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Antifertility effects of EP-1 (quinestrol and levonorgestrel) on Pacific rats (Rattus exulans)

Integrative Zoology 2024年第1期19卷 127-142页

作者： Jing LIU Feiyun tu Ming LIU Jichao WANG Zhibin ZHANG Ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikouHainanChina Secretariat Office International Society of Zoological Science and Society and Journal OfficeInstitute of ZoologyChinese Academy of SciencesBeijingChina State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijingChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina

Pest rodents pose a serious threat to island *** control could be an alternative approach to control the impact of rodents on these *** this study,we examined the antifertility effects of EP-1 baits containing quinestrol(E)and levonorgestrel(P)using a dose of 50 ppm E and P at three different ratios(E:P ratio=1:2,1:1,and 2:1)on Pacific rats(Rattus exulans)in the Xisha Islands,Hainan,*** to the control group,all animals in EP-1 treatment groups showed significantly decreased food intake and body *** treated males,there were obvious abnormalities in testis structure and a significant decrease of relative seminal vesicle weight,but no significant effect on relative uterine and ovarian weights(g kg-1 body weight),or ovarian structure in *** 8%sucrose to the original 50-ppm baits(E:P ratio=1:1)significantly increased bait palatability for males and *** dose induced uterine edema and abnormalities of ovarian structure in females but had no significant negative effect on the relative testis,epididymis,and seminal vesicle weights(g kg-1 body weight)or sperm density in *** summary,50-ppm EP-1(1:1)baits have the potential to disrupt the fertility of females,and 8%sucrose addition to the EP-1 baits(E:P ratio=1:1)could improve bait *** dose disrupted the testis structure in *** studies are needed to improve bait acceptance and assess the antifertility effects of EP-1(1:1)on Pacific rats in captive breeding trials and underfield conditions.

关键词： EP-1 fertility control island biodiversity conservation levonorgestrel quinestrol Rattus exulans

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Single-structure 3-axis Lorentz force magnetometer based on an AlN-on-Si MEMS resonator

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Microsystems & Nanoengineering 2024年第3期10卷 75-86页

作者： Cheng tu Xu-heng Ou-Yang Ying-jie Wu Xiao-sheng Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

This work presents a single-structure 3-axis Lorentz force magnetometer(LFM)based on an AlN-on-Si MEMS *** operation of the proposed LFM relies on the flexible manipulation of applied excitation currents in different directions and frequencies,enabling the effective actuation of two mechanical vibration modes in a single device for magnetic field measurements in three ***,the excited out-of-plane drum-like mode at 277 kHz is used for measuring the x-and y-axis magnetic fields,while the in-plane square-extensional mode at 5.4 MHz is used for measuring the z-axis magnetic *** different configurations of applied excitation currents ensure good crossinterference immunity among the three *** to conventional capacitive LFMs,the proposed piezoelectric LFM utilizes strong electromechanical coupling from the AlN layer,which allows it to operate at ambient pressure with a high *** understand and analyze the measured results,a novel equivalent circuit model for the proposed LFM is also reported in this work,which serves to separate the effect of Lorentz force from the unwanted capacitive *** demonstrated 3-axis LFM exhibits measured magnetic responsivities of 1.74 ppm/mT,1.83 ppm/mT and 6.75 ppm/mT in the x-,y-and z-axes,respectively,which are comparable to their capacitive counterparts.

关键词： resonator Lorentz structure

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NIR-IIb-triggered photodynamic therapy combined with chemotherapy platform based on rare-earth-doped nanoparticles

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Rare Metals 2024年第7期43卷 3220-3231页

作者： Zhuo tu Yong Wan Juan Ge Chen-Chen Li Tao Liang Zhen Li College of Health Science and Engineering College of Chemistry and Chemical EngineeringHubei University

