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The role of mesenchymal stem cell-derived exosomes in tumor progression

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BIOCELL 2023年第8期47卷 1757-1769页

作者： CARL RANDALL HARREL VALENTIN DJONOV ANA volarevic DRAGICA PAVLOVIC vladislav volarevic Regenerative Processing Plant LLCFloridaUSA Institute of Anatomy University of BernBernSwitzerland Department of Psychology Faculty of Medical SciencesUniversity of KragujevacKragujevacSerbia Department of Genetics Faculty of Medical SciencesUniversity of KragujevacKragujevacSerbia Department of Microbiology and Immunology Faculty of Medical SciencesUniversity of KragujevacKragujevacSerbia

Exosomes derived from mesenchymal stem cells(MSC-Exos)are nano-sized extracellular vesicles enriched with bioactive molecules,such as microRNAs,enzymes,cytokines,chemokines,immunomodulatory,trophic,and growth *** molecules regulate the survival,phenotype,and function of malignant and tumor-infiltrated immune *** to their nano-size and bilayer lipid envelope,MSC-Exos can easily bypass biological barriers and may serve as drug carriers to deliver chemotherapeutics directly into the tumor ***,we summarize current knowledge regarding molecular mechanisms responsible for MSC-Exos-dependent modulation of tumor progression and discuss insights regarding the therapeutic potential of MSC-Exos in the treatment of malignant diseases.

关键词： Mesenchymal stem cells Exosomes Immune response Therapy Malignant diseases

Therapeutic potential of mesenchymal stem cells in the treatment of acute liver failure

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World Journal of Gastroenterology 2022年第28期28卷 3627-3636页

作者： Carl Randall Harrell Dragica Pavlovic Valentin Djonov vladislav volarevic Regenerative Processing Plant LLC Palm HarborFL 34176United States Department of Genetics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Institute of Anatomy University of BernBern 3012Switzerland Department of Medical Genetics and Microbiology and Immunology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

Acute liver failure(ALF)is a severe and life-threatening condition in which rapid deterioration of liver function develops in a patient who has no preexisting liver *** stem cells(MSCs)are immunoregulatory stem cells which are able to modulate phenotype and function of all immune cells that play pathogenic role in the development and progression of *** in juxtacrine and paracrine manner attenuate antigen-presenting properties of dendritic cells and macrophages,reduce production of inflammatory cytokines in T lymphocytes,suppress hepatotoxicity of natural killer T(NKT)cells and promote generation and expansion of immunosuppressive T,B and NKT regulatory cells in acutely inflamed *** to their nano-sized dimension and lipid envelope,intravenously injected MSC-derived exosomes(MSC-Exos)may by-pass all biological barriers to deliver MSC-sourced immunoregulatoy factors directly into the liver-infiltrated immune cells and injured *** obtained by us and others revealed that intravenous administration of MSCs and MSC-Exos efficiently attenuated detrimental immune response and acute inflammation in the liver,suggesting that MSCs and MSC-Exos could be considered as potentially new remedies in the immunotherapy of *** this review,we emphasize the current knowledge about molecular and cellular mechanisms which are responsible for MSC-based modulation of liver-infiltrated immune cells and we discuss different insights regarding the therapeutic potential of MSCs in liver regeneration.

关键词： Mesenchymal stem cells Acute liver failure Therapy Immunomodulation Regeneration

Central Asia—A Global Model for the Formation of Epigenetic Deposits in a Platform Sedimentary Cover

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Journal of Earth Science 2022年第2期33卷 278-288页

作者： Igor Pechenkin vladislav Petrov FSBI All-Russian Scientific-Research Institute of Mineral Resources MoscowRussia Institute of Geology of Ore Deposits Petrography Mineralogy and Geochemistry RAS MoscowRussia

