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Management of residual penile curvature after penile prosthesis placement

Asian Journal of Andrology 2021年第2期23卷 129-134页

作者： Denis V Krakhotkin David J Ralph Gideon A Blecher volodymyr a chernylovskyi Francesco Greco Evgeny E Bakurov Ruslan A Bugaev Central District Hospital Outpatient DepartmentKamenolomniRostov Region 346480Russia University College London St Peter’s Andrology Centre and University College London Hospitals London W1G 6BJUnited Kingdom Monash University Department of SurgeryMelbourne 3168Australia The Alfred Hospital Department of UrologyMelbourne 3004Australia Department of Urology 1 City Clinical Hospital No.4Dnipro 49102Ukraine Department of Urology Humanitas GavazzeniBergamo 24125Italy Department of Surgery No.1 Rostov Regional Hospital ROKB 1Rostov-on-Don 344015Russia

Residual penile curvature is a common situation following the implantation of a penile prosthesis in patients with Peyronie’s ***,there is a variety of options for the correction of residual curvature,including penile modeling,plication techniques,as well as tunical incision/excision with or without grafting.A literature search of PubMed and Medline databases was conducted from 1964 until 2020,using search terms for all articles in the English *** this article,we provide a review of the techniques and the outcomes,according to the published literature.

关键词： grafting modeling penile curvature penile implant penile prosthesis Peyronie’s disease tunical plication

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Diagnostic value ultrasound signs of stones less than or equal to 10 mm and clinicoradiological variants of ureteric colic

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Asian Journal of Urology 2023年第1期10卷 39-49页

作者： Denis V.Krakhotkin volodymyr A.chernylovskyi Kemal Sarica Arman Tsaturyan Evangelos Liatsikos Jurijus Makevicius Nikolay Yu Iglovikov Dmitry N.Pikhovkin Central District Hospital Outpatient ClinicSadovaya Lane 23KamenolomniRostov RegionRussia Private Urological Practice DniproUkraine Department of Urology Biruni University HospitalInstanbulTurkey Department of Urology University Hospital of PatrasPatrasGreece Department of Urology Medical University of ViennaViennaAustria Institute for Urology and Reproductive Health Sechenov UniversityMoscowRussia Institute of Clinical Medicine Faculty of MedicineVilnius UniversityVilniusLithuania Department and Clinic of Urology S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian FederationSt.PetersburgRussia Central District Hospital Department of SurgeryLenina Avenue 28AksayRostov RegionRussia

Objective:To determine the diagnostic value of ultrasound signs of urinary stones less than or equal to 10 mm and to determine clinico-radiological variants of ureteric ***:A total of 455 ultrasound investigations were performed in patients referring to emergency department with urolithiasis and symptoms suspected of ureteric colic between January 2021 and May *** addition to microscopic evaluation of urine sediment to detect different crystals and non-contrast spiral computed tomography to detect stones,B-mode and color Doppler sonography was performed to assess the presence of acoustic shadow(AS)and twinkle artifacts(TA)as possible signs of stone(s)in ***:While the sensitivity and specificity of AS and TA were higher than 90%in patients with stones greater than 5 mm;positive prognostic values of these parameters were found to be extremely low for stones with sizes of 1-3 mm with specificity and sensitivity values not exceeding 53%.The sensitivity and specificity of AS and TA in the upper and lower ureters were higher for stones greater than or equal to 5 than for compared to those less than 5 *** the same time,the diagnostic values of TA and AS for middle ureter stones were very *** most prevalent clinico-radiological variants of ureteric colic were types I,III,and V being observed in 39%,28% and 21% cases,***:Our results demonstrate that TA and AS parameters seem to have a very low sensitivity and specificity in the diagnosis of urinary stones less than 5 *** diagnostic value of TA and AS increase significantly in stones greater than or equal to 5 ***,clinicians need to be very careful for overestimating the diagnostic values of TA and AS for stones less than 5 mm and non-contrast spiral computed tomography must be the method of choice for patients presenting to emergency department with ureteric colic.

