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Titanium oxide artificial synaptic device:Nanostructure modeling.and synthesis,memristive cross-bar fabrication,and resistive switching.investig.tion

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Nano Research 2023年第7期16卷 10222-10233页

作者： Vadim I.Avilov Roman V.Tominov Zakhar E.Vakulov Lev g.Zhavoronkov vladimir A.Smirnov Research Laboratory Neuroelectronics and Memristive Nanomaterials(NEUROMENA Lab) Southern Federal UniversityTaganrog 347922Russia Institute of Nanotechnolog.es Electronics and Electronic Equipment EngineeringSouthern Federal UniversityTaganrog 347922Russia

The paper shows the results of the mathematical model development and the numerical simulation of the oxyg.n vacancies,and the distribution of TiO,Ti_(2)O_(3),and TiO_(2)oxides in the titanium oxide nanostructure obtained by local anodic oxidation(anodization).The effect of the anodization voltag. pulse duration and amplitude on the titanium oxide composition distribution and the conduction channel formation was *** device prototypes based on electrochemical titanium oxide are fabricated and *** was shown that forming.free resistive switching.between the low resistances state(LRS)1.43±0.54 kΩand the hig. resistance state(HRS)28.75±9.75 kΩwere observed during.100,000 switching.cycles and LRS 1.49±0.23 kΩwas maintained for 10,000 *** resistive switching.of the synaptic device prototype was *** was shown that increasing.Uset from 0.5 to 1.5 V leads to different LRS from 3.96±0.19 to 0.71±0.10 kΩ.The results obtained can be used in the development of technolog.cal foundations for the formation of hig.-performance multilevel artificial synapses for elements of neuroelectronics and hardware neural networks.

关键词： artificial intellig.nce neuromorphic systems memristive cross bar resistive switching scanning.probe microscopy titanium oxide

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阿兰都城蔑怯思与蒙古征战考

西域研究 2024年第1期 110-126页

作者：弗拉其米尔·费奥多罗维奇·米诺尔斯基芮传明上海社会科学院历史研究所

13世纪,蒙古人对欧亚草原地区和东欧进行了所谓的“西征”。本文周密地考证了被蒙古军摧毁的阿兰人/阿速人(即奥赛梯人)的都城蔑怯思的方位。其主要资料来自志费尼和拉施德丁的相关记载,同时也包括其他中世纪史家的著述。本文不仅得出... 详细信息

13世纪,蒙古人对欧亚草原地区和东欧进行了所谓的“西征”。本文周密地考证了被蒙古军摧毁的阿兰人/阿速人(即奥赛梯人)的都城蔑怯思的方位。其主要资料来自志费尼和拉施德丁的相关记载,同时也包括其他中世纪史家的著述。本文不仅得出了“蔑怯思位于高加索山北麓主水道捷列克河之支流松佳河畔”的推论,而且还对志费尼、拉施德丁有关蒙古西征的史料作了详细考释,从而为“草原丝路”的研究提供了有价值的参考资料。

关键词：志费尼拉施德丁蒙古西征蔑怯思高加索山

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Quantifying.the actual sediment load flux into Lake Baikal:A case study of the main tributary——The Seleng. River(Russia)

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International Journal of Sediment Research 2022年第2期37卷 238-247页

作者： Tatiana Potemkina vladimir Potemkin Limnolog.cal Institute of the Siberian Branch of Russian Academy of Sciences

The sig.ificant reduction of sediment load flux into Lake Baikal from its main tributary-the Seleng. River beg.n in the mid-1970 s,and can be explained by climate chang. and socio-economic *** analysis was done of chang.s in hydro-meteorolog.cal parameters(water discharg.,sediment load,air temperature,and precipitation) and their tendencies over periods of 1946-1975(baseline) and1976-2017(warming..Chang.s in natural processes and human activity were neg.ig.ble during.the baseline *** the warming.period,ag.inst the backg.ound of an increase in temperature,the water discharg. had a slig.t decreasing.trend(-13%) whereas the sediment load has sig.ificantly decreased(-53%) these are consist with the precipitation chang.(-9.4%).Analysis of hydro-climatic data using.statistical methods showed that in the warming.period the g.eatest reduction in river sediment runoff occurred in the interval *** this period the sediment load was 768 × 10～3 t/yr,which is less than the averag. value during.the warming.period-1048 × 10～3 t/*** sedimentation in the Seleng. River delta,the actual sediment load flux from the Seleng. River into Lake Baikal amounted to 515 × 10～3 t/yr,which is three times less than the averag. multiyear value 1535 × 10～3 t/yr for observation period(1946-2017).

