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A harmonisation approach to traditional Chinese medicine registration in Asian countries

Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 143-147页

作者： vivian S.W.Chan Fung Independent Scholar 2 Woodward PlaceSt IvesNSW 2075Australia

The traditional Chinese medicine(TCM)industry is critical to not only for public health but also for economic *** to the european Union(eU)directives,under the eU framework for(traditional)herbal medicinal products,herbal medicines with long history of use can be registered in ***,there is a condition in this directive in which only those that have at least 10e15 years in the eU market are accepted for registration and/or marketing *** author opinion,the condition of 10-15 years of use in eU countries set within the eU regulatory framework is with consideration of the genetic differences which can result in variation in adverse drug responses among different world *** this concept in mind,it is reasonable to project the principal of the eU directive to the Asian countries where TCM is *** like China,Singapore,Japan and South Korea that have well established drug registration framework are in best position in executing the best practice and facilitate harmonization of registration for TCM within the ***,the registration process itself allows more safety and efficacy data to be collected systemically before and after product registration/marketing *** are valuable information for future drug *** therapeutic value of TCM is limitless,it has been left out in the eU regulatory framework,and the opportunity for it to be expanded and carried forward in modern medicines is shadowed by the limited number of TCM that are qualified to be registered under the eU regulatory *** early establishment of a harmonized risk-based registration process for TCM in Asian countries is *** will strengthen the database to substantiate the history of safe use and further preserving and expanding the therapeutic values of TCM within and beyond the Asian region.

关键词： Traditional Chinese medicines Population genetic Harmonization Registration Asian countries

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effects of length alteration of OPe-containing mono- and dinuclear alkynylplatinum(II) terpyridine complexes on photophysical, structural and morphological properties

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Nano Research 2024年第10期17卷 8893-8903页

作者： Jason Koon-Lam Poon Sammual Yu-Lut Leung eric Ka-Ho Wong vivian Wing-Wah Yam Institute of Molecular Functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong Kong 999077China

A series of mononuclear complexes and unsymmetric dinuclear alkynylplatinum(II)terpyridine complexes with oligo(paraphenylene ethynylene)(OPe)-derived backbone with a variation of the lengths of alkoxy chains and OPe backbones was *** morphological properties,packing lattice and gelation behaviors of the mononuclear complexes were systematically studied,and the thermodynamic parameters and packing lattices of the dinuclear complexes were also investigated,providing further insights into the roles of the non-covalent interactions and their delicate balance in constructing sophisticated supramolecular *** and nanotube formation have been observed upon a delicate control of the intermolecular interactions by altering the lengths and structural dimensions of the complexes.

关键词： supramolecular chemistry self-assembled nanostructures platinum(II)complexes metallogel

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extremely thin but very robust:Surprising cryptogam trait combinations at the end of the leaf economics spectrum

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Plant Diversity 2024年第5期46卷 621-629页

作者： Tana Wuyun Lu Zhang Tiina Tosens Bin Liu Kristiina Mark JoséÁngel Morales-Sanchez Jesamine Jöneva Rikisahedew vivian Kuusk Ülo Niinemets Institute of Agricultural and environmental Sciences Estonian University of Life SciencesKreutzwaldi 1Tartu 51014Estonia College of Landscape and Architecture Zhejiang A&F University666 Wusu StreetHangzhou 311300China estonian Academy of Sciences Kohtu 6Tallinn 10130Estonia

Leaf economics spectrum(LeS)describes the fundamental trade-offs between leaf structural,chemical,and physiological ***,structurally robust thick leaves with high leaf dry mass per unit area(LMA)exhibit lower photosynthetic capacity per dry mass(Amass).Paradoxically,“soft and thinleaved”mosses and spikemosses have very low Amass,but due to minute-size foliage elements,their LMA and its components,leaf thickness(LT)and density(LD),have not been systematically ***,we characterized LeS and associated traits in cryptogams in unprecedented details,covering five evolutionarily different *** found that mosses and spikemosses had the lowest LMA and LT values ever measured for terrestrial *** a broad range of species from different lineages,Amass and LD were negatively *** contrast,Amass was only related to LMA when LMA was greater than 14 g cm^(-2).In fact,low Amass reflected high LD and cell wall thickness in the studied *** conclude that evolutionarily old plant lineages attained poorly differentiated,ultrathin mesophyll by increasing *** plant lineages,LD,not LMA,is the trait that represents the trade-off between leaf robustness and physiology in the LeS.

