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Therapeutic potential of mesenchymal stem cells in the treatment of acute liver failure

World Journal of Gastroenterology 2022年第28期28卷 3627-3636页

作者： Carl Randall Harrell Dragica Pavlovic Valentin Djonov vladislav Volarevic Regenerative Processing Plant LLC Palm HarborFL 34176United States Department of Genetics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Institute of Anatomy University of BernBern 3012Switzerland Department of Medical Genetics and Microbiology and Immunology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

Acute liver failure(ALF)is a severe and life-threatening condition in which rapid deterioration of liver function develops in a patient who has no preexisting liver *** stem cells(MSCs)are immunoregulatory stem cells which are able to modulate phenotype and function of all immune cells that play pathogenic role in the development and progression of *** in juxtacrine and paracrine manner attenuate antigen-presenting properties of dendritic cells and macrophages,reduce production of inflammatory cytokines in T lymphocytes,suppress hepatotoxicity of natural killer T(NKT)cells and promote generation and expansion of immunosuppressive T,B and NKT regulatory cells in acutely inflamed *** to their nano-sized dimension and lipid envelope,intravenously injected MSC-derived exosomes(MSC-Exos)may by-pass all biological barriers to deliver MSC-sourced immunoregulatoy factors directly into the liver-infiltrated immune cells and injured *** obtained by us and others revealed that intravenous administration of MSCs and MSC-Exos efficiently attenuated detrimental immune response and acute inflammation in the liver,suggesting that MSCs and MSC-Exos could be considered as potentially new remedies in the immunotherapy of *** this review,we emphasize the current knowledge about molecular and cellular mechanisms which are responsible for MSC-based modulation of liver-infiltrated immune cells and we discuss different insights regarding the therapeutic potential of MSCs in liver regeneration.

关键词： Mesenchymal stem cells Acute liver failure Therapy Immunomodulation Regeneration

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Energy flow problem solution based on state estimation approaches and smart meter data

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Global Energy Interconnection 2022年第5期5卷 551-563页

作者： Andrew V.Pazderin Ilya D.Polyakov vladislav O.Samoylenko Department of Automated Electrical Systems Ural Federal UniversityYekaterinburgMira 19Russia System Operator of United Power System YekaterinburgTolmacheva 6Russia

Accurate electric energy(EE)measurements and billing estimations in a power system necessitate the development of an energy flow distribution *** paper summarizes the results of investigations on a new problem related to the determination of EE flow in a power system over time intervals ranging from minutes to *** problem is referred to as the energy flow problem(EFP).Generally,the grid state and topology may fluctuate over *** attempt to use instantaneous(not integral)power values obtained from telemetry to solve classical electrical engineering equations leads to significant modeling errors,particularly with topology changes.A promoted EFP model may be suitable in the presence of such topological and state ***,EE flows are determined using state estimation approaches based on direct EE measurement data in Watt-hours(Volt-ampere reactive-hours)provided by electricity *** EFP solution is essential for a broad set of applications,including meter data validation,zero unbalance EE billing,and nontechnical EE loss check.

关键词： Automatic meter reading Advanced metering infrastructure Energy flow distribution Electricity losses Energy measurements State estimation.

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Selection of overburden surface mining method in West Virginia by analytical hierarchy process

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International Journal of Coal Science & Technology 2014年第3期1卷 306-314页

作者： Timothy A.Nolan vladislav Kecojevic Department of Mining Engineering West Virginia UniversityMorgantownWVUSA

The broad objective of this research was to improve current surface mining practices and reduce negative environmental impact of overburden removal in West Virginia(WV).The specific objectives were to(i)compare conventional surface mining method(drilling,blasting,digging,and loading)to a surface miner(SM)method,and(ii)apply the analytical hierarchy process(AHP)to help select the optimal mining method based on production,cost and environmental *** design and the procedures used in this research involve five interrelated modules:(i)rock properties of overburden in WV,(ii)drilling and blasting,(iii)digging and loading,(iv)SM method,and(v)comparative analysis and selection of the optimal mining method by *** of this research indicate that application of SM method would yield higher cost of overburden removal than conventional mining methods in rocks with a high unconfined compressive strength and abrasivity.A significant advantage of SM method,where applicable,is the elimination of the negative environmental impacts associated with blasting.

