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Higher radiation dose with a shorter treatment duration improves outcome for locally advanced carcinoma of anal canal

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World Journal of Gastroenterology 2007年第6期13卷 895-900页

作者： Kim Huang Daphne Haas-Kogan vivian.Weinberg Richard Krieg Department of Radiation Oncology University of California San Francisco CA United States Comprehensive Cancer Center Biostatistics Core University of California San Francisco CA United States

AIM： To assess whether radiation dose and duration of treatment influence local control and survival of patients with locally advanced anal cancer treated with definitive chemoradiation. METHODS： Twenty-eight consecutive patients who were treated with definitive radiation therapy for bulky anal cancers （〉 5 cm in size） were reviewed. Nineteen patients had T3 lesions, 8 patients had T4 lesions, and 15 patients had lymph node involvement. The median tumor size was 7.5 cm. All but one patient received concurrent chemoradiation. The median radiation dose was 54 Gy. The median duration of treatment was 58 d. RESULTS： With a median follow-up of 2.5 years in all patients and 7.8 years in living patients, the 2-year local recurrence-free probability was 570 and overall survival rate was 67%. Neither radiation dose nor duration of treatment alone was predictive of either time to local failure or overall survival. However, longer treatment breaks can potentially mask an advantage over higher radiation doses. Therefore, we examined those patients who received ≥ 54 Gy within 60 d, comparing them to the rest of the patients. Of patients who received ≥54 Gy within 60 d, local progression-free probability was 890 versus 420 for the rest of the group （P = 0.01）. CONCLUSION： Local failure is a significant problem in locally advanced carcinomas of-the anal canal. Higher radiation doses with limited treatment breaks may offer an increase in local control and survival.

关键词： Anal carcinoma Locally advanced Chemoradiation

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The ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells

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Bone Research 2022年第1期10卷 95-106页

作者： Zhenqing Liu Hye-Lim Lee Jin Sook Suh Peng Deng Chang-Ryul Lee Olga Bezouglaia Mojan Mirnia vivian.Chen Michael Zhou Zhong-Kai Cui Reuben HKim Min Lee Tara Aghaloo Christine Hong Cun-Yu Wang Division of Oral Biology and Medicine School of DentistryUniversity of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Department of Anatomy&Neurobiology University of CaliforniaIrvine(UCI)IrvineCA 92697USA Department of Orofacial Sciences School of DentistryUniversity of CaliforniaSan Francisco(UCSF)San FranciscoCA 94143USA School of Dentistry University of CaliforniaSan Francisco(UCSF)San FranciscoCA 94143USA Division of Diagnostic and Surgical Sciences School of DentistryUniversity of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA School of Dentistry University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Division of Advanced Prosthodontics School of DentistryUniversity of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Division of Constitutive and Regenerative Sciences School of DentistryUniversity of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Department of Bioengineering University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA

Osteoporosis is a highly prevalent public health burden associated with an increased risk of bone fracture, particularly in aging women. Estrogen, an important medicinal component for the preventative and therapeutic treatment of postmenopausal osteoporosis, induces osteogenesis by activating the estrogen receptor signaling pathway and upregulating the expression of osteogenic genes, such as bone morphogenetic proteins(BMPs). The epigenetic regulation of estrogen-mediated osteogenesis,however, is still unclear. In this report, we found that estrogen significantly induced the expression of lysine-specific demethylase 6B(KDM6B) and that KDM6B depletion by shRNAs led to a significant reduction in the osteogenic potential of ***, upon estrogen stimulation, estrogen receptor-α(ERα) was recruited to the KDM6B promoter, directly enhancing KDM6B expression. Subsequently, KDM6B was recruited to the BMP2 and HOXC6 promoters, resulting in the removal of H3K27me3 marks and activating the transcription of BMP2 and HOXC6, the master genes of osteogenic differentiation. Furthermore, we found that estrogen enhanced DMSC osteogenesis during calvarial bone regeneration and that estrogen’s pro-osteogenic effect was dependent on KDM6B in vivo. Taken together, our results demonstrate the vital role of the ERα/KDM6B regulatory axis in the epigenetic regulation of the estrogen-dependent osteogenic response.

