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Novel insights regarding the role of noncoding RNAs in diabetes

World Journal of Diabetes 2023年第7期14卷 958-976页

作者： Mirjana T Macvanin Zoran Gluvic vladan bajic Esma R Isenovic Department of Radiobiology and Molecular Genetics Vinča Institute of Nuclear Sciences-National Institute of the Republic of SerbiaUniversity of BelgradeBelgrade 11000Serbia Department of Endocrinology and Diabetes Clinic for Internal MedicineZemun Clinical HospitalSchool of MedicineUniversity of BelgradeBelgrade 11000Serbia

Diabetes mellitus(DM)is a group of metabolic disorders defined by hyperglycemia induced by insulin resistance,inadequate insulin secretion,or excessive glucagon *** 2021,the global prevalence of diabetes is anticipated to be 10.7%(537 million people).Noncoding RNAs(ncRNAs)appear to have an important role in the initiation and progression of DM,according to a growing body of *** two major groups of ncRNAs implicated in diabetic disorders are miRNAs and long noncoding *** are singlestranded,short(17–25 nucleotides),ncRNAs that influence gene expression at the post-transcriptional *** DM has reached epidemic proportions worldwide,it appears that novel diagnostic and therapeutic strategies are required to identify and treat complications associated with these diseases *** are gaining attention as biomarkers for DM diagnosis and potential treatment due to their function in maintaining physiological homeostasis via gene expression *** this review,we address the issue of the gradually expanding global prevalence of DM by presenting a complete and upto-date synopsis of various regulatory miRNAs involved in these *** hope this review will spark discussion about ncRNAs as prognostic biomarkers and therapeutic tools for *** examine and synthesize recent research that used novel,high-throughput technologies to uncover ncRNAs involved in DM,necessitating a systematic approach to examining and summarizing their roles and possible diagnostic and therapeutic uses.

关键词： Noncoding RNA miRNA Diabetes Circulating miRNA biomarkers Therapeutic target CRISPR/Cas9 system

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