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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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multiple Antibiotic Resistance and Heavy metal Resistance Profile of Bacteria Isolated from Giant Freshwater Prawn (macrobrachium rosenbergii) Hatchery

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Agricultural Sciences in China 2009年第6期8卷 740-745页

作者： S w Lee m Najiah w wendy A Zahrol m Nadirah Department of Fishery and Aquaculture Faculty of Agrotechnology and Food Science Universiti Malaysia Terengganu

In this article, antibiogram and heavy metal resistance profile of bacteria isolated from giant freshwater prawn （macrobrachium rosenbergii） hatchery in malaysia are described. Although giant freshwater prawn was introduced into malaysia since the 1980s, there was no database information on antibiogram and heavy metal resistance profile of bacteria from giant freshwater prawn （34. rosenbergii） hatchery in malaysia. Therefore, this study was carried out to determine the effectiveness of antibiotic and heavy metal resistance profile to control bacterial diseases in m. rosenbergii hatchery. The results can provide valuable information for local m. rosenbergii post-larval producer. Antibiotic sensitivity test was carried out by disk-diffusion method against 15 types of antibiotics as follows： oxolinic acid （2 μg）, ampicillin （10μg）, erythromycin （15μg）, furazolidone （15 μg）, lincomycin （15μg）, amoxicillin （25 μg）, colistin sulphate （25 μg）, doxycycline （30μg）, florfenicol （30 μg）, flumequine （30 lag）, nalidixic acid （30μg）, tetracycline （30μg）, oleandomycin （15μg）, fosfomycin （50μg）, and spiramycin （100 μg）, whereas heavy metal resistance profile of the present bacterial isolates was determined by 2-fold agar dilution technique. In this study, 5 types of bacteria were successfully isolated; they were Aeromonas spp. （n = 77）, Escherichia coli （n = 73）, Edwardsiella spp. （n = 62）, Salmonella spp. （n = 75）, and Vibrio spp. （n = 43）. The result showed that furazolidone was the most effective antibiotic to control the bacteria isolated in this study, approximately 89.7% of the bacterial isolates were sensitive to this antibiotic. multiple antibiotic resistance （mAR） index indicated that the hatchery water source and m. rosenbergii post-larval and sediment tanks were at high-risk exposure to the tested antibiotic. Furthermore, all the tested heavy metals （Cd2＋, Cr6＋, Hg2＋, and Cu2＋） failed to inhibit the growth of the bacterial isolates. Therefore, it indicated that the water

关键词： macrobrachium rosenbergii hatchery antibiotic heavy metal mAR index

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Formation region of emitted α and heavier particles inside radioactive nuclei

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Chinese Physics C 2020年第7期44卷 118-125页

作者： w.m.Seif A.m.H.Abdelhady Cairo University Faculty of ScienceDepartment of Physics12613 GizaEgypt Beni-Suef University Faculty of Navigation Science and Space Technology62514 Beni-SuefEgypt

we investigate the formation distance(R0)from the center of the radioactive parent nucleus at which the emitted cluster is most probably *** calculations are performed microscopically starting with the solution to the time-independent Schr?dinger wave equation for the cluster-core system,using nuclear potentials based on the Skyrme-SLy4 nucleon-nucleon interactions and folding Coulomb potential,to determine the incident and transmitted wave functions of the *** results show that the emitted cluster is mostly formed in the pre-surface region of the nucleus,under the effect of Pauli blocking from the saturated core *** deeperα-formation distance inside the nucleus allows less preformation probability and indicates a more stable nucleus for a longer ***,theα-particle tends to be formed at a slightly deeper region inside the nuclei,with larger isospin asymmetry,and in the closed shell *** the heavy clusters,we observed that the formation distance of the emitted clusters heavier thanα-particle increased via increasing the isospin asymmetry of the formed cluster rather than by increasing its mass *** partial half-life of a certain cluster-decay mode increased with increase of either the mass number or the isospin asymmetry of the emitted cluster.

