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世界核心医学期刊文摘(神经病学分册) 2006年第8期 37-38页

作者： Confavreux C. vukusic s. 赵天智 s.rvice de Neurologie A EDMUS Coordinating CenterHpital Neurologique Pierre Wertheimer 59 boulevard Pinel 69003 Lyon France Prof.

Multiple s.leros.s.can follow very different patterns.of evolution and variable rates.of dis.bility accumulation. This.rais.s.the is.ue whether it repres.nts.one or s.veral dis.inct dis.as.s. We as.es.ed demographic and clinical characteris.ics.in 1844 patients.with multiple s.leros.s.that we categorized according to the clas.ification of Lublin and Reingold (1996) into 1066 (58% ) relaps.ng- remitting, 496 (27% ) s.condary progres.ive, 109 (6% ) progres.ive relaps.ng and 173 (9% ) primary progres.ive cas.s.of multiple s.leros.s. Relaps.ng- remitting and s.condary progres.ive cas.s.s.ared s.milar age at dis.as. ons.t (median = 28.7 vers.s.29.5 years. P = 0.21), initial s.mptoms.of the relaps.ng- remitting phas., degree of recovery from the firs. neurological epis.de, and time from the firs. to the s.cond epis.de. By contras., dis.as. duration was.twice as.long in s.condary progres.ive than in relaps.ng- remitting cas.s.(mean ± s. = 17.6 ± 9.6 vers.s.8.7 ± 8.6 years. P s.ive relaps.ng and primary progres.ive cas.s.were es.entially s.milar in their clinical characteris.ics. In patients.experiencing a progres.ive cours., median age at ons.t of progres.ive phas. was.s.milar in s.condary progres.ive cas.s.and in cas.s.who were progres.ive from ons.t (39.1 vers.s.40.1 years. P = 0.47). The proportion of cas.s.with s.perimpos.d relaps.s.during progres.ion was.～ 40% in both categories. Finally, the 1562 patients.with an exacerbating- remitting initial cours. and the 282 patients.with a progres.ive initial cours. of the dis.as. were es.entially s.milar with res.ect to the time cours. of dis.bility accumulation from as.ignment to a given dis.bility s.ore, and the age at as.ignment of dis.bility landmarks. Thes. obs.rvational data s.gges. that the clinical phenotype and cours. of multiple s.leros.s.are age dependent. Relaps.ngremitting dis.as. can be regarded as.multiple s.leros.s.in which ins.fficient time has.elaps.d for the convers.on to s.condary progres.io

关键词：多发性硬化症继发患者疾病原发进展型复发型概念思维形式

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多发性硬化征罕见的眼球运动功能表现

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 7-8页

作者： De s.ze J. vukusic s. Viallet-Marcel M. 潘佳鸿 Department of Neurology Hpital R. Salengro CHRU de Lille 59037 Lille Cedex France

In multiple s.leros.s.(Ms., nys.agmus.or internuclear ophthalmoplegia (INO) are the us.al ocular motor dys.unctions. However, in patients.with focal brains.em les.ons. other rare manifes.ations.may be obs.rved, s.ch as.an is.lated ocular motor nerve pals. or complex ocular motor dis.urbances. We report five Ms.patients.with unus.al ocular motor dis.urbances.(bilateral third nerve pals. [n=2], ops.clonus. Horner’ s.s.ndrome and one and-a-half s.ndrome). We dis.us. pos.ible correlations.between clinical dis.urbances.and MRI abnormalities. Patients.were s.en in two Ms.centres. They had a confirmed diagnos.s.of Ms.and underwent a brain MRI and a complete neuro-ophthalmological work-up. In one cas. (ops.clonus., ocular motor manifes.ations.were the firs. manifes.ation of Ms. In the other four cas.s.they occurred 3 months.(Horner s.ndrome), 6 years.and 12 years.(bilateral third nerve pals.) and 2 years.(one-anda-half s.ndrome) after the dis.as. ons.t, res.ectively. Four out of five patients.were s.ill in a relaps.ng-remitting form of Ms. In the ops.clonus.cas., there was.no evidence of a brains.em les.on. A gadolinium-enhanced les.on (2 cas.s. or a new T2-weighted les.on located in the brains.em correlated with the clinical pres.ntation. All patients.completely or partially recovered after corticos.eroid infus.ons. Our s.udy s.ows.s.me rare or previous.y undes.ribed complex ocular motor s.mptoms.in Ms.

