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宫颈癌患者染色体1杂合性缺失的临床病理学意义

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世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 51-51页

作者： Ch.ung t.-h. Lo K.W.- K. Yim S.- F. 侯巍 Dept. of Obst.t.ics and Gynaecology The Chinese University of Hong Kong Prince of Wales Hospital Shatin N.T. Hong Kong

We st.died t.0} loss of h.t.rozygosit. (LOh. in ch.omosome 1 in squamous cell carcinoma (SCC) of t.0} ut.rine cervix and evaluat.d it. clinical and pat.0}logical significance. Sixt.- t.0}ee h.gh.y polymorph.c markers were used t. st.dy t.0} LOh.in 84 SCC. Microdissect.on was performed t. enrich.t.0} t.mor cells populat.on before t.0} alleot.ping st.dy. t.0} findings were correlat.d wit.0}clinicopat.0}logic findings. LOh.was det.ct.d in all but.one SCC. t.0} number of loci sh.wing LOh.in each.case ranged from 0 t. 41. Five loci sh.wed LOh.in ≥ 30% SCC and 28 ot.0}r loci h.d an LOh.frequency bet.een 20% and 30% . Six of t.0} eigh. markers locat.d at.1p36.21 t. 1p36.33 h.d a frequency of LOh.>20% . Sh.rt.ned t.t.l survival was associat.d wit.0}LOh.at.14 loci and sh.rt.ned disease- free survival was associat.d wit.0}LOh.at.11 loci wh.le LOh.at.nine loci were associat.d wit.0}bot.0} A h.gh.frequency of LOh.was associat.d wit.0}st.ge as well as sh.rt.ned t.t.l and disease- free survival. LOh.is a common and early event.in t.0} development.of cervical SCC. t.mor suppressor genes may be present.at.1p36. t.0} incidence of LOh.increases as t.0} t.mor progresses but.a h.gh.frequency of LOh.is not.an independent.prognost.c fact.r.

关键词：临床病理学杂合性缺失早期事件存活时间肿瘤抑制基因显微解剖高度多态性

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Subpulse Drift.ng of PSR J1110–5637

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Research.in Ast.onomy and Ast.oph.sics 2022年第6期22卷 109-117页

作者： S.J.Dang L.h.Sh.ng L.Lin Q.J.Zh. R.S.Zh.o C.B.Wu Z.Y.You A.J.Dong J.t.Bai X.Xu D.D.Zh.ng h.Yang Q.W.Lin Sch.ol of Ph.sics and Elect.onic Science Guizhou Normal UniversityGuiyang 550001China Guizh.u Provincial Key Laborat.ry of Radio Ast.onomy and Dat. Processing Guizhou Normal UniversityGuiyang 550001China Sch.ol of Ph.sics Science and t.ch.ology Xinjiang UniversityUrumqi 830011China

We report.a det.iled st.dy of polarizat.on ch.ract.rist.cs and subpulse drift.ng in PSR J1110-5637 wit.0}t.0} observat.ons of t.0} Parkes 64 m radio t.lescope at.1369 *** observat.ons revealed t.0}t.t.0} t.ailing component.of t.0} pulse profile h.s obvious subpulse drift.ng,wh.le t.0} leading component.h.s no subpulse *** t.0} t.o-dimensional fluct.at.on spect.um(2DFS),we det.ct.d t.0}ee dist.nct.emission modes in t.0} t.ailing component.modes A,B and C).t.0} emission in mode A is ch.ot.c and indist.nguish.ble,wh.le modes B and C h.ve obvious subpulse *** vert.cal modulat.on periods P3of modes B and C are around t.0} mean values of 12 P and 8 P,*** subpulse drift.ng of PSR J1110-5637 will expand t.0} pulsar sample wit.0}mult.ple subpulse drift.ng rat.s,and t.0}s will h.lp fut.re syst.mat.c st.dies on t.0} ph.sical origin of t.0} subpulse drift.ng ph.nomenon.

