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星形胶质细胞松散的兴奋-分泌耦合(英文)

神经损伤与功能重建 2016年第3期11卷 241-241页

作者： Nina Vardjan vladimir Parpura Robert Zorec 王晶(编译) celica biomedical Ljubljana Slovenia laboratory of neuroendocrinology-molecular cell physiology institute of pathophysiology faculty of medicine university of ljubljana Ljubljana Slovenia department of neurobiology center for glial biology in medicinecivitan international research centeratomic force microscopy & nanotechnology laboratories evelyn f. mc knight brain institute university of alabama at birmingham，Birmingham，Alabama 不详

星形胶质细胞在中枢神经系统中扮演重要角色。此外,作为分泌性细胞,星形胶质细胞还活跃地参与被膜囊泡介导的细胞间通讯。当囊泡膜与细胞质膜融合时,储存在这些囊泡中的胶质细胞信号分子流出细胞外。这个过程称之为胞吐作用,受SNARE蛋... 详细信息

星形胶质细胞在中枢神经系统中扮演重要角色。此外,作为分泌性细胞,星形胶质细胞还活跃地参与被膜囊泡介导的细胞间通讯。当囊泡膜与细胞质膜融合时,储存在这些囊泡中的胶质细胞信号分子流出细胞外。这个过程称之为胞吐作用,受SNARE蛋白调节,为细胞内钙水平升高所引起。钙来源于细胞内的内质网储存,它从细胞外的进入归因于星形胶质细胞的细胞钙动力学。本文探讨星形胶质细胞胞吐作用中的钙管理,以及储存胶质细胞信号分子的膜囊泡特性,包括囊泡融合和囊泡内容物流出的机械动力学。在星形胶质细胞中,细胞内钙水平增加和囊泡腔中分泌物流出的延迟略长于神经元。这种相对松散的兴奋-分泌耦合可能根据星形胶质细胞在神经网络调控中的参与来调整。

关键词：钙平衡 GPCR 囊泡释放胞吐作用星形胶质细胞分泌 SNAREs

度洛西汀和安慰剂在中国糖尿病周围神经痛患者中的疗效对比研究

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度洛西汀和安慰剂在中国糖尿病周围神经痛患者中的疗效对比研究

SATIETY研究:青少年首次使用第二代抗精神病药物的心脏代谢风险

中华医学会第十三次全国神经病学学术会议

作者：高妍宁光贾伟平周智广许樟荣刘志民刘超马建华李强陈璐璐文重远 Shuyu ZHANG Qi ZHANG Durisala DESAIAH vladimir SKLJAREVSKI 北京大学第一医院内分泌科上海交通大学附属瑞金医学院内分泌科上海交通大学附属第六人民医院内分泌科中南大学湘雅二院内分泌科中国人民解放军第306医院内分泌科上海长征医院内分泌科南京医科大学第一附属医院内分泌科南京市第一医院内分泌哈尔滨医科大学附属二院内分泌科武汉华中科技大学同济医学院协和医院内分泌科武汉大学人民医院内分泌科美国礼来公司

目的前期研究显示度洛西汀能有效治疗糖尿病周围神经痛(diabetic peripheral neuropathic pain,DPNP),且已在90个国家被批准用于治疗DPNP,其中包括美国和欧盟。本项研究旨在评估度洛西汀在中国DPNP患者中的疗效和安全性。

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中国处方药 2009年第12期8卷 60-60页

作者： Christoph U. Correll Peter Manu vladimir Olshanskiy

背景及目的：既往的研究表明，第二代抗精神病药物有心脏代谢风险，但对于初次使用此类药物的儿科和青少年患者，还未进行充分的安全性评价。本研究的目的是在之前未使用过抗精神病药物的儿科和青少年患者中，评价第二代抗精神病药物对... 详细信息

