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Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

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Light(Science & Applications) 2020年第1期9卷 346-357页

作者： Timur Ermatov Roman E.Noskov Andrey AMachnev Ivan Gnusov vsevolod atkin Ekaterina N.Lazareva Sergei V.German Sergey S.Kosolobov Timofei S.Zatsepin Olga V.Sergeeva Julia S.Skibina Pavel Ginzburg Valery V.Tuchin Pavlos G.Lagoudakis Dmitry A.Gorin Skolkovo Institute of Science and Technology 3 Nobelya str.Moscow 121205Russia Department of Electrical Engineering Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Light-Matter Interaction Centre Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Saratov State University 83 Astrakhanskaya str.Saratov 410012Russia Tomsk State University 36 Lenin’s av.Tomsk 634050Russia M.V.Lomonosov Moscow State University Leninskie Gory1-3Moscow 119992Russia SPE LLC Nanostructured Glass Technology 10150 Let OktjabrjaSaratov 410033Russia Center for Photonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny 141700Russia Institute of Precision Mechanics and Control of the Russian Academy of Sciences 24 Rabochaya str.Saratov 410028Russia

The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical *** common strategy,however,disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral ***,we address this issue by introducing the approach of in-fibre multispectral optical sensing(IMOS).The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid *** offers a unique opportunity to measure the refractive index at 42 wavelengths,with a sensitivity up to ~3000 nm per refractive index unit(RIU)and a figure of merit reaching 99 RIU^(−1) in the visible and near-infra-red spectral *** apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

关键词： refractive spectral microstructure

Masquerading bundle branch block with intermittent right ventricular pacing in a patient with acute coronary syndrome

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老年心脏病学杂志:英文版 2023年第10期20卷 762-766页

作者： vsevolod Tabachnikov Yuval Avidan Department of Cardiovascular Medicine Lady Davis Carmel Medical CenterHaifaIsrael

The relatively uncommon masquerading bundle branch block(MBBB),a concept initially introduced in 1958 by UNGER,et al.[1]and colleagues,refers to a conduction abnormality that consists of the right bundle branch block(... 详细信息

关键词： bundle branch

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亨利·摩尔微缩雕塑展

雕塑 2024年第3期 18-21页

作者：约翰·阿特金朱羿郎(翻译) 不详

“亨利·摩尔微缩雕塑展”的策展人,霍尔本博物馆馆长克里斯·斯蒂芬斯组织了这次亨利·摩尔雕塑小稿的展览,简明扼要地展示了摩尔在其漫长的职业生涯中对这种创作方法的坚守。展览以丰富的知识贯穿了摩尔职业生涯的各个阶段,记叙了这... 详细信息

“亨利·摩尔微缩雕塑展”的策展人,霍尔本博物馆馆长克里斯·斯蒂芬斯组织了这次亨利·摩尔雕塑小稿的展览,简明扼要地展示了摩尔在其漫长的职业生涯中对这种创作方法的坚守。展览以丰富的知识贯穿了摩尔职业生涯的各个阶段,记叙了这位雕塑家作品中具有里程碑意义的成就。此外,展览还连贯地展现了这种工作方法的亲和力,以及尺度问题对摩尔整体作品的重要性。

关键词：雕塑展策展人博物馆馆长尺度问题斯蒂芬斯雕塑家各个阶段职业生涯

Assessing suspended sediment fluxes with acoustic Doppler current profilers:case study from large rivers in Russia

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Big Earth Data 2022年第4期6卷 504-526页

作者： Sergey Chalov vsevolod Moreido Victor Ivanov Aleksandra Chalova Faculty of Geography Lomonosov Moscow State UniversityMoscowRussia Institute of Physics Kazan Federal UniversityKazanRussia Flood Hydrology Lab Water Problems Institute of Russian Academy of SciencesMoscowRussia

Surrogate measures are becoming increasingly used to measure suspended sediment flux,but only few particular computer techniques of data processing are recently *** study demonstrates capabilities of acoustic Doppler current profilers(ADCPs)to infer information regarding suspended-sand concentrations in river systems and calculate suspended sediment flux via big data analytics which includes process of analyzing and data mining of measurements based on ADCP signal backscatter intensity *** present here specific codes done by R language using RStudio software with open-source tidyverse and plotly packages aimed to generate tables containing data of suspended load for cells,verticals and whole cross-section based on backscattering values from 600 kH Teledyne RDInstruments RioGrande WorkHorse ADCP unit,as well perform estimates of morphometric,suspended sediment concentration(SSC)and velocity characteristics of the *** developed tools enabled to process large data array consisting of over 56,526,480 geo-referenced values of river depth,streamflow velocity,and backscatter intensity for each river cross-section measured at six case study sites in Russia.

关键词： Big data ADCP backscatter intensity sediment transport

Embedding of Pre-Lie Algebras into Preassociative Algebras

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Algebra Colloquium 2020年第2期27卷 299-310页

作者： vsevolod Gubarev University of Vienna Oskar-Morgenstern-Platz 11090ViennaAustria

With the help of Rota-Baxter operators and Grobner-Shirshov bases,we prove that every pre-Lie algebra can be injectively embedded into its universal enveloping preassociative algebra.

