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Prevalence of advanced liver fibrosis and steatosis in type-2 diabetics with normal transaminases:A prospective cohort study

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World Journal of Gastroenterology 2021年第6期27卷 523-533页

作者： Jasbir Makker Hassan Tariq Kishore Kumar Madhavi Ravi Danial Haris Shaikh vivien leung Umar Hayat Muhammad T Hassan Harish Patel Suresh Nayudu Sridhar Chilimuri Division of Gastroenterology Department of MedicineBronxCare Health SystemBronxNY 10457United States KU School of Medicine-Wichita University of KansasWichitaKS 67214United States Department of Medicine BronxCare Health SystemBronxNY 10457United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)and type-2 diabetes mellitus(T2DM)have an intricate bidirectional *** with T2DM,not only have a higher prevalence of non-alcoholic steatosis,but also carry a higher risk of progression to nonalcoholic *** still differ in their recommendations of screening for NAFLD among patients with *** To study the prevalence of NAFLD and advanced fibrosis among our patient population with *** During the study period(November 2018 to January 2020),59 adult patients with T2DM and 26 non-diabetic control group individuals were recruited *** with known significant liver disease and alcohol use were *** data and lab parameters were *** elastography was performed in all *** In the study group comprised of patients with T2DM and normal alanine aminotransferase levels(mean 17.8±7 U/L),81%had hepatic steatosis as diagnosed by *** hepatic fibrosis(stage F3 or F4)was present in 12%of patients with T2DM as compared to none in the control *** with T2DM also had higher number of individuals with grade 3 steatosis[45.8%vs 11.5%,(P<0.00001)and metabolic syndrome(84.7%vs 11.5%,P<0.00001)].CONCLUSION A significant number of patients with T2DM,despite having normal transaminase levels,have NAFLD,grade 3 steatosis and advanced hepatic fibrosis as measured by liver elastography.

关键词： Advanced liver fibrosis Diabetes Steatosis Normal transaminases Fatty liver disease Metabolic syndrome

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