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Perforator-based flaps for the treatment of burn scar contractures: a review

Burns & Trauma 2017年第1期5卷 9-16页

作者： C.M.Stekelenburg R.E.Marck P.d.H.M.Verhaegen K.W.Marck P.P.M.van Zuijlen Burn Center and department of Plastic Reconstructiveand Hand SurgeryRed Cross HospitalVondellaan 131942 LE BeverwijkThe Netherlands department of Plastic Reconstructiveand Hand SurgeryUniversity Medical CenterUtrechtThe Netherlands department of Plastic Reconstructiveand Hand SurgeryAcademical Medical CenterAmsterdamThe Netherlands department of Plastic Reconstructiveand Hand SurgeryMOVE Research InstituteVU University Medical CenterAmsterdamThe Netherlands department of Plastic Reconstructiveand Hand SurgeryIsalaZwolleThe Netherlands department of Plastic Surgery Medisch Centrum LeeuwardenLeeuwardenThe Netherlands.

Patients with burn scars often experience functional problems because of scar contractures. Surgical treatment may be indicated for those burn scar contractures. If the contractures are small and linear, the contraction bands can be treated with local transposition flaps like the Z-plasty. Broader, diffuse contractures are more challenging and require a different surgical approach, such as the use of local tissue. The use of perforator-based flaps is promising;however, their true clinical significance for this type of burn reconstructions still needs to be determined. Therefore, we performed a review to evaluate the role of perforator-based flaps for burn scar contracture treatment. Electronic databases were searched using a predefined search strategy. Studies evaluating the long-term outcome of perforator-based flaps for the treatment of burn scar contractures were included. The methodological quality was tested and data was summarized. Five hundred and ten papers were identified of which eleven met the inclusion criteria. One study was a randomized controlled trial;ten were cohort studies of a pre-postoperative design. The papers described outcomes of free flaps and local flaps. Most studies had methodological shortcomings and used inappropriate statistical methods. Perforator-based interposition flaps appear to be highly relevant for burn scar contracture treatment. However, due to the paucity and low quality of the studies that were assessed, no definitive conclusions about the true clinical significance could be reached. And therefore, only recommendations could be given for improvement of the quality of further primary research on the effectiveness of perforator-based flaps for burn scar contracture release.

关键词： Burn Scar Contracture Perforator flap

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标准放射剂量CT对结直肠肝转移的检测优于低剂量CT

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国际医学放射学杂志 2019年第2期42卷 238-238页

作者： C.T.Jensen N.A.Wagner-Bartak L.N.vu X.M.Liu B.Raval d.Martinez 马美清(译) 杜明珊(校) department of diagnostic Radiology University of Texas MD Anderson Cancer Center 不详

目的评价低剂量(Rd)与标准剂量(Sd)腹部增强CT扫描对结直肠癌肝转移的检测,并对滤过反投影(FBP)与迭代重建算法进行定性比较。材料与方法2017年5月—2017年11月进行该前瞻性研究,52例经活检证实并疑似肝转移的结直肠癌病人在基线CT时接... 详细信息

目的评价低剂量(Rd)与标准剂量(Sd)腹部增强CT扫描对结直肠癌肝转移的检测,并对滤过反投影(FBP)与迭代重建算法进行定性比较。材料与方法2017年5月—2017年11月进行该前瞻性研究,52例经活检证实并疑似肝转移的结直肠癌病人在基线CT时接受了双门静脉期CT扫描:Sd和Rd扫描在同一次屏气中完成。

关键词：肝转移低剂量 CT

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Video Analysis of Side hop Technique in Trials

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Journal of Sports Science 2017年第1期5卷 58-63页

作者： Rodolfo Vastola Silvia Coppola Albano daniele Francesca d'Elia Motion Analysis Laboratory Department of Human Philosophical and Educational Sciences University of Salerno Fisciano Salerno 84084 ltaly

Trials is a specialty of off-road cycling in which the rider has to face obstacle courses without resting feet on the ground. Technique in this sport has a great importance, since it reduces the risk of committing penalties and allows more efficient execution of the gesture. To improve technique, the motion analysis allows to study the gesture both qualitatively and quantitatively. In this work video analysis was used to study the side hop from rear wheel technique. Two different executions of this technique were analyzed. The primary purpose is the identification of the phases that make up the technical gesture. It was given an explanation to the movement strategies adopted in the execution of the jump in the two different situations.

