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matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： m.R.D.Rodrigues A.Bonasera m.Scisciò J.A.Pérez-Hernández m.Ehret F.Filippi P.L.Andreoli m.Huault H.Larreur D.Singappuli D.molloy D.Raffestin m.Alonzo G.G.Rapisarda D.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.mcNamee m.La Cognata S.Palmerini T.Carriere m.Cipriani G.Di Giorgio G.Cristofari R.De Angelis G.A.P.Cirrone D.margarone L.Giuffrida D.Batani P.Nicolai K.Batani R.Lera L.volpe D.Giulietti S.Agarwal m.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartimento di Fisica e Astronomia“E.majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain Dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of Sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of Sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of meV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

经皮冠状动脉血管重建术时的血压水平与冠状动脉支架内再狭窄的风险

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中华高血压杂志 2016年第7期24卷 698-698页

作者： Tocci G Barbato E Coluccia R modestino A Pagliaro B mastromarino V Giovannelli F Berni A volpe m 陈云叶鹏

血压水平增高使进行过经皮冠状动脉介入治疗（percutaneous coronary interventions,PCI）的患者10年内心血管病和死亡率的风险处于很高危的水平。该研究目的是探讨患者PCI时血压水平对今后发生支架内再狭窄（in stent restenosis,ISR... 详细信息

血压水平增高使进行过经皮冠状动脉介入治疗（percutaneous coronary interventions,PCI）的患者10年内心血管病和死亡率的风险处于很高危的水平。该研究目的是探讨患者PCI时血压水平对今后发生支架内再狭窄（in stent restenosis,ISR）风险的作用。方法：回顾性分析行PCI的患者796例,

关键词：支架内再狭窄 restenosis stent 可逆性心肌缺血心血管病介入治疗药物洗脱支架 eluting 血管造影内直径

Sleeve Gastrectomy with Duodenal Transit Bipartition (S-DTB): Preliminary Results and Technical Aspects of Its metabolic Structure

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Surgical Science 2024年第4期15卷 244-264页

作者： Paulo Reis Esselin de melo Ricardo Zorron Victor Ramos mussa Dib Carlos Augusto Scussel madalosso Rui Ribeiro Thonya Cruz Braga Paula volpe Carlos Eduardo Domene Paulo Reis Institute Goiania GO Brazil Alfredo Nasser University Center (UNIFAN) Goiania GO Brazil Department of Bariatric and metabolic Surgery CUF Descobertas Hospital Lisbon Portugal Victor Dib Institute Manaus AM Brazil Gastrobese Clinic Passo Fundo RS Brazil Lusiadas Amadora Hospital Lisbon Portugal Clianest Group Renaissance Hospital Goiania GO Brazil Integrated Center for Advanced medicine (CImAmED) Sao Paulo Brazil

Obesity is a significant and escalating health issue both in Brazil and globally, with over 650 million overweight adults worldwide. The treatment of obesity can be performed clinically, endoscopically or surgically;surgical treatment proves to be safe and more effective in terms of weight loss and long-term maintenance. Objective: This study aimed to monitor the progress of weight loss and comorbidity control in patients undergoing sleeve gastrectomy with duodenal bipartition. methods: This pilot project involved 8 patients divided into 2 arms. In the first arm, patients underwent sleeve gastrectomy with Roux-en-Y duodenoileal transit bipartition (S-RYDITB), while in the second arm, patients underwent sleeve gastrectomy with Roux-en-Y duodenojejunal transit bipartition (S-RYDJTB). Both procedures involved Roux-en-Y reconstruction without duodenal exclusion. In S-RYDITB, the duodenal-ileal anastomosis was performed 300 cm from the ileocecal valve (ICV), creating a 250 cm common channel and a 50 cm alimentary channel. In S-RYDJTB, a biliopancreatic loop was created 200 cm from the angle of Treitz, with a 1 m alimentary channel. Results: Five patients underwent the procedures, with one undergoing S-RYDITB and four undergoing S-RYDJTB. No adverse events such as hospitalizations, readmissions, reoperations, fistulas, bleeding, pulmonary embolism, diarrhea, dumping syndrome, or hypoglycemia occurred during the study period. The mean length of hospital stay was 2 days. The average BmI decreased from 37.27 kg/m2 preoperatively to 29.48 kg/m2 after 6 months. The significant percentage of weight loss was 21.22%, with excess weight loss of 63.6%. Ninety-five percent remission of comorbidities, including hypercholesterolemia, hypertriglyceridemia, diabetes, hypertension, steatosis, and pre-diabetes. Two patients underwent sleeve gastrectomy with duodenal bipartition using a single anastomosis. Conclusion: Duodenal switch surgery has gained worldwide recog

