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Visualizing traumatic brain injury:ocular clues for diagnosis and assessment

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Neural Regeneration Research 2025年第5期20卷 1399-1400页

作者： Morteza Abyadeh vivek Gupta Yuyi You Joao A.Paulo Mehdi Mirzaei ProGene Technologies Pty Ltd SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA

Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the *** is considered a silent public health epidemic causing significant death and disability *** were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.

关键词： diagnosis ocular injury

The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches

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Neural Regeneration Research 2017年第2期12卷 197-200页

作者： vivek Agrahari School of Pharmacy University of Missouri-Kansas City Kansas City MO USA

Delivering therapeutics to the central nervous system（CNS） and brain-tumor has been a major challenge. The current standard treatment approaches for the brain-tumor comprise of surgical resection followed by immunotherapy, radiotherapy, and chemotherapy. However, the current treatments are limited in providing significant benefits to the patients and despite recent technological advancements; brain-tumor is still challenging to treat. Brain-tumor therapy is limited by the lack of effective and targeted strategies to deliver chemotherapeutic agents across the blood-brain barrier（BBB）. The BBB is the main obstacle that must be overcome to allow compounds to reach their targets in the brain. Recent advances have boosted the nanotherapeutic approaches in providing an attractive strategy in improving the drug delivery across the BBB and into the CNS. Compared to conventional formulations, nanoformulations offer significant ad vantages in CNS drug delivery approaches. Considering the above facts, in this review, the physiological/anatomical features of the brain-tumor and the BBB are briefly discussed. The drug transport mechanisms at the BBB are outlined. The approaches to deliver chemotherapeutic drugs across the CNS into the brain-tumor using nanocarriers are summarized. In addition, the challenges that need to be addressed in nanotherapeutic approaches for their enhanced clinical application in brain-tumor therapy are discussed.

关键词： brain-tumor glioma CNS blood-brain barrier drug transport nanoformulation nanocarrier cell-mediated drug delivery

Improved properties and thermal stability of a titanium-stainless steel solid-state weld with a niobium interlayer

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Journal of Materials Science & Technology 2021年第20期79卷 191-204页

作者： Jianxiong Li Anupam vivek Glenn Daehn Department of Materials Science and Engineering The Ohio State University2041 College RoadColumbusOH43210USA

Stainless steel(SS)and titanium alloys can be welded in the solid-state by high speed oblique ***,the effect of a niobium(Nb)interlayer on weld strength and thermal stability is *** Ti/SS and Ti/Nb/SS welds were subjected to thermal exposure ranging from 300℃ to 950℃ for 1.5 *** exposure monotonically decreases the strength and toughness of the Ti/SS pair with a dramatic falloff in strength and change in failure mode from partial pullout failure to full interfacial fracture at 600℃.With the interlayer,toughness was increased versus baseline up to 700℃ thermal exposure and then intermetallic formation again caused falloff in *** for the production,properties and applications of these classes of welds are provided.

关键词： Impact spot welding Titanium alloy Stainless steel Nb interlayer Thermal exposure Phase transformation

Shock effects on the upper limit of the collision weld process window

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Advances in Manufacturing 2024年第2期12卷 365-378页

作者： Blake Barnett Anupam vivek Glenn Daehn Department of Materials Science and Engineering The Ohio State UniversityColumbusOH43210USA Army Research Directorate Army Research LaboratoryDEVCOMAberdeen Proving GroundHarfordMD21005USA

The maximum flyer impact velocity based on a dynamic solidification cracking mechanism is proposed to describe the upper limit of collision welding process ***,the upper limit of the weld window is governed by the evolution of dynamic stresses and temperatures at the weld *** formulations for the upper limit of the collision weld window assume that both the flyer and target are made of the same material and approximate stress propagation velocities using the acoustic velocity or the shear wave velocity of the weld ***,collision welding fundamentally depends on the impacts that generate shockwaves in weld members,which can dominate the stress propagation velocities in thin weld ***,this study proposes an alternative weld window upper limit that approximates stress propagation using shock velocities calculated from modified 1-D Rankine-Hugoniot *** shock upper limit is validated against the experimental and simulation data in the collision welding literature,and offers a design tool to rapidly predict more accurate optimal collision weld process limits for similar and dissimilar weld couples compared to existing models without the cost or complexity of high-fidelity simulations.

关键词： Collision welding Solid-state welding Shock impact Weld process modelling Explosive bonding Laser impulse welding(LIW)

THE CHARACTERIZATION OF EFFICIENCY AND SADDLE POINT CRITERIA FOR MULTIOBJECTIVE OPTIMIZATION PROBLEM WITH VANISHING CONSTRAINTS

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Acta Mathematica Scientia 2019年第2期39卷 382-394页

作者： Anurag JAYSWAL vivek SINGH Department of Applied Mathematics Indian Institute of Technology (Indian School of Mines)

In this article, we focus to study about modified objective function approach for multiobjective optimization problem with vanishing constraints. An equivalent η-approximated multiobjective optimization problem is constructed by a modification of the objective function in the original considered optimization problem. Furthermore, we discuss saddle point criteria for the aforesaid problem. Moreover, we present some examples to verify the established results.