关键词： Bike trials cycling vertical jump video analysis sport technique

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Images of Linear Block Codes over F_(q)+uF_(q)+vF_(q)+uvF_(q)

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Open Journal of Applied Sciences 2013年第1期3卷 27-31页

作者： Jane d.Palacio Virgilio P.Sison Institute of Mathematical Sciences and Physics University of the Philippines Los BanosCollegeLagunaPhilippines

In this paper, we considered linear block codes over Rq=Fq+uFq+vFq+uvFq, u2=v2=0,uv=vu where q=pm, m∈N . First we looked at the structure of the ring. It was shown that Rq is neither a finite chain ring nor a principal ideal ring but is a local ring. We then established a generator matrix for the linear block codes and equipped it with a homogeneous weight function. Field codes were then constructed as images of these codes by using a basis of Rq over Fq . Bounds on the minimum Hamming distance of the image codes were then derived. A code meeting such bounds is given as an example.

关键词： q-ary Images distance Bounds

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Achieve load balancing with a dynamic re-routing CICQ switching scheme

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Science China(Information Sciences) 2012年第2期55卷 407-418页

作者： HU HongChao,GUO YunFei,YI Peng & LAN JuLong department of Broadband Information Networks,National digital Switching System Engineering & Technological R&d Center(NdSC),Zhengzhou 450002,China department of Broadband Information Networks National Digital Switching System Engineering & Technological R&D Center (NDSC) Zhengzhou China

Multi-path based routing and switching can achieve network-wide load balancing and reduce the port conflicts of switching *** by this novel idea,in this paper,through analyzing the feasibility of implementing multi-next-hops in core switching networks comprehensively,we advance a switching scheme called MHRS(multi-next-hop re-routing switch)and a forwarding table management scheme called HMFT(hierarchical multi-stage forwarding table)to support multi-next-hop dynamical *** implements dynamical re-routing in the switches according its congestion status to achieve real-time load balancing,while HMFT can provide traffic with different forwarding paths based on their QoS *** analysis and simulation results show that switches equipped with HMFT and MHRS can provide good delay and throughput ***,they can reduce port conflicts significantly.

关键词： switching fabric scheduling policy load balancing dynamical re-routing

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Underwater video cameras allow for detection of North American giant salamanders (Cryptobranchus alleganiensis alleganiensis) in both captive and wild streams

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Aquaculture and Fisheries 2021年第1期6卷 106-110页

作者： Shem Unger Zeb Cline Hull Lauren diaz John d.Groves Lori A.Williams Catherine M.Bodinof Jachowski Carolina Headwaters L.L.C.MathewsNC28105United States Clemson University ClemsonSC29634United States North Carolina Zoological Park(Curator Emeritus) AsheboroNC27205United States North Carolina Wildlife Resources Commission RaleighNC27606United States

Captive propagation and translocation are becoming vital components of conservation and management strategies for Eastern hellbender(Cryptobranchus ***)***,aquaria,universities,and state and federal agencies are concomitantly collaborating on the protection,education,and maintenance of captive populations of this unusual,cryptic *** strategies include the use of artificial nesting structures,collection of eggs from the wild,and head-starting individuals in zoos or *** effects of these strategies need to be monitored,however,traditional survey and monitoring methods for the species in the wild involves rock-lifting,which has the potential to both harm habitat and alter reproductive ***,there is a need to develop effective,non-invasive and non-destructive methods of monitoring both wild and captive populations of Eastern ***,we compare two simple,affordable,underwater video and camera systems(borescope and Aqua-vu cameras)in their ability to 1)facilitate detection of adults under potential cover items and 2)facilitate nest detection and monitoring in both wild and captive *** cameras were successful in detecting individual hellbender presence,albeit with different resolutions and detection *** borescope was better at accessing deep cavities given its large flexible attachment which allowed for greater flexibility of scanning crevices of adult ***,search time increased and even low levels of suspended sediment reduced visibility with the *** Aqua-vu camera provided greater overall visibility and faster detection of individuals under both natural and artificial *** was a significant difference in the amount of time required to detect hellbenders with each camera design when searching under natural rocks(borescope:median=67.8 s,Aqua-vu:median=39.1 s;Kruskal Wallis Test H=15.62,pd artificial shelters(borescope:median=30.9 s,A

