检索结果-南通市图书馆

Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

Translational Neurodegeneration 2023年第1期12卷 604-637页

作者： Sina Shadfar Sonam Parakh Md Shafi Jamali Julie D.atkin Centre for Motor Neuron Disease Research Macquarie Medical SchoolMacquarie UniversitySydneyNSW 2109Australia La Trobe Institute for Molecular Science La Trobe UniversityBundooraMelbourneVIC 3086Australia

Redox homeostasis refers to the balance between the production of reactive oxygen species(ROS)as well as reactive nitrogen species(RNS),and their elimination by *** is linked to all important cellular activities and oxidative stress is a result of imbalance between pro-oxidants and antioxidant *** stress perturbs many cellular activities,including processes that maintain the integrity of *** acids are highly reactive and therefore particularly susceptible to *** DNA damage response detects and repairs these DNA *** DNA repair processes are therefore essential for maintaining cellular viability,but they decline considerably during *** damage and deficiencies in DNA repair are increasingly described in age-related neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis and Huntington’s ***,oxidative stress has long been associated with these ***,both redox dysregulation and DNA damage increase significantly during aging,which is the biggest risk factor for neurodegenerative ***,the links between redox dysfunction and DNA damage,and their joint contributions to pathophysiology in these conditions,are only just *** review will discuss these associations and address the increasing evidence for redox dysregulation as an important and major source of DNA damage in neurodegenerative *** these connections may facilitate a better understanding of disease mechanisms,and ultimately lead to the design of better therapeutic strategies based on preventing both redox dysregulation and DNA damage.

关键词： Redox dysregulation DNA damage Neurodegeneration Reactive oxygen species Oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phenotypic plasticity in rice:responses to fertilization and inoculation with arbuscular mycorrhizal fungi

引用

Journal of Plant Ecology 2016年第1期9卷 107-116页

作者： Shujuan Zhang Li Wang Fang Ma Jixian Yang Owen K.atkin State Key Laboratory of Urban Water Resource and Environment School of Municipal and Environmental EngineeringHarbin Institute of Technology73 Huanghe RoadNangang DistrictHarbin 150090China ARC Centre of Excellence in Plant Energy Biology Division of Plant SciencesResearch School of BiologyThe Australian National UniversityBuilding 134Sullivans Creek RoadCanberraAustralian Capital Territory 2601Australia

Aims Changes in the phenotype of crops(phenotypic plasticity)are known to play an important role in determining responses to nutrient availability,with the direction and magnitude of plasticity of individual traits being crucial for grain *** study analysed the direction,magnitude and hierarchy of plastic responses of yieldrelated traits(*** allocation and yield components)of rice(Oryza sativa L.)to nutrient *** estimated the effect of inoculation with arbuscular mycorrhizal fungi(AMF)on these characteristics of phenotypic *** A field experiment was carried out in northeast China,providing rice with six NPK fertilizer levels with or without inoculation with Glomus *** maturity,we quantified biomass allocation traits(shoot:root ratio and panicle:shoot ratio)and yield component traits(panicle number per hill,spikelet number per panicle,percentage of filled spikelets and seed weight).We also assessed the direction of change in each trait and the magnitude of trait *** Findings In non-inoculated plants,we found that biomass allocation and seed-number traits(*** number per hill,spikelet number per panicle and percentage of filled spikelets)responded to fertilization in the same direction,increasing with rising *** formation was the most plastic trait,while seed mass was the least plastic *** inoculation nullified the relationship between most biomass allocation and seed-number traits(except for that between panicle:shoot ratio and the percentage of filled spikelets)but increased the magnitude of plasticity in biomass allocation traits without altering the hierarchy of traits’*** results underscore the importance of plasticity of yield-related traits per se,and the impact of AMF on plasticity,for maintaining rice yields under low fertilization regimes.

关键词： fertilization plastic response rice nutrient availability symbiosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is resource allocation and grain yield of rice altered by inoculation with arbuscular mycorrhizal fungi?