关键词： Surface mining West Virginia Overburden Production rate Cost Environmental impact AHP model

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Laboratory diagnosis of nonpolio enteroviruses:A review of the current literature

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Biosafety and Health 2023年第2期5卷 112-119页

作者： Tarek Itani vladislav Chalapa Aleksandr Semenov Aleksandr Sergeev Yekaterinburg Research Institute of Viral Infections SRC VB VEKTORRospotrebnadzorYekaterinburgRussia Ural State Medical University YekaterinburgRussia

Infections by nonpolio enteroviruses(EVs)are highly prevalent,particularly among children and neonates,where they may cause substantial morbidity and *** diagnosis of these viral infections is important in patient prognosis and guidance of clinical *** the laboratory diagnosis of non-polio EVs is mainly based on molecular techniques,classical virus-isolation techniques are still used in refer-ence *** techniques,such as antigen detection and serology,are becoming obsolete and rarely used in *** important part of diagnosis and surveillance of EV infections is viral typing by VP1 gene sequencing using conventional Sanger technique and more recently,full-genome next-generation *** latter allows the typing of all EVs,better investigation of EV outbreaks,detection of coinfec-tion,and identification of severity markers in the EV genome.

关键词： Nonpolio enteroviruses Virus isolation Nucleic acid amplification tests Sanger sequencing Next-generation sequencing

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Study of Completed Archaeal Genomes and Proteomes:Hypothesis of Strong Mutational AT Pressure Existed in Their Common Predecessor

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Genomics, Proteomics & Bioinformatics 2010年第1期8卷 22-32页

作者： vladislav V.Khrustalev Eugene V.Barkovsky Department of General Chemistry Belarussian State Medical University

The number of completely sequenced archaeal genomes has been sufficient for a large-scale bioinformatic study. We have conducted analyses for each coding region from 36 archaeal genomes using the original CGS algorithm by calculating the total GC content （G＋C）, GC content in first, second and third codon positions as well as in fourfold and twofold degenerated sites from third codon positions, levels of arginine codon usage （Arg2： AGA/G; Arg4： CGX）, levels of amino acid usage and the entropy of amino acid content distribution. In archaeal genomes with strong GC pressure, arginine is coded preferably by GC-rich Arg4 codons, whereas in most of archaeal genomes with G＋C〈0.6, arginine is coded preferably by AT-rich Arg2 codons. In the genome of Haloquadratum walsbyi, which is closely related to GC-rich archaea, GC content has decreased mostly in third codon positions, while Arg4〉〉Arg2 bias still persists. Proteomes of archaeal species carry characteristic amino acid biases： levels of isoleucine and lysine are elevated, while levels of alanine, histidine, glutamine and cytosine are relatively decreased. Numerous genomic and proteomic biases observed can be explained by the hypothesis of previously existed strong mutational AT pressure in the common predecessor of all archaea.

关键词： G+C 3GC arginine mutational pressure archaea entropy

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Tailoring properties of reticulated vitreous carbon foams with tunable density

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Frontiers of Materials Science 2016年第2期10卷 157-167页

作者： Oleg SMORYGO Alexander MARUKOVICH Vitali MIKUTSKI Vassilis STATHOPOULOS Siarhei HRYHORYEU vladislav SADYKOV Powder Metallurgy Institute National Academy of Sciences of Belarus 41 Platonov Str. Minsk 220005 Belarus Technological Educational Institute of Sterea Ellada Psahna Evias 34400 Greece Belarusian National Technical University 65 Nezavisimosty Ave. Minsk 220013 Belarus Boreskov Institute of Catalysis Sibrian Branch of Russian Academy of Sciences 5 Lavrentiev Ave. 630090 Novosibirsk Russia Novosibirsk State University 2 Pirogova Str. 630009 Novosibirsk Russia

Reticulated vitreous carbon （RVC） foams were manufactured by multiple replications of a polyurethane foam template structure using ethanolic solutions of phenolic resin. The aims were to create an algorithm of fine tuning the precursor foam density and ensure an open-cell reticulated porous structure in a wide density range. The precursor foams were pyrolyzed in inert atmospheres at 700℃, 1100℃and 2000℃, and RVC foams with fully open cells and tunable bulk densities within 0.09-0.42 g/cm3 were synthesized. The foams were characterized in terms of porous structure, carbon lattice parameters, mechanical properties, thermal conductivity, electric conductivity, and corrosive resistance. The reported manufacturing approach is suitable for designing the foam microstructure, including the strut design with a graded microstructure.