关键词： Sediment load Climate chang. Human activity Seleng. River Lake Baikal

A comment on the article of Zoran Ivanovic and Marija Vlaski-Lafarg.(2022):On cancer,stemness and deep evolutionary homolog.es

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g.nes & Diseases 2023年第4期10卷 1139-1140页

作者： vladimir F.Niculescu Kirschenweg.1 Diedorf 86420Germany

The comment of Ivanovic and Vlaski-Lafarg. on my article“Cancer g.nes and cancer stem cells in tumorig.nesis:Evolutionary deep homolog. and controversies”opens up a welcome discussion on the evolutionary history of *** authors have appreciative words about my work,for which I am very *** this point,I would like to contribute a few words on polyploidy,cancer g.nes,ag.,and colonial org.nization.

关键词： cancer Cancer evolutionary

Cancer exploits a late premetazoan g.ne module conserved in the human g.nome

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g.nes & Diseases 2023年第4期10卷 1136-1138页

作者： vladimir F.Niculescu Kirschenweg.1 Diedorf 86420Germany

From an evolutionary perspective,the human cancer g.nome is based on an ancient g.ne module developed by the common ancestor of the Amoebozoa,Metazoa,and Fung.(AMF).^(1)The transition phase to multicellularity(premetazoan period)was a rather long.period of evolu-tionary attempts and *** this time,suppressor g.nes were evolved to deactivate the g.S cell system inherited from the AMF ancestor.

关键词： ancient evolved Cancer

Cancer g.nes and cancer stem cells in tumorig.nesis:Evolutionary deep homolog. and controversies

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g.nes & Diseases 2022年第5期9卷 1234-1247页

作者： vladimir F.Niculescu Kirschenweg.1 Diedorf 86420Germany

In the past,contradictory statements have been made about the ag. of cancer *** phylostratig.aphic studies sug.est that cancer g.nes emerg.d during.the transitional period from unicellularians(UC)to early metazoans(EM),life cycle studies sug.est that they arose *** controversy could not be *** methods use data from somatic tumor g.ne collections containing.or lacking.polyploidy g.nes(Pg.C g.nes)and compare them to g.nes from evolutionary node taxa.I analyze whether the selected taxa are suitable to resolve the above contradiction or *** cancer and amoebae life cycles have a reproductive asexual g.rmline that produces g.rmline stem cells(g.Cs)and somatic cell lines that *** the g.rmline loses its reproductive function,the soma-to-g.rm transition forms a new reproductive *** reproductive polyploidy of cancer is homolog.us to the reproductive polyploidy of unicellular *** repair DNA defects,reorg.nize the involved g.nome architecture and produce new *** present study refutes the dog.a of the early metazoan orig.n of *** has a unicellular life cycle that was adopted by early metazoans to rescue themselves from evolutionary dead *** metazoans controlled the unicellular life cycle throug. suppressor and anti-suppressor g.nes that could suspend or reactivate *** are the archetypes of tumor suppressor g.nes and *** of mammalians and humans that reach a similar impasse as early metazoans can reactivate the conserved life cycle of unicellularians.

关键词： Cancer Entamoeba g.ne ag. Life cycle Polyploidy CSCs EMT Pg.C

Humanization for neurolog.cal disease modeling.A roadmap to increase the potential of Drosophila model systems

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Animal Models and Experimental Medicine 2023年第3期6卷 230-236页

作者： vladimir L.Katanaev Department of Cell Physiolog. and Metabolism Faculty of MedicineUniversity of GenevaGenevaSwitzerland HumanaFly Facility Faculty of MedicineUniversity of GenevaGenevaSwitzerland

Neuroscience and neurolog. research is dominated by experimentation with *** 75%of neurolog. disease-associated g.nes have ortholog. in Drosophila mel-anog.ster,the fruit fly amenable to complex neurolog.cal and behavioral ***,non-vertebrate models including.Drosophila have so far been unable to sig.ificantly replace mice and rats in this field of *** reason for this situ-ation is the predominance of g.ne overexpression(and g.ne loss-of-function)meth-odolog.es used when establishing.a Drosophila model of a g.ven neurolog.cal disease,a strateg. that does not recapitulate accurately enoug. the g.netic disease condi-tions.I arg.e here the need for a systematic humanization approach,whereby the Drosophila ortholog. of human disease g.nes are replaced with the human *** approach will identify the list of diseases and the underlying.g.nes that can be adequately modeled in the fruit fly.I discuss the neurolog.cal disease g.nes to which this systematic humanization approach should be applied and provide an example of such an application,and consider its importance for subsequent disease modeling.and drug.discovery in Drosophila.I arg.e that this paradig. will not only advance our un-derstanding.of the molecular etiolog. of a number of neurolog.cal disorders,but will also g.adually enable researchers to reduce experimentation using.rodent models of multiple neurolog.cal diseases and eventually replace these models.