关键词： alpha-decay cluster decay Skyrme-SLy4 nucleon-nucleon interaction formation region

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PRECIPITATION BEHAVIOR OF m_(2)N IN A HIGH-NITROGEN AUSTENITIC STAINLESS STEEL DURING ISOTHERmAL AGING

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Acta metallurgica Sinica(English Letters) 2007年第2期20卷 95-101页

作者： F. Shi L.J. wang w.F. Cui C.m. Liu School of materials ＆ metallurgy Northeastern UniversityShenyang 110004 China

The precipitation behavior of m2N and the microstructural evolution in a Cr-mn austenitic stainless steel with a high nitrogen content of 0.43mass% during isothermal aging has been investigated using optical microscopy （ Om）, scanning electron microscopy （SEm）, and transmission electron microscopy （TEm）. The aging treatments have led to the decomposition of nitrogen supersaturated austenitic matrix through discontinuous cellular precipitation. The precipitated cells comprise alternate lamellae of m2N precipitate and austenitic matrix. This kind of precipitate morphology is similar to that of pearlite. However, owing to the non-eutectoidic mechanism of the reaction, the growth characteristic of the cellular precipitates is different from that of pearlite in Fe-C binary alloys. m2N precipitate in the cell possesses a hexagonal crystal structure with the parameters a = 0.4752nm and c = 0.4429nm, and the orientation relationship between the m2V precipitates and austenite determined from the SADP is [01^-10]m2N//[101]γ, [2^-1^-10]m2N//[010]γ.

关键词： austenitic stainless steel high nitrogen microstructureisothermal aging precipitation

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Finding vibrations of inclined cable structures by approximately solving governing equations for exterior matrix

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Applied mathematics and mechanics(English Edition) 2015年第11期36卷 1383-1402页

作者： w.PAULSEN m.mANNING Department of mathematics and Statistics Arkansas State University

In this paper, how to compute the eigenfrequencies of the structures composed of a series of inclined cables is shown. The physics of an inclined cable can be complicated, so solving the differential equations even approximately is difficult. However, rather than solving the system of 4 first-order equations governing the dynamics of each cable, the governing equations are instead converted to a set of equations that the exterior matrix satisfies. Therefore, the exterior matrix method （Emm） is used without solving the original governing equations. Even though this produces a system of 6 first-order equations, the simple asymptotic techniques to find the first three terms of the perturbative solution can be used. The solutions can then be assembled to produce a 6 x 6 exterior matrix for a cable section. The matrices for each cable in the structure are multiplied together, along with the exterior matrices for each joint. The roots of the product give us the eigenfrequencies of the system.

关键词： exterior matrix method (Emm) eigenfrequency inclined cable

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Biosorption of copper ions from dilute aqueous solutions on base treated rubber (Hevea brasiliensis) leaves powder: kinetics, isotherm, and biosorption mechanisms

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Journal of Environmental Sciences 2008年第10期20卷 1168-1176页

作者： w.S.wan Ngah m.A.K.m.Hanafiah School of Chemical Sciences Universiti Sains malaysia Penang 11800 malaysia.

The effciency of sodium hydroxide treated rubber (Hevea brasiliensis) leaves powder (NHBL) for removing copper ions from aqueous solutions has been investigated. The e?ects of physicochemical parameters on biosorption capacities such as stirring speed, pH, biosorbent dose, initial concentrations of copper, and ionic strength were studied. The biosorption capacities of NHBL increased with increase in pH, stirring speed and copper concentration but decreased with increase in biosorbent dose and ionic strength. The isotherm study indicated that NHBL fitted well with Langmuir model compared to Freundlich and Dubinin-Radushkevich models. The maximum biosorption capacity determined from Langmuir isotherm was 14.97 mg/g at 27°C. The kinetic study revealed that pseudo- second order model fitted well the kinetic data, while Boyd kinetic model indicated that film diffusion was the main rate determining step in biosorption process. Based on surface area analysis, NHBL has low surface area and categorized as macroporous. Fourier transform infrared (FT-IR) analyses revealed that hydroxyl, carboxyl, and amino are the main functional groups involved in the binding of copper ions. Complexation was one of the main mechanisms for the removal of copper ions as indicated by FT-IR spectra. Ion exchange was another possible mechanism since the ratio of adsorbed cations (Cu2+ and H+) to the released cations (Na+, Ca2+, and mg2+) from NHBL was almost unity. Copper ions bound on NHBL were able to be desorbed at > 99% using 0.05 mol/L HCl, 0.01 mol/L HNO3, and 0.01 mol/L EDTA solutions.

关键词： copper treated rubber leaves powder kinetics isotherm ion exchange desorption

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macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

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world Journal of methodology 2025年第1期15卷 88-94页

作者： Chinmay mahatme madhurima Kaushik Veerappan Rathinasabapathy Saravanan Karthik Kumar Virna m Shah Department of General Ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Neuro-ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Vitreoretina Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia

BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NmOSD)or myelin oligodendrocyte glycoprotein antibody disease(mOGAD),has a very similar presentation but different prognostic implications and longterm management *** and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated *** the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural *** To study the macular microvascular and structural changes on OCTA in atypical optic *** This observational cross-sectional study involved 8 NmOSD and 17 mOGAD patients,diagnosed serologically,as well as 10 healthy *** vascular density(mVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using *** There was a significant reduction in mVD in NmOSD and mOGAD affected as well as unaffected eyes when compared with healthy *** and mOGAD affected eyes had significant GCIPL thinning compared with healthy *** unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to mOGAD unaffected *** comparing NmOSD with mOGAD,there was no significant difference in terms of mVD or GCIPL in the affected or unaffected *** Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NmOSD and mOGAD cases.