关键词： Rota-Baxter operator GrÖbner-Shirshov basis pre-Lie algebra preassociative algebra(dendriform algebra)

复合材料高强度粘合剂减少飞机紧固件使用的研究

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复合材料高强度粘合剂减少飞机紧固件使用的研究

作者： vsevolod Kostin 上海交通大学

学位级别：硕士

在本文中评估了薄壁复合结构构件胶接接头中粘接层厚度对整个接头强度影响,提供了对现有的用于预测粘合接头强度理论方法的批判性分析。通过一系列文献研究了胶接剂的厚度对强度影响,了解到复合板胶胶接接头强度的理论估计结果与实验结... 详细信息

在本文中评估了薄壁复合结构构件胶接接头中粘接层厚度对整个接头强度影响,提供了对现有的用于预测粘合接头强度理论方法的批判性分析。通过一系列文献研究了胶接剂的厚度对强度影响,了解到复合板胶胶接接头强度的理论估计结果与实验结果之间存在一定差距。之后,通过假设初始断裂区的大小和形状的变化与粘合剂层的厚度相关,发现预测胶接接头承载能力的最有效方法是通过断裂能释放强度和胶层预断裂区形成的断裂力学能量模型计算失效强度,最终将粘合剂接头强度的预测结果与实验数据进行比较得到了较为吻合的结果。

关键词：飞机粘接接头碳纤维粘接层厚度

An approach to net-centric control automation of technological processes within industrial IoT systems

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Advances in Manufacturing 2017年第4期5卷 388-393页

作者： Nikita Voinov Igor Chernorutsky Pavel Drobintsev vsevolod Kotlyarov Institute of Computer Science and Technology Peter the Great St. Petersburg Polytechnic UniversityPolytechnicheskaya 29 Saint Petersburg Russia 195251

The use of industrial internet networks with net- centric control is the driving trend behind the future material manufacturing of goods and services. The promising future of this approach is provided by these complex net-centric systems functioning with high relia- bility. The problem of intelligent net-centric control and reliable network functioning is fundamental, with the additional requirement that the system should preserve stakeholder security and privacy according to policies. The issue is that such systems are characterized by complex multi-parameter operability modes controlled by various criteria. This study considers an approach to providing reliable management of complicated Internet of things （IoT） systems. This is achieved by solving multi-criteria tasks over many processes of various physical natures. Corresponding methods of hierarchical decomposition of multi-criteria tasks, process levels of multi-criteria opti- mization, specifics of aggregation levels, and the master equation of the optimization process are described.

关键词： Net-centric control Technological process Internet of things (IoT) Reliability Multi-criteria optimization

Arrestins:structural disorder creates rich functionality

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Protein & Cell 2018年第12期9卷 986-1003页

作者： vsevolod V.Gurevich Eugenia V.Gurevich Vladimir N.Uversky Department of Pharmacology Vanderbilt UniversityNashvilleTN 37232USA Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute Morsani College of Medicine University of South FloridaTampaFL 33612USA Institute for Biological Instrumentation Russian Academy of SciencesPushchinoMoscow RegionRussia 142290

Arrestins are soluble relatively small 44-46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners. There are binding partners that demonstrate preference for each of the known arrestin conformations: free, receptor-bound, and microtubule-bound. Recent evidence suggests that conformational flexibility in every functional state is the defining characteristic of arrestins. Flexibility, or plasticity, of proteins is often described as structural disorder, in contrast to the fixed conformational order observed in high-resolution crystal structures. However, protein-protein interactions often involve highly flexible elements that can assume many distinct conformations upon binding to different partners. Existing evidence suggests that arrestins are no exception to this rule: their flexibility is necessary for functional versatility. The data on arrestins and many other multi-functional proteins indicate that in many cases, "order" might be artificially imposed by highly non-physiological crystallization conditions and/or crystal packing forces. In contrast, conformational flexibility (and its extreme case, intrinsic disorder) is a more natural state of proteins, representing true biological order that underlies their physiologically relevant functions.

关键词： EPR GPCR NMR arrestin crystal structure disorder protein-protein interactions

How genetic errors in GPCRs affect their function:Possible therapeutic strategies

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Genes & Diseases 2015年第2期2卷 108-132页

作者： Henriette Stoy vsevolod V.Gurevich University of Tu¨bingen Tu¨bingen 72074Germany Department of Pharmacology Vanderbilt UniversityNashvilleTN 37232USA

Activating and inactivating mutations in numerous human G protein-coupled receptors(GPCRs)are associated with a wide range of disease *** we use several class A GPCRs with a particularly large set of identified disease-associated mutations,many of which were biochemically characterized,along with known GPCR structures and current models of GPCR activation,to understand the molecular mechanisms yielding pathological *** on this mechanistic understanding we also propose different therapeutic approaches,both conventional,using small molecule ligands,and novel,involving gene therapy.

关键词： Activation Agonist Mutation Gene therapy Genetic disorder GPCR