背景及目的：既往的研究表明，第二代抗精神病药物有心脏代谢风险，但对于初次使用此类药物的儿科和青少年患者，还未进行充分的安全性评价。本研究的目的是在之前未使用过抗精神病药物的儿科和青少年患者中，评价第二代抗精神病药物对机体组织和代谢参数的影响。

关键词：第二代抗精神病药物青少年患者心脏代谢风险安全性评价代谢参数机体组织类药物

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智能制造专题主编寄语

Engineering 2021年第6期 7-10页

作者：李培根 vladimir Marik 高亮沈卫明 The State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and Engineering Huazhong University of Science and Technology Czech Institute of Informatics Robotics and Cybernetics Czech Technical University in Prague

智能制造是制造业发展的一大趋势,其核心是新一代信息通信技术(如5G、人工智能、工业互联网等)与先进制造技术的深度融合。智能制造涵盖产品的全生命周期,包括产品的设计、生产、物流、服务、回收等阶段,人在其中起到重要作用。本期智...

智能制造是制造业发展的一大趋势,其核心是新一代信息通信技术(如5G、人工智能、工业互联网等)与先进制造技术的深度融合。智能制造涵盖产品的全生命周期,包括产品的设计、生产、物流、服务、回收等阶段,人在其中起到重要作用。本期智能制造专题收录了智能制造领域的部分最新研究成果,将有力促进该领域的快速发展。本专题包含8篇论文,其中1篇观点论文和7篇研究论文,

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Perineural invasion as a prognostic factor in patients with stage Ⅰ-Ⅲ rectal cancer –5-year follow up

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World Journal of Gastrointestinal Oncology 2020年第5期12卷 592-600页

作者： Milica Stojkovic Lalosevic Tamara Milovanovic Marjan Micev Mirjana Stojkovic Sanja Dragasevic Milos Stulic Ivan Rankovic vladimir Dugalic Zoran Krivokapic Aleksandra Pavlovic Markovic Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaBelgrade 11000Serbia School of Medicine University of BelgradeBelgrade 11000Serbia Clinic for Digestive Surgery-First Surgical Clinic Clinical Center of SerbiaBelgrade 11000Serbia

BACKGROUND Rectal cancer(RC)is one of the most common diagnosed cancers,and one of the major causes of cancer-related death *** of the current guidelines rely on TNM classification regarding therapy regiments,however recent studies suggest that additional histopathological findings could affect the disease *** To determine whether perineural invasion alone or in combination with lymphovascular invasion have an effect on 5-years overall survival(OS)of RC *** A prospective study included newly diagnosed stage I-III RC patients treated and followed at the Digestive Surgery Clinic,Clinical Center of Serbia,between the years of 2014–*** patients had their diagnosis histologically confirmed in accordance with both TMN and Dukes *** addition,the patient’s demographics,surgical details,postoperative pathological details,differentiation degree and their correlation with OS was *** Of 245 included patients with stage Ⅰ-Ⅲ RC,lymphovascular invasion(LVI)was identified in 92 patients(38%),whereas perineural invasion(PNI)was present in 46 patients(19%).Using Kaplan-Meier analysis for overall survival rate,we have found that both LVI and PNI were associated with lower survival rates(P<0.01).Moreover when Cox multiple regression model was used,LVI,PNI,older age,male gender were predictors of poor prognosis(HR=5.49;95%CI:2.889-10.429;P<0.05).CONCLUSION LVI and PNI were significant factors predicting worse prognosis in early and intermediate RC patients,hence more aggressive therapy should be reserved for these patients after curative resection.

关键词： Lymphovascular invasion Perineural invasion Rectal cancer

1989—1990年中天山的冰川径流状况研究(英文)

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冰川冻土 1993年第3期15卷 442-459页

作者： vladimir B. Aizen Elena M. Aizen(Institute of Geography of the Russian Academy of Sciences, Borisovskiy Pr. 36, Korp. 3, 115563 Moscow, RUSSIA)Victor N. Nesterov(Institute of Oceanography, Far East Branch Russian Academy of Science, Kaplunova str.8, flat 175, Vladivostok 690013 RUSSIA )David D. Sexton(Scott Polar Research Institute, University of Cambridge Lensfield Road, Cambridge ENGLAND CB2 IER.)