Photodynamic therapy（PDT）,with high spatiotemporal selectivity,minimal side effects and less drug resistance,has emerged as a promising approach for the treatment of ***,inadequate penetration depth and poor efficacy seriously restrict its practical *** address these challenges,we developed a combined therapy platform（RENP@C/D-FA） based on rare-earth-doped nanoparticles（RENPs） with a structure of NaErF4:Tm（0.5%）@NaYF4,on which photosensitizer Ce6（chlorin e6） and chemo-therapeutic drug（DOX）(doxorubicin) were loaded by encapsulating with an amphiphilic polymer distearoyl phosphatidylethanolamine-polyethylene glycol-folic acid（DSPE-PEG-FA）.RENPs with NaErF4as the matrix possess multiple excitation/emission peaks,enabling activation of PDT under near-infrared-Ⅱb（NIR-Ⅱb,1500-1700 nm） excitation and luminescence imaging in NIR-Ⅱb region by absorbing 808 nm near-infrared ***,DOX can be selectively released in the acidic microenvironment of *** from the tumor targeting capability of folic acid,this platform can successfully ablate tumor cells and inhibit tumor growth by combining PDT and *** innovative approach holds great promise as a powerful tool for cancer treatment,showing the potential to revolutionize PDT.

关键词： Photodynamic therapy Rare-earth-doped nanoparticles NIR-IIb Chemotherapy Combined therapy

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Aryl hydrocarbon receptor:Linking environment to aging process in elderly patients with asthma

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Chinese Medical Journal 2024年第4期137卷 382-393页

作者： Tianrui Yang Rongjun Wan Wei tu Sai Nithin Avvaru Peisong Gao Division of Allergy and Clinical Immunology Department of MedicineJohns Hopkins University School of MedicineBaltimoreMD 21224USA Department of Geriatric Medicine The First People’s Hospital of Yunnan ProvinceKunmingYunnan 650032China Department of Respiratory Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China The State Key Laboratory of Respiratory Disease for Allergy Shenzhen Key Laboratory of Allergy and ImmunologyShenzhen University School of MedicineShenzhenGuangdong 518055China

Aging is a significant risk factor for various diseases,including asthma,and it often leads to poorer clinical outcomes,particularly in elderly *** is recognized that age-related diseases are due to a time-dependent accumulation of cellular damage,resulting in a progressive decline in cellular and physiological functions and an increased susceptibility to chronic *** effects of aging affect not only the elderly but also those of younger ages,posing significant challenges to global ***,understanding the molecular mechanisms associated with aging in different diseases is *** intriguing factor is the aryl hydrocarbon receptor(AhR),which serves as a cytoplasmic receptor and ligand-activated transcription factor and has been linked to the aging ***,we review the literature on several major hallmarks of aging,including mitochondrial dysfunction,cellular senescence,autophagy,mitophagy,epigenetic alterations,and microbiome ***,we provide an overview of the impact of AhR on these hallmarks by mediating responses to environmental exposures,particularly in relation to the immune ***,we explore how aging hallmarks affect clinical characteristics,inflammatory features,exacerbations,and the treatment of *** is suggested that AhR signaling may potentially play a role in regulating asthma phenotypes in elderly populations as part of the aging process.

关键词： Aging Environment Reactive oxygen species Senescence Aryl hydrocarbon receptor Asthma

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Towards Blockchain-Based Secure BGP Routing,Challenges and Future Research Directions

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Computers, Materials & Continua 2024年第5期79卷 2035-2062页

作者： Qiong Yang Li Ma Shanshan tu Sami Ullah MuhammadWaqas Hisham Alasmary Faculty of Information Technology Beijing University of TechnologyBeijing100124China School of Information Science and Technology North China University of TechnologyBeijing100144China Department of Computer Science Shaheed Benazir Bhutto UniversitySheringal18050Pakistan School of Computing and Mathematical Science Faculty of Engineering and ScienceUniversity of GreenwichLondonSE109LSUK School of Engineering Edith Cowan UniversityPerth6027Australia Department of Computer Science King Khalid UniversityAbha61421Saudi Arabia

Border Gateway Protocol(BGP)is a standard inter-domain routing protocol for the Internet that conveys network layer reachability information and establishes routes to different *** BGP protocol exhibits security design defects,such as an unconditional trust mechanism and the default acceptance of BGP route announcements from peers by BGP neighboring nodes,easily triggering prefix hijacking,path forgery,route leakage,and other BGP security ***,the traditional BGP security mechanism,relying on a public key infrastructure,faces issues like a single point of failure and a single point of *** decentralization,anti-tampering,and traceability advantages of blockchain offer new solution ideas for constructing secure and trusted inter-domain routing *** this paper,we summarize the characteristics of BGP protocol in detail,sort out the BGP security threats and their ***,we analyze the shortcomings of the traditional BGP security mechanism and comprehensively evaluate existing blockchain-based solutions to address the above problems and validate the reliability and effectiveness of blockchain-based BGP security methods in mitigating BGP security ***,we discuss the challenges posed by BGP security problems and outline prospects for future research.

