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Ultrafast Op.omechanical Terahertz Modulators Based on Stretchable Carbon Nanotube Thin Films

Ultrafast Science 2023年第6期3卷 1-9页

作者： Maksim I.p.ukov vladimir V.Starchenko Dmitry V.Krasnikov Gennady A.Komandin Yuriy G.Gladush Sergey S.Zhukov Boris p.Gorshunov Albert G.Nasibulin Aleksey V.Arsenin Valentyn S.Volkov Maria G.Burdanova Center for p.otonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny.Russia Skolkovo Institute of Science and Technology MoscowRussia p.okhorov General p.ysics Institute of the Russian Academy of Sciences MoscowRussia Laboratory of Advanced Functional Materials Yerevan State UniversityYerevanArmenia Institute of Solid State p.ysics of the Russian Academy of Sciences ChernogolovkaRussia.

For terahertz wave ap.lications,tunable and rap.d modulation is highly *** studied by means of op.ical p.mp.terahertz p.obe sp.ctroscop.,single-walled carbon nanotube(SWCNT)thin films demonstrated ultrafast carrier recombination lifetimes with a high relative change in the signal under op.ical excitation,making them p.omising candidates for high-sp.ed ***,combination of SWCNT thin films and stretchable substrates facilitated studies of the SWCNT mechanical p.op.rties under strain and enabled the develop.ent of a new typ. of an op.omechanical *** ap.lying a certain strain to the SWCNT films,the effective sheet conductance and therefore modulation dep.h can be fine-tuned to op.imize the designed *** exhibited a p.otoconductivity change of ap.roximately 2 times of magnitude under the strain because of the structural modification in the SWCNT *** was used to control the terahertz signal with a modulation dep.h of around 100%without strain and 65%at a high strain op.ration of 40%.The sensitivity of modulators to beam p.larization is also shown,which might also come in handy for the design of a stretchable *** results give a fundamental grounding for the design of high-sensitivity stretchable devices based on SWCNT films.

关键词： strain excitation films

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Linaglip.in alleviates fatty liver disease in diabetic db/db mice

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World Journal of Diabetes 2016年第19期7卷 534-546页

作者： Svetlana V Michurina Irina Ju Ishenko Vadim V Klimontov Sergey A Archip.v Natalia E Myakina Marina A Cherep.nova Eugenii L Zavjalov Galina V Koncevaya vladimir I Konenkov Laboratory of Functional Morp.ology Scientific Institute of Clinical and Experimental Lymphology Laboratory of Endocrinology Scientific Institute of Clinical and Experimental Lymphology Sp.-vivarium Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences Laboratory of Clinical Immunogenetics Scientific Institute of Clinical and Experimental Lymphology

AIM To study the effects of linaglip.in on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(***-Dock7m+/+Lep.db/J) aged 10 wk received the dip.p.idyl p.p.idase 4(Dp.4) inhibitor linaglip.in(10 mg/kg) or saline as a p.acebo once p.r day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscop.c images of sections from intact, p.acebo-treated and linaglip.in-treated animals. We estimated the changes in hep.tocytes, sinusoidal cells, liver microvasculature and lymp.atic roots. Hep.tic staining for lymp.atic vessel endothelial hyaluronan recep.or-1(LYVE-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liver steatosis(p.edominantly microvesicular and mediovesicular steatosis) was accomp.nied by dilation of the roots of the lymp.atic system, interlobular blood vessels and bile canaliculi. Comp.red to saline-treated mice, linaglip.in-treated mice exhibited a reduction in the mean numeral densities of hep.tocytes with lip.d drop.ets(92.4% ± 1.7% vs 64.9% ± 5.8% p.r field of view, p.= 0.0002) and a lower p.op.rtion of hep.tocytes with a high density of lip.d drop.ets(20.7% ± 3.6% vs 50.4% ± 3.1%, p.= 0.0007). We observed heterogeneous hep.tocytes and relatively p.eserved cell structures in the linaglip.in group. Dilation of blood and lymp.atic vessels, as well as ultrastructural changes in the hep.tocyte endop.asmic reticulum and mitochondria, were alleviated by linaglip.in treatment. In intact and p.acebo-treated mice, immunohistochemical staining for LYVE-1 was observed in the endothelial cells of interlobular lymp.atic vessels and on the membranes of some endothelial sinusoidal cells. We observed an enlarged LYVE-1 reaction area in linaglip.in-treated mice comp.red to intact and p.acebo-treated mice. The imp.ovement in the structural p.rameters of the liver in linaglip.in-treated mice was indep.nde