关键词： Ureteric colic Urolithiasis Ultrasound Twinkle artifact Non-contrast computed tomography

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New insights into the pathogenesis of Peyronie’s disease:A narrative review

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Chronic Diseases and Translational Medicine 2020年第3期6卷 165-181页

作者： Denis V.Krakhotkin volodymyr A.chernylovskyi Alexandre Mottrie Francesco Greco Ruslan A.Bugaev Outpatient Department Central District HospitalKamenolomniRostov Region.Russia Department of Urology 1 City Clinical Hospital No-4DniproUkraine Department of Urology Onze Li eve Vrouw HospitalAalstBelgium ORSI Academy Me lieBelgium Department of Urology Humanitas GcivazzeniBergamoItaly

Peyronie’s disease(PD)is a benign,progressive fibrotic disorder characterized by scar or plaques within the tunica albuginea(TA)of the *** study provides new insights into the pathogenesis of PD based on data from different studies regarding the roles of cytokines,cell signaling pathways,biochemical mechanisms,genetic factors responsible for fibrogenesis.A growing body of literature has shown that PD is a chronically impaired,localized,wound healing process within the TA and the Smith *** is caused by the influence of different pathological stimuli,most often the effects of mechanical stress during sexual intercourse in genetically sensitive individuals with unusual anatomical TA features,imbalanced matrix metalloproteinase/tissue inhibitor of metalloproteinase(MMP/TIMP),and suppressed antioxidant systems during chronic *** intracellular signal cascades are activated during fibrosis along with low expression levels of their negative regulators and transforming growth factor-β1 *** development of multikinase agents with minimal side effects that can block several signal cell pathways would significantly improve fibrosis in PD tissues by acting on common downstream mediators.

关键词： Peyronie’s disease Cell signal pathway Penile curvature Myofibroblast Extracellular matrix

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A Prospective, Observational Study of Use Combination Silodosin 8 mg Plus Serenoa Repens, Urtica Dioica, Cucurbita Pepo (Rotaprost) Compared With Silodosin 8 mg Alone in Treatment Patients with Benign Prostate Hyperplasia

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Clinical Complementary Medicine and Pharmacology 2022年第3期2卷 55-62页

作者： Denis V.Krakhotkin volodymyr A.chernylovskyi Ruslan A.Bugaev Dmitry N.Pikhovkin Central District Hospital Outpatient ClinicKamenolomni 346480Rostov RegionRussia Department of Urology City Clinical Hospital No.4Dnipro 49102Ukraine Central District Hospital Department of SurgeryAksay 346720Rostov RegionRussia

Background:Benign prostatic hyperplasia(BPH)is one of the most common causes of lower urinary tract symp-toms(LUTS)in older ***,there are several plant extracts used for the treatment of LUTS due to ***:The aim of this study is to compare the effect of combining silodosin 8 mg with Serenoa repens,Urtica dioica,Cucurbita pepo(Rotaprost 530 mg)compared to silodosin 8 mg and Rotaprost 530 mg alone in patients with LUTS/***:Four hundred five men with symptomatic BPH were recruited for the study from June 2020 to Jan-uary *** hundred eighty-nine patients were followed up for 6 *** participants provided writ-ten informed *** prospective study included analysis of three treatment groups:Group I patients(n=130)received a combination of silodosin 8 mg and Rotaprost 530 mg(containing a dry extract of Serenoa repens 80 mg,a dry extract of Urtica dioica 150 mg,a dry extract of Cucurbita pepo seeds 200 mg,zinc(in the form of zinc picolinate)0.105 mg,and selenium(as sodium selenite)22.5μg);the group II(n=129)re-ceived silodosin 8 mg alone,and the group III(n=130)received Rotaprost 530 mg *** were measured by changes from baseline in International Prostate Symptom Score(IPPS)total score,PSA value,prostate volume,residual urine after urination,and maximum flow *** significance was set at P<***:In group I,IPSS,prostate volume,and maximum urinary flow rate(Qmax)improved significantly(P<0.05)compared with groups II and III during *** volume in group I showed a significant decrease only during 6 months of therapy(P<0.05).No serious adverse effects were registered in the three ***:Combination therapy with silodosin 8 mg significantly reduced LUTS/BPH,Qmax,and prostate volume compared with silodosin 8 mg *** 530 mg can also reduce PSA by at least 20.6−25.7%after 6-months of treatment.

关键词： BPH Silodosin Serenoa repens Urtica dioica Cucurbita pepo Lower urinary tract symptoms

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