关键词： BGP security blockchain prefix hijacking trust model secure routing

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Unraveling the complexity of polycystic ovary syndrome with animal models

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Journal of Genetics and Genomics 2024年第2期51卷 144-158页

作者： Huanju Liu Mixue tu Zhiyong Yin Dan Zhang Jun Ma Feng He Center for Genetic Medicine The Fourth Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China Key Laboratory of Women's Reproductive Health of Zhejiang Province and Department of Reproductive Endocrinology Women's HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China Zhejiang Provincial Clinical Research Center for Child Health Women's HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China Clinical Research Center on Birth Defect Prevention and Intervention of Zhejiang Province HangzhouZhejiang 310006China Institute of Genetics Zhejiang University International School of MedicineHangzhouZhejiang 310058China Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorder HangzhouZhejiang 310058China

Polycystic ovary syndrome (PCOS) is a highly familial and heritable endocrine disorder. Over half of the daughters born to women with PCOS may eventually develop their own PCOS-related symptoms. Progress in the treatment of PCOS is currently hindered by the complexity of its clinical manifestations and incomplete knowledge of its etiopathogenesis. Various animal models, including experimentally induced, naturally occurring, and spontaneously arising ones, have been established to emulate a wide range of phenotypical and pathological traits of human PCOS. These studies have led to a paradigm shift in understanding the genetic, developmental, and evolutionary origins of this disorder. Furthermore, emerging evidence suggests that animal models are useful in evaluating state-of-the-art drugs and treatments for PCOS. This review aims to provide a comprehensive summary of recent studies of PCOS in animal models, highlighting the power of these disease models in understanding the biology of PCOS and aiding high-throughput approaches.

关键词： Polycystic ovary syndrome Animal model Genetc manipulation Developmnental progtanning Drug screening

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Experimental study on temperature fluctuations on plate surface induced by coaxial-jet flow

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Nuclear Science and Techniques 2024年第5期35卷 139-153页

作者： Xue-Yao Xiong Zun-Quan Liu Guo-Yan Zhou Xing Luo Shan-tung tu Key Laboratory of Pressure Systems and Safety(MOE) East China University of Science and TechnologyShanghai 200237China Institute of Thermodynamics Gottfried Wilhelm Leibniz University Hannover30823 GarbsenGermany

In nuclear reactors,temperature fluctuations of fluids may cause fatigue damage to adjacent structures;this is referred to as thermal *** on thermal striping in the upper plenum has mainly focused on fluid *** experimental studies have been reported on solid structures in a fluid field with a coaxial *** study entailed an experimental study of the temperature fluctuations in the fluid and on a plate surface caused by a coaxial *** temperature fluctuations of the fluid and plate surfaces located at different heights were *** cause of the temperature fluctuation was analyzed using a transient temperature *** results show that the mixing of the hot and cold fluids gradually becomes uniform in the positive axial *** average surface temperatures tended to be *** the jet reaches the plate surface,the swing of the jet center,contraction and expansion of the cold jet,and changes in the jet shape result in temperature *** intensity of the temperature fluctuation was affected by the *** attention should be paid when the plate is located at a lower height,and between the hot and cold-fluid nozzles.

关键词： Temperature fluctuation Thermal striping Coaxial jet Thermal mixing The upper plenum of nuclear reactor

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Assessment of the Characteristics of Demersal Fish Communities Using Species-and Trait-Based Approaches in the Coastal Habitats Along Rongcheng Bay,Shandong Peninsula,China

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Journal of Ocean University of China 2024年第3期23卷 786-796页

作者： YUAN Shunjie SUN Xin tu Zhong SUN Jie WANG Xianning ZHANG Peidong Key Laboratory of Mariculture(Ocean University of China) Ministry of EducationQingdao 266003China Shandong Fisheries Development and Resource Conservation Center Yantai 264003China