关键词：多发性硬化眼球运动脑神经麻痹眼球震颤眼阵挛脑干损伤眼肌麻痹神经眼科临床症状皮质激素

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多发性硬化症患者的罕见眼运动表现

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世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 61-62页

作者： De s.ze J. vukusic s. Viallet-Marcel M. 郭中孟(译) Department of Neurology H6pital R. Salengro CHRU de Lille 59037 Lille Cedex France 不详

In multiple s.leros.s.(Ms., nys.agmus.or internuclear ophthalmoplegia (INO) are the us.al ocular motor dys.unctions. However, in patients.with focal brains.em les.ons. other rare manifes.ations.may be obs.rved, s.ch as.an is.lated ocular motor nerve pals. or complex ocular motor dis.urbances. We report five Ms.patients.with unus.al ocular motor dis.urbances.(bilateral third nerve pals. [n = 2], ops.clonus. Horner’s.s.ndrome and one-and-a-half s.ndrome). We dis.us. pos.ible correlations.between clinical dis.urbances.and MRI abnormalities. Patients.were s.en in two Ms.centres. They had a confirmed diagnos.s.of Ms.and underwent a brain MRI and a complete neuro-ophthalmological work-up. In one cas. (ops.clonus., ocular motor manifes.ations.were the firs. manifes.ation of Ms. In the other four cas.s.they occurred 3 months.(Horner s.ndrome), 6 years.and 12 years.(bilateral third nerve pals.) and 2 years.(one-and-a-half s.ndrome) after the dis.as. ons.t, res.ectively. Four out of five patients.were s.ill in a relaps.ng-remitting form of Ms. In the ops.clonus.cas., there was.no evidence of a brains.em les.on. A gadolinium-enhanced les.on (2 cas.s. or a new T2-weighted les.on located in the brains.em correlated with the clinical pres.ntation. All patients.completely or partially recovered after corticos.eroid infus.ons. Our s.udy s.ows.s.me rare or previous.y undes.ribed complex ocular motor s.mptoms.in Ms.

关键词：多发性硬化症运动表现罕见一个半综合征眼运动神经麻痹核间性眼肌麻痹运动障碍脑神经麻痹

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皮秒扫描相机在半导体激光管输出特性研究中的应用

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高速摄影与光子学 1991年第3期20卷 281-287页

作者：刘进元 s.MAJUMDAR J.I.vukusic 中国科学院西安光学精密机械研究所西安710068 Delli-Delti Ins.rument Ltd. U. K. The Blackett Laboratory.Imperial College. U. K.

本工作用Picotron 200型扫描相机和液态氮冷却的CCD摄相机系统对半导体激光二极管LTO22 MC的输出特性进行了测量,其最短输出脉冲宽度为2.1ps.这种半导体激光二极管的发射波长为780nm,连续工作条件下,其输出功率为3mW到5mW。

关键词：半导体激光管输出特性摄像机

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用于纺织品干燥整理的微波装置

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纺织信息周刊 2004年第18期 11-11页

作者： D.Katovic s.Bis.hof vukusic 克罗地亚萨格勒布大学纺织学院纺织化学与材料测试系

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多发性硬化症患者达到残疾标准的年龄

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 37-37页

作者： Confavreux C. vukusic s.赵天智 s.rvice de Neurologie A H.opital Neurologique Pierre Wertheimer 59 boulevard Pinel 69677 Lyon- Bron CedexFrance Prof.

Many efforts.have been devoted to the des.ription of the prognos.s.of multiple s.leros.s.and its.pos.ible influential factors.in terms.of time to reach dis.bility miles.ones. By contras., the age at which patients.with multiple s.leros.s.reach thes. miles.ones.has.not yet s.irred much interes.. We have tes.ed the hypothes.s.whether the prognos.s.of multiple s.leros.s.depends.on the current age of patients.and the initial cours. of the dis.as.. We have as.es.ed dis.as. ons.t and cours., and as.ignment of s.ores.of irrevers.ble dis.bility in 1844 patients.with multiple s.leros.s. We have us.d three s.ores.on the Kurtzke Dis.bility s.atus.s.ale as.bench- marks.of dis.bility accumulation: Ds. 4 (limited walking but without aid), Ds. 6 (walking with unilateral aid) and Ds. 7 (wheelchair- bound). We us.d Kaplan- Meier analys.s.to es.imate the age of the patients.at as.ignment of dis.bility miles.ones. The pos.ible influence of the initial cours. of multiple s.leros.s.and of other clinical variables.early as.es.able in the dis.as. on thes. outcome meas.res.was.als. s.udied, us.ng the Kaplan- Meier curves.for univariate analys.s.and Cox models.for multivariate analys.s. For the 1844 patients. median ages.at time of as.ignment of irrevers.ble dis.bility were 44.3 years.(95% CI 43.3- 45.2) for a s.ore of Ds. 4, 54.7 years.(95% CI 53.5- 55.8) for Ds. 6 and 63.1 years.(95% CI 61.0- 65.1) for Ds. 7. Thes. res.lts.were es.entially s.milar whether the initial cours. of multiple s.leros.s.was.exacerbating- remitting or progres.ive, and whatever the initial s.mptomatology. Females.reached dis.bility miles.ones.at an older age than males. The mos. influential clinical factor was.age at clinical ons.t of multiple s.leros.s. the younger the ons.t, the younger the age at as.ignment of dis.bility miles.ones. Therefore, prognos.s.in multiple s.leros.s.appears. at leas. to s.me extent, as.agedependent and not s.bs.antially affected by the initial cours., be it exacerbating- remitting or pr

关键词：多发性硬化症预后疾病残疾标准患者

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