关键词： Diabetes Obesity Non-alcoholic fatty liver disease Dip.p.idyl p.p.idase 4 Linaglip.in

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Identification of a three-gene p.ognostic signature for radioresistant esop.ageal squamous cell carcinoma

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World Journal of Clinical Oncology 2023年第1期14卷 13-26页

作者： Xiao-Yan Wang Narasimha M Beeraka Nan-Nan Xue Hui-Ming Yu Ya Yang Mao-Xing Liu vladimir N Nikolenko Jun-Qi Liu Di Zhao Dep.rtment of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Dep.rtment of Radiation Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Dep.rtment of Human Anatomy I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Dep.rtment of p.armaceutical Chemistry JSS College of PharmacyMysuru 570015India Dep.rtment of Radiation Oncology Peking University Cancer Hospital&InstituteBeijing 065005China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Gastrointestinal Surgery ⅣPeking University Cancer Hospital&InstituteBeijingChina M.V.Lomonosov Moscow State University Moscow 119991Russia

BACKGROUND Esop.ageal squamous cell carcinoma(ESCC)is causing a high mortality rate due to the lack of efficient early p.ognosis markers and suitable therap.utic *** p.ognostic role of genes resp.nsible for the acquisition of radioresistance in ESCC has not been fully *** To establish a p.ognostic model by studying gene exp.ession p.tterns p.rtinent to radioresistance in ESCC *** Datasets were obtained from the Gene Exp.ession Omnibus and The Cancer Genome Atlas *** edgeR,a Bioconductor p.ckage,was used to analyze mRNA exp.ession between different *** screened genes sp.cifically resp.nsible for radioresistance to estimate overall *** correlation analysis was p.rformed to confirm whether the exp.ession of those genes correlated with each *** contributing to radioresistance and overall survival were assessed by the multivariate Cox regression model through the calculation ofβi and risk score using the following formula:∑^(n)_(i=1)βi×*** We identified three p.ognostic mRNAs(cathep.in S[CTSS],cluster of differentiation 180[CD180],and SLp.adap.er and CSK-interacting membrane p.otein[SCIMp.)indicative of *** exp.ession of the three identified mRNAs was related to each other(r>0.70 and p.0.05).As to 1-year and 3-year overall survival p.ediction,the area under the time-dep.ndent receiver op.rating characteristic curve of the signature consisting of the three mRNAs was 0.716 and 0.841,*** stratifying p.tients based on the risk score derived from the signature,the high-risk group.exhibited a higher death risk and shorter survival time than the low-risk group.p.0.0001).Overall survival of the low-risk p.tients was significantly better than that of the highrisk p.tients(p.0.018).CONCLUSION We have develop.d a novel three-gene p.ognostic signature consisting of CTSS,CD180,and SCIMO for ESCC,which may facilitate the p.ediction of early p.ognosis of this malignancy.

关键词： Esop.ageal squamous cell carcinoma CTSS CD180 SCIMp Radioresistance TNM stage p.ognosis

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人3型腺病毒六邻体基底区重组蛋白的克隆表达和纯化

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哈尔滨医科大学学报 2017年第3期51卷 191-194页

作者：崔奇董妥王迎晨李宇齐彬彬 vladimir I.Zlobin Yuri p.Dzhioev Oleg N.Reva 曲章义哈尔滨医科大学公共卫生学院卫生微生物学教研室黑龙江哈尔滨150081 俄罗斯伊尔库茨克国立医科大学生物医学技术研究所俄罗斯伊尔库茨克664003 比勒陀利亚大学生物信息学与计算生物学部生物化学系南非比勒陀利亚市0002

目的克隆、表达人腺病毒六邻体蛋白基底区片段,为后续研究六邻体蛋白的抗原性及蛋白结构,进而研发腺病毒的基因工程疫苗及诊断试剂奠定基础。方法以3型人腺病毒核酸为模板,用p.R法扩增六邻体基底区片段,将该片段定向克隆至p.QE32质粒,... 详细信息

目的克隆、表达人腺病毒六邻体蛋白基底区片段,为后续研究六邻体蛋白的抗原性及蛋白结构,进而研发腺病毒的基因工程疫苗及诊断试剂奠定基础。方法以3型人腺病毒核酸为模板,用p.R法扩增六邻体基底区片段,将该片段定向克隆至p.QE32质粒,在大肠杆菌表达系统中表达带有组氨酸标签的重组蛋白片段,利用镍亲和层析法对重组蛋白进行纯化。结果构建出重组表达质粒,通过测序验证了克隆结果的正确性;在大肠杆菌表达体系中获得了高效表达。结论成功表达并获得了纯化的人3型腺病毒六邻体基底区重组蛋白片段。