引用

Journal of Plant Ecology 2015年第4期8卷 436-448页

作者： Shujuan Zhang Li Wang Fang Ma Keith J.Bloomfield Jixian Yang Owen K.atkin State Key Laboratory of Urban Water Resource and Environment School of Municipal and Environmental EngineeringHarbin Institute of Technology73 Huanghe RoadNangang DistrictHarbin 150090China ARC Centre of Excellence in Plant Energy Biology Division of Plant ScienceResearch School of BiologyThe Australian National UniversityBuilding 46Sullivans Creek RoadCanberraAustralian Capital Territory 0200Australia

Aims our study quantified the combined effects of fertilization and inoculation with arbuscular mycorrhizal fungi(AMF)on grain yield and allocation of biomass and nutrients in field-grown rice(Oryza sativa l.).Methods a two-factor experiment was conducted at a field site in northeast of China(in shuangcheng,Heilongjiang Province,songhua river basin):six nitrogen-phosphorus-potassium fertilizer levels were provided(0,20,40,60,80 and 100%of the local norm of ferti-lizer supply),with or without inoculation with Glomus *** maturity,we quantified the percentage of root length colonization by AMF,grain yield,shoot:root ratios,shoot N and P contents and nutrients allocated to panicles,leaves and *** Findingsas expected,inoculation resulted in greatly increased AMF colo-nization,which in turn led to higher shoot:root ratios and greater shoot N ***:root ratios of inoculated rice increased with increasing fertilization while there was a significant interaction between fertilization and inoculation on shoot:root ***,a F inoculation increased panicle:shoot ratios,panicle N:shoot N ratios and panicle P:shoot P ratios,especially in plants grown at low fertilizer ***,inoculated rice exhibited higher grain yield,with the maximum improvement(near 62%)at the lower fertilizer *** results showed that(i)AMFinoculated plants conform to the functional equilibrium theory,albeit to a reduced extent compared to non-inoculated plants and(ii)AMF inoculation resulted in greater allocation of shoot biomass to panicles and increased grain yield by stimulating N and P redis-tribution to panicles.

关键词： arbuscular mycorrhizal fungi resource allocation rice grain yield fertilizer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一次乙状结肠镜检预防结直肠癌

引用

国外医学（肿瘤学分册） 1993年第5期20卷 305-307页

作者： atkin WS 李春元

结直肠癌普查的理论基础英国每年有新确诊的结直肠癌28000例及因该病死亡者19000例.目前结直肠癌的5年存活率仅35%,这表明虽然该病在治疗方面开展了一些外科新技术与辅助性化疗,但仍不能明显提高存活率,其主要原因是多数病例确诊时已是... 详细信息

结直肠癌普查的理论基础英国每年有新确诊的结直肠癌28000例及因该病死亡者19000例.目前结直肠癌的5年存活率仅35%,这表明虽然该病在治疗方面开展了一些外科新技术与辅助性化疗,但仍不能明显提高存活率,其主要原因是多数病例确诊时已是晚期.乙状结肠镜检普查可能对预防结直肠癌有效。

关键词：结肠镜检预防结肠肿瘤直肠肿瘤

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

如何解决白金浇铸问题

引用

中国宝玉石 1997年第2期 20-23页

作者： Richard atkin

由于全球对白金首饰的要求增加,愈来愈多亚洲珠宝制造商在他们的产品系列中加添白金首饰,但白金的特性使之成为一种难以加工的金属。美国纽约Lou atkin Castings Inc总裁Richard atkin研究白金浇铸已将近15年,他在本文中提供一些解决白... 详细信息

由于全球对白金首饰的要求增加,愈来愈多亚洲珠宝制造商在他们的产品系列中加添白金首饰,但白金的特性使之成为一种难以加工的金属。美国纽约Lou atkin Castings Inc总裁Richard atkin研究白金浇铸已将近15年,他在本文中提供一些解决白金浇铸问题的方案。本文引自atkin先生在1995年世界白金协会研讨会上所发表的演讲。

关键词：白金浇铸金饰品首饰制作

来源：

维普期刊数据库

同方期刊数据库评论