关键词： Obesity Bariatric Surgery metabolic Surgery Duodenal Switch

预测20年总死亡与心血管病死亡风险增加的尿酸阈值

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中华高血压杂志 2020年第1期28卷 99-99页

作者： Virdis A masi S Casiglia E Tikhonoff V Cicero AFG Ungar A Rivasi G Salvetti m Barbagallo Cm Bombelli m Dell'Oro R Bruno B Lippa L D'Elia L Verdecchia P mallamaciF Cirillo m Rattazzi m Cirillo P Gesualdo L mazza A Giannattasio C maloberti A volpe m Tocci G GeorgiopoulosG Iaccarino G Nazzaro P Parati G Palatini P Galletti F Ferri C Desideri G Viazzi F Pontremoli R muiesan mL Grassi G Borghi C 赵狄(摘译) 刘莉(审校) 不详

目前识别心血管病风险不同分层的血清尿酸水平仍未确定。采用基于人群的大数据,研究人员评估了总死亡和与心血管病死亡(cardiovascular mortality,CVm)风险增加的血清尿酸水平。尿酸与心脏健康(uric acid right for heart health,URRAH... 详细信息

目前识别心血管病风险不同分层的血清尿酸水平仍未确定。采用基于人群的大数据,研究人员评估了总死亡和与心血管病死亡(cardiovascular mortality,CVm)风险增加的血清尿酸水平。尿酸与心脏健康(uric acid right for heart health,URRAH)研究是一项收集意大利几个基于大型人群纵向研究大数据的多中心回顾性观察性研究(随访20年),患者均在意大利高血压协会的高血压诊所就诊。

关键词：心血管病尿酸水平死亡风险

The Unexpected Existence of Coding and Non-Coding Fragments along the Eukaryotic Gene

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Advances in Biological Chemistry 2015年第2期5卷 98-125页

作者： Pietro volpe Department of Biology University of Rome “Tor Vergata” Rome Italy National Institute of Biostructures and Biosystems Rome Italy

The pathways leading to synthesis and post-synthetic modification of DNA employed methionine as donor of atoms: the carbon that came from its –CH3 served for DNA replication and repair either in bacteria or humans;its entire –CH3 served instead for building N6-methyladenine and 5-methylcytosine on bacterial DNA and 5-methylcytosine alone on human DNA. In humans, although a slight extra-S asymmetric methylation appeared de novo yielding on parental DNA 5’-m5CpC-3’/ 3’-GpG-5’, 5’-m5CpT-3’/3’-GpA-5’ and 5’-m5CpA-3’/3’-GpT-5’ monomethylated dinucleotide pairs, a heavy symmetric methylation involved in S semiconservatively newly made DNA to guarantee genetic maintenance of –CH3 in 5’-m5CpG-3’/3’-Gpm5C-5’ dimethylated dinucleotide pairs. In this framework, an inverse correlation was found between bulk genomic DNA methylation occurring in S and bulk polyA-containing pre-mRNA transcription taking place in G1 and G2. Thus, probes of 1 × 106 Daltons (constructed using sheared by sonication newly made methylated DNA filaments) revealed a modular organization in genes: after the hypermethylated promoter, they exhibited an alternation of unmethylated coding and methylated uncoding sequences. This encouraged the search for a language that genes regulated by methylation should have in common. An initial deciphering of restriction minimaps with hypomethylatable exons vs. hypermethylatable promoters and introns was improved when the bisulfite technique allowed a direct sequencing of m5C. In lymphocytes, where the transglutaminase gene is inactive, its promoter exhibited two fully methylated CpG-rich domains at 5’ and one fully unmethylated CpG-rich domain at 3’, including the site +1 and a 5’-UTR. At variance, in HUVEC cells, where the transglutaminase gene is active, in the first CpG-rich domain of promoter few doublets lost their –CH3. Such an inverse correlation suggested new hypotheses especially in connection with repair-modification: UV radiation would cause demethylation in g