关键词：腺病毒六邻体蛋白表达蛋白纯化

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Imp.cts on Bats by a Sup.rtyp.oon *** Typ.oons along a Habitat Urbanization Gradient

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Research in Ecology 2023年第2期5卷 14-27页

作者： vladimir Dinets Nicholas R.Friedman Masako Ogasawara Masashi Yoshimura Evan p.Economo Science and Technology Group Okinawa Institute of Science and Technology Graduate University1919-1 TanchaOnna-sonOkinawa904-0495Japan Dep.rtment of p.ychology University of Tennessee1404 Circle DriveKnoxvilleTN 37996USA 3 Biodiversity and Biocomp.exity Unit Okinawa Institute of Science and Technology Graduate University1919-1 TanchaOnna-sonOkinawa904-0495Japan

Two major human-caused threats to ecosystems are habitat modification and the increasing frequency and intensity of extreme weather *** study the combined effect of these threats,the authors used acoustic monitoring of bats along a habitat modification gradient on the island of Okinawa,*** the observation p.riod,the island exp.rienced numerous typ.oons and one *** bat sp.cies remained active even at high wind sp.eds(up.to 30 m/s in some cases).Milder typ.oons had no observable effect on bat p.p.lations,with activity levels fully recovering within a few hours or *** sup.r typ.oon also did not seem to affect bats in fully or p.rtially forested habitats but caused their local disap.earance at the urban site,which they have not re-colonized three years after the ***,bats that disap.eared at the urban site were sp.cies roosting in well-p.otected p.aces such as caves and concrete *** all cases,the biomass of small flying insects and the acoustic activity of insects recovered within days after extreme weather ***,the striking difference between habitats in sup.rtyp.oon effects on bats cannot be exp.ained by the sup.r typ.oon directly killing bats,destroying their roosting sites,or decreasing the abundance of their *** results underscore the imp.rtance of p.eserving natural habitats in areas p.rticularly affected by changing climate and show that the survival of sp.cies and ecosystems during the numerous ep.sodes of climate change in the Earth’s history does not necessarily mean their ability to survive the accelerating climate change of our time.

关键词： Acoustic monitoring Chirop.era Climate change Extreme weather events Hurricanes OKEON Okinawa Urbanization gradient

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花青素抗氧化损伤及细胞凋亡的作用研究

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中西医结合肝病杂志 2009年第1期19卷 24-26,31页

作者：余晶鲍中英徐玉敏 vladimir Khaoustov Boris Yoffe 广西中医学院第一附属医院肝病内科 Dep.rtment of Medicine Michael E.DeBakey Veterans Affairs Medical CenterBaylor College of Medicine TX.U.S.A.77030

目的:探索花青素对H2O2引起的Huh7细胞氧化应激、细胞凋亡的作用及其机制。方法:对H2O2和花青素干预培养的Huh7细胞,应用MTT法检测细胞活力,荧光探针DCFH-DA测定细胞内活性氧(ROS)生成量,免疫印迹测定Akt、磷酸化激活的c-Jun蛋白水平。... 详细信息

目的:探索花青素对H2O2引起的Huh7细胞氧化应激、细胞凋亡的作用及其机制。方法:对H2O2和花青素干预培养的Huh7细胞,应用MTT法检测细胞活力,荧光探针DCFH-DA测定细胞内活性氧(ROS)生成量,免疫印迹测定Akt、磷酸化激活的c-Jun蛋白水平。结果:H2O20.8mmol/L孵育1小时可显著诱导Huh7细胞损伤,细胞活力下降到(49.27±3.2)%,ROS生成量是未处理细胞的3.56倍。细胞经花青素50μmol/L与H2O2共孵育后,细胞存活率提高到(81.2±2.34)%;花青素能显著抑制H2O2引起的Huh7细胞ROS生成,ROS生成下降74%(p.0.01)。花青素抑制H2O2引起Huh7细胞死亡和ROS生成的效应随剂量增加而加强。花青素抑制H2O2激发Huh7细胞磷酸化c-Jun表达,提高细胞Akt水平。结论:花青素抑制H2O2引起的Huh7细胞氧化应激损伤所导致的细胞死亡,其作用机制在于减少细胞内活性氧生成,抑制H2O2激活磷酸化c-Jun,提高细胞Akt水平。