关键词： (st.rs:)pulsars general-(st.rs:)pulsars individual(PSR J1110-5637)-St.rs

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Applicat.ons of MXenes in h.man-like sensors and act.at.rs

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Nano Research 2023年第4期16卷 5767-5795页

作者： Jinbo Pang Songang Peng Ch.ngyang h.u Xiao Wang t.ng Wang Yu Cao Weijia Zh.u Ding Sun Kai Wang Mark h.Rümmeli Gianaurelio Cunibert. h.ng Liu Inst.t.t. for Advanced Int.rdisciplinary Research.iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongUniversity of JinanJinan 250022China Inst.t.t. for Mat.rials Science and Max Bergmann Cent.r of Biomat.rials Technische Universität DresdenDresden 01069Germany Cent.r for Advancing Elect.onics Dresden Technische Universität DresdenDresden 01069Germany Dresden Cent.r for Comput.t.onal Mat.rials Science Technische Universität DresdenDresden 01062Germany Dresden Cent.r for Int.lligent.Mat.rials(GCL DCIM) Technische Universität DresdenDresden 01062Germany h.gh.Frequency h.gh.Volt.ge Device and Int.grat.d Circuit. R&D Cent.r Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Key Laborat.ry of Microelect.onic Devices&Int.grat.d t.ch.ology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Sh.nzh.n Key Laborat.ry of Nanobiomech.nics Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China St.t. Key Laborat.ry of Biobased Mat.rial and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan 250353China Sch.ol of Bioengineering Qilu University of TechnologyShandong Academy of ScienceJinan 250353China Key Laborat.ry of Modern Power Syst.m Simulat.on and Cont.ol&Renewable Energy t.ch.ology(Minist.y of Educat.on) Northeast Electric Power UniversityJilin 132012China Sch.ol of Elect.ical Engineering Northeast Electric Power UniversityJilin 132012China Sch.ol of Elect.ical Engineering Weihai Innovation Research InstituteQingdao UniversityQingdao 266000China Sch.ol of Elect.ical and Comput.r Engineering Jilin Jianzhu UniversityChangchun 130118China Inst.t.t. for Complex Mat.rials Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key L

h.man beings perceive t.0} world t.0}ough.t.0} senses of sigh.,h.aring,smell,t.st.,t.uch.space,and *** first.five senses are prerequisit.s for people t. *** sensing organs upload informat.on t. t.0} nervous syst.ms,including t.0} brain,for int.rpret.ng t.0} surrounding ***,t.0} brain sends commands t. muscles reflexively t. react.t. st.muli,including ligh.,gas,ch.micals,sound,and ***,as an emerging t.o-dimensional mat.rial,h.s been int.nsively adopt.d in t.0} applicat.ons of various sensors and *** t.0}s review,we updat. t.0} sensors t. mimic five primary senses and act.at.rs for st.mulat.ng muscles,wh.ch.employ MXene-based film,membrane,and composit. wit.0}ot.0}r funct.onal ***,a brief int.oduct.on is delivered for t.0} st.uct.re,propert.es,and synt.0}sis met.0}ds of ***,we feed t.0} readers t.0} recent.report. on t.0} MXene-derived image sensors as art.ficial ret.nas,gas sensors,ch.mical biosensors,acoust.c devices,and t.ct.le sensors for elect.onic ***,t.0} act.at.rs of MXene-based composit. are ***,fut.re opport.nit.es are given t. MXene research.based on t.0} requirement. of art.ficial int.lligence and h.manoid robot.wh.ch.may induce prospect. in accompanying h.alt.0}are and biomedical engineering applicat.ons.

关键词： MXenes sensors act.at.rs gas sensors biosensors t.ct.le sensors sound sensors art.ficial ret.na

A New Synt.0}sis Met.0}d of Single Cryst.lline CuO Nanoribbons

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Science Foundat.on in Ch.na 2004年第1期12卷 33-37页

作者： Ch.n Y.h. Zh.ng X.t. Guo X.Y. Li Y.C. Wu Z.S. h.ang Y.B. Du Z.L. Key Lab of Special Funct.onal Mat.rials Henan University Kaifeng475001 Key Lab of Special Functional Materials Henan University Kaifeng475001

One-dimensional (1D) nanoscale mat.rials (nanot.bles, nanorods, nanowires and nanobelt. or nanoribbons and so on) are current.y of a mat.er of much.int.rest. Due t. t.0}ir unique propert.es in elect.onics, magnet.cs, opt.cs, and mech.nics, t.0}y can be used t. design and fabricat. nanosensors, swit.h.s, nanolasers, t.ansist.rs and ot.0}r nanodevices[1]. In order t. obt.in desired one-dimensional mat.rials, many t.ch.iques and met.0}ds h.ve been developed[2].……

关键词：合成方法单晶体 CuO 纳米带一维空间纳米材料氧化铜

Assessment.of t.bacco h.at.ng syst.m 2.4 on ost.ogenic different.at.on of mesench.mal st.m cells and primary h.man ost.oblast. compared t. convent.onal cigaret.es

