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Harboring CAR-t cells using an injectable scaffold to treat solid tumors

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National Science Review 2024年第5期11卷 91-92页

作者： Li tang Institute of Bioengineering (IBI) école polytechnique fédérale de Lausanne (EPFL)

Genetic expression of chimeric antigen receptors (CAR) enables t cells to target and kill cancer cells in an MHCindependent manner, resulting in a potent antitumor response [1]. to date, more than 10 CAR-t cell products have been approved globally for the treatment of hematologic disorders such as relapsed/refractory B-cell acute lymphoblastic leukemia, non-Hodgkin lymphoma, and multiple myeloma [2,3].

关键词： IMMUNOtHERAPY CANCER

Spatiotemporal mapping of(ultra‐)mafic magmatic mine areas:Implications of economic and political realities in China

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Deep Underground Science and Engineering 2024年第1期3卷 91-102页

作者： Heling Li Liang tang tim t.werner Zhengmeng Hou Fan Meng Jingjing Li College of Earth Sciences Chengdu University of TechnologyChengduChina Institute of Subsurface Energy Systems Clausthal University of TechnologyClausthal ZellerfeldGermany School of Geography Earth and Atmospheric SciencesFaculty of ScienceThe University of MelbourneMelbourneVictoriaAustralia

the spatiotemporal extension/expansion of mine areas is affected by multiple *** far,very little has been done to examine the interaction between mine areas and political or economic ***(ultra‐)mafic magmatic mines in China played a specific role in supporting national development and providing an ideal research subject for monitoring their *** this study,remote sensing and mining‐related GIS data were used to identify and analyze 1233(ultra‐)mafic magmatic mine area polygons in China,which covered approximately 322.96 km2 of land and included a V–ti–Fe mine,a copper–nickel mine,a chromite mine,an asbestos mine,and a diamond *** was found that(1)the areal expansion of mines is significantly related to the mine types,perimeter,topography,and population density.(2)the mine area variation also reflects market and policy *** temporal expansion of the mine area from 2010 to 2020 followed an S‐shaped pattern(with the turning point occurring in 2014),closely related to iron overcapacity and tightened mining policies.(3)the complexity(D)of the mine area may reflect mine design and excavation *** be specific,lower D indicates early‐stage or artisanal/small‐scale mining,whereas higher D represents large‐scale *** study demonstrates that the detailed mapping of mine land can serve as an indicator to implement miningrelated market and policy ***(ultra‐)mafic mines area data set can be accessed at https://***/record/7636616#.Y-p0uXaZOa0.

关键词： complexity mine area mining and socioeconomic interaction spatiotemporal distribution (ultra‐)mafic magmatic mine

Single-cell RNA sequencing in juvenile idiopathic arthritis

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Genes & Diseases 2024年第2期11卷 633-644页

作者： Xiwen Luo Xuemei tang Department of Rheumatology and Immunology Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Child Infection and Immunity Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China

Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children,with onset before age 16 and lasting for more than 6 *** is a highly heterogeneous condition with various consequences for health and quality of *** some JIA patients,early detection and intervention remain *** a result,further investigation of the complex and unknown mechanisms underlying JIA is *** in technology now allow us to describe the biological heterogeneity and function of individual cell populations in *** this review,we hope to provide novel ideas and potential targets for the diagnosis and treatment of JIA by summarizing the current findings of single-cell RNA sequencing studies and understanding how the major cell subsets drive JIA pathogenesis.

关键词： Juvenile idiopathic arthritis Macrophage Macrophage activation syndrome Monocyte Single-cell RNA sequencing Synoviocyte t cell

Supported Recyclable Metal-free Frustrated Lewis Pair Catalyst for Catalytic Hydrogenation of Substituted Pyridines to Piperidines

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Chemical Research in Chinese Universities 2024年第4期40卷 682-689页

作者： MA Shaohua tang Zhiyong CAS Key Laboratory for Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing100190P.R.China University of Chinese Academy of Sciences Beijing100049P.R.China

the construction of heterogeneous frustrated Lewis pairs(FLPs)catalysts is crucial for realizing highly efficient and recyclable pyridines catalytic *** this work,we prepared a recyclable heterogenous FLPs catalyst CMP-BF with conjugated microporous polymer CMP-ethynyl as the support via self-catalyzed 1,1-carboboration reaction with commercial Lewis acid B(C_(6)F_(5))_(3).the as-synthesized CMP-BF demonstrates superior heterogenous catalytic hydrogenation performance(conversion>99%),and considerable stability(84%conversion after three cycles)in recyclable hydrogenation of 2,*** work provides insights into the fabrication and catalytic application of recyclable heterogenous FLP catalysts.

