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Prehabilitation of overweight and obese patients with dysglycemia awaiting bariatric surgery: Predicting the success of obesity treatment

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World Journal of Diabetes 2022年第12期13卷 1096-1105页

作者： Maja cigrovski Berkovic Ines Bilic-Curcic Anna Mrzljak Silvija Canecki Varzic vjekoslav cigrovski Department of Endocrinology Diabetes and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Faculty of Medicine University of Osijek Osijek 31000Croatia Department of Endocrinology and Diabetes Clinical Hospital Centre OsijekOsijek 31000Croatia Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia

Bariatric surgery offers the best health results in overweight and obese patients but is not a risk and/or complication-free treatment.In cases with additional hyperglycemia,the burden of surgery can be even higher and alter both shortterm and long-term outcomes.Although bariatric surgery offers glycemic improvements and in the case of early onset diabetes disease remission,weight loss results are lower than for obese patients without diabetes.Different multimodal programs,usually including interventions related to patients’performance,nutritional and psychological status as well as currently available pharmacotherapy before the surgery itself might considerably improve the immediate and late postoperative course.However,there are still no clear guidelines addressing the prehabilitation of obese patients with dysglycemia undergoing bariatric surgery and therefore no unique protocols to improve patients’health.In this minireview,we summarize the current knowledge on prehabilitation before bariatric surgery procedures in patients with obesity and dysglycemia.

关键词： Bariatric surgery Obesity Dysgylcemia Diabetes outcome Prehabilitation

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What is the gut feeling telling us about physical activity in colorectal carcinogenesis?

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World Journal of Clinical Cases 2020年第23期8卷 5844-5851页

作者： Maja cigrovski Berkovic vjekoslav cigrovski Ines Bilic-Curcic Anna Mrzljak Department for Endocrinology Diabetes and MetabolismClinical Hospital DubravaZagreb 10000Croatia Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Department of Pharmacology Faculty of MedicineJ J Strossmayer University OsijekOsijek 31000Croatia Department of Medicine Merkur University HospitalZagreb 10000Croatia Department of Medicine School of MedicineUniversity of ZagrebZagreb 10000Croatia

In the last decades,more efforts are focused on the prevention and treatment of malignant diseases,given the increase in all cancers incidence A lifestyle change,including healthy eating habits and regular physical activity,has significantly impacted colorectal cancer prevention.The effect of dose-dependent physical activity on mortality and recurrence rates of colorectal carcinoma has been unequivocally demonstrated in observational studies.However,clear recommendations are not available on the frequency,duration,and intensity of exercise in patients with colorectal cancer due to the lack of evidence in randomized clinical trials.Regarding pathophysiological mechanisms,the most plausible explanation appears to be the influence of physical activity on reducing chronic inflammation and insulin resistance with a consequent positive effect on insulin growth factor 1 signaling pathways.

关键词： Physical activity Colorectal cancer Insulin signaling pathway Inflammation Gut microbiota

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Fear of hypoglycemia,a game changer during physical activity in type 1 diabetes mellitus patients

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World Journal of Diabetes 2021年第5期12卷 569-577页

作者： Maja cigrovski Berkovic Ines Bilic-Curcic Lavinia La Grasta Sabolic Anna Mrzljak vjekoslav cigrovski Department of Endocrinology DiabetesMetabolism and Clinical PharmacologyUniversity Hospital DubravaZagreb 10000Croatia Department of Pharmacology Faculty of MedicineUniversity of J.J.Strossmayer OsijekOsijek 31000Croatia Department of Pediatric Endocrinology Diabetes and MetabolismUniversity Hospital Centre Sestre MilosrdniceZagreb 10000Croatia Department of Medicine Merkur University HospitalZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Faculty of Kinesiology University of ZagrebZagreb 10000Croatia

Hypoglycemia limits optimal glycemic management of patients with type 1 diabetes mellitus(T1DM).Fear of hypoglycemia(FoH)is a significant psychosocial consequence that negatively impacts the willingness of T1DM patients to engage in and profit from the health benefits of regular physical activity(e.g.,cardiometabolic health,improved body composition,cardiovascular fitness,quality of life).Technological advances,improved insulin regimens,and a better understanding of the physiology of various types of exercise could help ameliorate FoH.This narrative review summarizes the available literature on FoH in children and adults and tools to avoid it.

关键词： Hypoglycemia Fear of hypoglycemia Type 1 diabetes mellitus Physical activity Modern technology Exercise management

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