关键词： disease modeling Drosophila humanization neurolog.cal diseases

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Hig.-temperature annealing.of(201)β-g._(2)O_(3) substrates for reducing.structural defects after diamond sawing

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Journal of Semiconductors 2023年第12期44卷 125-132页

作者： Pavel Butenko Michael Boiko Mikhail Sharkov Aleksei Almaev Aleksnder Kitsay vladimir Krymov Anton Zarichny vladimir Nikolaev MISiS University Moscow 119049Russia Perfect Crystala LLC St.Petersburg 194223Russia Tomsk State University Tomsk 634050Russia

A commercial epi-ready(201)β-g._(2)O_(3) wafer was investig.ted upon diamond sawing.into pieces measuring.2.5×3 mm^(2).The defect structure and crystallinity in the cut samples has been studied by X-ray diffraction and a selective wet etching.*** density of defects was estimated from the averag. value of etch pits calculated,including.near-edg. reg.ons,and was obtained close to 109 cm^(-2).Blocks with lattice orientation deviated by ang.es of 1-3 arcmin,as well as non-stoichiometric fractions with a relative strain about(1.0-1.5)×10^(-4)in the[201]direction,were *** perfection was shown to decrease sig.ificantly towards the cutting.lines of the *** reduce the number of structural defects and increase the crystal perfection of the samples via increasing.defect motion mobility,the thermal annealing.was *** and formation of a mosaic structure coupled with dislocation wall appearance upon 3 h of annealing.at 1100℃ was *** fractions characterized by non-stoichiometry phases and the block deviation *** annealing.for 11 h improved the homog.neity and perfection in the *** averag. density of the etch pits dropped down sig.ificantly to 8×10^(6) cm^(-2).

关键词： g.llium oxide epi-ready substrate etch pits crystal defect mosaic structure crystal perfection

On the helium bubble swelling.in nano-oxide dispersion-streng.hened steels

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Journal of Materials Science & Technolog. 2022年第10期105卷 172-181页

作者： vladimir Krsjak Tielong.Shen Jarmila Deg.ova Stanislav Sojak Erik Korpas Pavol Nog. Werner Eg.er Bing.heng.Li vladimir Slug.n Frank A.g.rner Slovak University of Technolog. Faculty of Electrical Engineering and Information TechnologyInstitute of Nuclear and Physical EngineeringIlkovicova 3Bratislava 81219Slovakia Chinese Academy of Sciences Institute of Modern PhysicsLanzhou 730000China Slovak University of Technolog. Faculty of Materials Science and TechnologyAdvanced Technologies Research InstituteJana Bottu 2781/25Trnava 91724Slovakia Universität der Bundeswehr München Institut für Angewandte Physik und Messtechnik LRT2Werner-Heisenberg-Weg 39Neubiberg85577Germany Southwest University of Science and Technolog. State Key Laboratory for Environment-friendly Energy MaterialsMianyangSichuan 621010China Texas A&M University Nuclear Engineering DepartmentCollege StationTX 77843USA Radiation Effects Consulting.LLC Richland WA 99354USA

The development of structural materials resistant to harsh radiation environments requires an in-depth understanding.of the early stag. of the ag.ng.*** radiation environments with hig. transmutation helium production rates such as in fusion and spallation applications,even materials with otherwise acceptable radiation stability may suffer from radiation embrittlement related to helium bubble *** theoretical modeling.of helium-assisted cavity nucleation in pure metals and simple alloys provides some useful g.idelines at the atomic scale level,these,however,do not overlap with the size resolution of available experimental *** this study,we employed slow positron beam spectroscopy to characterize the nucleation and g.owth of nano-scale helium bubbles in martensitic steels streng.hened by thermodynamically stable nano-oxide *** combination with transmission electron microscopy,we experimentally characterized the evolution of helium bubbles from small clusters of radiation-induced vacancies to larg. cavities well resolvable by *** radiation resistance of oxide-dispersion streng.hened steels dominates only in the early stag.s of bubble evolution,where positron lifetime measurements provide a missing.piece of the microstructural puzzle conventionally constructed by TEM.

关键词： Ion irradiation Bubble swelling Helium Positron annihilation spectroscopy Oxide dispersion streng.hened steels

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