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Bovine Serum Albumin-Conjugated Ferrimagnetic Iron Oxide Nanoparticles to Enhance the Biocompatibility and Magnetic Hyperthermia Performance

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Nano-Micro Letters 2016年第1期8卷 80-93页

作者： viveka kalidasan Xiao Li Liu Tun Seng Herng Yong Yang Jun Ding Department of Materials Science and Engineering Faculty of Engineering National University of Singapore Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical Engineering Northwest University

Magnetic hyperthermia is a fast emerging, non-invasive cancer treatment method which is used synergistically with the existing cancer therapeutics. We have attempted to address the current challenges in clinical magnetic hyperthermia-improved biocompatibility and enhanced heating characteristics, through a single combinatorial approach. Both superparamagnetic iron oxide nanoparticles(SPIONs) of size 10 nm and ferrimagnetic iron oxide nanoparticles(FIONs) of size 30 nm were synthesized by thermal decomposition method for comparison studies. Two different surface modifying agents, viz, Cetyl Trimethyl Ammonium Bromide and 3-Aminopropyltrimethoxysilane, were used to conjugate Bovine Serum Albumin(BSA) over the iron oxide nanoparticles via two different methods—surface charge adsorption and covalent amide bonding, respectively. The preliminary haemolysis and cell viability experiments show that BSA conjugation mitigates the haemolytic effect of the iron oxide nanoparticles on erythrocytes and is non-cytotoxic to the healthy Baby Hamster Kidney cells. It was observed from the results that due to better colloidal stability, the SAR value of the BSA-iron oxide nanoparticles is higher than the iron oxide nanoparticles without BSA, irrespective of the size of the iron oxide nanoparticles and method of conjugation. The BSA-FIONs seem to show improved biocompatibility, as the haemolytic index is less than 2 % and cell viability is up to 120 %, when normalized with the control. The SAR value of BSAFIONs is 2300 Wg^(-1) when compared to 1700 Wg^(-1) of FIONs without BSA conjugation. Thus, we report here that BSA conjugation over FIONs(with a high saturation magnetization of 87 emug^(-1)) provide a single combinatorial approach to improve the biocompatibility and enhance the SAR value for magnetic hyperthermia, thus addressing both the current challenges of the same.

关键词： Magnetic hyperthermia Ferrimagnetic iron oxide nanoparticles Bovine serum albumin Haemolysis Cell viability Specific absorption rate

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Fondaparinux:A cornerstone drug in acute coronary syndromes

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World Journal of Cardiology 2022年第1期14卷 40-53页

作者： Mohammed Yunus Khan Chandrashekhar K Ponde viveka Kumar Kumar Gaurav Medical Affairs Dr.Reddy's Laboratories LtdHyderabad 500018India Department of Cardiology P.D.Hinduja Hospital&Medical Research CentreMumbai 400016India Department of Cardiology Max Super Speciality HospitalNew Delhi 110017India

In acute coronary syndrome(ACS),the use of anticoagulants in conjunction with antiplatelet agents in the acute phase has resulted in reduced ischemic events and is more effective than either class of drug used *** parenteral anticoagulation is essential at the time of diagnosis,a balance must be made between ischemic benefit and the increased risk of bleeding when prescribing *** events associated with anticoagulants,such as heparin-induced thrombocytopenia,bleeding problems,and the need for close monitoring of anticoagulant activity,have contributed to finding agents that reduce these *** like the Organization to Assess Strategies in Ischemic Syndromes 5 and 6 and their meta-analysis have proven the efficacy of Fondaparinux over the entire ACS *** convenience of administration(once daily),lack of monitoring,reduction in mortality,and better safety profile make Fondaparinux a simple and effective anti-coagulant for the management of ACS.

关键词： Acute coronary syndrome Anti-coagulant therapy Antiplatelet therapy Fondaparinux Unfractionated heparin Enoxaparin

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Polyunsaturated fatty acid-producing marine thraustochytrids:A potential source for antimicrobials

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Journal of Coastal Life Medicine 2015年第11期 848-851页

作者： Kaliyamoorthy kalidasan Sunil Kumar Sahu Kasinathan Kayalvizhi Kandasamy Kathiresan Centre of Advanced Study in Marine Biology Faculty of Marine SciencesAnnamalai UniversityParangipettai-608502Tamil NaduIndia

Objective:To evaluate the antimicrobial activity of marine thraustochytrids extracted from different ***:Crude extracts were derived from marine thraustochytrids,isolated from decaying mangrove leaf *** extracts were tested for antibacterial activity by using agar disc diffusion method against 10 clinical bacterial *** extracts were also analysed for presence of functional chemical groups by using Fourier transform infrared ***:Thraustochytrid extracts exhibited potent antibacterial activity against both Gramnegative and-positive *** antibacterial activity was observed prominently in butanol extract,followed by petroleum ether,methanol and chloroform *** antibacterial activity was maximum[(21.33±1.52)mm]against Staphylococcus aureus and minimum[(7.00±2.00)]mm against Klebsiella pneumonia and Salmonella ***:Thraustochytrids isolated from decaying mangrove leaf litter are potential sources of antibacterial compounds against clinical pathogens,which are called for further investigation of thraustochytrids as natural antibiotics.

关键词： Mangrove Leaf litter Thraustochytrids Polyunsaturated fatty acid Antibacterial activity

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Antimicrobial and anticoagulant activities of the spine of stingray Himantura imbricata

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Journal of Coastal Life Medicine 2014年第2期 89-93页

作者： Kaliyamoorthy kalidasan Velayudham Ravi Sunil Kumar Sahu Murugan Lakshmi Maheshwaran Kathiresan Kandasamy Centre of Advanced Study in Marine Biology Faculty of Marine SciencesAnnamalai UniversityParangipettai-608502Tamil NaduIndia

Objective:To study the spine structure of stingray Himantura imbricata(***)and to evaluate the anticoagulant properties of the spine extract obtained through various solvents extracts followed by antibacterial activity against human ***:Spines of *** were collected from Nagappattinam coast,Tamil Nadu,India and their spines were observed under the light *** grounded spines were subjected to extraction of metabolites using methanol,ethanol,chloroform and *** activity was evaluated by disc diffusion technique against 10 human ***,anticoagulant activity was also assessed by following United States Pharmacopeia ***:Light microscopic observation of spine revealed that the venom apparatus of the stingray *** consisted of two to three spines,glandular tissue and a *** spine extract showed potent antibacterial activity against all tested *** activity(14 mm)was found against Staphylococcus *** extract showed 91.50 USP units/mg of anticoagulant ***:Microscopic observations gave new insight about the spine structure of the *** spine extracts of *** showed potent activity against human pathogens revealed by the good zone of *** extracts conferred the most prominent antibacterial *** anticoagulant activity was also comparable with that of standard heparin.

关键词： Stingrays Himantura imbricata Spine Antimicrobial activity Anticoagulant activity

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