关键词： Captive propagation Hellbender Aquatic science Freshwater conservation Underwater camera systems

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联合应用纳米金和磷酸钙骨水泥支架促进牙髓干细胞的增殖和成骨分化

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南京医科大学学报（自然科学版） 2018年第5期38卷 590-594页

作者：夏阳陈慧敏胡姝颖孙剑飞郭宇马珊珊东南大学江苏省生物材料与器件重点实验室江苏南京210009 南京医科大学口腔疾病研究江苏省重点实验室江苏南京210029

目的:磷酸钙骨水泥(calcium phosphate cement,CPC)支架以其良好的生物相容性和骨引导活性而广泛应用于组织工程骨缺损的修复中,但是其骨引导活性有限。因此考虑联合应用纳米金(gold nanoparticles,Au NPs)以促进牙髓干细胞的增殖和成... 详细信息

目的:磷酸钙骨水泥(calcium phosphate cement,CPC)支架以其良好的生物相容性和骨引导活性而广泛应用于组织工程骨缺损的修复中,但是其骨引导活性有限。因此考虑联合应用纳米金(gold nanoparticles,Au NPs)以促进牙髓干细胞的增殖和成骨分化。方法:以CPC支架作为基底接种牙髓干细胞,在培养基中添加5μg/m L Au NPs进行干细胞培养,以常规培养基组为对照。用透射电镜检测Au NPs的形貌。以荧光显微镜检测细胞接种4 h后的黏附状态,以CCK-8检测细胞增殖情况,检测细胞碱性磷酸酶的活性,并进行茜素红染色以说明矿化物形成情况。结果:Au NPs为均匀的球形,直径20 nm左右。细胞接种后4 h,实验组和对照组的细胞黏附状态没有显著差异。CPC上Au NPs培养基中的细胞14 d时数量多于对照组(P<0.05);且Au NPs培养基中细胞的碱性磷酸酶活性显著增高(P<0.05),矿化物的形成也显著增多(P<0.05)。结论:CPC支架联合Au NPs可显著促进牙髓干细胞的增殖和成骨分化。

关键词：纳米金磷酸钙骨水泥牙髓干细胞增殖成骨分化

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Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells

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Cellular & Molecular Immunology 2017年第4期14卷 360-370页

作者： Cynthia M Fehres Sanne duinkerken Sven CM Bruijns Hakan Kalay Sandra J van Vliet Martino Ambrosini Tanja d de Gruijl Wendy WJ Unger Juan J Garcia-Vallejo Yvette van Kooyk department of Molecular Cell Biology and Immunology VU University Medical Center Amsterdam the Netherlands department of Medical Oncology VU University Medical Center Amsterdam the Netherlands

The potential of the skin immune system to generate immune responses is well established, and the skin is actively exploited as a vaccination site. Human skin contains several antigen-presenting cell subsets with specialized functions. In particular, the capacity to cross-present exogenous antigens to Cd8^＋ T cells is of interest for the design of effective immunotherapies against viruses or cancer. Here, we show that primary human Langerhans cells （LCs） were able to cross-present a synthetic long peptide （SLP） to Cd8^＋ T cells. In addition, modification of this SLP using antibodies against the receptor langerin, but not dectin-1, further enhanced the cross-presenting capacity of LCs through routing of internalized antigens to less proteolytic early endosome antigen 1 ^＋ early endosomes. The potency of LCs to enhance Cd8^＋ T-cell responses could be further increased through activation of LCs with the toll-like receptor 3 ligand polyinosinic：polycytidylic acid （phC）. Altogether, the data provide evidence that human LCs are able to cross-present antigens after langerin-mediated internalization. Furthermore, the potential for antigen modification to target LCs specifically provides a rationale for generating effective anti-tumor or anti-viral cytotoxic T lymphocyte responses.

