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A comment on the article of.Zoran Ivanovic and Marija Vlaski-Laf.rge(2022):On cancer,stemness and deep evolutionary homologies

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Genes & Diseases 2023年第4期10卷 1139-1140页

作者： vladimir f.Niculescu Kirschenweg 1 Diedorf 86420Germany

The comment of.Ivanovic and Vlaski-Laf.rge on my article“Cancer genes and cancer stem cells in tumorigenesis:Evolutionary deep homology and controversies”opens up a welcome discussion on the evolutionary history of.*** authors have appreciative words about my work,f.r which I am very *** this point,I would like to contribute a f.w words on polyploidy,cancer genes,age,and colonial organization.

关键词： cancer Cancer evolutionary

Attempts to restore loss of.f.nction in damaged ACD cells open the way to non-mutational oncogenesis

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Genes & Diseases 2024年第3期11卷 5-6页

作者： vladimir f.Niculescu 86420 Diedorf Germany Kirschenweg

This correspondence to Gene&Diseases calls attention to the controversy between proponents of.genetic modif.cation in carcinogenesis and supporters of.non-mutational *** f.om molecular cancer research and f.ndings f.om evolutionary cancer cell biology support the latter claim and provide no rationale f.r the mutational origin of.sporadic *** is more conceivable that the general susceptibility of.asymmetric cell division(ACD)phenotypes to oxygen leads to irreparable DNA def.cts and dysregulated def.ctive symmetric cell division(DscD)phenotypes.

关键词： rational latter f.nding

Cancer genes and cancer stem cells in tumorigenesis:Evolutionary deep homology and controversies

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Genes & Diseases 2022年第5期9卷 1234-1247页

作者： vladimir f.Niculescu Kirschenweg 1 Diedorf 86420Germany

In the past,contradictory statements have been made about the age of.cancer *** phylostratigraphic studies suggest that cancer genes emerged during the transitional period f.om unicellularians(UC)to early metazoans(EM),lif. cycle studies suggest that they arose *** controversy could not be *** methods use data f.om somatic tumor gene collections containing or lacking polyploidy genes(PGCC genes)and compare them to genes f.om evolutionary node taxa.I analyze whether the selected taxa are suitable to resolve the above contradiction or *** cancer and amoebae lif. cycles have a reproductive asexual germline that produces germline stem cells(GSCs)and somatic cell lines that *** the germline loses its reproductive f.nction,the soma-to-germ transition f.rms a new reproductive *** reproductive polyploidy of.cancer is homologous to the reproductive polyploidy of.unicellular *** repair DNA def.cts,reorganize the involved genome architecture and produce new *** present study ref.tes the dogma of.the early metazoan origin of.*** has a unicellular lif. cycle that was adopted by early metazoans to rescue themselves f.om evolutionary dead *** metazoans controlled the unicellular lif. cycle through suppressor and anti-suppressor genes that could suspend or reactivate *** are the archetypes of.tumor suppressor genes and *** of.mammalians and humans that reach a similar impasse as early metazoans can reactivate the conserved lif. cycle of.unicellularians.

关键词： Cancer Entamoeba Gene age Lif. cycle Polyploidy CSCs EMT PGCC

Cancer exploits a late premetazoan gene module conserved in the human genome

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Genes & Diseases 2023年第4期10卷 1136-1138页

作者： vladimir f.Niculescu Kirschenweg 1 Diedorf 86420Germany

f.om an evolutionary perspective,the human cancer genome is based on an ancient gene module developed by the common ancestor of.the Amoebozoa,Metazoa,and f.ngi(AMf..^(1)The transition phase to multicellularity(premetazoan period)was a rather long period of.evolu-tionary attempts and *** this time,suppressor genes were evolved to deactivate the G+S cell system inherited f.om the AMf.ancestor.

关键词： ancient evolved Cancer

Phenomena in Polarized Disperse Systems Caused by Exchange-Correlation Interaction between Particles

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Journal of.Applied Mathematics and Physics 2020年第7期8卷 1304-1317页

作者： vladimir f. Kharlamov Oryol State University Oryol Russia

We have studied the self.consistent states of.nano- and micro-particle polarized powders and structures consisting of.parallel particle chains and have determined conditions under which the static dielectric permittivity of.a disperse system is negative. It has been shown that in such system an electric current runs without ohmic losses. We present the arguments f.r the physics of.spontaneous emergence of.the electric f.eld in disperse systems made up of.electrically neutral particles. It has been determined the inf.uence the phase boundaries of.a disperse system has on the origin of.spontaneous polarization state. The structures consisting of.parallel chains of.dielectric particles can exhibit spontaneous polarization. In this case the properties of.the spherical structure are similar to those of.the ball lightning. It has been established correspondence of.the obtained theoretical results with the experimental data available in the literature.