关键词： multiobjective optimization problem with vanishing constraints efficient solution invexity η-Lagrange function saddle point

Rogue gene networks gone awry in Alzheimer’s disease

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Neural Regeneration Research 2021年第12期16卷 2415-2416页

作者： Emily Miyoshi vivek Swarup Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Institute for Memory Impairments and Neurological Disorders(MIND) University of CaliforniaIrvineCAUSA

The human brain consists of billions of cells encompassing hundreds of distinct cell-types,each with unique functions and *** of the molecular architecture of the brain has been revolutionized by nextgeneration sequencing(NGS),as evident by recent transcriptomic and genetic/epigenetic *** paved the way to perform largescale,genome-wide sequencing studies on human postmortem brain tissue,and this offered an unprecedented opportunity to elucidate the genetic bases of polygenic neurological disorders,like Alzheimer’s disease(AD).

关键词： Alzheimer properties. hundreds

Characterization of 3D microstructure,thermal conductivity,and heat flow of cement-based foam using imaging technique

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Frontiers of Structural and Civil Engineering 2021年第3期15卷 643-651页

作者： Farnaz BATOOL Muhammad Saad KHAN vivek BINDIGANAVILE Department of Civil Engineering NED University of Engineering&TechnologyKarachi75270Pakistan Department of Civil and Environmental Engineering University of AlbertaEdmontonT6G2R3Canada

This study presents the results of the 3D microstructure,thermal conductivity,and heat flow in cement-based foams and examines their changes with a range of *** were captured using X-ray micro computed tomography(micro-CT)imaging technique on cement-based foam samples prepared with densities of 400,600,and 800 kg/m^(3).These images were later simulated and quantified using 3D data visualization and analysis *** on the analysis,the pore volume of 11000µm^(3)was determined across the three densities,leading to optimal ***,distinct pore diameters of 15µm for 800 kg/m^(3),and 20µm for 600 and 400 kg/m^(3)were found to be *** of the pores were spherical,with only 10%appearing elongated or *** addition,a difference of 15%was observed between the 2D and 3D porosity ***,a difference of 5%was noticed between the experimentally measured thermal conductivity and the numerically predicted value and this variation was constant across the three cast *** 3D model showed that heat flows through the cement paste solids and with an increase in porosity this flow reduces.

关键词： 3D pore volume distribution X-ray tomography 3D shape factor heat flow

Pumpkin seeds as nutraceutical and functional food ingredient for future:A review

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Grain & Oil Science and Technology 2024年第1期7卷 12-29页

作者： Arunima Singh vivek Kumar Department of Food Technology Harcourt Butler Technical UniversityKanpur 208002UPIndia

Pumpkin belongs to the family of Cucurbitaceae,which comprises several species that has economical as well as agronomical *** parts of pumpkin are edible and laden with beneficial neutraceutical *** seeds are valuable source protein which can help in eradicating protein malnutrition and lipids(rich in PUFAs)contains essential as well as non essential fatty acids which prevents from various ailments like cancer and other cardiovascular ***,seeds of pumpkin are abundant in macro(magnesium,phosphorous,potassium,sodium and calcium)and micro minerals(iron,copper,manganese,zinc and selenium),they can be used as an incredible dietary supplement which in turn helps in curbing various deficiency *** review enlightens the characteristics of pumpkin seeds,process of valorization of pumpkin seeds and the effect of processing on their nutritional composition which have been studied currently with the aim to use this wonder seeds for human *** seeds possess many bioactive compounds like polyphenols,flavonoids,phytosterols and squalene which makes it a lucrative raw material for pharmacological and food *** seeds work as anti-depressant and helps majorly in the treatment of benign prostate hyperplasia(BHP).Daily consumption of pumpkin seeds can reduce the chances of Alzheimer's and Parkinson's *** seeds are rich in tocopherols and can be used for oil extraction for edible purposes and utilized in other food formulations for future use.

关键词： Pumpkin seed Neutraceutical properties Nutritional composition Tocopherols Squalene β-Carotene Waste valorization

Detection of QTL(quantitative trait loci) associated with wood density by evaluating genetic structure and linkage disequilibrium of teak

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Journal of Forestry Research 2019年第6期30卷 2247-2258页

作者： vivek Vaishnav Shamim Akhtar Ansari Institute of Forest Productivity

To find the quantitative trait loci associated with wood density in teak(Tectona grandis L.f.), 21 co-dominant markers including 13 site specific recombinase and 8 EST-based co-dominant markers designed from lignin biosynthesis genes were applied to 174 teak plus tree clones at the National Germplasm Bank, Chandrapur,India. The germplasm bank exhibited 10.6% coefficient of variation for wood densities with 84.5 ± 31.3 genetic polymorphism(%). The highly panmictic set of genotypes(FST= 0.035 ± 0.004) harbored 96.47 ± 0.40 genetic variability(%). The average allelic frequency of the 21 codominant markers was 0.65 ± 0.11 with 12.9% pairs of loci in significant LD(p\0.05, R^2 values [ 0.1), confirming their suitability for a strong marker-trait association study. The marker CCoAMT-1 was significantly(p\0.01) associated with wood density showing stability by both GLM and MLM models and explained 4.3% of the phenotypic effect. The marker from the EST representing CCoAMT can be further developed for gene-assisted selection of elite genotypes of teak with greater wood density. Therefore, we believe that the report will help accelerate the genetic improvement and advance the breeding program of the species.

关键词： Association mapping Expressed sequence tags(EST) General linear model(GLM) Linkage disequilibrium(LD) Lignin Mixed linear model(MLM) Principal co-ordinate analysis(PCoA)