关键词： Investment strategy Leaf density Leaf structural traits LMA estimation bias Non-seed plants Trait trade-offs

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Gravity tectonics controls on reservoir-scale sandbodies:Insights from 3D seismic geomorphology of the canyons buried in the upper slope of the eastern Niger delta basin

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energy Geoscience 2024年第3期5卷 244-260页

作者： vivian O.Oguadinma Jean-Yves Reynaud Vincent Delhaye-Prat Tony Akpi Scott Thackrey Ademola Lanisa Massimo Dall’Asta Univ.Lille CNRSUniv.Littoral Côte d'OpaleUMR 8187LOGLaboratoire d'Océanologie et de GéosciencesF 59000 LilleFrance Total energies e&P Africa-HUB CSTJFAvenue Larribau64000PauFrance

High-resolution 3D seismic data analysis was integrated with a calibrated well and biostratigraphy data to present the first overview of a buried Pleistocene canyon system on the upper slope of the eastern Niger Delta,the Galabor *** maps of specific horizons allow documenting the changing morphologies and infill lithologies of two main branches of the canyon through two stages of activity separated by a reference horizon dated at 0.99 Ma based on well *** the upper slope,growth faults dissect the canyon heads,the catchment of which encroaches a network of valleys incised on the outer *** canyon fill is composed of muddy channels and mass-transport deposits,largely derived from the collapse of canyon walls and sand-rich bodies forming a tract sourced by shelf-edge deltas at the outlet of the incised ***-density turbiditic processes likely control the distribution of sand bodies along the canyon,ranging from tributary fans on the upper slope to 6 km-wide meander belts on the middle *** sandy deposits accumulate in minibasins formed along the canyon path,downstream of the subsiding hanging wall of the growth faults and upstream of shale ridges that damp the flow in the *** results show that canyons can be major targets for sand reservoir exploration on the upper slope of large muddy deltas.

关键词： Geomorphology Submarine canyon 3D seismic Fault Shale ridge Reservoir Channel

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Chronic Pain Management after Necrotizing Soft Tissue Infection (NSTI): A Case Report

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Case Reports in Clinical Medicine 2024年第9期13卷 382-390页

作者： Kinyungu Njoroge vivian Matubia Ngugi Kinyungu School of Medicine and Surgery Kenya Methodist University Meru Kenya Basset Medical Center NY St Georges University School of Medicine True Blue Grenada ITAV Pain Management Donald and Barbara Zucker School of Medicine at Hofstra/Northwell New York USA

Background: Necrotizing soft tissue infections (NSTIs) are potentially life threatening medical emergencies associated with devastating and rapidly spreading destruction of soft tissues. Atypical presentations and delayed early diagnosis can be significant challenges in managing NSTIs. The infectious process can start at any part of the body with rapid progression leading to limb amputation and high mortality rate. We present a case of a patient with NSTI, the sequelae and management of the chronic pain that developed. Aim: This case report looks to shed light on the importance of a plan for management of subacute and chronic pain in treating patients who present with Necrotizing soft tissue infection. Case presentation: A 53-year-old female who presented with septicemia and was subsequently admitted and treated for NSTI in 2014 resulting in amputation of her distal foot, toe digits, and now with ongoing chronic wound of the lower extremities along with chronic pain. Conclusion: Chronic pain as part of the sequelae of Necrotizing soft tissue infections needs to be anticipated by the health care management team in order to optimize patient care post operatively.

关键词： Necrotizing Soft Tissue Infections (NSTIs) Chronic Pain Sequelae

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Application of Predictive Model for efficient Cassava (Manihot esculenta Crantz) Yield in the Face of Climate Variability in enugu State, Nigeria

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American Journal of Climate Change 2024年第2期13卷 361-389页

作者： emeka Bright Ogbuene Tonia Nkiru Nwobodo Obianuju Gertrude Aloh Achoru Fred emeka Josiah C. Ogbuka vivian Amarachi Ozorme Andrew M. Oroke Obiageli Jacinta Okolo Anwara Obianuju Amara e. S. enemuo Centre for environmental Management and Control (CeMAC) University of Nigeria Nsukka Nigeria Department of Geography University of Nigeria Nsukka Nigeria Department of Geography and Meteorology Enugu State University of Science and Technology (ESUT) Enugu Nigeria School of Civil engineering Newcastle University Newcastle upon Tyne UK

