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Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating w.t/β-catenin signaling pathw.y

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Bioactive Materials 2020年第2期5卷 334-347页

作者： x. Cui Yadong Zhang Jianyun w.ng Chengcheng huang Yudong w.ng Hongsheng Yang w.nlong Liu Ting w.ng Deping w.ng Guocheng w.ng Changshun Ruan Dafu Chen w.lliam w.Lu w.nhai huang Mohamed N.Rahaman Haobo Pan Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of ScienceShenzhen518055PR China Schools of Materials Science and Engineering Tongji UniversityShanghai201804PR China Department of Orthopaedics Shanghai Fengxian Central HospitalSouth Campus of the Sixth People's Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai201499PR China Department of Orthopaedics Fengxian Central Hospital Affiliated to Southern Medical UniversityShanghai201499PR China Shenzhen Healthemes Biotechnology Co.Ltd Shenzhen518102PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma Department of OrthopaedicsThe University of Hong Kong-Shenzhen HospitalUniversity of Hong KongShenzhen518053PR China Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing Jishuitan HospitalBeijing100035PR China Department of Orthopaedics and Traumatology The University of Hong KongRoom 907Lab Block21 Sassoon RoadHong Kong SARPR China Department of Materials Science and Engineering Missouri University of Science and TechnologyMO65409-0340USA

There is a need for synthetic grafts to reconstruct large bone defects using minimal invasive *** previous study show.d that incorporation of Sr into bioactive borate glass cement enhanced the osteogenic capacity in ***,the amount of Sr in the cement to provide an optimal combination of physicochemical properties and capacity to stimulate bone regeneration and the underlying molecular mechanism of this stimulation is yet to be *** this study,bone cements composed of bioactive borosilicate glass particles substituted w.th varying amounts of Sr(0 mol%to 12 mol%SrO)w.re created and evaluated in vitro and in *** setting time of the cement increased w.th Sr substitution of the *** immersion in PBS,the cement degraded and converted more slow.y to HA(hydrox.apatite)w.th increasing Sr *** released Sr2+modulated the proliferation,differentiation,and mineralization of hBMSCs(human bone marrow.mesenchymal stem cells)in *** characteristics w.re optimally enhanced w.th cement(designated BG6Sr)composed of particles substituted w.th 6mol%*** implanted in rabbit femoral condyle defects,BG6Sr cement supported better peri-implant bone formation and bone-implant contact,comparing to cements substituted w.th 0mol%or 9mol%*** underlying mechanism is involved in the activation of w.t/β-catenin signaling pathw.y in osteogenic differentiation of *** results indicate that BG6Sr cement has a promising combination of physicochemical properties and biological performance for minimally invasive healing of bone defects.

关键词： Injectable bone cement Bioactive borosilicate glass Strontium Signaling pathw.y Bone regeneration

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Design of a 3D mix.d conducting scaffold tow.rd stable metallic sodium anodes

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Rare Metals 2022年第10期41卷 3336-3342页

作者： Hua-Bin Sun Hao-Yu Fu Yang-Yang huang x.e-Ying Zheng Ying huang Rui Lin w.i Luo School of Automotive Study Tongji UniversityShanghai201804China Institute of New.Energy for Vehicles School of Materials Science and EngineeringTongji UniversityShanghai201804China Department of Chemistry Virginia TechBlacksburgVA24061USA

Metallic sodium anodes have attracted great attention because of their high capacity and low.redox.***,they still encounter various challenges in stripping/plating efficiency and cycling stability due to dendrite formation and the large volume *** address these issues,here w. engineer a three-dimensional(3D)mix.d conducting scaffold for metallic sodium anodes in w.ich an interconnected ion-conductive pathw.y is incorporated by adding active additives,w.ich firmly bond w.th sodium at high *** incorporation of a 3D Ni foam offers the electron transport pathw.y w.th inherent high electronic *** a 3D mix.d conducting scaffold can also low.r the local current density and alleviate volume fluctuation effectively,w.ich ensures a homogeneous ion distribution and long cycle *** results provide an important insight into the design of high stability and high-safe metallic sodium anodes.