Metallogenic specialization of sedimentary cover in Central Asia is determined by its tectonic setting that governs the hydrodynamic regime(exfiltrational or infiltrational)and as a consequence,the hydrogeochemical zonality(type of water and its gaseous and microcomponent composition).Hydrodynamic conditions(distribution of recharge and discharge areas)determine the direction of stratal water flow and location of mineralization resulted from the change in geochemical,thermodynamic,lithological,structural and other *** exfiltrational regime suggests a dependence of the epigenetic mineralization upon the distribution and degree of preservation of hydrocarbon ***,hydrocarbon matter serves as a reducing barrier and ore-concentrating factor during the formation of polymineral concentrations related to stratal oxidation *** supergene epigenetic ore-forming processes are induced by the interaction between the Earth’s sedimentary cover and *** rocks themselves commonly serve as a source of ore *** ore deposition zones on geochemical barriers and ore material source are often located significantly apart from each *** trend of these processes is determined by the position of ore-bearing depressions in large tectonic blocks.

关键词： Central Asia Kyzyl Kum Bukantau ore-forming systems epigenetic ore deposit geology

Interactive mobile equipment safety task-training in surface mining

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International Journal of Mining Science and Technology 2021年第4期31卷 743-751页

作者： Lazar Zujovic vladislav Kecojevic Dragan Bogunovic Department of Mining Engineering West Virginia UniversityMorgantown 26501USA North American Coal Corporation Farmington 87401USA

Improving the quality of equipment training for the Heavy Equipment Operators(HEO)is a critical task in improving safety and eliminating equipment-related injuries in *** of major responsibilities for the HEOs is proper machine *** miner safety training includes the use of hardcopy documents and video ***,modern mobile and computer technology offers tremendous potential to improve the training *** this study,we apply a 360-degree camera,opensource platform WordPress^(TM),and the software Unity3D in order to create materials and tools for the HEOs safety training to help trainees better understand the pre-shift safety machine *** computer-based safety task training developed in this research is tested and implemented at a surface mine in the southern United States.

关键词： Heavy equipment operators Safety task training 360-degree image/video Virtual reality

Theoretical and experimental studies of gas preparation system for pressurization and reactive control system of launch vehicle

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Chinese Journal of Aeronautics 2024年第7期37卷 168-177页

作者： Valeriy TRUSHLYAKOV vladislav URBANSKY Vadim YUDINTSEV Department of Aviation and Rocket Building Omsk State Technical UniversityOmsk 644050Russia

A new gas preparation system(GasPS-RCS)is proposed to solve two tasks:(A)to heat helium gas for tank pressurization;(B)to prepare gas for the Launch Vehicle(LV)Reactive Control System(RCS)at the LV orientation and stabilization sections of the LV on passive parts of the flight trajectory,to provide conditions for launching the Liquid Rocket Engine(LRE).The system includes a gas generator based on hydrogen peroxide,a separator for water separation,heat exchangers independent of the LRE,and gas-jet *** proposed new system allowed to reduce the length of pressurizing gas lines and reduce the increased helium gas consumption during the heat exchanger warm-up interval of the LRE during its launch.A special advantage of the proposed system is the possibility of ground testing of heat exchangers without an operating LRE.A mathematical model based on the first law of thermodynamics was used to perform a comparative analysis of GasPS-RCS with traditional pressurization and RCS *** validate the mathematical model,the experimental studies of helium pressurizing of a liquid nitrogen tank were *** results show that the deviation of experimental and calculated values for pressure is 1.1%and for temperature up to 2%.According to the results of comparative analysis,the GasPS-RCS is 259 kg lighter for the first stage and 80 kg lighter for the second stage of the LV.