Biodiversity declines have motivated many studies on the relationship between species diversity and ecosystem *** this study,we described the spatial-temporal characteristics of demersal fish communities along a coastal habitat in Rongcheng Bay,Shandong Peninsula,China with both species-based and biological trait-based *** field survey was carried out monthly using traps from April to October of 2018,and divided into three seasons(spring:April and May;summer:June,July and August;autumn:September,October and November).The study area included five distinct habitats:seagrass bed,natural rocky reef,bare sand,artificial reef together with natural rocky reef,and artificial reef together with bare *** analyzed the fish communities with three taxonomic diversity indices,including Shannon-Wiener,Simpson,and Pielou Evenness,as well as four functional diversity indices,including FRic,FEve,FDiv,and FDis,based on 7 functional groups which are categorized into 27 *** results showed that there were no significant differences in taxonomic diversity indices among different habitats in the three ***,significant differences were found in the functional richness of fish communities among different habitats in three *** bed represented the highest functional richness in spring and *** study demonstrates that seagrass bed is very important in enhancing the functional diversity of fish communities in a complex *** study also indicates that the combination of taxonomic diversity and functional diversity will provide a more detailed description of the characteristics of fish communities.

关键词： complex habitat biological traits biodiversity fish communities

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Estimation-free spatial-domain image reconstruction of structured illumination microscopy

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 45-58页

作者： Xiaoyan Li Shijie tu Yile Sun Yubing Han Xiang Hao Cuifang kuang Xu Liu State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and Engineering Zhejiang University Hangzhou 310027P.R.China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311200 P.R.China Collaborative Innovation Center of Extreme Optics Shanxi University TaiyuanShanxi 030006P.R.China A dvanced Biomedical Imaging Facility-Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology WuhanHubei 430074P.R.China

Structured illumination microscopy(SIM)achieves super-resolution(SR)by modulating the high-frequency information of the sample into the passband of the optical system and subsequent image *** traditional Wiener-filtering-based reconstruction algorithm operates in the Fourier domain,it requires prior knowledge of the sinusoidal illumination patterns which makes the time-consuming procedure of parameter estimation to raw datasets necessary,besides,the parameter estimation is sensitive to noise or aberration-induced pattern distortion which leads to reconstruction ***,we propose a spatial-domain image reconstruction method that does not require parameter estimation but calculates patterns from raw datasets,and a reconstructed image can be obtained just by calculating the spatial covariance of differential calculated patterns and differential filtered datasets(the notch filtering operation is performed to the raw datasets for attenuating and compensating the optical transfer function(OTF)).Experiments on reconstructing raw datasets including nonbiological,biological,and simulated samples demonstrate that our method has SR capability,high reconstruction speed,and high robustness to aberration and noise.

关键词： Structured illumination microscopy image reconstruction spatial domain digital micromirror device(DMD)

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Recent advances on liquid intercalation and exfoliation of transition metal dichalcogenides: From fundamentals to applications

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Nano Research 2024年第3期17卷 2088-2110页

作者： Yan tu Lingbin Xie Mengyang Zhang Shujuan Liu Zhongzhong Luo Longlu Wang Qiang Zhao State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Jiangsu Province Engineering Research Center for Fabrication and Application of Special Optical Fiber Materials and DevicesNanjing University of Posts and TelecommunicationsNanjing 210023China

The weak van der Waals gap endows two dimensional transition metal dichalcogenides(2D TMDs)with the potential to realize guest intercalation and host ***,the liquid intercalation and exfoliation is a facile,low-cost,versatile and scalable strategy to modulate the structure and physiochemical property of TMDs via introducing foreign species into *** this review,firstly,we briefly introduce the resultant hybrid superlattice and disperse nanosheets with tailored properties fabricated via liquid intercalation and ***,we systematically analyze the intercalation phenomenon and limitations of various intercalants in chemical or electrochemical ***,we intensely discuss diverse functionalities of resultant materials,focusing on their potential applications in energy conversion,energy storage,water purification,electronics,thermoelectrics and ***,we highlight the challenges and outlooks for precise and mass production of 2D TMDs-based materials via liquid intercalation and *** review enriches the overview of liquid intercalation and exfoliation strategy,and paves the path for relevant high-performance devices.

关键词： two-dimensional transition metal dichalcogenides hybrid superlattice intercalation exfoliation

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