Climate variability as occasioned by conditions such as extreme rainfall and temperature, rainfall cessation, and irregular temperatures has considerable impact on crop yield and food security. This study develops a predictive model for cassava yield (Manihot esculenta Crantz) amidst climate variability in rainfed zone of enugu State, Nigeria. This study utilized data of climate variables and tonnage of cassava yield spanning from 1971 to 2012;as well as information from a questionnaire and focus group discussion from farmers across two seasons in 2023 respectively. Regression analysis was employed to develop the predictive model equation for seasonal climate variability and cassava yield. The rainfall and temperature anomalies, decadal change in trend of cassava yield and opinion of farmers on changes in rainfall season were also computed in the study. The result shows the following relationship between cassava and all the climatic variables: R2 = 0.939;P = 0.00514;Cassava and key climatic variables: R2 = 0.560;P = 0.007. The result implies that seasonal rainfall, temperature, relative humidity, sunshine hours and radiation parameters are key climatic variables in cassava production. This is supported by computed rainfall and temperature anomalies which range from −478.5 to 517.8 mm as well as −1.2˚C to 2.3˚C over the years. The questionnaire and focus group identified that farmers experienced at one time or another, late onset of rain, early onset of rain or rainfall cessation over the years. The farmers are not particularly sure of rainfall and temperature characteristics at any point in time. The implication of the result of this study is that rainfall and temperature parameters determine the farming season and quantity of productivity. Hence, there is urgent need to address the situation through effective and quality weather forecasting network which will help stem food insecurity in the study area and Nigeria at large. The study made recommendations such as a

关键词： Climate Variability Cassava (Manihot esculenta Crantz) Predictive Model Yield

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Resilience, the 6th Vital Sign: Conceptualizing, Contextualizing, and Operationalizing All Six Vital Signs

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Health 2024年第7期16卷 657-673页

作者： Rose e. Constantino Betty J. Braxter Chi Ching vivian Hui Larissa C. Allen Lillian J. Wolfe Katherine H. endres Jezyl Cempron Cutamora Laurence L. Garcia Daisy R. Palompon Kathleen Thimsen Brayden N. Kameg Margarete L. Zalon Department of Health and Community Systems School of Nursing University of Pittsburgh Pittsburgh PA USA Undergraduate Affairs School of Nursing University of Pittsburgh Pittsburgh PA USA The Hong Kong Polytechnic University Hong Kong China School of Nursing Adjunct Faculty at the University of Pittsburgh Pittsburgh PA USA School of Nursing University of Pittsburgh Pittsburgh PA USA Department of Health Promotion and Development School of Nursing University of Pittsburgh Pittsburgh PA USA College of Nursing Cebu Normal University Cebu City Philippines School of Nursing University of Nevada Las Vegas USA Department of Health and Community Systems University of Pittsburgh PA USA Department of Nursing University of Scranton Scranton PA USA

There are five vital signs that healthcare providers assess: temperature, pulse, respiration, blood pressure, and pain. Normal levels for the five vital signs are published by the American Heart Association, and other specialty organizations, however, the sixth vital sign (resilience) which adopts the measure of immune resilience is suggested in this paper. Resilience is the ability of the immune system to respond to attacks and defend effectively against infections and inflammatory stressors, and psychological resilience is the capacity to resist, adapt, recover, thrive, and grow from a challenge or a stressor. Individuals with better optimal immune resilience had better health outcomes than those with minimal immune resilience. The purpose of this paper is to conceptualize, contextualize, and operationalize all six vital signs. We suggest measuring resilience subjectively and objectively. Subjectively, use a 5-item guided interview revised from the Connor-Davidson Resilience Scale (CDRC), a scale of 10 items. The revised CDRC scale is a 5-item scale. The scale is rated on a 5-point Likert scale from 0 (not true) to 4 (true all the time). The total score ranges from 0 to 20, with higher total scores indicating greater resilience. The scale demonstrated good construct validity and internal consistency (α = 0.85) during the development of the scale. The CD-RISC had a good Cronbach’s alpha level of 0.85. The Revised CD-RISC can be completed in 2 - 4 minutes. To measure resilience objectively, we suggest using Immune Resilience (IR) levels, the level of resilience to preserve and/or rapidly restore immune resilience functions that promote disease resistance and control inflammation and other inflammatory stress. IR levels are gauged with two peripheral blood metrics that quantify the balance between CD8 and CD4 T-cell levels and gene expression signatures tracking longevity-associated immunocompetence and mortality- or entropy-associated inflammation. IR deregulation i