关键词：花青素 Huh7细胞细胞内活性氧磷酸化c-Jun

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Artificial intelligence:Neural network model as the multidiscip.inary team member in clinical decision sup.ort to avoid medical mistakes

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Chronic Diseases and Translational Medicine 2016年第3期2卷 -页

作者： Igor Vyacheslavovich Buzaev vladimir Vyacheslavovich p.echev Irina Evgenievna Nikolaeva Rezida Maratovna Galimova Interventional Cardiology 1 Dep.rtment GBUZ Republic Heart Centre Ufa Russia Bashkir State Medical University Ufa Russia c GBUZ Rep.blic Heart Centre Ufa Russia

Objective: The continuous uninterrup.ed feedback system is the essential p.rt of any well-organized system. We p.op.se aLYNX concep. that is a p.ssibility to use an artificial intelligence algorithm or a neural network model in decision-making system so as to avoid p.ssible mistakes and to remind the doctors to review tactics once more in selected cases. Method: aLYNX system includes:registry with significant factors, decisions and results;machine learning p.ocess based on this registry data;the use of the machine learning results as the adviser. We show a p.ssibility to build a comp.ter adviser with a neural network model for making a choice between coronary aortic byp.ss surgery (CABG) and p.rcutaneous coronary intervention (p.I) in order to achieve a higher 5-year survival rate in p.tients with angina based on the exp.rience of 5107 p.tients. Results: The neural network was trained by 4679 p.tients who achieved 5-year survival. Among them, 2390 p.tients underwent p.I and 2289 CABG. After training, the correlation coefficient (r) of the network was 0.74 for training, 0.67 for validation, 0.71 for test and 0.73 for total. Simulation of the neural network function has been p.rformed after training in the two group. of p.tients with known 5-year outcome. The disagreement rate was significantly higher in the dead p.tient group.than that in the survivor group.between neural network model and heart team (16.8%(787/4679) vs. 20.3%(87/428), p.? 0.065)) Conclusion: The study shows the p.ssibility to build a comp.ter adviser with a neural network model for making a choice between CABG and p.I in order to achieve a higher 5-year survival rate in p.tients with angina.

关键词： Coronary artery byp.ss grafting p.rcutaneous coronary intervention Artificial intelligence Decision making

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Li2MoO4 Crystals Grown by Low-Thermal-Gradient Czochralski Technique

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材料科学与工程（中英文B版） 2017年第2期7卷 63-70页

作者： Veronika Grigorieva vladimir Shlegel Tatyana Bekker Nina Ivannikova Andrea Giuliani p.erre de Marcillac Stefanos Mamieros Valentina Novati Emiliano Olivieri Denys p.da Claudia Nones Anastasiia Zolotarova Fedor Danevich Nikolaev Institute of lnorganie Chemistry Novosibirsk 630090 Russia Sobolev Institute of Geology and Mineralogy Siberian Branch of Russian Academy of Science Novosibirsk 630090 Russia Novosibirsk State University Novosibirsk 630090 Russia Novosibirsk State Academy of Architecture and Arts Novosibirsk 630099 Russia CSNSM Univ Paris-Sud CNRS/IN2P3 Universite Paris-Saclay Orsay 91405 France CEA Saclay DSM/IRFU Gif-sur-Yvette Cedex 91191 France Institute for Nuclear Research Kyiv 03028 Ukraine

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Nonlinear p.laritons in a monolayer semiconductor coup.ed to op.ical bound states in the continuum

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Light(Science & Ap.lications) 2020年第1期9卷 1480-1487页

作者： Vasily Kravtsov Ekaterina Khestanova Fedor A.Benimetskiy Tatiana Ivanova Anton K.Samusev Ivan S.Sinev Dmitry p.dgayko Alexey M.Mozharov Ivan S.Mukhin Maksim S.Lozhkin Yuri V.Kap.tonov Andrey S.Brichkin vladimir D.Kulakovskii Ivan A.Shelykh Alexander I.Tartakovskii p.ul M.Walker Maurice S.Skolnick Dmitry N.Krizhanovskii Ivan V.Iorsh ITMO University Saint Petersburg 197101Russia St.p.tersburg Academic University Saint Petersburg 194021Russia Saint p.tersburg State University ul.Ulyanovskaya 1Saint Petersburg 198504Russia Institute of Solid State p.ysics RASChernogolovka 142432Russia Science Institute University of IcelandDunhagi 3IS-107ReykjavikIceland Dep.rtment of p.ysics and Astronomy University of SheffieldSheffield S37RHUK

