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Nature meets technology:Harnessing nanotechnology to unleash the power of phytochemicals

Clinical Traditional Medicine and Pharmacology 2024年第3期5卷 111-124页

作者： divya Teli Riyansi Satasia Vishwa Patel Ruchi Nair Rudri Khatri Dhvani Gala Pankti C.Balar Kishan Patel Anu Sharma Palak Vadodariya vivek P.Chavda Department of Pharmaceutical Chemistry L.M.college of pharmacyAhmedabadGujarat380009India Department of Chemistry School of ScienceGujarat UniversityAhmedabadGujarat380009India Pharmacy section L.M.college of pharmacyAhmedabadGujarat380009India Department of Chemistry University at BuffaloBuffaloNY 14260United States of America Department Pharmaceutical Sciences University of MassachusettsBostonMA 02125United States of America Faculty of Pharmacy Marwadi UniversityRajkotGujarat360006India Department of Pharmaceuticals and Pharmaceutical Technology L.M.college of pharmacyAhmedabadGujarat380009India

Background:Phytochemicals encompass a diverse array of bioactive substances originating from plants,exhibit-ing a broad spectrum of possible health-promoting ***,the clinical uses of these compounds are restricted due to their limited solubility,stability,bioavailability,and target ***-based delivery methods present a viable approach to address these problems and enhance the properties and biological activity of *** have the potential to augment the solubility,bioavailability,and pharmacokinetics of phytochemicals by means of several *** potential approach to enhance the surface area and solubility of phytochemicals is by lowering their particle *** process of adsorption of surfactants onto phytochemical particles can lead to the formation of micelles,which exhibit solubility in ***-mulations have the potential to enhance the uptake of phytochemicals across many biological barriers,including the intestinal ***:To study the potential of nanoformulation in enhancing the therapeutic action of phytochemicals Method:Systemic review was performed while considering some aspects of PRISM ***:The nanoparticles have a great potential in delivering the phytochemicals and could of great help in the management of various ***,exhaustive research and clinical trials are yet demanded to provide the evidential proof for the ***:In conclusion,the utilisation of ligand-functionalized nanoparticles enables the precise targeting of phytochemicals to particular cells or *** field of nanotechnology has significant promise in transform-ing the advancement and administration of phytochemicals for medicinal and preventative *** utilisation of nanotechnology holds promise in addressing the obstacles related to the physicochemical charac-teristics of phytochemicals,hence enabling the development of enhanced and precise delivery

关键词： Phytochemicals Nanotechnology Bioactivity Enhancement

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Clinical Significance of Liver Function Abnormality in Patients with COVID-19:A Single-center Experience from Western India

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 878-888页

作者： Chetan R.Kalal Harshad Joshi vivek kumar.divya gopal Darshana Rathod Ashish Shukla Tarang Gianchandani Chetan Bhatt Department of Gastroenterology Hepatology and Liver TransplantSir HN Reliance Foundation Hospital and Research Cen-treMumbaiMaharashtraIndia Department of Critical Care Sir HN Reliance Foundation Hospital and Research CentreMumbaiMaharashtraIndia Department of Administration Sir HN Reliance Foundation Hospital and Research CentreMumbaiMaharashtraIndia

Background and Aims:The impact of coronavirus disease-2019(COVID-19)on liver function remains to be fully *** study was designed to investigate such and determine the clinical significance in determining mortality ***:A retrospective study was conducted in patients with COVID-19 from March 2020 to July *** details were retrieved from electronic medical records to obtain clinical characteristics,medical history,laboratory tests,therapeutic intervention,and outcome ***:A total of 184 patients with COVID-19 were included(median age:45.5 years),comprised of 62.5%*** total,22(12.0%)patients had severe infection and 162(88.0%)had mild to moderate ***,95(51.6%)showed abnormal liver function test(LFT)and 17(9.2%)showed normal LFT at *** median age,hospital stay,and LFT were significantly higher in severe ***-severe infection(p<0.001).Out of 12 deaths,the majority were due to severe infection(n=11).Deaths were also due to acute respiratory distress syndrome(n=5),cardiac reasons(n=3),and sepsis with multiorgan failure(n=3).The median age,hospital stay and number of intensive care unit admissions were higher in patients having abnormal LFT compared to normal *** of elevated aspartate aminotransferase(42.8%and 40.4%),alanine transaminase(43.7%and 41.6%),and hypoalbuminemia(71.4%and72.7%)at admission and discharge were more common in severe *** mean survival was significantly lower in severe infection compared to those with non-severe disease(17.2 vs.52.3 days;p<0.001).Conclusions:Incidence of abnormal liver function was higher in patients with severe COVID-19 and was associated with prolonged hospital stay;mortality was associated with severity of *** ruling out the risk of liver injury,it is crucial to vigilantly monitor the liver function parameters in patients with COVID-19 admitted to hospital.