通过冰川学、气象学、日射、地球化学和同位素分析,以及野外观测和统计分析,认清了控制—内陆冰川作用大系统的各主要过程。野外工作包括不同天气类型和不同高度(积累区、粒雪界和消融区)的气象条件、各辐射和热量平衡分量、积累和消融... 详细信息

通过冰川学、气象学、日射、地球化学和同位素分析,以及野外观测和统计分析,认清了控制—内陆冰川作用大系统的各主要过程。野外工作包括不同天气类型和不同高度(积累区、粒雪界和消融区)的气象条件、各辐射和热量平衡分量、积累和消融。.划分了成冰带,提出系统内水转换的估算方法,可能对各水文要素作短期和长期预报。

关键词：冰川径流天山

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至正钱考

中国钱币 2006年第3期 26-31页

作者：乌拉基米尔.彼勒耶夫谢尔盖.斯达诺维奇曹光胜

It was a very short time for minting of Zhi Zheng Tong Bao coin in the year of 1352,the coins with no time recording might be mint during the year of 1354-1358,the five in one and ten in one value recording coins were... 详细信息

关键词：钱币学蒙古帝国《元史》元顺帝统治者时间收藏家铸造元代史料

Nanosize Magnetic Films and Powders Prepared by Extraction-Pyrolysis Technique

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材料科学与工程（中英文版） 2010年第2期4卷 19-25页

作者： N. Patrusheva Tamara P. Polyakova Klavdiya A. Seredkin vladimir N. Komogorcev Sergey V. Patrushev Valery S. Patrin Gennady Siberian Federal University Krasnoyarsk Russia Institute of Physics Siberian Branch of Russian Academy of Science Krasnoyarsk Russia Institute of Chemistry and Chemical Technology SB RAS Krasnoyarsk Russia

Nanosize ferrite thin films and powders were prepared by extraction-pyrolysis technique. Thin films Fe2CoO4 with grain size 18 nm and 10 nm have been obtained depending on the pyrolysis regimes. Films possessed the magnetic and magneto optical properties. Cobalt ferrite films in nanocrystalline form would ideally suite for magneto-optical recording media and fine microstructure (crystallite size < λ/10) would prevent from media optical noise. Magnetic nanoparticles of cobalt ferrite with the size of ~ 40 nm were obtained by the same extraction–pyrolysis technique in a mesoporous silicon dioxide (MSM-41) molecular sieve matrix. Synthesized nanoparticles are magnetically hard materials with a coercive field of Hc(4.2 K) = 9.0 kOe and Hc(300 K) = 1.8 kOe and a reduced remanent magnetization of Mr/Ms(4.2 K) = 0.83 and Mr/Ms(300 K) = 0.49.

关键词：纳米磁性薄膜粉体技术萃取铁氧体薄膜制备裂解晶粒尺寸磁性纳米微粒

Global wood anatomical perspective on the onset of the Late Antique Little Ice Age (LALIA) in the mid-6th century CE

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Science Bulletin 2022年第22期67卷 2336-2344页

