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Advances in prostate cancer research models:From transgenic mice to tumor xenografting models

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Asian Journal of Urology 2016年第2期3卷 64-74页

作者： Yuejiao Huang Chun Cheng Chong Zhang Yonghui Zhang Miaomiao Chen Douglas w.Strand Ming Jiang Department of Oncology Affiliated Cancer Hospital of Nantong UniversityNantongJiangsuChina Department of Immunology Nantong University School of MedicineNantongJiangsuChina Laboratory of Nuclear Receptors and Cancer Research Center for Basic Medical ResearchNantong University School of MedicineNantongJiangsuChina Department of Urology UT Southernwestern Medical CenterDallasTXUSA Institute of Medicine and Public Health Division of EpidemiologyDepartment of MedicineVanderbilt-Ingram Cancer CenterVanderbilt University Medical CenterNashvilleTNUSA

The identification of the origin and molecular characteristics of prostate cancer(PCa)has crucial implications for personalized *** development of effective treatments for PCa has been limited;however,the recent establishment of several transgenicmouse lines and/or xenografting models is better reflecting the disease in *** appropriate models,valuable tools for elucidating the functions of specific genes have gone deep into prostate development and *** the present review,we summarize a number of important PCa research models established in our laboratories(PSA-Cre-ERT2/PTEN transgenic mouse models,AP-OX model,tissue recombination-xenografting models and PDX models),which represent advances of translational models from transgenic mouse lines to human tumor *** understanding of the developments of these models will offer new insights into tumor progression and may help explain the functional significance of genetic variations in ***,this understanding could lead to new modes for curing PCa based on their particular biological phenotypes.

关键词： Prostate cancer Transgenic mouse lines Tumor xenografting models Translational medical systems

Spontaneous Bilateral Carotid Artery Dissection Revealing Multifocal Fibromuscular Dysplasia

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Case Reports in Clinical Medicine 2019年第9期8卷 250-257页

作者： w. Bnouhanna w. Fakir M. Rahmani M. Benabdeljlil S. Aï di Department of Neurology A and Neuropsychology Mohamed V University H&ocirc pital des Spécialités Ibn Sina University Hospital Rabat Morocco

Background: Fibromuscular dysplasia (FMD) is a rare idiopathic segmental non-arteriosclerotic and non-inflammatory arterial disease of small to medium-sized vessels. Although it is considered a benign entity, FMD can lead to potentially severe cerebrovascular complications. we present an atypical clinical case of ischemic stroke (IS) caused by bilateral carotid dissection revealing multifocal FMD. Case Report: A 43-year-old right-handed female with no medical history suddenly developed somnolence with left-sided weakness. Clinical examination revealed left hemiplegia and left central facial paralysis with an NIHSS score: 22. Cerebral tomography (CT) with arterial angiogram revealed abilateralis of the middle cerebral arteries (MCA), a double dissection of the internal carotids (IC), aneurysmal ectasia of the left IC, and aneurysm of the M2 segment of the MCA. Brain magnetic resonance imaging (MRI) with arterial angiography confirmed the bilateral dissection. A cerebral angiography (CA) revealed a radiological pattern of multifocal FMD. The angiography of the aorta and its branches showed adiffuse dysplasia of the renal arteries. The patient was put under antiaggregants. The modified Rankin score (mRS) after three months was three. Conclusion: Cerebrovascular FMD has typical angiographic features, the “string of beads” appearance being the most common. Although the risk of a stroke in patients with cervical FMD is low, it can lead to a severe stroke and the long-term risks are unknown. Patient registries should be encouraged to better understand the mechanisms and evolutionary profile of FMD and alert clinicians to this potentially disabling condition.

关键词： Fibromuscular Dysplasia Carotid Disease Stroke

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影响硅油取出结果诸因素的临床分析

华中科技大学学报（医学版） 2004年第3期33卷 353-356页

作者：姜发纲 Klaus w.Ruprecht 华中科技大学同济医学院附属协和医院眼科 Department of Ophthalmology and Eye Hospital University of Saarland 66424 Hamburg(Saar) Germany

目的　阐明硅油取出后与视网膜脱离和视力下降有关的各种危险因素。方法　对行硅油取出术的 94眼进行回顾性研究。结果　有 19眼 (2 0 % )术后出现视网膜脱离 ,30眼 (32 % )视力减退。术前及术后低眼压、术后视网膜前膜、初发病变为视... 详细信息

目的　阐明硅油取出后与视网膜脱离和视力下降有关的各种危险因素。方法　对行硅油取出术的 94眼进行回顾性研究。结果　有 19眼 (2 0 % )术后出现视网膜脱离 ,30眼 (32 % )视力减退。术前及术后低眼压、术后视网膜前膜、初发病变为视网膜巨大裂孔及复发性视网膜脱离、初始视力低于 0 0 2等因素是对视网膜解剖复位及视力有影响的危险因素。结论　在用硅油填充等手段治疗视网膜巨大裂孔或复发性视网膜脱离时 ,特别是当初始视力低于0 0 2时 ,医生和患者都应清楚治疗结果不理想的可能性很大。