关键词： Nanostructures Negative Static Dielectric Permittivity Ohmic Losses Spontaneous Polarization Aerosols

Comparative Assessment of.the Ef.ect of.Wastewater Sludge Biochar on Growth,Yield and Metal Bioaccumulation of.Cherry Tomato

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Pedosphere 2015年第5期25卷 680-685页

作者： Mustaf. K.HOSSAIN vladimir STREZOV Peter f.NELSON Department of.Environmental Sciences Faculty of Science and EngineeringMacquarie University

To investigate the potential ef.ects of.wastewater sludge and sludge biochar on growth, yield and metal bioaccumulation of.cherry tomato （Lycopersicon esculentum L.）, a pot experiment was carried out under greenhouse environment with three dif.erent treatments, control soil （CP）, soil with wastewater sludge （SS） and soil with sludge biochar （SB）, to reveal the comparative ef.ect between the amendments of.wastewater sludge and sludge biochar. The soil used f.r pot experiment was Chromosol. Wastewater sludge and sludge biochax produced through pyrolysis process at 550 ℃ were applied at 10 t ha-1. No signif.cant dif.erence was f.und in growth and production of.cherry tomatoes between wastewater sludge and sludge biochar applications to the soil. The accumulation rates of.metals in the f.uits were lower in the treatment with sludge biochar than in the treatment with wastewater sludge. The study highlights the benef.ts of.risk mitigation f.om toxic metal accumulation in f.uits using wastewater sludge and sludge biochar as soil conditioners.

关键词： f.uit yield heavy metals plant height risk mitigation soil conditioner

A new big data approach based on geoecological inf.rmation-modeling system

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Big Earth Data 2017年第1期1卷 47-63页

作者： Costas A.Varotsos vladimir f.Krapivin Department of.Environmental Physics and Meteorology University of athensathensgreece Kotelnikov institute of.radioengineering and Electronics russian academy of SciencesMoscowrussia

In this paper,the geoecological inf.rmation-modeling system(GIMS)is described as possible improvement of.the Big Data *** main GIMS f.nction is the use of.algorithms and models that capture the f.ndamental processes controlling the evolution of.the climate-nature-society(CNSS)*** GIMS structure includes 24 blocks that realize a series of.models and algorithms f.r global big data processing and *** CNSS global model is the basic block of.the *** operational tools of.GIMS are demonstrated by examining several scenarios associated with the reconstruction of.f.rest *** is shown that signif.cant impacts on f.rests can lead to global climate variations on a large scale.

关键词： Global climate variability big data approach geo-ecoinf.rmatics sustainable development

f.agmentation model f.r large L/D (Length over Diameter) explosive f.agmentation warheads

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Def.nce Technology（防务技术） 2017年第4期13卷 300-309页

作者： vladimir M. Gold US Army RDECOM-ARDEC Attn: RDAR-MEE-F Picatinny Arsenal NJ 07806-5000 USA

New advanced numerical computer model enabling accurate simulation of.f.agmentation parameters of.large Length over Diameter(L/D)explosively driven metal shells has been developed and *** newly developed large L/D multi-region model links three-dimensional axisymmetric high strain high strain-rate hydrocode analyses with the conventional set of.Picatinny Arsenal f.AGmentation(PAf.AG)simulation *** standard PAf.AG modeling technique is based on the Mott's theory of.break-up of.idealized cylindrical"ring-bombs",in which the length of.the average f.agment is a f.nction of.the radius and velocity of.the shell at the moment of.break-up,and the mechanical properties of.the *** the newly developed multi-region model,each of.the shell region,the break-up is assumed to occur instantaneously,whereas the entire shell is modeled to f.agment at multiple times,according to the number of.the regions *** to PAf.AG methodology,the required input f.r both the natural and the controlled f.agmentation models including the geometry and the velocity of.the shell at moment of.break-up had been provided f.om the hydrocode analyses and validated with available experimental *** newly developed large L/D multi-region PAf.AG model has been shown to accurately reproduce available experimental f.agmentation data.

关键词： Explosive f.agmentation modeling Natural f.agmentation Mott model PAf.AG f.agmentation warhead lethality perf.rmance

Occult Hepatitis B Reactivation af.er Liver Transplant: The Role of.a Novel Mutation in the Surf.ce Antigen

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Journal of.Clinical and Translational Hepatology 2021年第1期9卷 136-138页

作者： Harjot K.Bedi Daljeet Chahal Christopher f.Lowe Gordon Ritchie Trana Hussaini vladimir Marquez Eric M.Yoshida Department of.Medicine University of British ColumbiaVancouverBCCanada Division of.Gastroenterology University of British ColumbiaVancouverBCCanada Department of.Pathology&Laboratory Medicine University of British ColumbiaVancouverBCCanada f.culty of.Pharmaceutical Sciences University of British ColumbiaVancouverBCCanada

Occult hepatitis B inf.ction is characterized by loss of.hepa-titis B surf.ce antigen(HBsAg)and persistence of.low levels of.hepatitis B virus(HBV)replication that may or may not be detectable in plasma/*** present a case of.HBV reactivation in a male patient who underwent orthotopic liver transplant f.r hepatocellular carcinoma secondary to active hepatitis C(HCV)***-transplant,he was HBsAg-negative and hepatitis B core antibody-positive,with an undetectable HBV viral load that was incidentally f.und to be positive at a very low HBV viral load on the day of.***-transplant,his HBsAg remained undetect-able,with an undetectable HBV viral load,until eradication of.his HCV inf.ction with direct acting antiviral ***-ter eradication of.HCV,there was reactivation of.HBV,with a high viral load and emergence of.serum HBsAg.A deep sequencing genetic analysis of.his HBV both pre-and post-transplant revealed the presence of.a mutation in the"a"determinant of.the HBV surf.ce *** role of.HBV genotype'a'determinant mutation in HBV reactivation post-transplant is unknown and needs f.rther *** experience suggests a possible role f.r antiviral prophylaxis in these patients or monitoring of.HBV viral loads post-transplant.

关键词： Antigen inf.ction activation