关键词： Engine restart Reactive control system Tank pressurization Cryogenics Hydrogen peroxide Heat exchanger

Age and chemical composition of the globular cluster NGC 6652

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Research in Astronomy and Astrophysics 2020年第8期20卷 252-260页

作者： Margarita Eugene Sharina vladislav Vladimirovich Shimansky Special Astrophysical Observatory Russian Academy of SciencesNizhnii Arkhyz369 l67Russia Kazan Federal University 18 Kremlyovskaya streetKazan420008Russia

We present the results of determination of the age,helium mass fraction(Y),metallicity([Fe/H]),and abundances of the elements C,N,O,Na,Mg,Ca,Ti,C and Mn for the Galactic globular cluster NGC *** use its medium-resolution integrated-light spectrum from the library of Schiavon and our population synthesis method to fulfill this *** select the evolutionary isochrone and stellar mass function for our analysis,which provide the best approximation to the shapes and intensities of the observed Balmer line *** determined elemental abundances,age and metallicity are characteristic of stellar populations in the Galactic Bulge.

关键词： globular clusters:general globular clusters:abundances globular clusters:individual:NGC 6652

Evaluation of rope shovel operators in surface coal mining using a Multi-Attribute Decision-Making model

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International Journal of Mining Science and Technology 2014年第2期24卷 259-268页

作者： Vukotic Ivana Kecojevic vladislav Department of Mining Engineering West Virginia University

Rope shovels are used to dig and load materials in surface mines. One of the main factors that influence the production rate and energy consumption of rope shovels is the performance of the operator. This paper presents a method for evaluating rope shovel operators using the Multi-Attribute Decision-Making （MADM） model. Data used in this research were collected from an operating surface coal mine in the southern United States. The MADM model consists of attributes, their weights of importance, and alter- natives. Shovel operators are considered the alternatives, The energy consumption model was developed with multiple regression analysis, and its variables were included in the MADM model as attributes. Preferences with respect to min/max of the defined attributes were obtained with multi-objective opti- mization. Multi-objective optimization was conducted with the overall goal of minimizing energy con- sumption and maximizing production rate. Weights of importance of the attributes were determined by the Analytical Hierarchy Process （AHP）, The overall evaluation of operators was performed by one of the MADM models, i.e., PROMETHEE If. The research results presented here may be used by mining professionals to held evaluate the performance of rode shovel operators in surface mining.

关键词： Rope shovel Operator evaluation Production rate Energy consumption AHP

TRANSCRANIAL NEAR-INFRARED SPECTROSCOPY OF SMOKING BRAINS

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 227-234页

作者： OLIVIA PUCCI SANDER STEPANOV vladislav TORONOV Department of Physics Ryerson University 350 Victoria StreetTorontoONCanada M5B 2K3

We used a mobile wireless near-infrared sensor for the noninvasive recording of cerebral hemoglobin concentration changes during cigarette *** measurement included 5 min of rest,5 min of smoking imitation,and 5 min of actual *** observed significant effects of the tobacco smoking on temporal changes in the human brain at time scales ranging from 200 ms to about 1 *** most reproducible effects were an increase of the heartbeat rate and a decrease in the heartbeat power spectral density during *** but highly individual changes due to smoking were observed in temporal patterns of hemodynamic fluctuations in 5–50 s time *** have also found statistically significant slow increases in both oxy-and deoxy-hemoglobin concentrations during smoking.

关键词： Near-infrared spectroscopy hemoglobin brain smoking

Management of Control Impacts Based on Maximizing the Spread of Influence

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International Journal of Automation and computing 2019年第3期16卷 341-353页

作者： Alexander Tselykh vladislav Vasilev Larisa Tselykh Institute of Computer Technologies and Information Safety Southern Federal University.Rostov-on-Don 344006.Russia Department of Economics and Business Rostov State University of EconomicsRostov-on-Don 344002.Russia

The choice of fulcrums for control of socio-economic systems represented by direc ted weighted signed graphs is a topic of current *** article proposes a new method for identifying nodes of impact and influential nodes,which will provide a guaranteed positive system response over the growth *** task is posed as an optimization problem to maximize the ratio of the norms of the accumulated increments of the growth vector and the exogenous impact *** algorithm is reduced to solving a quadratic programming problem with nonlinear *** selection of the most effective vertices is based on the cumulative gains of the component projections onto the solution *** examples arc provided to illustrate the effectiveness of the proposed method.

关键词： Directed weighted graphs control impact spread of influence optimization algorithm growth model