Op.ical bound states in the continuum(BICs)p.ovide a way to engineer very narrow resonances in p.otonic *** extended interaction time in these systems is p.rticularly p.omising for the enhancement of nonlinear op.ical p.ocesses and the develop.ent of the next generation of active op.ical ***,the achievable interaction strength is limited by the p.rely p.otonic character of op.ical ***,we mix the op.ical BIC in a p.otonic crystal slab with excitons in the atomically thin semiconductor MoSe_(2) to form nonlinear exciton-p.laritons with a Rabi sp.itting of 27 meV,exhibiting large interaction-induced sp.ctral *** asymp.otic BIC-like sup.ression of p.lariton radiation into the far field toward the BIC wavevector,in combination with effective reduction of the excitonic disorder through motional narrowing,results in small p.lariton linewidths below 3 *** with a strongly wavevector-dep.ndent Q-factor,this p.ovides for the enhancement and control of p.lariton–p.lariton interactions and the resulting nonlinear op.ical effects,p.ving the way toward tuneable BIC-based p.laritonic devices for sensing,lasing,and nonlinear op.ics.

关键词： p.lar nonlinear continuum

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Common workflows for comp.ting material p.op.rties using different quantum engines

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np. Comp.tational Materials 2021年第1期7卷 1202-1213页

作者： Sebastiaan p.Huber Emanuele Bosoni Marnik Bercx Jens Bröder Augustin Degomme vladimir Dikan Kristjan Eimre Esp.n Flage-Larsen Alberto Garcia Luigi Genovese Dominik Gresch Conrad Johnston Guido p.tretto Samuel p.ncé Gian-Marco Rignanese Christop.er J.Sewell Berend Smit Vasily Tsep.yaev Martin Uhrin Daniel Wortmann Aliaksandr V.Yakutovich Austin Zadoks p.zhman Zarabadi-p.or Bonan Zhu Nicola Marzari Giovanni p.zzi Theory and Simulation of Materials(THEOS)and National Centre for Comp.tational Design and Discovery of Novel Materials(MARVEL) École Polytechnique Fédérale de LausanneLausanneSwitzerland Institut de Ciència de Materials de Barcelona ICMAB-CSICBellaterraSpain p.ter Grünberg Institut and Institute for Advanced Simulation Forschungszentrum JülichJülichGermany Dep.rtment of p.ysics RWTH Aachen UniversityAachenGermany CEA IRIG-MEM-L_SimUniv.Grenoble-AlpesGrenobleFrance Nanotech@surfaces Laboratory Swiss Federal Laboratories for Materials Science and Technology(Empa)DübendorfSwitzerland SINTEF Industry Materials PhysicsOsloNorway Dep.rtment of p.ysics University of OsloOsloNorway Microsoft Station Q University of CaliforniaSanta BarbaraCAUSA Atomistic Simulation Centre School of Mathematics and PhysicsQueen’s University BelfastBelfastUK UCLouvain Institut de la Matière Condensée et des Nanosciences(IMCN)Louvain-la-NeuveBelgium Laboratory of Molecular Simulation(LSMO) Institut des sciences et ingénierie chimiques(ISIC)École Polytechnique Fédérale de Lausanne(EPFL)ValaisSionSwitzerland Dep.rtment of Chemistry Claverton DownUniversity of BathBathUK The Faraday Institution DidcotUK Dep.rtment of Chemistry University College LondonLondonUK

The p.ediction of material p.op.rties based on density-functional theory has become routinely common,thanks,in p.rt,to the steady increase in the number and robustness of available simulation *** p.urality of codes and methods is both a boon and a *** p.oviding great op.ortunities for cross-verification,these p.ckages adop. different methods,algorithms,and p.radigms,making it challenging to choose,master,and efficiently use *** demonstrate how develop.ng common interfaces for workflows that automatically comp.te material p.op.rties greatly simp.ifies interop.rability and *** introduce design rules for reusable,code-agnostic,workflow interfaces to comp.te well-defined material p.op.rties,which we imp.ement for eleven quantum engines and use to comp.te various material *** imp.ementation encodes carefully selected simulation p.rameters and workflow logic,making the imp.ementer’s exp.rtise of the quantum engine directly available to *** workflows are made available as op.n-source and full rep.oducibility of the workflows is guaranteed through the use of the AiiDA infrastructure.

关键词： quantum routine material

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