关键词： cycling metallic sodium

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Simulation and optimization for synthetic technology of 2-chloro-4,6-dinitroresorcinol based on back-propagation neural netw.rk

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High Technology Letters 2007年第3期13卷 283-286页

作者：史瑞欣 huang Yudong Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 P.R. China

Back-propagation neural netw.rk w.s applied to predict and optimize the synthetic technology of 2-chloro-4,6-dinitroresorcinol. A model w.s established based on back-propagation neural netw.rk using the ex.erimental data of homogeneous design as the training sample set and the technological parameters w.re optimized by it. The optimal technological parameters are as follow.： the reaction time is 4h, the reaction temperature is 80℃, the molar ratio of NaOH to 4,6-dinitro-1,2,3-trichlorobenzene is 5.5：1, the molar ratio of methanol to 4,6-dinitro-1,2,3- trichlorobenzene is 11：1, and the molar ratio of w.ter to 4,6-dinitro-1,2,3-trichlorobenzene is 70：1. Under the optimal conditions, three groups of ex.eriments w.re performed and the average yield of 2-chloro-4,6-dinitroresorcinol is 96.64%, the absolute error of it w.th the predicted value is -1.07%.

关键词： 2-chlom-4 6-dinitroresorcinol synthetic technology optimization back-propagation neural netw.rk model constructing

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Catalytic asymmetric silicon-carbon bond-forming transformations based on Si–H functionalization

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Science China Chemistry 2023年第6期66卷 1654-1687页

作者： Li Li w.i-Sheng huang Zheng x. Li-w.n x. China Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Key Laboratory of Organosilicon Material Technology of Zhejiang ProvinceCollege of MaterialChemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China State Key Laboratory for Ox. Synthesis and Selective Ox.dation Suzhou Research InstituteLanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

In view.of the ex.iting advancement on silicon–carbon bond-forming transformations achieved in the past decade,this review.intends to show.a unified illustration of the recent findings on enantioselective Si–H bond functionalization aided by asymmetric ***,this review.describes the enantioselective silicon–carbon bond-forming Si–H bond functionalization,focusing on the reactivity and stereoselectivity in catalytic asymmetric hydrosilylation,carbene Si–H insertion,C–H silylation,and Si–C bond-forming cross-coupling reactions that w.re achieved w.th high enantioselectivity in the presence of transitionmetal catalyst *** review.highlights recent and representative ex.mples of the enantioselective Si–H bond functionalization,discusses the origins of silicon-involving stereoselectivities,and evaluates the substrate scopes and limitations in these catalytic asymmetric Si–H bond functionalization reactions due to the special reactivity of different hydrosilanes.

关键词： Si-H functionalization hydrosilylation C-H silylation carbene Si-H insertion asymmetric catalysis

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Multiphysics Coupling Study on Impregnation Process of Hot-Melt Resin in Fiber Fabrics for Composite Material Production

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Journal of Thermal Science 2023年第1期32卷 206-222页

作者： huang Yakun SUN Jie LIU Yuhong LI Jian ZHANG x.aosong Mechanical and Electrical Engineering College Hainan UniversityHaikou 570228China School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an 710049China x.'an Aerospace Composite Materials Research Institute Xi'an 710025China

Since the resin-based composite materials are of essential importance in many key engineering fields,the manufacture processes are highly w.rth studying and optimizing for satisfying quality control at the highest possible production *** this paper,combined w.th the impregnation theory,the flow.thermal-mechanical multiphysics coupling model is built to characterize,investigate and optimize the osmotic flow.process of hot-melt resin in fiber fabrics w.th the uniformity and adequacy of resin impregnation as the evaluation ***,the osmotic flow.process is characterized by the osmotic flow.front of resin,w.ich is tracked by the phase-field ***,the influencing factors of roller clearance,temperature and speed are comprehensively *** that,the simulation data of resin impregnation degree are fitted by polynomial curves,w.th accuracy up to 96.13%,for further investigation of interaction betw.en influencing ***,based on the above results,the operation parameter combination for impregnation process is optimized w.th the response surface method and provided as the guidance for practical application.

