检索结果-南通市图书馆

Rilmenidine prevents blood pressure increase in rats with compromised nitric oxide production

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第12期25卷 74-80页

作者： Mria GEROV,Jozef TRK,Ol’ga pechV,Jana MATUKOV Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute of Pathophysiology Medical School Comenius University Bratislava Slovak Republic Now in Center for Blood Research and Department of Pathology Harvard MedicalSchool Boston USA.

AIM: To search tools of high blood pressure in the model of nitric oxide (NO)-defective hypertension, and the study focused on the effect of rilmenidine, agonist of imidazoline receptors, which was suggested to modulate central sympathetic outflow. METHODS: Three experimental groups, each consisting of 7 rats, were used: (I) rats with inhibition of NO synthase (NOS) by NG-nitro-L-arginine methyl ester (L-NAME) 40 mg·kg-1·d-1 for 4 weeks in drinking water, (II) rats with inhibited NOS as in group I , plus agonist of imidazoline receptors rilmenidine 3 mg·kg-1·d-1 for 4weeks by gavage, and(III) control rats. Systolic blood pressure wasmeasured weekly noninvasively. At the end of experiment aortic ring isometric tension was followed, NOS expression (aorta, left ventricle), and NOS activity (left ventricle and brain) were determined. RESULTS: In the group I systolic blood pressure in- creased significantly, aortic ring relaxation to acetylcholine was significantly attenuated. Rilmenidine administered simultaneously with L-NAME (group II) prevented the increase of blood pressure which did not differ significantly from control values; aortic ring relaxation to acetylcholine did not differ from control. No change in NOS expres- sion (aorta and left ventricle) was found in groups I and II. Significant decline in NOS activity (left ventricle and brain) wasfound in groups I and II. CONCLUSION: Rilmenidinehas aremarkable role inNO-defective hypertension, possibly by inhibiting central sympathetic outflow and by affecting receptors in vascular smooth muscle also. The prime cause of hypertension in this experimental model - the compromised production of NO due to inhibition of NOS - was not affected by rilmenidine.

关键词： NO deficiency hypertension imidazoline receptor nitric-oxide synthase sympathetic activity

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.w.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Sexual signal conspicuity is correlated with tail autotomy in an anoline lizard

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2022年第1期68卷 129-132页

作者： Kelly LinwUTHRICH Derek STOCK Janelle B.talavera Breanna J.PUTMAN Lindsey SwIERK Department of Biological Sciences Binghamton UniversityState University of New YorkBinghamtonNY 13902USA Department of Biology California State UniversityNorthridgeCA 91330-8303USA Department of Biology California State UniversitySan BernardinoCA 92407USA Department of Ecology and Evolutionary Biology University of California621 Young Drive SouthLos AngelesCA 90095-1606USA Department of Herpetology and Urban Nature Research Center Natural History Museum of Los Angeles CountyLos AngelesCA 90007USA School of Forestry and Environmental Studies Yale UniversityNew HavenCT 06511USA Amazon Conservatory for Tropical Studies IquitosLoreto 16001Peru The Morpho Institute Kansas CityMO 64113USA

Sexual selection favors conspicuous signals that animals can use to communicate with conspecifics and/or to attract ***,natural and sexual selection are often in opposition,as conspicuous sexual signals can also be detected by eavesdropping predators,forcing these signals to also evolve in light of natural selection(Andersson 1994).

关键词： signal evolve selection

Effects of a blend of Saccharomyces cerevisiae-based direct-fed microbial and fermentation products on plasma carbonylmetabolome and fecal bacterial community of beef steers

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2020年第2期11卷 504-513页

作者： James A.Adeyemi Sunday O.Peters Marcos De Donato Andres pech Cervantes Ibukun M.Ogunade College of Agriculture Communitiesand the EnvironmentKentucky State UniversityFrankfortKY 40601USA Department of Animal Science Berry CollegeMount BerryGA 30149USA Tecnologico de Monterrey Escuela de Ingenieria y CienciasQueretaroMexico Agricultural Research Station Fort Valley State UniversityFort ValleyGA 31030USA

Background:Previous studies have evaluated the metabolic status of animals fed direct-fed microbial(DFM)using enzyme-based assays which are time-consuming and limited to a few *** addition,little emphasis has been placed on investigating the effects of DFM on hindgut *** examined the effects of dietary supplementation of a blend of Saccharomyces cerevisiae-based DFM and fermentation products on the plasma concentrations of carbonyl-containing metabolites via a metabolomics approach,and fecal bacterial community,via 16S rRNA gene sequencing,of beef steers during a 42-day receiving *** newly weaned steers were randomly assigned to receive a basal diet with no additive(CON;n=20)or a basal diet supplemented with 19 g of Commence™(PROB;n=20)for a 42-day ***™(PMI,Arden Hills,MN)is a blend of 6.2×1011 cfu/g of ***,3.5×1010 cfu/g of a mixture of Enterococcus lactis,Bacillus subtilis,Enterococcus faecium,and Lactobacillus casei,and the fermentation products of these aforementioned microorganisms and those of Aspergillus oryzae and Aspergillus *** d 0 and 40,rectal fecal samples were collected randomly from 10 steers from each treatment *** d 42,blood was collected for plasma ***:A total number of 812 plasma metabolites were *** to 305 metabolites[fold change(FC)≥1.5,FDR≤0.01]including glucose,hippuric acid,and 5-hydroxykynurenamine were increased by PROB supplementation,whereas 199 metabolites(FC≤0.63,FDR≤0.01)including acetoacetate were *** of PROB increased(P≤0.05)the relative abundance of Prevotellaceae UCG-003,Megasphaera,Dorea,Acetitomaculum,and *** contrast,the relative abundance of Elusimicrobium,Moheibacter,Stenotrophomonas,Comamonas,and uncultured bacterium belonging to family p-2534-18B5 gut group(phylum Bacteroidetes)were reduced(P≤0.05).Conclusions:The results of this study demonstrated that supplementation of PROB altered both the plasma carbonyl metab