关键词： antigen cross-presentation dectin-1 early endosomes human Langerhans cells langerin

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本多生酸双氢链霉素首次临床试验

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中华结核和呼吸杂志 1958年第4期06卷 346-346页

作者： R. Lesobre et al., Bull. et mém. Soc. méd. hop. Paris, 苏绍丹(译)

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What is a tree in the Mediterranean Basin hotspot?A critical analysis

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Forest Ecosystems 2019年第2期6卷 159-177页

作者： Frédéric Médail Anne-Christine Monnet daniel Pavon Toni Nikolic Panayotis dimopoulos Gianluigi Bacchetta Juan Arroyo Zoltán Barina Marwan Cheikh Albassatneh Gianniantonio domina Bruno Fady Vlado Matevski Stephen Mifsud Agathe Leriche Aix Marseille Univ Avignon UnivCNRSIRDIMBE.Technopole de l’Arbois-Méditerranéecedex 4BP 8013 545 Aix-en-ProvenceFrance Macedonian Academy of Sciences and Arts Krste Misirkov 21000 SkopjeRepublic of Macedonia EcoGozo Regional Development Directorate-Ministry for GozoFlat 6Sunset Court BTriq MarsalfornXaghraGozoMalta Faculty of Science University of ZagrebHorvatovac 102aHR-10000 ZagrebCroatia department of Biology Division of Plant BiologyLaboratory of BotanyUniversity of PatrasUniversity Campus26504 RioGreece Centro Conservazione Biodiversità Dipartimento di Scienze della Vita e dell’AmbienteUniversitàdegli Studi di CagliariViale S.Ignazio da Laconi1309123 CagliariItaly departamento de Biologia Vegetal y Ecologia Universidad de SevillaApartado 109541080 SevillaSpain department of Botany Hungarian Natural History MuseumPf.137Budapest 1431Hungary Sorbonne University IEES Bat 44-34cc 237.4Place JussieuParisFrance department of Agriculture Food and Forest SciencesUniversity of PalermoViale delle Scienze bldg.490128 PalermoItaly INRA UR629Ecologie des forêts méditerranéennesAvignonFrance

Background: Tree species represent 20% of the vascular plant species worldwide and they play a crucial role in the global functioning of the biosphere. The Mediterranean Basin is one of the 36 world biodiversity hotspots, and it is estimated that forests covered 82% of the landscape before the first human impacts, thousands of years ago. However, the spatial distribution of the Mediterranean biodiversity is still imperfectly known, and a focus on tree species constitutes a key issue for understanding forest functioning and develop conservation strategies. Methods: We provide the first comprehensive checklist of all native tree taxa (species and subspecies) present in the Mediterranean-European region (from Portugal to Cyprus). We identified some cases of woody species difficult to categorize as trees that we further called "cryptic trees". We collected the occurrences of tree taxa by"administrative regions", i.e. country or large island, and by biogeographical provinces. We studied the species-area relationship, and evaluated the conservation issues for threatened taxa following IUCN criteria. Results: We identified 245 tree taxa that included 210 species and 35 subspecies, belonging to 33 families and 64 genera. It included 46 endemic tree taxa (30 species and 16 subspecies), mainly distributed within a single biogeographical unit. The countries with the highest tree richness are Greece (146 taxa), Italy (133), Albania (122), Spain (155), Macedonia (116), and Croatia (110). The species-area relationship clearly discriminated the richest central-eastern (Balkans) and northern (Alpine and Cevenno-Pyrenean) biogeographical provinces, against the five western provinces in the Iberian Peninsula. We identified 44 unrecognized "cryptic trees", representing 21% of the total trees. Among the 245 taxa identified, 19 are considered to be threatened (15 CR+EN+vu) or near threatened (4 NT) by IUCN. Conclusions: The Mediterranean-European region includes an unsuspectedly high nu

关键词： Plant biogeography Mediterranean region Threatened trees Tree definition Tree distributions

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