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Preparatory training attenuates drastic response of the insulin-like growth factor binding protein 1 at the point of maximal oxygen consumption in handball players

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Journal of Sport and Health Science 2017年第3期6卷 372-377页

作者： Olgica Nedic Milos Sunderic Goran Miljus Zoran Valdevit vladimir jakovljevic Marija Glibetic Vesna Vucic Institute for the Application of Nuclear Energy University of BelgradeBelgrade 11080Serbia Faculty of Sport and Physical Education University of BelgradeBelgrade 11000Serbia Department of Physiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Centre of Research Excellence in Nutrition and Metabolism Institute for Medical ResearchUniversity of BelgradeBelgrade 11000Serbia

Background:Intensive exercise changes physiological need for glucose and several biochemical pathways responsible for its metabolism *** them are those which involve insulin,insulin-like growth factor(IGF-1),and IGF-binding proteins(IGFBPs).Different types and degrees of exercise,as well as an athlete's fitness,may induce a range of responses regarding concentrations and time needed for the *** idea of the work was to find out whether and how insulin/IGF axis responds to additional physical activity in the already trained subjects and if so,is the adaptation potentially beneficial from the aspect of metabolic ***:The effect of 4-week intensive training on campus(preparatory training) on the levels of insulin,IGF-1,and IGFBPs during maximal progressive exercise test(MPET) on a treadmill was compared to the results obtained during MPET conducted after a regular training season of a female elite handball team(n = 17,age:17 ± 1 years,height:171 ± 8 cm,weight:65 ± 8 kg,body mass index:22 ± 1 kg/m^2 at the beginning of the study;there were no significant changes at the end).Serum samples were obtained from players immediately before the test(basal),at the end of the test after reaching the point of maximal oxygen consumption(VO_(2max)),and after ***:The concentration of insulin decreased at VO_(2max),but remained higher in players after preparatory training(12.2 ± 2.5 m U/L vs.8.9 ± 4.4 m U/L,p = 0.049).The level of IGFBP-1 decreased in players at VO_(2max) in either case of training,but it remained much higher in tests performed after the preparatory regime than before(p = 0.029).Concentrations of IGF-1,IGFBP-2,-3,and-4 did not change ***:The inverse relation between insulin and IGFBP-1 was lost during MPET,as these 2 molecules changed in the same *** results obtained suggest less severe stress-induced depression of insulin and IGFBP-1 after preparatory *** another metabolic mechanism

关键词： Female IGF-binding proteins(IGFBPs) Insulin Insulin-like growth factor I(IGF-1) Progressive exercise test VO_(2max)

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Nitric oxide and tumour necrosis factor alpha in the process of pseudoexfoliation glaucoma

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1138-1142页

作者： Tatjana S.Sarenac Vulovic Sladjana M.Pavlovic vladimir LJ.jakovljevic Katarina B.Janicijevic Nemanja S.Zdravkovic Department of Ophthalmology Clinical Center Kragujevac Center for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences University of Kragujevac Department of Physiology Faculty of Medical SciencesUniversity of Kragujevac Faculty of Medical Sciences University of Kragujevac

AIMTo establish the role of nitric oxide (NO), ascorbic acid and tumour necrosis factor-α (TNF-α) in the pathogenesis of pseudoexfoliation glaucoma (XFG).METHODSOur study included 120 patients who were referred for cataract surgery. All patients were divided into four groups according to clinical findings: XFG, early and late pseudoexfoliation syndrome (XFS), and cataract (without pseudoexfoliation). Serum and aqueous humour levels of the ascorbic acid, NO and TNF-α were measured. The concentrations of the ascorbic acid and NO were measured by an appropriate spectrophotometric method. Enzyme-linked immunosorbent assay (ELISA) was used to determine TNF-α *** humour concentration of ascorbic acid was significantly lower in patients with late XFS (0.61±0.11 mmol/L) and XFG (0.48±0.15 mmol/L) compared to patients with early XFS (0.9±0.15 mmol/L) and cataract (1.16±0.22 mmol/L), while there was no difference in serum concentration in all examined groups. Aqueous humour concentration of NO was significantly higher in patients with XFG (77.7±11.4 µmol/L) compared to patients with early XFS (50.27±9.34 µmol/L) and cataract (49.77±7.1 µmol/L), while serum concentration was increased in the early stage of XFS (73.26±8.29 µmol/L). Aqueous humour level of proinflammatory cytokine TNF-α was increased in patients with XFS (early 460.04±18.32 pg/mL; late 502.42±53.23 pg/mL) and XFG (510.34±43.07 pg/mL), while there was no difference in serum level in all examined groups of *** ascorbic acid and elevated NO and inflammation related cytokine TNF-α level in aqueous humour of the patients with developed XFG suggest that oxidative stress induces local inflammation.