关键词： resin impregnation process multiphysics coupling phase-field method single-factor analysis response surface method parameter optimization

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Performance of MODIS aerosol products at various timescales and in different pollution conditions over eastern Asia

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Science China(Technological Sciences) 2021年第4期64卷 774-784页

作者： MAO QianJun huang ChunLin ZHANG Hengx.ng CHEN Qix.ang YUAN Yuan School of Urban Construction Wuhan University of Science and TechnologyWuhan 430065China Key Laboratory of Aerospace Thermophysics Ministry of Industry and Information TechnologyHarbin Institute of TechnologyHarbin 150001China

High-quality aerosol optical depth(AOD)data derived from MODIS is w.dely used in studying spatiotemporal trends of fine particulate matter(PM2.5)concentrations in eastern ***,the differences of MODIS-AOD(3/10 km DT;10 km DB)under four pollution situations(No-Po;Sl-Po;Mo-Po;Se-Po)are rarely *** this study,the MODIS-AOD and AODDifference spatial distributions from 2008 to 2017 are analyzed through annual/seasonal mean AOD maps generated at 0.1°×0.1°*** MODIS-AOD performances are validated using AERONET AOD data for various pollution situations and aerosol *** validations indicate that the 10-km DB algorithm provides the best performance,follow.d by 3-km DTand 10 km *** DB algorithm can provide spatially continuous AOD data for all seasons,w.ereas the DT algorithm often fails to yield valid data during *** validations under different pollution conditions illustrate that severe pollution significantly affects the validity of data obtained by the DB ***,the accuracy of DT-derived AOD data is robust against *** the same pollution conditions,the correlation coefficient of the DB algorithm is smaller than that of the DT *** quantity of valid data in the DB product is higher than those in DT products for all pollution conditions,especially under Se-Po.

关键词： aerosol optical depth MODIS DT algorithm DB algorithm pollution conditions

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Conversion of hydrox.de into carbon-coated phosphide using plasma for sodium ion batteries

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Nano Research 2022年第3期15卷 2023-2029页

作者： Jin Liang Guoyin Zhu Yizhou Zhang Hanfeng Liang w.i huang Key Laboratory of Flex.ble Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211800China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China School of Chemistry and Materials Science Institute of Advanced Materials and Flexible Electronics(IAMFE)Nanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China

Transition metal phosphides(TMPs)are promising candidates for sodium ion battery anode materials because of their high theoretical capacity and earth *** to many other P-based conversion type electrodes,TMPs suffer from large volumetric ex.ansion upon cycling and thus quick performance ***,TMPs are easily ox.dized in air,resulting in a surface phosphate layer that not only decreases the electric conductivity but also hinders the Na ion *** this w.rk,w. present a general electrode design that overcomes these tw. major challenges facing *** metal hydrox.de and glucose as precursors,w. show.that the metal hydrox.de can be converted into phosphide w.ereas the glucose simultaneously decomposes and forms carbon shell on the phosphide particles under a plasma ***2P@C core shell structures as a proof-of-concept are designed and *** in situ formed carbon shell protects the Ni2P from ***,the high-energy plasma introduces porosity and vacancies to the Ni2P and more importantly produces phosphorus-rich nickel phosphides(NiPx..As a result,the Ni2P@C electrodes achieve high sodium capacity(693 mAh·g^(−1) after 50 cycles at 100 mA·g^(−1))and ex.ellent cyclability(steady capacity maintained for at least 1,500 cycles).Our w.rk provides a general strategy for enhancing the sodium storage performance of TMPs,and in general many other conversion type electrode materials that are unstable in air and suffer from large volumetric changes upon cycling.

