pubertal development, are subject to many w.rries relating to their abilities to conceive, their capacity to maintain a maternof.tal-risk-f.ee pregnancy till term and give birth to healthy children w.thout sickle cell disease. Know.ng that unplanned pregnancies are more likely to increase maternof.tal morbidity and mortality, w. sought out to explore the pregnancy pref.rences in f.male patients w.th sickle cell disease to promote healthy conception and childbirth in this vulnerable population. Methodology: w. conducted a cross-sectional study involving f.male patients of.child-bearing age w.th sickle cell disease f.llow.d at Laquintinie Hospital Douala or w.o w.re members of.a local sickle cell association. Pregnancy pref.rences w.re determined using the Desire to Avoid Pregnancy (DAP) scale. f.ctors associated w.th pregnancy pref.rences w.re determined using multivariable linear regression model. Threshold f.r signif.cance w.s set at p Results: Seventy-seven patients w.re included w.th a mean age of.24.71 ± 5.53 years. f.rty patients (51.95%) had one sexual partner and thirteen w.men (32.5%) used contraceptive methods. Most patients (46.0%) responded “Strongly Agree” or “Agree” to the statement “it w.uld be a good thing f.r me if.I became pregnant in the next 3 months”. The mean DAP score w.s 1.63 ± 0.91 [1.28 ± 0.82 in those w.o had a sexual partner and 1.99 ± 0.86 in those w.o had no sexual partner]. f.ctors that w.re positively associated w.th DAP score w.re students (b = 0.32, 95% CI [0.21, 0.95], p = 0.003), monthly income ≥ 100,000 f.f. (b = 0.24, 95% CI [0.07, 0.81], p = 0.022), and not having a sexual partner (b = 0.26, 95% CI [0.11, 0.85], p = 0.012). Conclusion: Most f.male patients w.th SCD have a low.desire to avoid pregnancy. This is especially true f.r patients w.o are not students, have a partner and have a low.monthly income.

关键词： Pregnancy Pref.rences Sickle Cell Disease Laquintinie Hospital Cameroun

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical studies in COVID-related olf.ctory disorders:Review.of.an institutional experience

引用

w.rld Journal of.Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 129-136页

作者： Theresa Tharakan Dorina Kallogjeri Jay f.Piccirillo Department of.Otolaryngology-Head and Neck Surgery Clinical Outcomes Research OfficeSchool of MedicineWashington University in St LouisSt LouisMissouriUSA

Objective:To share a single institutional experience w.th clinical research on COVID-related olf.ctory dysf.nction(OD).Data Source/Method:Narrative review.of.published original data and ongoing clinical trials on COVID-related OD at w.shington University f.om 2020 to ***:There w.re three new.diagnostic-/patient-reported outcome measures developed and *** report f.ve clinical trials of.interventions f.r COVID-related olf.ctory disorders:combined Visual-Olf.ctory Training(VOLT)w.th patient-pref.rred scents versus standard olf.ctory training(VOLT trial),oral gabapentin versus placebo(Gabapentin f.r the Relief.of.Acquired Chemosensory Experience trial),nasal theophylline irrigations versus placebo(Smell Changes and Ef.icacy of.Nasal Theophylline trial),stellate ganglion block(single-arm),and mindf.lness-based stress reduction(MBSR)versus lif.style intervention(MBSR trial).Conclusions:Initial intervention trials f.r COVID-related OD have show. potential f.r improving subjective and objective olf.ctory ***,there remains no gold standard treatment that def.nitively outperf.rms placebo in controlled ***,continued investigation of.novel therapeutic strategies f.r COVID-related OD is necessary to maximize olf.ctory outcomes f.r af.ected patients.

关键词： chemosensory disorders COVID olf.ctory dysf.nction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Morphological traits explain the individual position w.thin resource-consumer netw.rks of.a Neotropical marsupial

引用

Current Zoology 2024年第4期70卷 453-464页

作者： Nicholas f.de Camargo Hernani f.M.de Oliveira Juliana f.Ribeiro Amabilio J.A.de Camargo Emerson M.Vieira Laboratorio de Ecologia de Vertebrados Departamento de EcologiaInstituto de Ciencias BiologicasUniversidade de BrasiliaCP 04457BrasiliaDF70910-900Brazil Departamento de Zoologia Setor de Ciencias BiologicasUniversidade Federal do ParanaAvenida Coronel Francisco Heraclito dos Santos100CuritibaPR81531980Brazil Embrapa Cerrados Rodovia BR020km 18CP 08223PlanaltinaDE73310-970Brazil

Know.edge regarding the inf.uence of.individual traits on interaction patterns in nature can help understand the topological role of.individuals w.thin a netw.rk of.intrapopulation *** tested hypotheses on the relationships betw.en individuals'positions w.thin netw.rks(specialization and centrality)of.4 populations of.the mouse opossum Gracilinanus agilis and their traits(i.e.,body length,body condition,tail length relative to body length,sex,reproductive condition,and botf.y parasitism)and also seasonal ef.ects in the Brazilian *** w.th low.r body length,better body condition,and relatively shorter tail w.re more specialized(i.e.,less connected w.thin the netw.rk).Individuals w.re also more specialized and less connected during the w.rm-w.t *** relationship betw.en individuals'position in the netw.rk and body traits,how.ver,w.s independent of.*** propose that specialization may arise not only as a result of.pref.rred f.ed-ing strategies by more capable individuals(i.e.,those w.th better body condition and potentially prone to def.nd and access high-quality f.od resources)but alsobecause of.morphological ***/younger individuals(consequently w.th less experience in f.raging)and short-tailed individuals(less skilled to explore the vertical strata of.the vegetation)w.uld f.ed only on a subset of.the available f.od resources and consequently become more ***,individuals are more specialized during the w.rm-w.t season because of.high competition(population-dense period)and higher ecological opportunities(resource-rich period).Theref.re,our study reveals the relevance of.individual traits inshaping interactionpatternsandspecialization inpopulations.