关键词： Beef steer Carbonyl Fecal bacteria Lactate-utilizing bacteria Plasma metabolomics

Narrow versus broad:sexual dimorphism in the wing form of western European species of the subgenus Avaritia(Culicoides,Ceratopogonidae)

在线全文

学校读者我要写书评

暂无评论

Integrative Zoology 2021年第5期16卷 769-784页

作者： Francesc MUÑOZ-MUÑOZ Nonito PAGÈS Ana.F.DURAO Marion ENGLAND Doreen wERNER Sandra talavera Departament de Biologia Animal de Biologia Vegetal i d’EcologiaFacultat de BiociènciesUniversitat Autònoma de BarcelonaBarcelonaSpain Centre de Recerca en Sanitat Animal(CReSA) UAB-IRTACampus de la Universitat Autònoma de BarcelonaBarcelonaSpain CIRAD UMR ASTREGuadeloupeFrance ASTRE CIRADINRAeUniversitéde MontpellierMontpellierFrance The Pirbright Institute SurreyUK Leibniz-Centre for Agricultural Landscape Research MünchebergGermany

while wing form is known to differ between males and females of the genus Culicoides,detailed studies of sexual dimorphism are *** this study,we analyze sex-specific differences in the wing form of 5 species of the subgenus Avaritia,using geometric morphometrics and comparative phylogenetic *** results confirm the existence of marked sexual dimorphism in the wing form of the studied species and reveal for the first time that while there is a shared general pattern of sexual shape dimorphism within the subgenus,sexual size dimorphism,and particular features of sexual shape dimorphism differ among *** shape dimorphism was found to be poorly associated to size and the evolutionary history of the *** tight association of sexual shape dimorphism with aspect ratio suggests that the shape of the wing is optimized for the type of flight of each sex,that is,dispersal flight in females versus aerobatic flight in ***,the fact that interspecific shape differences are greater and more strongly associated to aspect ratio in males than in females might be indicating that in males the selective pressures affecting flight performance characteristics are more heterogeneous and/or stronger than in females among the studied species.

关键词： aspect ratio geometric morphometrics phylogenetic signal shape size

HVOF-sprayed HAp/S53P4 BG composite coatings on an AZ31 alloy for potential applications in temporary implants

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第1期12卷 345-360页

作者： Carlos A.Poblano-Salas John Henao Astrid L.Giraldo-Betancur Paola Forero-Sossa Diego German Espinosa-Arbelaez Jorge A.González-Sánchez Luis R.Dzib-Pérez Susana T.Estrada-Moo Idelfonso E.pech-pech CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-Cinvestav Libramiento Norponiente#2000.Fraccionamiento Real de JuriquillaQuerétaro 76230Mexico Universidad Tecnológica de Querétaro Av.Pie de la Cuesta N°2501Querétaro 76148Mexico CIDESI Av.Playa Pie de la Cuesta No 702Col.San PabloQuerétaro 76125Mexico Center for Corrosion Research Autonomous University of CampecheAv.Héroe de Nacozari No.480P.C.24070San Francisco de CampecheCam.Mexico

Bioactive thermal spray coatings produced via high-velocity oxygen fuel spray(HVOF)from hydroxyapatite(HAp)and bioactive glasses(BG)have the potential to be employed on temporary implants due to the ability of both HAp and BG to dissolve and promote osseointegration,considering that both phases have different reaction and dissolution rates under in-vitro *** the present work,75%***-25%wt.S53P4 bioactive glass powders were HVOF-sprayed to obtain HAp/S53P4 BG composite coatings on a bioresorbable AZ31 *** study is focused on exploring the effect of the stand-off distance and fuel/oxygen ratio variation as HVOF parameters to obtain stable structural coatings and to establish their effect on the phases and microstructure produced in those *** characterization techniques,such as scanning electron microscopy,X-ray diffraction,and Fourier transform infrared spectroscopy,were employed to characterize relevant structural and microstructural properties of the composite *** results showed that thermal gradients during coating deposition must be managed to avoid delamination due to the high temperature achieved(max 550℃)and the differences in coefficients of thermal *** was also found that both spraying distance and oxygen/fuel ratio allowed to keep the hydroxyapatite as the main phase in the *** addition,in-vitro electrochemical studies were performed on the obtained HAp/S53P4 BG composite coatings and compared against the uncoated AZ31 *** results showed a significant decrease in hydrogen evolution(at least 98%)when the bioactive coating was applied on the Mg alloy during evaluation in simulated body fluid(SBF).