关键词： expression stimulation ERα

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Osteocyte morphology and orientation in relation to strain in the jaw bone

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International Journal of Oral Science 2018年第1期10卷 36-43页

作者： vivian.Wu René F. M. van Oers Engelbert A. J. M. Schulten Marco No Helder Rommel G. Bacabac Jenneke Klein-Nulend Department of Oral Cell Biology Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam Movement Sciences University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands Department of Dental Materials Science Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam Movement Sciences University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands Department of Oral and Maxillofacial Surgery VU University Medical Center/Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam Movement Sciences Amsterdam The Netherlands Department of Physics Medical Biophysics Group University of San Carlos Cebu City Philippines

Bone mass is important for dental implant success and is regulated by mechanoresponsive osteocytes. We aimed to investigate the relationship between the levels and orientation of tensile strain and morphology and orientation of osteocytes at different dental implant positions in the maxillary bone. Bone biopsies were retrieved from eight patients who underwent maxillary sinus-floor elevation with β-tricalcium phosphate prior to implant placement. Gap versus free-ending locations were compared using 1) a three-dimensional finite-element model of the maxilla to predict the tensile strain magnitude and direction and 2) histology and histomorphometric analyses. The finite-element model predicted larger, differently directed tensile strains in the gap versus freeending locations. The mean percentage of mineralised residual native-tissue volume, osteocyte number(mean ± standard deviations:97 ± 40/region-of-interest), and osteocyte shape(90% elongated,10% round) were similar for both locations. However, the osteocyte surface area was 1.5-times larger in the gap than in the free-ending locations, and the elongated osteocytes in these locations were more cranially caudally oriented. In conclusion, significant differences in the osteocyte surface area and orientation seem to exist locally in the maxillary bone, which may be related to the tensile strain magnitude and orientation. This might reflect local differences in the osteocyte mechanosensitivity and bone quality, suggesting differences in dental implant success based on the location in the maxilla.

关键词： SINUS FLOOR ELEVATION MINERAL DENSITY MAXILLARY HISTOMORPHOMETRY TOMOGRAPHY IMPLANTS SPINE

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The effect of SiO2 nanoparticles derived from hydrothermal solutions on the performance of portland cement based materials

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Frontiers of Earth Science 2017年第4期11卷 436-445页

作者： Ismaei FLORES-vivian.Rani G.K PRADOTO Mohamadreza MOINI Marina KOZHUKHOVA Vadim POTAPOV Konstantin SOBOLEV Department of Civil Engineering and Mechanics Advanced and Nano Cement-Based Materials Laboratory University ofWisconsin-Milwaukee Milwaukee 53211 USA Universidad Aut6noma de Nuevo Le6n Av. Universidad s/n Cd. Universitaria San Nicoldts de los Garza 66455 Nuevo Le6nMExico The Belgorod State Technological University named after V.G. Shoukhov Belgorod Russia Geotechnological Research Center Far East Branch of Russian Academy of Science Petropavlovsk-Kamchatsky 683002 Russia

The nanoparticles of SiO2 were used in cement systems to modify the rheological behavior, to enhance the reactivity of supplementary cementitious materials, and also to improve the strength and durability. In this research, low-cost nano-SiO2 particles from natural hydrothermal solutions obtained by membrane ultrafiltration and, optionally, by cryochemical vacuum sublimation drying, were evaluated in portland cement based systems. The SiO2-rich solutions were obtained from the wells of Mutnovsky geothermal power station （Far East of Russia）. The constant nano-SiO2 dosage of 0.25% （as a solid material by weight of cementitious materials） was used to compare the cement systems with different nanoparticles against a reference mortar and a commercially available nano-SiO2. Nanoparticles were characterized by X-Ray Diffraction （XRD）, BET Surface Area, Scanning Electron Microscope （SEM） and Fourier Transform Infrared （FTIR） spectroscopy techniques. It was demonstrated that the addition of polycarboxylate ether superplasticizer and the dispersion treatment using an ultrasound processor can be used to facilitate the distribution ofnano-SiOz particles in the mixing water. The effect ofnano-SiO2 particles in portland cement mortars was investigated by evaluating the flow, heat of hydration and compressive strength development. It was demonstrated that the use ofnano- SiO2 particles can reduce the segregation and improve strength properties.

