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Effect of p120 Catenin Silencing on Biological Behaviors of PANC-1 Cells

Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第5期32卷 707-712页

作者：程张军 volker assfag 石欣林士波夏江燕杨平华 Norbert Hüser 沈锋 Department of General Surgery the Affiliated Zhongda HospitalSoutheast University Eastern Hepatobiliary Surgical Hospital Second Military Medical University Department of Surgery Klinikum rechts der IsarTechnische Universitt München

This study examined the possible role of p120ctn in the pathogenesis and development of pan-creatic ***-1 cells,a kind of human pancreatic carcinoma cell line,were cultured in this study.p120ctn was immunocytochemically detected in PANC-1 *** recombinant lentivirus vector was constructed to knock down the p120ctn expression of PANC-1 ***-time quantitative PCR (RQ-PCR) and Western blotting were used to determine the expression of p120ctn and E-cadherin in PANC-1 cells after p120ctn *** adhesion,invasion and migration capacity of PANC-1 cells after p120ctn knockdown was detected by cell adhesion,invasion and migration *** growth was measured by the MTT *** cycle and apoptosis were analyzed by fluorescence-activated cell *** results showed that p120ctn knockdown led to significantly down-regulated E-cadherin and a reduced cell-to-cell adhesion ability in PANC-1 ***-mediated knockdown of p120ctn reduced invasion and migration capacity of PANC-1 cells,inhibited cell growth,caused a significant decrease in the percentage of cells in G1,an increase in S,and promoted apoptosis of PANC-1 *** was concluded that p120ctn plays a pivotal role in the proliferation and metastasis of pancreatic carcinoma,suggesting that p120ctn is a novel target for pancreatic carcinoma treatment.

关键词： p120ctn pancreatic carcinoma invasion migration small hairpin RNA interference

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