检索结果-南通市图书馆

A novel method for clustering cellular data to improve classification

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEwS pharmacokinetics study

在线全文

学校读者我要写书评

暂无评论

world Journal of Gastroenterology 2025年第2期31卷 102-112页

作者： Thanaboon Chaemsupaphan Aviv Pudipeddi Hui-Yu Lin Sudarshan Paramsothy Viraj C Kariyawasam Melissa Kermeen Rupert w Leong Department of Gastroenterology and Liver Services Concord Repatriation General HospitalSydney 2139New South WalesAustralia faculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand faculty of Medicine and Health University of SydneySydney 2139New South WalesAustralia Department of Gastroenterology Tan Tock Seng HospitalSingapore 308433Singapore faculty of Medicine and Health Sciences Macquarie UniversitySydney 2139New South WalesAustralia Department of Gastroenterology and Hepatology Blacktown HospitalSydney 2148New South WalesAustralia Blacktown Clinical School Western Sydney UniversitySydney 2148New South WalesAustralia

BACKGROUND Ulcerative colitis(UC)is a chronic inflammatory condition requiring continuous treatment and *** is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thiopurines on vedolizumab trough concentrations is *** To investigate the exposure-response relationship of vedolizumab and the impact of thiopurine withdrawal in UC patients who have achieved sustained clinical and endoscopic remission during maintenance *** This is a post-hoc analysis of prospective randomized clinical trial(VIEwS)involving UC patients across 8 centers in Australia from 2018 to *** in clinical and endoscopic remission were randomized to continue or withdraw thiopurine while receiving *** evaluated vedolizumab serum trough concentrations,presence of anti-vedolizumab antibodies,and clinical outcomes over 48 weeks to assess exposure-response asso-ciation and impact of thiopurine *** There were 62 UC participants with mean age of 43.4 years and 42%were *** participants received vedolizumab as maintenance therapy with 67.7%withdrew *** serum trough concentrations remained stable over 48 weeks regardless of thiopurine use,with no anti-vedolizumab antibodies ***-tients with clinical remission had higher trough concentrations at week *** quartile analysis,a threshold of>11.3μg/mL was associated with sustained clinical remission,showing a sensitivity of 82.4%,specificity of 60.0%,and an area of receiver operating characteristic of 0.71(95%CI:0.49-0.93).Patients discontinuing thiopurine required higher vedolizumab concentrations for achieving *** A positive exposure-response relationship between vedolizumab trough concentrations and UC outcomes suggests that monitoring drug levels may be *** thiopurine did not influence vedolizumab levels,its with-drawal may necessitate higher vedolizumab trough concentrations to maintain remi

关键词： Pharmacokinetic Vedolizumab Thiopurine Ulcerative colitis Trough concentration Antibody Inflammatory bowel diseases

Male contraception:prospects for the new millennium

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2000年第1期2卷 3-12页

作者： w.M.Hair f.C.w.wu Department of Medicine University of Manchester Manchester MI3 9WL UKDepartment of Medicine University of Manchester Manchester MI3 9WL UK

Effective regulation of human fertility has global consequences in terms of resource depletion, pollution and pover-ty. Current family planning services predominantly target a female clientele with few significant developments in malefertility regulation for over a century. The last two decades have witnessed a gathering interest, initially from the scien-tific community, and laterally from industry, in the development of safe, reliable, reversible methods of contraceptionfor men. This review summarises the methods of male fertility regulation which are currently available and critically ex-amines the published data on novel developments in male hormonal contraception which offer the potential of improvedcontraceptive choice for all in new millennium. (Asian J Androl 2000; 2: 3 - 12)

关键词： contraception male contraceptive agents male contraceptive devices gonadotropins testosterone androgen

Performance of LIDAR- and radar-based turbulence intensity measurement in comparison with anemometer-based turbulence intensity estimation based on aircraft data for a typical case of terrain-induced turbulence in association with a typhoon