关键词： foam vitreous carbon reticulated cellular structure pyrolysis

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FSpot:Fast and Efficient Video Encoding Workloads Over Amazon Spot Instances

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Computers, Materials & Continua 2022年第6期71卷 5677-5697页

作者： Anatoliy Zabrovskiy Prateek Agrawal vladislav Kashansky Roland Kersche Christian Timmerer Radu Prodan University of Klagenfurt Klagenfurt9020Austria Lovely Professional University Phagwara144411India Petrozavodsk State University Petrozavodsk185035Russia Bitmovin Klagenfurt9020Austria

HTTP Adaptive Streaming(HAS)of video content is becoming an undivided part of the Internet and accounts for most of today’s network *** compression technology plays a vital role in efficiently utilizing network channels,but encoding videos into multiple representations with selected encoding parameters is a significant ***,video encoding is a computationally intensive and time-consuming operation that requires high-performance resources provided by on-premise infrastructures or public *** turn,the public clouds,such as Amazon elastic compute cloud(EC2),provide hundreds of computing instances optimized for different purposes and clients’***,there is a need for algorithms and methods for optimized computing instance selection for specific tasks such as video encoding and transcoding ***,the encoding speed directly depends on the selected encoding parameters and the complexity characteristics of video *** this paper,we first benchmarked the video encoding performance of Amazon EC2 spot instances using multiple×264 codec encoding parameters and video sequences of varying ***,we proposed a novel fast approach to optimize Amazon EC2 spot instances and minimize video encoding ***,we evaluated how the optimized selection of EC2 spot instances can affect the encoding *** results show that our approach,on average,can reduce the encoding costs by at least 15.8%and up to 47.8%when compared to a random selection of EC2 spot instances.

关键词： EC2 spot instance encoding time prediction adaptive streaming video transcoding clustering HTTP adaptive streaming MPEG-DASH cloud computing optimization Pareto front

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Operational method for determining bottom hole pressure in mechanized oil producing wells,based on the application of multivariate regression analysis

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Petroleum Research 2021年第4期6卷 351-360页

作者： Inna N.Ponomareva vladislav I.Galkin Dmitriy A.Martyushev Department of Oil and Gas Technologies Perm National Research Polytechnic UniversityPermRussia614990 Department of Oil and Gas Geology Perm National Research Polytechnic UniversityPermRussia614990

One of the major tasks of monitoring production well operations is to determine bottom-hole flowing *** overwhelming majority of wells in the Perm Krai are serviced using borehole pumps,which makes it difficult to take direct bottom-hole flowing pressure *** bottomhole filtration pressure(BHFP)in these wells is very often determined by recalculating the parameters measured at the well mouth(annulus pressure,dynamic fluid level depth).The recalculation is done by procedures based on analytically determining the characteristics of the gas-liquid mixture in the wellbore,which is very inconsistent to perform due to the mixture's complex *** article proposes an essentially different approach to BHFP measurements that relies on the mathematical processing of the findings of more than 4000 parallel mouth and deep investigations of the oil production wells of a large oil-production *** a result,multivariate mathematical models are elaborated that allow reliably determining the BHFP of oil-production wells in operation.