关键词： ascorbic acid nitric oxide pseudoexfoliation tumour necrosis factor alpha

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Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension

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World Journal of Gastroenterology 2012年第4期18卷 331-339页

作者： Andreja Vujanac vladimir jakovljevic Dusica Djordjevic vladimir Zivkovic Mirjana Stojkovic Dragan Celikovic Nebojsa Andjelkovic Aleksandra Jurisic Skevin Dragan Djuric Department of Physiology Faculty of MedicineUniversity of Kragujevac Department of Gastroenterology and Echosonography Unit Clinical Centre of Belgrade Internal Clinic Clinical Centre "Kragujevac"Faculty of MedicineUniversity of Kragujevac Department of Physical Medicine and Rehabilitation Faculty of MedicineUniversity of Kragujevac Institute of Medical Physiology Belgrade University School of Medicine

AIM:Тo examine the effects of nitroglycerine on portal vein haemodynamics and oxidative stress in patients with portal ***:Thirty healthy controls and 39 patients with clinically verified portal hypertension and increasedvascular resistance participated in the *** di-ameters,portal diameters and portal flow velocities were recorded using color flow imaging/pulsed Doppler ***-section area,portal flow and index of vascular resistance were *** collected blood samples,superoxide anion radical (O 2-),hydrogen per-oxide (H 2 O 2),index of lipid peroxidation (measured as TBARS) and nitric oxide (NO) as a marker of endothelial response (measured as nitrite-NO 2-) were ***-dependent analysis was performed at basal state and in 10th and 15th min after nitroglycerine (sublingual 0.5 mg) ***:Oxidative stress parameters changed sig-nificantly during the study.H 2 O 2 decreased at the end of study,probably via O 2-mediated disassembling in Haber Weiss and Fenton reaction;O 2-increased signifi-cantly probably due to increased diameter and tension and decreased shear rate *** O 2-and H 2 O 2 degradation products,like hydroxyl radical,initi-ated lipid *** blood flow was to some extent lower in patients than in controls due to double paradoxes,flow velocity decreased,shear rate decreased significantly indicating non Newtonian char-acteristics of portal blood ***:This pilot study could be a starting point for further investigation and possible implemen-tation of some antioxidants in the treatment of portal hypertension.

关键词： Portal hypertension Endothelium Nitroglycerine Oxidative stress Portal vein haemodynamics

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The impact of health expenditures on public health in BRICS nations

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Journal of Sport and Health Science 2019年第6期8卷 516-519页

作者： Mihajlo jakovljevic Yuriy Timofeyev Natalia V.Ekkert Julia V.Fedorova Galina Skvirskaya Sergey Bolevich vladimir A.Reshetnikov Division of Health Economics Lund UniversityLund SE 22007Sweden National Research University Higher Schools of Economics Moscow 101000Russia Department for Health Care and Public Health Sechenov First Moscow State Medical UniversityMoscow 119991Russia Center for Master Programs Sechenov First Moscow State Medical UniversityMoscow 119991Russia Department of Human Pathology Sechenov First Moscow State Medical UniversityMoscow 119991Russia

*** of the BRICS emerging economies Since the late 1980s,accelerated globalization has provided economic growth opportunities in mature and emerging *** rapidly developing nations of Brazil,Russia,India,China,and South Africa(BRICS nations)have a combined economic output that makes BRICS countries the world's major emerging economies.

关键词： BRICS nations impact

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