关键词： Coding vs. Non-Coding Pre-messenger RNA Regions Exons and Introns multigenic and monogenic Transcriptional Units Regulation of Gene Expression Repair-modification

müller-Weiss disease:Four case reports

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World Journal of Orthopedics 2020年第11期11卷 507-515页

作者： Antonio volpe Luca monestier Teresa malara Giacomo Riva Giuseppe La Barbera michele FrancescoSurace Foot and Ankle Clinic Policlinico Abano TermeAbano Terme 35031Italy Orthopedic and Trauma Unit ASST Sette LaghiVarese 21100Italy Department of Biomedical Science and Functional Images Universitàdi MessinaMessina 98122Italy Interdisciplinary Research Centre for Pathology and Surgery of the musculoskeletal System Department of Biotechnology and Life Sciences(DBSV)University of InsubriaVarese 21020Italy

BACKGROUND müller-Weiss disease(mWD)is an idiopathic foot condition characterized by spontaneous tarsal“scaphoiditis”in *** bilateral and affecting females during the 4th-6th decades of life,the pathogenesis of mWD remains unclear:It has been traditionally considered a spontaneous osteonecrosis of the *** typical presentation of mWD is a long period of subtle discomfort followed by prolonged standing,atraumatic,disabling ***,there is no gold standard for the treatment of patients with *** support initial conservative *** treatment should be considered for failure of conservative therapies longer than 6 *** indication for surgery is severity of symptoms rather than severity of *** treatment options include core decompression,internal fixation of the tarsal navicular,open or arthroscopic triple fusion,talo-navicular or talo-navicular-cuneiform arthrodesis,and navicular excision with reconstruction of the medial *** SUmmARY In this study,we report four patients affected by *** and radiographic assessment,follow-up and treatment are *** As it is frequently misdiagnosed,mWD is challenging for orthopedic *** diagnosis and effective treatment are mandatory to avoid sequelae.

关键词： müller-Weiss Etiopathogenesis Review Treatment Case report

An evaluation of sustainability and societal impact of high-power laser and fusion technologies:a case for a new European research infrastructure

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High Power Laser Science and Engineering 2021年第4期9卷 66-69页

作者： S.Atzeni D.Batani C.N.Danson L.A.Gizzi m.Perlado m.Tatarakis V.Tikhonchuk L.volpe Dipartimento SBAI Universitàdi Roma"La Sapienza"Roma 00161Italy CELIA Universitéde Bordeaux-CNRS-CEAUMR 510733405 TalenceFrance AWE AldermastonReading RG74PRUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondon SW72AZUK Istituto Nazionale di Ottica Consiglio Nazionale delle Ricerche56125 PisaItaly Instituto Fusión Nuclear"Guillermo Velarde"Universidad Politecnica 28006 MadridSpain Institute of Plasma Physics and Lasers Hellenic Mediterranean University Research Centre74100 RethymnoGreece Department of Electronic Engineering Hellenic Mediterranean University73133 ChcmiaGreece ELI-Beamlines Center Institute of PhysicsCzech Academy of Sciences25241 Dolni BrezanyCzech Republic Centro de Laseres Pulsados(CLPU) Parque CientificoE-37185 VillamayorSalamancaSpain Laser-Plasma Chair at the University of Salamanca E-37185 VillamayorSalamancaSpain