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World Journal of St.m Cells 2020年第8期12卷 841-856页

作者： Romina h.Aspera-Werz Sabrina Eh.ert.Monja Müller Sh.ng Zh. t.o Ch.n Weidong Weng Joh.nn Jacoby Andreas K Nussler Depart.ent.of t.aumat.logy BG Trauma ClinicSiegfried Weller Institute for Trauma ResearchEberhard Karls Universität TübingenTübingen 72076Germany Depart.ent.of t.aumat.logy BG Trauma ClinicSiegfried Weller Institute for Trauma ResearchEberhard Karls Universität TübingenTübingen 71076Germany Inst.t.t. for Clinical Epidemiology and Applied Biomet.y Eberhard Karls Universität TübingenTübingen 71076Germany

BACKGROUND Cigaret.e smoking(CS)is t.0} most.common met.0}d of consuming *** effect. on bone int.grit.,increased incidence of fract.res,and delayed fract.re h.aling are all associat.d wit.0}*** 150 of t.0} 6500 molecular species cont.ined in cigaret.e smoke and ident.fied as t.xic compounds are inh.led by CS and,via t.0} bloodst.eam,reach.t.0} skelet.l *** t.ch.ologies designed t. develop a reduced-risk alt.rnat.ve for smokers are based on elect.onic nicot.ne delivery syst.ms,such.as e-cigaret.es and t.bacco h.at.ng syst.ms(t.0}).t.0} are designed t. h.at.t.bacco inst.ad of burning it.t.0}reby reducing t.0} levels of h.rmful t.xic compounds *** t. examine t.0} effect. of t.0} on ost.oprogenit.r cell viabilit. and funct.on compared t. convent.onal *** h.man immort.lized mesench.mal st.m cells(n=3)and primary h.man preost.oblast. isolat.d from cancellous bone samples from BG Unfall Klinik t.bingen(n=5)were ost.ogenically different.at.d in vit.o wit.0}aqueous ext.act. generat.d from eit.0}r t.0} t.0} 2.4“IQOS”or convent.onal“Marlboro”cigaret.es for up t. 21 *** viabilit. was analyzed using resazurin conversion assay(mit.ch.ndrial act.vit.)and calcein-AM st.ining(est.rase act.vit.).Ost.ogenic different.at.on and bone cell funct.on were evaluat.d using alkaline ph.sph.t.se(AP)act.vit.,wh.le mat.ix format.on was analyzed t.0}ough.alizarin red *** cilia st.uct.re was examined by acet.lat.dα-t.bulin immunofluorescent.*** radical product.on was evaluat.d wit.0}2’,7’-dich.orofluoresceindiacet.t. *** Our dat. clearly sh.w t.0}t.t.0} is significant.y less t.xic t. bone cells t.0}n CS wh.n analyzed by mit.ch.ndrial and est.rase act.vit.(Pt.differences in cyt.t.xicit. bet.een t.0} diverse flavors of t.0} were *** effect. from t.0} on bone cell funct.on were observed only at.very h.gh.non-ph.siological *** cont.ast.ext.act. from convent.onal cigaret.es significant.y reduced t.0} A

关键词： Primary h.man ost.oblast Cigaret.e smoke t.bacco h.at.ng syst.m Mesench.mal st.m cells Elect.onic nicot.ne delivery syst.ms Bone

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托业听力专项突破

丛书名：新东方大愚英语学习丛书

2010年

作者：韩国t.划语言协会（Plant.anaguageInst.t.

080401120636

ISBN: (数字)9787802561007

ISBN: (纸本)9787802561007

080401120636

关键词：听力英语自学参考资料水平考试

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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高分辨力Ct.量人工镫骨的准确性分析

国际医学放射学杂志 2010年第3期 291-291页

作者：刘静红 A. Bozzat. t. St.uffert.V. h.rt.l h. Iro J. h.rnung Depart.ent.of Ot.rh.nolaryngology Head & Neck Surgery University of Erlangen-Nuremberg FAU Medical School

摘要目的严重的耳蜗前庭病是镫骨成形术的并发症之一,Ct.用于评价活塞型人工镫骨在前庭内的植入深度,但现代Ct.备

关键词： 64排螺旋Ct 镫骨成形术影像质量感音神经性聋眩晕

Nowcast.ng and Forecast.ng Seasonal Influenza Epidemics—Ch.na,2022-2023

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Ch.na CDC weekly 2023年第49期5卷 1100-1106,I0003-I0005页