关键词： Pyridine hydrogenation Frustrated Lewis pair Conjugated microporous polymer

Homological transfer between Additive Categories and Higher Differential Additive Categories

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1325-1344页

作者： Xi tang Zhao Yong HUANG School of Science Guilin University of Aerospace TechnologyGuilin 541004P.R.China Department of Mathematics Nanjing UniversityNanjing 210093P.R.China

Given an additive category C and an integer n≥*** higher differential additive category consists of objects X in C equipped with an endomorphism ϵ_(X)satisfying ϵ_(X)^(n).Let R be a,finite-dimensional basic algebra over an algebraically closed field and t the augmenting functor from the category of finitely generated left R-modules to that of finitely generated left R/(t^(n))-*** is proved that a finitely generated left R-module M isτ-rigid(respectively,(support)τ-tilting,almost completeτ-tilting)if and only if so is t(M)as a left R[t]/(t^(n))-***,R isτm-selfinjective if and only if so is R[t]/(t^(n)).

关键词： Higher differential objects wakamatsu tilting subcategories G_(ω)-projective modules sup-portτ-tilting modules τ_(m)-selfinjective algebras precluster tilting subcategories

A Least-squares-based Iterative Method with Better Convergence for PF/OPF in Integrated transmission and Distribution Networks

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 953-962页

作者： Kunjie tang Shufeng Dong Yonghua Song College of Electrical Engineering Zhejiang UniversityHangzhou 310027China State Key Laboratory of Internet of things for Smart City and Department of Electrical and Computer Engineering University of MacaoMacao SARChina IEEE

the limitations of the conventional master-slavesplitting(MSS)method,which is commonly applied to power flow and optimal power flow in integrated transmission and distribution(I-t&D)networks,are first *** that the MSS method suffers from a slow convergence rate or even divergence under some circumstances,a least-squares-based iterative(LSI)method is *** with the MSS method,the LSI method modifies the iterative variables in each iteration by solving a least-squares problem with the information in previous iterations.A practical implementation and a parameter tuning strategy for the LSI method are ***,a LSI-PF method is proposed to solve I-t&D power flow and a LSIheterogeneous decomposition(LSI-HGD)method is proposed to solve optimal power *** experiments demonstrate that the proposed LSI-PF and LSI-HGD methods can achieve the same accuracy as the benchmark ***,these LSI methods,with appropriate settings,significantly enhance the convergence and efficiency of conventional ***,in some cases,where conventional methods diverge,these LSI methods can still converge.

关键词： Fixed-point theory integrated transmission and distribution networks least-squares-based iterative method master-slave-splitting method optimal power flow power flow

U-Pb zircon ages and petrogeochemistry and tectonic implications of gabbro and granite in southwest Lahad Datu area of Sabah, Malaysia

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Acta Oceanologica Sinica 2024年第2期43卷 94-110页

作者： Zhigang Zhao wu tang Shixiang Liu Huafeng tang Pujun wang Zhiwen tian China National Offshore Oil Corporation(CNOOC)Research Institute Co. Ltd.Beijing 100028China College of Earth Sciences Jilin UniversityChangchun 130061China