Fusion energy research is delivering impressive new results emerging from different infrastructures and industrial devices evolving rapidly from ideas to proof-of-principle demonstration and aiming at the conceptual design of reactors for the production of electricity.A major milestone has recently been announced in laser fusion by the Lawrence Livermore National Laboratory and is giving new thrust to laser-fusion energy research *** we discuss how these circumstances strongly suggest the need for a European intermediate-energy facility dedicated to the physics and technology of laser-fusion ignition,the physics of fusion materials and advanced technologies for high-repetitionrate,high-average-power broadband *** believe that the participation of the broader scientific community and the increased engagement of industry,in partnership with research and academic institutions,make most timely the construction of this infrastructure of extreme scientific attractiveness.

关键词： fusion energy high power lasers plasmas inertial fusion high energy density

Cytotoxic Properties of Lyophilized Beers in a malignant Cell Line

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Food and Nutrition Sciences 2014年第1期5卷 45-51页

作者： Carmela Spagnuolo Idolo Tedesco maria Grazia volpe Stefania Bilotto maria Russo Gian Luigi Russo Institute of Food Sciences National Research Council Avellino Italy Institute of Food Sciences National Research Council Avellino Italy.

moderate beer consumption can be considered as part of a healthy diet since it may protect against heart disease, cancer and osteoporosis. The protective effects of beer reside in its polyphenol content whose chemical composition appears extremely complex. In the present study, five commercial beers with different polyphenol content (ranging between 690 - 2400 μm equivalents of quercetin) were employed to investigate their cytotoxic effect in vitro on HL-60 cells derived from a human promyelocytic leukemia cell line. A significant reduction in cell viability was measured after 48 hours treatment. Lyophilized beers with higher polyphenol content showed the highest cytotoxicity compared to those with lower concentrations. However, when the assay was performed applying equal amounts of total polyphenols from different lyophilized beers, the sample possessing lowest amount of polyphenols (690 μm equivalents of quercetin) resulted the most effective in reducing cell viability. These data suggest that the biological activities of polyphenols present in beer are not simply dependent upon their total concentration, but qualitative profile and relative concentrations are even more important in determining their antiproliferative effects on cancer cells.

关键词： Beers Cytotoxicity Polyphenol Flavonoids HL-60

A 2D scintillator-based proton detector for high repetition rate experiments

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High Power Laser Science and Engineering 2019年第4期7卷 15-20页

作者： m.Huault D.De Luis J.I.Apinaniz m.De marco C.Salgado N.Gordillo C.Gutierrez Neira J.A.Perez-Hemandez R.Fedosejevs G.Gatti L.Roso L.volpe Centro de Laseres Pulsados Building M5Science ParkCalle Adaja 837185 VillamayorSalamancaSpain Universidad de Salamanca Patio de Escuelas 137008 SalamancaSpain CmAm Universidad Autonoma de MadridCampus de CantoblancoE-28049 MadridSpain Grupo de Electronica y Semiconductores Departamento de Fisica AplicadaUniversidad Autonoma de MadridCantoblancoE-28049 MadridSpain University of Alberta 116 St85 AveEdmontonAB T6G 2R3AlbertaCanada Laser-Plasma Chair at the University of Salamanca Patio de Escuelas 1SalamancaSpain

We present a scintillator-based detector able to measure the proton energy and the spatial distribution with a relatively simple *** has been designed and built at the Spanish Center for Pulsed Lasers(CLPU)in Salamanca and tested in the proton accelerator at the Centro de micro-Análisis de materiales(CmAm)in *** detector is capable of being set in the high repetition rate(HRR)mode and reproduces the performance of the radiochromic film *** represents a new class of online detectors for laser-plasma physics experiments in the newly emerging high power laser laboratories working at HRR.

关键词： high repetition rate laser particle acceleration online detector proton diagnostic scintillator