关键词： Conceptualization Contextualization Operationalization Body Temperature Pulse Respiration Blood Pressure Pain Resilience

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佛罗里达的生命奇迹

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世界博览 2024年第8期 40-45页

作者： vivian(文/图) 不详

在一个漆黑的夜晚,我与海龟共同倾听海浪的声音,感受着从很久很久之前就延续下来的生命奇迹。2亿年前,海龟的家还在陆地上,直到恐龙时代来临,海龟为了生存游向大海。但是,陆地却给它们留下了刻在基因里的印记——每一只海龟的生命,都是... 详细信息

在一个漆黑的夜晚,我与海龟共同倾听海浪的声音,感受着从很久很久之前就延续下来的生命奇迹。2亿年前,海龟的家还在陆地上,直到恐龙时代来临,海龟为了生存游向大海。但是,陆地却给它们留下了刻在基因里的印记——每一只海龟的生命,都是从细密的沙子中开始的。

关键词：生命奇迹佛罗里达海龟倾听陆地恐龙时代

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费尔岛,孤单小岛上的美丽花纹

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世界博览 2024年第7期 40-45页

作者： vivian(文/图) 不详

人们总说时尚就是一个个轮回,从人奶奶衣橱里翻出的旧衣服,很有可能就是当今最流行的款式。最近在时尚圈“刷屏”的费尔岛毛衣就印证了这一点,这种诞生于19世纪初的毛衣样式在这几年频频出现在时尚品牌的T台上,也让人们知道了费尔岛这... 详细信息

人们总说时尚就是一个个轮回,从人奶奶衣橱里翻出的旧衣服,很有可能就是当今最流行的款式。最近在时尚圈“刷屏”的费尔岛毛衣就印证了这一点,这种诞生于19世纪初的毛衣样式在这几年频频出现在时尚品牌的T台上,也让人们知道了费尔岛这座孤单的小岛。

关键词：费尔时尚品牌时尚圈孤单 19世纪初小岛

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Psychiatric Sequelae of Chronic Pruritic Dermatoses

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Open Journal of Medical Psychology 2024年第2期13卷 25-38页

作者： kelly Frasier vivian Li Kathleen Click Christina Dudzik Michelle Sobotka evadne Rodriguez Karina Stech Nuvance Health/Vassar Brothers Medical Center Poughkeepsie NY USA School of Osteopathic Medicine Kansas City University Kansas City MO USA Touro College of Osteopathic Medicine Middleton Campus Middletown NY USA Abrazo Health Network Goodyear AZ USA School of Medicine University of Missouri-Columbia Columbia MO USA Lewis Katz School of Medicine at Temple University Philadelphia PA USA

This comprehensive review investigates the significant psychological impact and profound psychological comorbidities found in individuals suffering from chronic pruritic dermatoses, including atopic dermatitis, chronic urticaria, and prurigo nodularis. Highlighting the complex, reciprocal relationship between pruritus and psychiatric conditions such as depression, anxiety, and sleep disturbances, this paper elucidates the comprehensive impact of dermatological disorders on the skin in addition to the far-reaching effects on an individual’s psychological well-being. By evaluating the efficacy of integrated psychodermatological interventions, including cognitive behavioral therapy, mindfulness practices, pharmacological treatments, and innovative telepsychiatry and digital health solutions, this review aims to lay the foundation for a more holistic approach to treatment of concurrent dermatological and psychiatric conditions. Future research endeavors should delve deeper into the mechanistic foundation of the pruritus-psychiatry interface, the refinement of tailored treatment strategies, and the evaluation of long-term patient outcomes. In doing so, this review seeks to contribute to the optimization of patient care and well-being, underscoring the pivotal role of addressing both dermatological and psychological needs in achieving comprehensive health outcomes.

关键词： Psychodermatology Chronic Pruritic Dermatoses Psychological Comorbidities Integrated Interventions Pruritus-Psychiatry Interface

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