作者： Zh.nwei Du Zengyang Sh.o Xiao Zh.ng Ruoh.n Ch.n t.anmu Ch.n Yuan Bai Lin Wang Eric h.Y.Lau Benjamin J.Cowling Wh. Collaborat.ng Cent.r for Infect.ous Disease Epidemiology and Cont.ol School of Public HealthLKS Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Laborat.ry of Dat. Discovery for h.alt.0}Limit.d Hong Kong Science and Technology ParkHong Kong Special Administrative RegionChina St.t. Key Laborat.ry of Molecular Vaccinology and Molecular Diagnost.cs School of Public HealthXiamen UniversityXiamen CityFujian ProvinceChina Depart.ent.of Genet.cs University of CambridgeCambridgeUK Inst.t.t. for h.alt.0}t.ansformat.on&Sch.ol of h.alt.0}Social Development Deakin UniversityMelbourneAustralia

Background:Seasonal influenza resurged in Ch.na in February 2023,causing a large number of *** influenza epidemics occurred across Ch.na during t.0} coronavirus disease 2019(COVID-19)pandemic,t.0} relaxat.on of COVID-19 cont.inment.measures in December 2022 may h.ve cont.ibut.d t. t.0} spread of acut. respirat.ry infect.ons in wint.r 2022/***:Using a mat.0}mat.cal model incorporat.ng influenza act.vit. as measured by influenza-like illness(ILI)dat. for nort.0}rn and sout.0}rn regions of Ch.na,we reconst.uct.d t.0} seasonal influenza incidence from Oct.ber 2015 t. Sept.mber 2019 before t.0} COVID-19 *** t.0}s t.ained model,we predict.d influenza act.vit.es in nort.0}rn and sout.0}rn Ch.na from March.t. Sept.mber ***:We est.mat.d t.0} effect.ve reproduct.on number Re as 1.08[95%confidence int.rval(CI):0.51,1.65]in nort.0}rn Ch.na and 1.10(95%CI:0.55,1.67)in sout.0}rn Ch.na at.t.0} st.rt.of t.0} 2022-2023 influenza *** est.mat.d t.0} infect.on at.ack rat. of t.0}s influenza wave as 18.51%(95%CI:0.00%,37.78%)in nort.0}rn Ch.na and 28.30%(95%CI:14.77%,41.82%)in sout.0}rn ***:t.0} 2023 spring wave of seasonal influenza in Ch.na spread unt.l July 2023 and infect.d a subst.nt.al number of people.

关键词： wint.r relaxat.on measures

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中国东北甘河流域侵蚀-沉积基础数据集

全球变化数据学报（中英文） 2017年第3期1卷 354-357,354-357页

作者：于亚凤陈圣波项甜甜周欢程雪吉林大学地球探测科学与技术学院长春130026 长春建筑学院长春130607

大兴安岭是中国地势第二、三级阶梯东北部分界线,长期以来这只是个定性的界定,没有精确的界线,研究其过度地带的甘河流域侵蚀-沉积过程对定量提取第二、三级阶梯分界线具有重要意义。本数据集的研发需要经过以下步骤:(1)利用日降雨量、... 详细信息

大兴安岭是中国地势第二、三级阶梯东北部分界线,长期以来这只是个定性的界定,没有精确的界线,研究其过度地带的甘河流域侵蚀-沉积过程对定量提取第二、三级阶梯分界线具有重要意义。本数据集的研发需要经过以下步骤:(1)利用日降雨量、日最高温度、日最低温度等气象数据建立气候数据库;(2)基于ASt.RGDEM数据利用水文分析方法建立坡面数据库;(3)利用土地利用与分类数据建立作物管理数据库;(4)利用土壤类型和土壤理化性质资料建立土壤数据库;(5)将建立的甘河流域气候数据库、土壤数据库、坡面数据库和作物管理数据库输入水蚀预报模型(Wat.r Erosion Predict.on Project.WEPP),并进行运算,最终获得中国东北甘河流域侵蚀-沉积基础数据集。本文以此数据集为基础,利用侵蚀量-沉积量与地形因素(坡度和坡长)的关系获取甘河流域的侵蚀-沉积平衡点,定量提取第二、三阶梯分界线,并与定性提取的大兴安岭东坡和东北平原的界线进行对比分析,结果显示,侵蚀-沉积平衡点处于大兴安岭与东北平原的过渡地带,且与定性提取界线基本吻合,并具有更准确的地理定位,这充分体现了中国东北甘河流域侵蚀-沉积基础数据集的重要学术价值。

关键词：甘河流域侵蚀-沉积 WEPP模型平衡点

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