关键词： Coatings Composites Thermal spray Temporary implants Hydrogen evolution

Effect of brazing parameters on fillet size and microstructure of cladded fin-microchannel tube joints

在线全文

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2020年第12期30卷 3240-3253页

作者： J.C.GUÍA-TELLO M.I.pech-CANUL E.TRUJILLO-VÁZQUEZ M.A.pech-CANUL centro de investigación en materiales avanzados(cimav) laboratorio nacional de nanotecnologíamiguel de cervantes no.120chihuahuachi8.31136méxico centro de investigación y de estudios avanzados del instituto politécnico nacional-unidad saltillo av.industria metalúrgica no.1062parque industrial saltillo-ramos arizperamos arizpecoahuila25900méxico conacyt-facultad de ciencias físico matemáticas benemérita universidad autónoma de pueblaav.san claudiocd universitariajardines de san manuelpueblapuebla72570méxico cinvestav-mérida km 6 ant.carr.a progresoap 73 cordemexméridayu3.97310méxico

This work concerns the optimization of furnace brazing conditions for joining micro-multiport aluminum tubes and fins made with AA4343/AA3003/AA4343 brazing sheet in mini-assemblies mimicking the core of an automotive heat *** method was used for design of experiment,considering five process parameters with two levels of *** aim was to maximize the fillet size of the brazed joints,which has an important influence on the thermal integrity and mechanical *** length measurements of brazed joints were performed with a metallographic *** statistical analysis allowed to obtain the optimum values of process parameters(peak temperature,residence time,heating rate,microchannel tube type and flux).At a 95%confidence level,the variability of fillet length is most significantly affected by the peak brazing temperature(77%),residence time(15%)and heating rate(7%).The predicted maximum fillet length was(152±11)μm,which was corroborated by confirmation *** microstructural analysis of tube−fin joints showed that variations in peak temperature and residence time affect only the size of the eutectic zone of fillet formed,but not the nature or composition of the constituent phases.

关键词： brazing cladded fin Taguchi method fillet size microstructure aluminum peak temperature optimization

Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Jing-wen Xie Meng-Ting wang Yan Jin Si Li Jian-Hua Qin Shuang-Quan Zang Tomas C.w.Mak College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry and Chemical Engineering Luoyang Normal University Department of Chemistry The Chinese University of Hong Kong

Circularly polarized luminescence （CPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for CPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a Cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with Cd2+ions to obtain 2D layers structure,L/*** L/D-Cu4-Cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and CPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the wLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

关键词：

Soil ecosystem changes by vegetation on old-field sites over five decades in the Brazilian Atlantic forest

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2022年第2期33卷 667-677页

作者： Danielle Cristina Ortiz Tancredo Augusto Feitosa de Souza Tatiani Maria pech Marie Luise Carolina Bartz Dilmar Baretta Alexandre Siminski Júlia Carina Niemeyer Federal University of Santa Catarina Ulysses Gaboardikm 3CuritibanosSC 89520-000Brazil Postgraduate Programme in Agricultural and Natural Ecosystems(PPGEAN) Federal University of Santa CatarinaUlysses Gaboardikm 3CuritibanosSC 89520-000Brazil Centre for Functional Ecology Department of Life SciencesUniversity of Coimbra3000-456 CoimbraPortugal Department of Animal Science UDESC OesteSanta Catarina State UniversityChapecóSC 89815-630Brazil

Vegetation types alter soil ecosystems by changing soil fauna community activities and soil physi-cal-chemical ***,it is unclear how tree species(natural forest,native and exotic tree plantations)promote changes in the soil ecosystem,and if these changes alter functional groups of soil fauna and ecosystem *** determine the effects of five decades of old-field veg-etation on soil ecosystems in the Brazilian Atlantic Forest,field sampling of three ecosystems(exotic tree species Pinus elliottii ***,endangered tree species Arau-caria angustifolia(Bertol.)Kuntze plantation,and a natural ecosystem)were carried out,as well using bait-lamina tests and bioassays with collembolans,earthworms and seeds of Lactuca sativa *** sampling evaluated the soil fauna community and soil physical-chemical *** bait-lamina test in situ was carried out for 14-days to deter-mine fauna feeding activity,and the bioassays evaluated the reproduction of Folsomia candida,the avoidance of Eisenia andrei,and germination of *** in the soil from each *** results are:(1)vegetation type altered the soil fauna community composition;(2)soil fauna feeding was reduced in the plantations compared to the natural eco-system;(3)a physical barrier was created by recalcitrant litter that compromised fauna community structure and seed bank germination in situ;and,(4)changes in soil physical-chemical properties promoted decomposers.

关键词： Endangered tree species Exotic tree species Forest ecosystem Soil fauna functional groups Soil invertebrates