作者： Ulf Büntgen Alan Crivellaro Dominique Arseneault Mike Baillie David Barclay Mauro Bernabei Jarno Bontadi Gretel Boswijk David Brown Duncan A.Christie Olga V.Churakova Edward R.Cook Rosanne D’Arrigo Nicole Davi Jan Esper Patrick Fonti Ciara Greaves Rashit M.Hantemirov Malcolm K.Hughes Alexander V.Kirdyanov Paul J.Krusic Carlos Le Quesne Fredrik C.Ljungqvist Michael Mc.Cormick vladimir S.Myglan Kurt Nicolussi Clive Oppenheimer Jonathan Palmer Chun Qin Frederick Reinig Matthew Salzer Markus Stoffel Max Torbenson Mirek Trnka Ricardo Villalba Nick Wiesenberg Greg Wiles Bao Yang Alma Piermattei Department of Geography University of CambridgeCambridge CB23ENUK Swiss Federal Research Institute(WSL) Birmensdorf 8903Switzerland Global Change Research Centre(CzechGlobe) Brno 60300Czech Republic Department of Geography Faculty of ScienceMasaryk UniversityBrno 61300Czech Republic Forest Biometrics Laboratory Faculty of Forestry“Stefan cel Mare”University of SuceavaSuceava 720229Romania Department of Biology Chemistry and GeographyUniversity of Quebec in RimouskiRimouski Qc.G5L 3A1Canada Archaeology&Palaeoecology School of Natural and Built EnvironmentQueen’s University BelfastBelfast BT71NNUK Department of Geology State University of New York at CortlandCortland NY 13045USA CNR-IBE Institute of BioEconomyNational Research CouncilTrento 38121Italy School of Environment The University of AucklandAuckland 1010New Zealand Laboratorio de Dendrocronología y Cambio Global Universidad Austral de ChileValdivia 509000Chile Center for Climate and Resilience Research(CR) Santiago 8370449Chile Cape Horn International Center(CHIC) Punta Arenas 6200000Chile Institute of Ecology and Geography Siberian Federal UniversityKrasnoyarsk 660041Russia Tree-Ring Laboratory Lamont-Doherty Earth ObservatoryColumbia UniversityPalisades NY 10964USA Department of Environmental Science William Paterson UniversityWayne NJ 07470USA Department of Geography Johannes Gutenberg UniversityMainz 55099Germany Institute of Plant and Animal Ecology Ural BranchRussian Academy of SciencesYekaterinburg 620144Russia Ural Institute of Humanities Ural Federal UniversityYekaterinburg 620002Russia Laboratory of Tree-Ring Research University of ArizonaTucson AZ 85721USA Sukachev Institute of Forest SB RAS Krasnoyarsk 660036Russia Department of Physical Geography Bolin Centre for Climate ResearchStockholm UniversityStockholm 10691Sweden Department of History Stockholm UniversityStockholm 10691Sweden Bolin Centre for Climate Research Stockholm UniversityStockholm 10691Sweden Swedish Collegium for Advanced Study

Linked to major volcanic eruptions around 536 and 540 CE, the onset of the Late Antique Little Ice Age has been described as the coldest period of the past two millennia. The exact timing and spatial extent of this exceptional cold phase are, however, still under debate because of the limited resolution and geographical distribution of the available proxy archives. Here, we use 106 wood anatomical thin sections from 23forest sites and 20 tree species in both hemispheres to search for cell-level fingerprints of ephemeral summer cooling between 530 and 550 CE. After cross-dating and double-staining, we identified 89Blue Rings(lack of cell wall lignification), nine Frost Rings(cell deformation and collapse), and 93Light Rings(reduced cell wall thickening) in the Northern Hemisphere. Our network reveals evidence for the strongest temperature depression between mid-July and early-August 536 CE across North America and Eurasia, whereas more localised cold spells occurred in the summers of 532, 540–43, and548 CE. The lack of anatomical signatures in the austral trees suggests limited incursion of stratospheric volcanic aerosol into the Southern Hemisphere extra-tropics, that any forcing was mitigated by atmosphere-ocean dynamical responses and/or concentrated outside the growing season, or a combination of factors. Our findings demonstrate the advantage of wood anatomical investigations over traditional dendrochronological measurements, provide a benchmark for Earth system models, support cross-disciplinary studies into the entanglements of climate and history, and question the relevance of global climate averages.

关键词： Blue Rings Climate extremes Dendrochronology Late Antiquity Tree rings Volcanic eruptions