关键词： ultrafiltration cryochemical vacuum sublimation drying nanoparticles portland cement heat of hydration,surface area compressive slxength

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Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer

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Engineering 2021年第10期7卷 1393-1412页

作者： Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro vivian.de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas Chronic Disease Program(UFIEC) Carlos III Health InstituteMadrid E-28220Spain Department of Biochemistry and Molecular Biology Faculty of Optics and OptometryComplutense University of MadridMadrid E-28040Spain Gastroenterology Unit San Carlos Clinical HospitalMadrid E-28040Spain Surgical Pathology Department San Carlos Clinical HospitalMadrid E-28040Spain Translational Oncology Division OncoHealth InstituteJimenez Diaz Foundation University HospitalMadrid E-28040Spain Department of Biochemistry Faculty of MedicineAlberto Sols Institute of Biomedical ResearchCSIC-UAMMadrid E-28029Spain Department of Analytical Chemistry Faculty of Chemical SciencesComplutense University of MadridMadrid E-28040Spain Center for Biological Research Spanish National Research Council(CSIC)MadridE-28040Spain Molecular Pathology and Therapeutic Targets Group La Paz University Hospital(IdiPAZ)Madrid E-28046Spain

Colorectal cancer(CRC)is the second leading cause of cancer-related death *** five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced *** against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early ***,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid *** that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to *** bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC *** validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC *** together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here

关键词： Autoantibodies Diagnosis Colorectal cancer Exosomes Tumor microenviroment Humoral immune response Point of care Biosensors

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Is California＇s Aging Infrastructure the Principal Contributor to the Recent Trend of Power Outage？

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通讯和计算机（中英文版） 2016年第5期13卷 225-233页

作者： vivian.Sultan Ahmed Alzahrani Hind Bitar Norah Alharbi Claremont Graduate University Center for Information Systems and Technology Claremont CA USA

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The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Propertiesnand Therapeutic Resistance in Nasopharyngeal Carcinoma

The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Pr...

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2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Qian Zhong Zhi-Hua Liu Zhi-Rui Lin Ze-Dong Hu Li Yuan Yan-min Liu Ai-JunnZhou Li-Hua Xu Li-Juan Hu Xin-Yuan Guan Jia-Jie Hao vivian.W.Y.Lui Ling Guo Hai-Qiang Mai Ming-Yuan Chen Fei Han Yun-Fei Xia Jennifer R.Grandis Xing Zhang Mu-Sheng Zeng State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center Innovation Center of Cancer Medicine National Institute of Biological Sciences Department of Pain Treatment the Fourth People’s Hospital of Kunming city Department of Oncology and Hematology The First Affiliated Hospital of Guangzhou Medical University Department of Medical Oncology Affiliated Tumor Hospital of Guangzhou Medical University State Key Laboratory of Molecular Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong Kong Department of Nasopharyngeal Carcinoma Sun Yat-Sen University Cancer Center Department of Radiation Oncology Sun Yat-Sen University Cancer Center Department of Otolaryngology Head and Neck Surgery and Clinical and Translational Science Institute University of California at San Francisco

Background: Nasopharyngeal carcinoma(NPC) is most common head and neck cancer in Southeast Asia. Because local recurrence and distant metastasis are still the main causes of NPC treatment failure, it is urgent to identify new tumor markers and therapeutic targets for advanced NPC. Methods: RNAseq was applied to look for interchromosome translocation in NPC. PCR, FISH and immunoprecipitation were used to examine the fusion gene expression at RNA, DNA, and protein levels in NPC biopsies. MTT assay, colony formation assay, sphere formation assay, co-IP, ChIP assay, and in vivo chemoresistance assay were applied to explore the function of RARS-MAD1 L1 in NPC. Results: We demonstrated that RARSMAD1 L1 was present in 10.03%(35/349) primary NPC biopsies and 10.7%(9/84) in head and neck cancer(HNC) samples. RARS-MAD1 L1 overexpression increased cell proliferation, colony formation, and tumorigenicity in vitro, and the silencing of endogenous RARS-MAD1 L1 reduced cancer cell growth and colony formation in vitro. Additionally, RARS-MAD1 L1 increased the side population(SP) ratio and induced chemo-and radio-resistance. Furthermore RARS-MAD1 L1 interacted with AIMP2, which resulted in activation of FBP1/c-Myc pathway. The silencing of FUBP1 or the administration of a c-Myc inhibitor abrogated the cancer stem cell(CSC)-like characteristics induced by RARS-MAD1 L1. The expression of cMyc and ABCG2 was higher in RARS-MAD1 L1 positive HNC samples than in negative samples. Conclusion: Taken together, our findings indicate that RARS-MAD1 L1 might contribute to tumorigenesis, CSC-like properties and therapeutic resistance, at least in part, through the FUBP1/c-Myc axis, implying that RARS-MAD1 L1 might serve as an attractive target for therapeutic intervention for NPC.

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