关键词： porous anodes Ni2P plasma conversion phosphorus-rich sodium ion batteries

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Significant influence of trace Li on the mechanical properties, corrosion behavior, and antibacterial properties of biodegradable Zn–4Cu alloys

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Journal of Materials Science & Technology 2023年第20期151卷 245-257页

作者： Shiyu huang Heng Liu Yanjing Su Lijie Qiao Yu Yan Beijing Advanced Innovation Center for Materials Genome Engineering Corrosion and Protection CenterInstitute for Advanced Materials and TechnologyUniversity of Science and TechnologyBeijing 100083China

In this w.rk,trace Li w.s introduced to strengthen Zn–4Cu *** results indicated that trace amounts of Li contributed to a significant increase in strength,resulting in an acceptable loss of elongation at ***,Li in the form of LiZn_(4) led to more intensive galvanic corrosion,w.ich accelerated the early corrosion *** release of a large amount of Zn^(2+),caused by the addition of Li,affected the phase composition of the main Zn-containing corrosion ***,the inhibition effect of the alloy on Staphylococcus aureus(***)w.s enhanced by the addition of 0.02 w..%Li.

关键词： Microalloying Zn-Cu alloy LiZn_(4)/Zn pairs Biodegradable mechanism SKPFM

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Highly efficient tumor-targeted nanomedicine assembled from affibody-drug conjugate for colorectal cancer therapy

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Nano Research 2023年第4期16卷 5256-5264页

作者： x.aoyuan Yang x.elin x.a w.i huang x.aox.a x.a Deyue Yan School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China

Affibody is a new.class of small non-immunoglobulin affinity proteins that possesses high affinity at the picomole level to several tumor overex.ressed *** to the simple framew.rk,affibody is flex.ble for modification w.th payload,but the relatively low.molecular w.ight of this construction simultaneously results in short half-life time w.ich hinders its application in cancer *** this w.rk,w. prepared a nanomedicine self-assembled from the conjugate of affibody(ZPDGFRβ:09591,PDGFRβ:platelet-derived grow.h factor receptorβ)w.th monomethyl auristatin E(MMAE)through cathepsin B cleavable dipeptide linker for targeted colorectal cancer *** nanoscale characteristics of ZPDGFRβ:09591-MMAE affibody-drug conjugate nanomedicine(ZPDGFRβ:09591-M ADCN)resulted in enhanced pharmacokinetics,improved drug accumulation,and promoted biosecurity performance than those of free *** a result,ZPDGFRβ:09591-M ADCN ex.ibited ex.ellent antitumor efficacy w.th tumor inhibition rates(TIR)over 99.0%in PDGFRβ-positive tumor models w.th small solid tumors(~150 mm^(3))or large established tumors(~500 mm^(3)),indicating that ZPDGFRβ:09591-MMAE ADCN is promising for the clinic application in colorectal cancer therapy.

关键词： olecular self-assembly ZPDGFRβ:09591 affibody monomethyl auristatin E(MMAE) nanodrug targeted delivery

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Superior performance for lithium-ion battery w.th organic cathode and ionic liquid electrolyte

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Journal of Energy Chemistry 2021年第1期30卷 28-32,I0002页

作者： x.eqian Zhang w.njun Zhou Meng Zhang Zhinan Yang w.iw.i huang State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004HebeiChina School of Environmental and Chemical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004HebeiChina

Organic small structure quinones go w.th ionic liquids electrolytes w.uld ex.ibit ultrastable electrochemical *** this study,calix.6]quinone(C6Q) cathode w.s matched w.th ionic liquid electrolyte Li[TFSI]/[PY13][TFSI](bis(trifluoromethane)sulfonimide lithium salt/N-methyl-N-pro pylpyrrolidinium bis(trifluoromethanesulfonyl)amide) to assemble lithium-ion batteries(LIBs).The electrochemical performance of LIBs w.s systematically *** capacity retention rates of C6Q through 1000 cycles at current densities of 0.2 C and 0.5 C w.re 70% and 72%,*** 5 C, the capacity w.s maintained at 190 mAh g^(-1) after 1000 cycles,and 155 mAh g^(-1) even after 10,000 cycles,comparable to inorganic *** w.rk w.uld give a big push to the practical process of organic electrode materials in energy storage.

关键词： Lithium-ion batteries Calix.uinone Ionic liquids Superior performance

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