关键词： Optical coherence tomography angiography Atypical optic neuritis macular microvascular changes Neuromyelitis optica spectrum disorders myelin oligodendrocyte glycoprotein antibody disorder

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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world Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele L Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

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Recent applications of carbon-based composites in defence industry: A review

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Defence Technology（防务技术） 2022年第8期18卷 1281-1300页

作者： m.m.Harussani S.m.Sapuan Gohar Nadeem Tahrim Rafin w.Kirubaanand Advanced Engineering materials and Composites Research Centre(AEmC) Department of Mechanical and Manufacturing EngineeringUniversiti Putra Malaysia43400UPM SerdangSelangorMalaysia Laboratory of Biocomposite Technology Institute of Tropical Forestry and Forest Products(INTROP)Universiti Putra Malaysia43400UPM SerdangSelangorMalaysia Department of Civil Engineering Universiti Putra Malaysia43400UPM SerdangSelangorMalaysia Department of Civil Engineering Balochistan University of Engineering&TechnologyKhuzdar89100BalochistanPakistan

Carbon-based composites, including carbon reinforced composites and carbon-matrix composites, in defence technologies have raised a lot of attention due to its significant physical capabilities, superior thermal and mechanical stability, and its eco-friendly nature. Carbon-based composite which incorporating with various carbonaceous materials such as coke, char, black carbon, activated carbon, carbon fibre and other carbon nanomaterials (carbon nanotubes, carbon nanofibres, graphene and graphite) are the greatest viable option for the development of advanced defence technologies. In this review article the characteristics of carbon-based materials and its composites are discussed for their distinct application in defence sectors;aeronautics, maritime, automotive, electronics, energy storage, electromagnetic interference (EmI) shielding and structures. The origin of carbonaceous materials and its production techniques were discussed. Carbon-based composites have a promising future in defence technology, particularly in chemical sensors, drug delivery agents, radar technologies, and nanocomposites due to their low cost, easy availability, flexibility in design and processing.

关键词： Carbon materials Char Carbon CNT Graphene Composite Defence technology

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The boring billion? - Lid tectonics, continental growth and environmental change associated with the Columbia supercontinent

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Geoscience Frontiers 2013年第6期4卷 681-691页

作者： Nick m.w.Roberts NERC Isotope Geosciences Laboratory British Geological SurveyKeyworthNottingham NG12 5GGUK

The evolution of Earth＇s biosphere,atmosphere and hydrosphere is tied to the formation of continental crust and its subsequent movements on tectonic *** supercontinent cycle posits that the continental crust is periodically amalgamated into a single landmass,subsequently breaking up and dispersing into various continental *** is possibly the first true supercontinent,it amalgamated during the 2.0-1.7 Ga period,and collisional orogenesis resulting from its formation peaked at 1.95-1.85 *** and palaeomagnetic evidence indicate that Columbia remained as a quasi-integral continental lid until at least 1.3 *** break-up attempts are evidenced by dyke swarms with a large temporal and spatial range; however,palaeomagnetic and geologic evidence suggest these attempts remained *** than dispersing into continental fragments,the Columbia supercontinent underwent only minor modifications to form the next supercontinent （Rodinia） at 1.1 -0.9 Ga; these included the transformation of external accretionary belts into the internal Grenville and equivalent collisional *** Columbia provides evidence for a form of ‘lid tectonics’,modern style plate tectonics occurred on its periphery in the form of accretionary *** detrital zircon and preserved geological record are compatible with an increase in the volume of continental crust during Columbia＇s lifespan; this is a consequence of the continuous accretionary processes along its *** quiescence in plate tectonic movements during Columbia＇s lifespan is correlative with a long period of stability in Earth＇s atmospheric and oceanic *** variability starting at 1.3 Ga in the environmental record coincides with the transformation of Columbia to Rodinia; thus,the link between plate tectonics and environmental change is strengthened with this interpretation of supercontinent history.

关键词： Rodinia Columbia Supercontinents Continental growth Lid tectonics mesoproterozoic

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