关键词： ALT/AST Hospital stay Hypoalbuminemia Liver injury Severe disease

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A Secure Three-Party Authenticated Key Exchange Protocol for Social Networks

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Computers, Materials & Continua 2022年第6期71卷 6293-6305页

作者： vivek kumar Sinha divya Anand Fahd S.Alharithi Ahmed H.Almulihi Department of Computer Science and Engineering Lovely Professional UniversityPhagwaraPunjab144411India Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

The 3PAKE(Three-Party Authenticated Key Exchange)protocol is a valuable cryptographic method that offers safe communication and permits two diverse parties to consent to a new safe meeting code using the trusted *** have been explored numerous 3PAKE protocols earlier to create a protected meeting code between users employing the trusted ***,existing modified 3PAKE protocols have numerous drawbacks and are incapable to provide desired secrecy against diverse attacks such as manin-the-middle,brute-force attacks,and many others in social *** this article,the authors proposed an improved as well as safe 3PAKE protocol based on the hash function and the symmetric encryption for the social *** authors utilized a well-acknowledged AVISPA tool to provide security verification of the proposed 3PAKE technique,and findings show that our proposed protocol is safer in opposition to active as well as passive attacks namely the brute-force,man-in-the-middle,parallel attack,and many ***,compared to other similar schemes,the proposed protocol is built with a reduced computing cost as our proposed protocol consumes less time in execution and offers high secrecy in the social networks with improved *** a result,this verified scheme is more efficient as well as feasible for implementation in the social networks in comparison to previous security *** multifarious authors carried out extensive research on 3PAKE protocols to offer safe communication,still there are vital opportunities to explore and implement novel improved protocols for higher safety in the social networks and mobile commerce environment in the future in opposition to diverse active as well as passive attacks.

关键词： AVISPA tool 3PAKE protocol hash function symmetric encryption social networks

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Secure and Optimal LOADng Routing for IoT with Composite RoutingMetric

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Computers, Materials & Continua 2023年第1期74卷 655-669页

作者： divya Sharma Sanjay Jain vivek Maik Department of Electronics and Communication New Horizon College of EngineeringBengaluru560103India CMR Institute of Technology Bengaluru560037India Department of Electronics and Communication SRM Institute of Science and TechnologyKattankulathurChennai603203India

Security is the one of the major challenges for routing the data between the source and destination in an Internet of Things(IoT)*** overcome this challenge,a secure Lightweight On-demand Ad hoc Distancevector—Next Generation(LOADng)Routing Protocol is proposed in this *** the LOADng protocol is the second version of Ad Hoc On-Demand Distance Vector(AODV)protocol,it retains most of the basic functionality and characteristics of *** the route discovery process,the cyclic shift transposition algorithm(CSTA)is used to encrypt the control packets of the LOADng protocol to improve its *** approach only derives transposition and substitution without product cipher with respect to input *** this,for choosing the best probable path between the source and destination,routing metrics such as link quality Indicator(LQI),hop count(HC)and queue length(QL)are included in the control *** data is then securely sent using CSTA using the optimal secure path *** Results depict that the proposed secure and optimal LOADng(SO-LOADng)using CSTA encryption obtains better throughput,delivery ratio encryption time and decryption time than the existing state-ofart approaches.

关键词： IoT LOADng CSTA link quality indicator queue length

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Optimized Tuning of LOADng Routing Protocol Parameters for IoT

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Computer Systems Science & Engineering 2023年第8期46卷 1549-1561页

Interconnected devices and intelligent applications have slashed human intervention in the Internet of Things(IoT),making it possible to accomplish tasks with less human ***,it faces many problems,including lower capacity links,energy utilization,enhancement of resources and limited resources due to its openness,heterogeneity,limited resources and *** is challenging to route packets in such a constrained *** an IoT network constrained by limited resources,minimal routing control overhead is required without packet *** constrained environments can be improved through the optimal routing *** is challenging to route packets in such a constrained ***,this work is motivated to present an efficient routing protocol for enhancing the lifetime of the IoT *** On-demand Ad hoc Distance-vector Routing Protocol—Next Generation(LOADng)protocol is an extended version of the Ad Hoc On-Demand Distance Vector(AODV)*** AODV,LOADng is a lighter version that forbids the intermediate nodes on the route to send a route reply(RREP)for the route request(RREQ),which originated from the source.A resource-constrained IoT network demands minimal routing control overhead and faster packet ***,in this paper,the parameters of the LOADng routing protocol are optimized using the black widow optimization(BWO)algorithm to reduce the control overhead and ***,the performance of the proposed model is analyzed with the default LOADng in terms of delay,delivery ratio and *** results show that the LOADng-BWO protocol outperforms the conventional LOADng protocol.

