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Drain amylase value as an early predictor of pancreatic fistula after cephalic duodenopancreatectomy

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World Journal of Gastroenterology 2014年第26期20卷 8691-8699页

作者： vladimir D dugalic Djordje M Knezevic Vladan N Obradovic Miroslava G Gojnic-dugalic Slavko V Matic Aleksandra R Pavlovic-Markovic Predrag D dugalic Srbislav M Knezevic Department of Hepatobiliary and Pancreatic Surgery First Surgical University HospitalClinical Center of SerbiaSchool of MedicineUniversity of Belgrade St. Joseph’s Hospital Health Center Clinic for Gynecology and Obstetrics Clinical Center of SerbiaSchool of MedicineUniversity of Belgrade Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaSchool of MedicineUniversity of Belgrade Clinic for Gastroenterology and Hepatology University Hospital Zemun

AIM: To determine predictors of clinically relevant pancreatic fistulas (CRPF) by measuring drain fluid amylase (DFA) in the early postoperative period.

关键词： Cephalic duodenopancreatectomy Periampullary tumors Pancreatic fistula Drain fluid amylase level Prediction

Primary retroperitoneal mucinous cystadenoma:A case report

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World Journal of Gastroenterology 2015年第17期21卷 5427-5431页

作者： Srbislav Knezevic Igor Ignjatovic Snezana Lukic Slavko Matic vladimir dugalic Djordje Knezevic Marjan Micev Sanja Dragasevic Clinic for Digestive Surgery-First Surgical Clinic Clinical Center of SerbiaUniversity of Belgrade11000 BelgradeSerbia Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaUniversity of Belgrade11000 BelgradeSerbia Department of Pathology Clinic for Digestive Surgery-First Surgical ClinicClinical Center of SerbiaUniversity of Belgrade11000 BelgradeSerbia

Primary retroperitoneal mucinous cystic tumors are extremely *** tumors can be classified as a primary retroperitoneal mucinous cystadenoma with or without borderline malignancy or primary retroperitoneal mucinous *** most common of these is primary retroperitoneal mucinous cystadenoma,which almost always occurs in female patients;only ten cases have been reported in *** most common clinical findings for this tumor type include nonspecific abdominal pain and a palpable abdominal mass.A definitive diagnosis is usually obtained from histopathology after surgical ***,we report the case of a 60-year-old female patient who complained of abdominal pain that had been present for 3 mo and presented with a palpable abdominal *** computed tomography scanning revealed a large,unilocular cystic mass in the left retroperitoneal *** intervention was performed and the tumor was completely *** examination confirmed that the tumor was a primary retroperitoneal mucinous *** years after surgery,the patient remains disease free.

关键词： Cystic tumor Differential diagnosis Histopathology Mucinous cystadenoma Retroperitoneum

Perineural invasion as a prognostic factor in patients with stage Ⅰ-Ⅲ rectal cancer –5-year follow up

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World Journal of Gastrointestinal Oncology 2020年第5期12卷 592-600页

作者： Milica Stojkovic Lalosevic Tamara Milovanovic Marjan Micev Mirjana Stojkovic Sanja Dragasevic Milos Stulic Ivan Rankovic vladimir dugalic Zoran Krivokapic Aleksandra Pavlovic Markovic Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaBelgrade 11000Serbia School of Medicine University of BelgradeBelgrade 11000Serbia Clinic for Digestive Surgery-First Surgical Clinic Clinical Center of SerbiaBelgrade 11000Serbia

BACKGROUND Rectal cancer(RC)is one of the most common diagnosed cancers,and one of the major causes of cancer-related death *** of the current guidelines rely on TNM classification regarding therapy regiments,however recent studies suggest that additional histopathological findings could affect the disease *** To determine whether perineural invasion alone or in combination with lymphovascular invasion have an effect on 5-years overall survival(OS)of RC *** A prospective study included newly diagnosed stage I-III RC patients treated and followed at the Digestive Surgery Clinic,Clinical Center of Serbia,between the years of 2014–*** patients had their diagnosis histologically confirmed in accordance with both TMN and Dukes *** addition,the patient’s demographics,surgical details,postoperative pathological details,differentiation degree and their correlation with OS was *** Of 245 included patients with stage Ⅰ-Ⅲ RC,lymphovascular invasion(LVI)was identified in 92 patients(38%),whereas perineural invasion(PNI)was present in 46 patients(19%).Using Kaplan-Meier analysis for overall survival rate,we have found that both LVI and PNI were associated with lower survival rates(P<0.01).Moreover when Cox multiple regression model was used,LVI,PNI,older age,male gender were predictors of poor prognosis(HR=5.49;95%CI:2.889-10.429;P<0.05).CONCLUSION LVI and PNI were significant factors predicting worse prognosis in early and intermediate RC patients,hence more aggressive therapy should be reserved for these patients after curative resection.

关键词： Lymphovascular invasion Perineural invasion Rectal cancer

Low-grade fibromyxoid sarcoma of the liver: A case report

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World Journal of Clinical Cases 2021年第1期9卷 175-182页

作者： vladimir dugalic Igor I Ignjatovic Jelena Djokic Kovac Nikola Ilic Jelena Sopta Slavenko R Ostojic Dragan Vasin Marko D Bogdanovic Igor Dumic Tamara Milovanovic Department of Hepatobiliary&Pancreatic Surgery Clinic for Digestive SurgeryClinical Center of SerbiaBelgrade 11000Serbia Department of Radiology Clinical Center of SerbiaBelgrade 11000Serbia Clinic for Vascular and Endovascular Surgery Clinical Center of SerbiaBelgrade 11000Serbia Institute of Pathology University of BelgradeBelgrade 11000Serbia Mayo Clinic Health System Mayo Clinic College of Medicine and ScienceRochesterNY 10029United States Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaSchool of MedicineUniversity of BelgradeBelgrade 11000Serbia

BACKGROUND Low grade fibromyxoid sarcoma(LGFMS)is a rare and benign mesenchymal tumor with indolent course,most commonly found in young or middle-aged *** majority of the LGFMSs are located in the trunk and deep soft tissue of the lower *** appear as well circumscribed,although not encapsulated,which often leads to incomplete surgical *** their seemingly benign appearance,these tumors have aggressive behavior with high metastatic and recurrence *** histopathologic examination of the specimen and its immunohistochemical analysis are mandatory for a precise *** SUMMARY We report a case of a 38 year-old-man who presented with jaundice and upper abdominal ***-detector computed tomography and magnetic resonance imaging showed a large left liver tumor mass,extending to the hepatoduodenal *** hepatectomy was performed with resection and reconstruction of hepatic artery and preservation of middle hepatic *** examination confirmed the tumor being a low-grade fibromyxoid *** and a half years after surgery,the patient died after being diagnosed with spine *** Due to poor response to all modalities of adjuvant treatment,we consider that the focus of treatment should be on surgery as the only option for curing the disease.

关键词： Fibromyxoid sarcoma Liver Resection Histopathology Case report