关键词： Production well Bottom-hole flowing pressure BHFP determination Technique Multivariate statistical model Regression analysis Multilevel modeling

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High-throughput systematic topological generation of low-energy carbon allotropes

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npj Computational Materials 2021年第1期7卷 126-132页

作者： vladislav A.Blatov Changhao Yang Dingyi Tang Qingfeng Zeng Andrey A.Golov Artem A.Kabanov School of Materials Science and Engineering Northwestern Polytechnical UniversityYouyi West Rd.127Xi’an 710072PR China Samara Center for Theoretical Materials Science(SCTMS) Samara State Technical UniversityMolodogvardeyskaya St.244Samara 443100Russia Samara Center for Theoretical Materials Science(SCTMS) Samara UniversityAc.Pavlov St.1Samara 443011Russia MSEA International Institute for Materials Genome Jinxiu Rd.1Gu’an 065500PR China Samara Branch ofР.N.Lebedev Physical Institute of the Russian Academy of Sciences Novo-Sadovaya St.221443011 SamaraRussia

The search for new materials requires effective methods for scanning the space of atomic configurations,in which the number is *** we present an extensive application of a topological network model of solid-state transformations,which enables one to reduce this infinite number to a countable number of the regions corresponding to topologically different crystalline *** have used this model to successfully generate carbon allotropes starting from a very restricted set of initial structures;the generation procedure has required only three steps to scan the configuration space around the *** a result,we have obtained all known carbon structures within the specified set of restrictions and discovered 224 allotropes with lattice energy ranging in 0.16–1.76 eV atom^(−1) above diamond including a phase,which is denser and probably harder than *** have shown that this phase has a quite different topological structure compared to the hard allotropes from the diamond polytypic *** have applied the tiling approach to explore the topology of the generated phases in more detail and found that many phases possessing high hardness are built from the tiles confined by six-membered *** have computed the mechanical properties for the generated allotropes and found simple dependences between their density,bulk,and shear moduli.

关键词： carbon energy topological

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Hybrid Triboelectric-Electromagnetic Nanogenerators for Mechanical Energy Harvesting:A Review

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Nano-Micro Letters 2021年第12期13卷 163-220页

作者： Joao V.Vidal vladislav Slabov Andrei L.Kholkin Marco P.Soares dos Santos Department of Physics and CICECO-Aveiro Institute of Materials University of Aveiro3810-193 AveiroPortugal Department of Physics and I3N University of Aveiro3810-193 AveiroPortugal Laboratory of Functional Low-Dimensional Structures National University of Science and Technology MISISMoscowRussia Department of Mechanical Engineering Centre for Mechanical Technology and Automation(TEMA)University of Aveiro3810-193 AveiroPortugal

Motion-driven electromagnetictriboelectric energy generators(E-TENGs) hold a Hybrid triboelectric-electromagnetic generators C A Bgreat potential to provide higher voltages,higher currents and wider operating bandwidths than Cantilever generators1 μm both electromagnetic and triboelectric generators Rotating generatorsSliding generators standing alone. Therefore,they are promising solutions to autonomously supply a broad range of Flexible blade generators Magnetoelectric highly sophisticated devices. This paper provides generators a thorough review focused on major recent breakLinear generators Multidimensional generators throughs in the area of electromagnetic-triboelectric vibrational energy harvesting. A detailed Pendulum generators analysis was conducted on various architectures including rotational,pendulum,linear,sliding,cantilever,flexible blade,multidimensional and 1 cm magnetoelectric,and the following hybrid technologies. They enable highly e cient ways to harvest electric energy from many forms of vibrational,rotational,biomechanical,wave,wind and thermal sources,among others. Open-circuit voltages up to 75 V,short-circuit currents up to 60 mA and instantaneous power up to 144 mW were already achieved by these nanogenerators. Their transduction mechanisms,including proposed models to make intelligible the involved physical phenomena,are also overviewed here. A comprehensive analysis was performed to compare their respective construction designs,external excitations and electric outputs. The results highlight the potential of hybrid E-TENGs to convert unused mechanical motion into electric energy for both large-and small-scale ***,this paper proposes future research directions toward optimization of energy conversion e ciency,power management,durability and stability,packaging,energy storage,operation input,research of transduction mechanisms,quantitative standardization,system integration,miniaturization and multi-energy hybrid cells.

关键词： E-TENG Hybrid triboelectric-electromagnetic Nanogenerators Energy harvesting

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