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第7期14卷 469-481页

作者： P.w.CHAN Y.f.LEE Hong Kong Observatory

The Hong Kong Observatory (HKO) provides low-level turbulence alerting service for the Hong Kong International Airport (HKIA) through the windshear and turbulence warning system (wTwS). In the wTwS, turbulence intensities along the flight paths of the airport are estimated based upon correlation equations established between the surface anemometer data and the turbulence data from research aircraft before the opening of the airport. The research aircraft data are not available on day-to-day basis. The remote sensing meteorological instruments, such as the Doppler light detection and ranging (LIDAR) and radar, may be used to provide direct measurements of turbulence intensities over the runway corridors. The performances of LIDAR- and radar-based turbulence intensity data are studied in this paper based on actual turbulence intensity measurements made on 423 commercial jets for a typical case of terrain-induced turbulence in association with a typhoon. It turns out that, with the tuning of the relative operating characteristic (ROC) curve between hit rate and false alarm rate, the LIDAR-based turbulence intensity measurement performs better than the anemometer-based estimation of wTwS for turbulence intensity at moderate level or above. On the other hand, the radar-based measurement does not perform as well when compared with wTwS. By combining LIDAR- and radar-based measurements, the performance is slightly better than wTwS, mainly as a result of contribution from LIDAR-based measurement. As a result, the LIDAR-based turbulence intensity measurement could be used to replace anemometer-based estimate for non-rainy weather conditions. further enhancements of radar-based turbulence intensity measurement in rain would be necessary.

关键词： fault tolerant High availability quadruple vital computer (HAQVC) Reliability availability maintainability and safety (RAMS)

Speeding up transmissions of unknown quantum information along Ising-type quantum channels

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2017年第1期26卷 125-130页

作者： w J Guo L f wei Quantum Optoelectronics Laboratory Southwest Jiaotong University Chengdu 610031 China State Key Laboratory of Optoelectronic Materials and Technologies School of Physics Sun Yat-Sen University Guangzhou 510275 China

Quantum teleportation with entanglement channels and a series of two-qubit SwAP gates between the nearestneighbor qubits are usually utilized to achieve the transfers of unknown quantum state from the sender to the distant receiver. In this paper, by simplifying the usual SwAP gates we propose an approach to speed up the transmissions of unknown quantum information, specifically including the single-qubit unknown state and two-qubit unknown entangled ones,by a series of entangling and disentangling operations between the remote qubits with distant interactions. The generic proposal is demonstrated specifically with experimentally-existing Ising-type quantum channels without transverse interaction; liquid NMR-molecules driven by global radio frequency electromagnetic pulses and capacitively-coupled Josephson circuits driven by local microwave pulses. The proposal should be particularly useful to set up the connections between the distant qubits in a chip of quantum computing.

关键词： unknown quantum information transfers Ising-type quantum chains NMR molecules superconducting circuits

Stability and nonlinear vibrations of a flexible pipe parametrically excited by an internal varying flow density

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2020年第1期36卷 206-219页

作者： w.D.Xie X.f.Gao w.H.Xu State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin30072China

Pipes are often used to transport multiphase flows in many engineering *** total fluid flow density inside a pipe may vary with time and *** this paper,a simply supported pipe conveying a variable density flow is modeled theoretically,and its stability and nonlinear vibrations are investigated in *** variation of the flow density is simulated using a mathematical *** equation governing the vibration of the pipe is derived according to Euler-Bernoulli beam *** the internal flow density varies with time,the pipe is excited *** stability of the pipe is determined by floquet *** simple parametric and combination resonances are *** a higher mass ratio(mean flow mass/pipe structural mass),higher flow velocity,or smaller end axial tension,the pipe becomes unstable more easily due to wider parametric resonance *** the subcritical flow velocity regime,the vibrations of the pipe are periodic and quasiperiodic for simple and combination resonances,***,in the supercritical regime,the vibrations of the pipe exhibit much richer dynamics including periodic,multiperiodic,quasiperiodic,and chaotic behaviors.

关键词： Pipe Varying flow density Parametric excitation Stability Nonlinear vibrations