关键词： Internet of things optimization algorithm routing protocol LOADng

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Evaluation of antimicrobial activity and bronchodialator effect of a polyherbal drug-Shrishadi

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Asian Pacific Journal of Tropical Biomedicine 2012年第11期2卷 905-909页

作者： divya kumari Kajaria Mayank Gangwar Dharmendra kumar Amit kumar Sharma Ragini Tilak gopal Nath Yamini Bhusan Tripathi JS Tripathi SK Tiwari Faculty of Aurveda Department of KayachikitsaInstitute of Medical SciencesBanaras Hindu UniversityVaranasi-221005(Uttar pradesh) Department of Microbiology Institute of Medical SciencesBanaras Hindu UniversityVaranasi- 221005 (Uttar pradesh) Department of Medicinal Chemistry Institute of Medical SciencesBanaras Hindu UniversityVaranasi- 221005 (Uttar pradesh) Faculty of Aurveda Department of KayachikitsaInstitute of Medical SciencesBanaras Hindu University

Objective:To investigate antimicrobial and bronchodialator effect of hydroalcholic extract of polyherbal drug Shirishadi containing Shirisha(Albezzia lebbeck),Nagarmotha(Cyprus ratandus) & Kantakari(Solanum xanthocarpum).Methods:Antimicrobial activity was evaluated by discdiffusion method and MIC,MBC,MFC were calculated by micro dilution *** extract of this preparation was investigated for its phytochemical analysis,phenol and Oavonoid were determined by speclrophotometric method and in vivo bronchodilator effect was analysed by convulsion ***:The phytochemical tests revealed presence of alkaloids, anthraquinones,carbohydrates,flavonoids,saponins and *** antimicrobial result showed the MIC of 6.25 mg/*** Staphylococcus aureus and 12.5 mg/*** Escherichia coli and 12.5 mg/mL against remaining bacteria tested,with strong antifungal *** maximum inhibition zone is found against Pseudomonas aeruginosa with MIC 16 mg/mL Drug showed significant bronchodilator effect with 27.86%& 36.13%increase in preconvulsion time of guinea pigs prebeated with 100 & 200 mg/kg body weight of ***:The study reveals that the extracts possess antibacterial activity and antifungal activity in a dose dependent manner. This antimicrobial property may be due to presence of several saponins,further studies are highly needed for the drug development.

关键词： Shrishadi-polyherbal drug Phytochemical Phenolic & flavonoid content Candida species Bronchodilator

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Nonlinear mixing-based terahertz emission in inclined rippled density plasmas

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Chinese Physics B 2023年第6期32卷 384-390页

作者： K gopal A P Singh S divya Rajdhani College Department of Physics&ElectronicsUniversity of DelhiNew DelhiIndia Computational Plasma Dynamics Laboratory Rajdhani CollegeDepartment of Physics&ElectronicsUniversity of DelhiNew DelhiIndia

We propose to investigate the THz field generation using nonlinear mixing mechanism of laser beat wave with inclined rippled density *** laser pulses with frequencies(ω_(1),ω_(2)) and wave vectors(k_(1),k_(2)) co-propagate and resultant laser beat wave forms at beat frequency(ω_(1)-ω_(2)).Laser beat wave imparts a nonlinear force on the ambient electrons and pushes them outward with nonlinear velocity v_(NL).Coupling of induced density perturbation and nonlinear velocity v_(NL)generates nonlinear currents at laser beat frequency that further generates electromagnetic field E_((ω_(1)-ω_(2))) in terahertz(THz)*** the present scheme,density ripples are introduced at an angle with respect to laser propagation and flat Gaussian index(f) is introduced in laser field profile that transform curved top of Gaussian field envelope into flat top field *** combined effect of flat laser pulses with inclined density ripples in plasmas shows 10-fold enhancement in THz field amplitude when flat-Gaussian index(f) varies from 1 to ***,the THz field intensifies when density ripples inclination increases upto a certain angle and then decreases.

关键词： terahertz inclined ripple flat laser laser plasma interaction

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