关键词：硅油取出复发性视网膜脱离巨大裂孔视力低危险因素临床分析病变

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菲律宾蛤仔生长性状基因型与环境互作研究

大连海洋大学学报 2018年第2期33卷 197-202页

作者：段强田静曹纬楠武禹安李杰霍忠明聂鸿涛闫喜武大连海洋大学水产与生命学院辽宁大连116023 辽宁省盘锦市盘山县河蟹技术研究所辽宁盘山124100 辽宁省贝类良种繁育工程技术研究中心辽宁大连116023

为研究菲律宾蛤仔Ruditapes philippinarum基因型和环境的相作效应,采用双列杂交方法构建了AA、AB、BB、BA 4个基因型家系遗传材料,分别在不同温度、盐度和养殖环境条件下养殖30~45 d,以壳长生长为指标分析基因型与环境互作遗传效应。... 详细信息

为研究菲律宾蛤仔Ruditapes philippinarum基因型和环境的相作效应,采用双列杂交方法构建了AA、AB、BB、BA 4个基因型家系遗传材料,分别在不同温度、盐度和养殖环境条件下养殖30~45 d,以壳长生长为指标分析基因型与环境互作遗传效应。结果表明:基因型与温度互作遗传效应中,温度对基因型存在显著影响(PBA>AB>AA,BA>AB>AA>BB,AA>BA>AB>BB,但温度与基因型互作效应不显著(P>0.05);基因型与盐度互作遗传效应中,盐度对基因型存在显著影响(PAB>BA>BB,但盐度与基因型互作效应不显著(P>0.05);在室外土池、室内循环水槽、室内水桶3种养殖环境下,环境对壳长生长存在显著影响(P室内循环水>室内水桶,环境对基因型也存在显著影响(PAB>BA>BB,且养殖环境和基因型的交互作用也存在显著影响(PAB>BA>AA。本研究结果为蛤仔遗传育种工作提供了参考依据。

关键词：菲律宾蛤仔家系基因型环境互作

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METEOROLOGICAL AND CHEMICAL CONTROLS ON THE VERTICAL DISTRIBUTION OF BEIJING SUMMER COARSE AND FINE AEROSOLS

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Advances in Atmospheric Sciences 1986年第4期3卷 432-442页

作者：王明星,John w.winchester,吕位秀,任丽新,洪钟祥 Institute of Atmospheric Physics Academia Sinica Beijing Dept.of Oceanography Florida State University Tallahassee FL 32306 U.S.A Institute of Atmospheric Physics Academia Sinica Beijing Institute of Atmospheric Physics Academia Sinica Beijing Institute of Atmospheric Physics Academia Sinica Beijing

Vertical profiles of fine and coarse aerosol particles were determined by cascade impaetors at the meteorological tower in Beijing for three days and one night, July 18-23, 1980. Coarse mode aerosols showed a maximum concentration at 47 m when there was an inversion at about 140 m height, and a rather uniform distribution when there was no inversion. This may indicate a two-component origin of coarse particles at the tower site, one being surface dust and the other being tall stack emissions. Fine mode aerosols showed more complex vertical profiles. Median particle size distributions of most metals were bimodat, indicating distinct coarse particle dispersion and fine accumulation mode processes. A chemical thermodynamfc calculation indicates that fine mode Si can result from the reduction of silica to volatile SiO during coal combustion with limited air supply, a process which should release substantial amounts of carbon monoxide to the atmosphere.

关键词： mode show METEOROLOGICAL AND CHEMICAL CONTROLS ON THE VERTICAL DISTRIBUTION OF BEIJING SUMMER COARSE AND FINE AEROSOLS

Catalytically active interfaces in titania nanorod-supported copper catalysts for CO oxidation

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Nano Research 2020年第2期13卷 533-542页

作者： wasim U.Khan Season S.Chen Daniel C.w.Tsang wey Yang Teoh Xijun Hu Frank L.Y.Lam Alex C.K.Yip Department of Chemical and Process Engineering The University of Canterbury Christchurch 8041New Zealand Department of Civil and Environmental Engineering.The Hong Kong Polytechnic University Hong Kong.China School of Chemical Engineering The University of New South WalesSydneyNSW 2052Australia Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyHong KongChina

One-dimensional titanium dioxide nanorod(TNR)-supported Cu catalysts(2.5 wt.%-12.5 wt.%)were synthesized using deposition-precipitation.X-ray photoelectron spectroscopy,temperature programmed reduction and CO chemisorption measurements showed that Cu doping over TNR offered metal-support interactions and interfacial active sites that had a profound impact on the catalytic *** role of the Cu-TNR interface was investigated by comparing the catalytic activity of Cu-TNR catalysts with that of pure CuO nanoparticles in CO *** presence of highly dispersed copper species,a high number of interfacial active sites,CO adsorption capacity and surface/lattice oxygen were found to be responsible for the excellent activity of 7.5CU-TNR(ie,Cu loading of 7.5 wt.%on TNR).Moreover,the Cu-TNR catalysts followed the Langmuir-Hinshelwood reaction mechanism with 7.5CU-TNR,exhibiting an apparent activation energy of 44.7 kJ/*** TNR-supported Cu catalyst gave the highest interfacial catalytic activity in medium-temperature CO oxidation(120-240℃)compared to other commonly used supports,including titanium dioxide nanoparticles(TiO2-P25),silica(SiO2)and alumina(Al20g)in which copper species were nonhomogeneously *** study confirms that medium-temperature CO oxidation is highly sensitive to the morphology and structure of the supporting material.

关键词： supported catalysts nanorod oxygen species interfacial active sites CO oxidation