the southwest Lahad Datu felsic rocks were previously thought to have formed in the late triassic as part of the microcontinental crystalline *** on U-Pb ages,geochemistry,and the Hfisotopes of zircon from the southeastern Sabah gabbro and granite,in this study,the tectonic properties of the Sabah area during the triassic were *** weighted average U-Pb zircon ages of the gabbro and granite samples were determined to be(230.9±2.5)Ma and(207.1±3.3)Ma,*** granite had SiO_(2) contents of 66.54%-79.47%,low tiO_(2) contents of 0.08%-0.3%,Al_(2)O_(3) contents of 10.97%-16.22%,Na_(2)O contents of 5.91 %-6.39%,and low K_(2)O contents of 0.15%-0.65%.the chondrite-normalized rare earth element(REE) patterns exhibit light REE enrichment,with right-sloping *** primitive mantle-normalized trace element spider diagrams exhibit th,U,La,Sr,and Zr enrichment and Nb,ta,P and ti depletions,i.e.,the geochemical characteristics of typical island arc igneous *** tectonic discriminant diagram indicates that the granite is a volcanic arc *** Hf isotopic an alysis of gabbro zircon revealed that the zircons have ε_(Hf)(t)values of 12.08-16.24(mean of 14.32) and two-stage model ages(t_(DM2)) of 223-491 Ma(mean of 347 Ma).this indicates that the diagenetic magma of the gabbro was mainly derived from melting of newly formed crustal *** ophiolite in southeast Sabah has existed since the early Late *** crystalline basement granite in southeastern S abah was emplaced lasted from late triassic to early *** on previous studies and global plate reconstruction models,it is speculated that the southeastern Sabah granite may have been formed in an island arc setting,i.e.,where the oceanic crust of the Paleo-tethys Ocean collided with the oceanic crust of the Panthalassa Ocean.

关键词： Sabah early late triassic ophiolite granite tectonic properties

Digital twin-Assisted Semi-Federated Learning Framework for Industrial Edge Intelligence

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China Communications 2024年第5期21卷 314-329页

作者： wu Xiongyue tang Jianhua Marie Siew Shien-Ming wu School of Intelligent Engineering South China University of TechnologyGuangzhou 511442China Electrical and Computer Engineering Department Carnegie Mellon UniversityPittsburghPA 15213United States

the rapid development of emerging technologies,such as edge intelligence and digital twins,have added momentum towards the development of the Industrial Internet of things(IIo t).However,the massive amount of data generated by the IIo t,coupled with heterogeneous computation capacity across IIo t devices,and users’data privacy concerns,have posed challenges towards achieving industrial edge intelligence(IEI).to achieve IEI,in this paper,we propose a semi-federated learning framework where a portion of the data with higher privacy is kept locally and a portion of the less private data can be potentially uploaded to the edge *** addition,we leverage digital twins to overcome the problem of computation capacity heterogeneity of IIo t devices through the mapping of physical *** formulate a synchronization latency minimization problem which jointly optimizes edge association and the proportion of uploaded nonprivate *** the joint problem is NP-hard and combinatorial and taking into account the reality of largescale device training,we develop a multi-agent hybrid action deep reinforcement learning(DRL)algorithm to find the optimal *** results show that our proposed DRL algorithm can reduce latency and have a better convergence performance for semi-federated learning compared to benchmark algorithms.

关键词： digital twin edge association industrial edge intelligence(IEI) semi-federated learning

Bioinspired synthesis of cochlearol B and ganocin A

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Chinese Chemical Letters 2024年第7期35卷 242-246页

作者： Zhenhao wang Yuliang tang Ruyu Li Shuai tian Yu tang Dehai Li Key Laboratory of Marine Drugs Chinese Ministry of Education/Sanya Oceanographic Institute Ocean University of ChinaQingdao 266003/Sanya 572025China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and TechnologyQingdao 266237China Marine Biomedical Research Institute of Qingdao Ocean University of ChinaQingdao 266071China

Described here is a divergent,biosynthetically inspired synthesis of cochlearol B and ganocin *** steps of the synthesis include the chromene unit construction through a biomimetic acid-catalyzed[4+2]ring cyclization.A photochemical[2+2]cycloaddition was featured to construct the cyclobutane core of cochlearol *** skeletal rearrangements of cochlearol B afforded ganocin A,that one of them was Lewis acid mediated epoxide rearrangement and another was DDQ induced cyclobutane formed tetrahydrofuran *** described syntheses not only achieved these natural products in an efficient manner,but also provided insight into the biosynthetic relationship between the two different skeletons.

关键词： Biomimetic rearrangement Avarane skeleton Cascade reactions Lewis acid total synthesis