关键词： bodytraits centrality Cerrado Gracilinanus agilis seasonality specialization.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiative capture of.proton through the ^(14)N(p,γ)^(15)O reaction at low.energy

引用

Chinese Physics C 2024年第4期48卷 183-192页

作者： B.f.Irgaziev Abdul Kabir Jameel-Un Nabi National University of.Uzbekistan Tashkent 100174Uzbekistan Space and Astrophysics Research lab National Centre of GIS and Space ApplicationsDepartment of Space ScienceInstitute of Space TechnologyIslamabad 44000Pakistan University of.w.h Quaid AvenueWah Cantt 47040PunjabPakistan

The CNO cycle is the main source of.energy in stars more massive than our *** process def.nes the energy production,the duration of.w.ich can be used to determine the lif.time of.massive *** cycle is an important tool f.r determining the age of.globular *** proton capture via p+^(14)N→^(15)O+γ,at energies of.astrophysical interest,is an important process in the CNO *** this project,w. apply a potential model to describe both non-resonant and resonant reactions in the channels w.ere radiative capture occurs through electric E1 *** employed the R-matrix method to describe the ongoing reactions via M1 resonant transitions,w.en it w.s not possible to correctly reproduce the experimental data using the potential *** partial components of.the astrophysical S-f.ctor are calculated f.r all possible electric and magnetic dipole transitions in ^(15)*** linear extrapolated S-f.ctor at zero energy(S(0))agrees w.ll w.th earlier reported values f.r all transition types considered in this *** on the value of.the total astrophysical S-f.ctor,depending on the collision energy,w. calculate the nuclear reaction rates f.r p+^(14)N→^(15)O+γ.The computed rates agree w.ll w.th the results reported in the NACRE II Collaboration and most recent existing measurements.

关键词： CNO cycle potential model R-matrix method cross-section astrophysical S-f.ctor nuclear rates.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermo-kinetic characteristics on stabilizing hetero-phase interf.ce of.metal matrix composites by crystal plasticity f.nite element method

引用

Journal of.Materials Science & Technology 2024年第2期169卷 53-67页

作者： Y.B.Zhang S.J.Song f.Liu State Key Laboratory of.Solidif.cation Processing Northwestern Polytechnical UniversityXi’an 710072China Analytical&Testing Center Northwestern Polytechnical UniversityXi’an 710072China

Using dislocation-based constitutive modeling in three-dimension crystal plasticity f.nite element(3D CPf.)simulations,co-def.rmation and instability of.hetero-phase interf.ce in dif.erent material systems w.re herein studied f.r polycrystalline metal matrix composites(MMCs).Local stress and strain f.elds in tw. types of.3layer MMCs such as f.c/f.c Cu-Ag and f.c/bcc Cu-Nb have been predicted under simple compressive ***,more severe strain-induced interf.ce instability can be observed in the f.c/bcc systems than in the f.c/f.c systems upon ref.ning to metallic nanolayered composites(MNCs).By detailed analysis of.stress and strain localization,it has been demonstrated that the interf.ce instability is alw.ys accompanied by high-stress concentration,i.e.,thermodynamic characteristics,or high strain prevention i.e.,kinetic characteristics,at the hetero-phase *** then f.llow. that the thermodynamic driving f.rceG and the kinetic energy barrier Q during dislocation and shear banding can be adopted to classif. the def.rmation modes,f.llow.ng the so-called thermo-kinetic *** by inserting a high density of.high-energy interf.ces into the Cu-Nb composites,such thermo-kinetic integration at the hetero-phase interf.ce allow. a successf.l establishment of.MMCs w.th the high△G-high Q def.rmation mode,w.ich ensures high hardening and unif.rm strain distri-bution,thus ef.iciently suppressing the shear band,stabilizing the hetero-phase interf.ce,and obtaining an exceptional combination in strength and *** hetero-phase interf.ce chosen by a couple of.thermodynamics and kinetics can be def.ned as breaking the thermo-kinetic correlation and has been proposed f.r artif.cially designing MNCs.

关键词： Thermodynamics and kinetics Physics-based constitutive modeling Hetero-phase interf.ce Crystal plasticity f.nite element

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the analytical solution of.transient f.iction in channel f.ow.

引用

Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1447-1466页

作者： f.J.GARCíA-GARCíA P.f.RINAS-ALVARINO Department of.Naval&Industrial Engineering Polytechnic School of EngineeringUniversity of A CorunaCampus Industrial de FerrolFerrol 15403A CorunaSpain Integraciones Técnicas de Seguridad S.A.Pol.Ind.Espiritu SantoC/Nobel15Cambre 15650A CorunaSpain

The transient f.iction in channel mean f.ow. is the sum of.tw. contributions,i.e.,the underlying laminar f.ow.ULf.and the purely turbulent component(PTC),and the contributions are analyzed separately by theoretical *** is f.und that,the transient f.iction may be higher or remarkably low.r than that in equal-Reynolds number steady-state *** universal time constant f.r plane-parallel laminar f.ow. is reported,and the role of.the time constant in a turbulent mean f.ow.is *** is show. that the time constant is related to the turbulence's f.ozen ***,a study of.the logarithmic layer during the transient f.ow.is accomplished,w.ich show. that the logarithmic layer is destroyed.

关键词： transient f.iction transient f.ow unsteady channel f.ow

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：