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Elevated cardiovascular risk and acute events in hospitalized colon cancer survivors:A decade-apart study of two nationwide cohorts

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World Journal of Clinical Oncology 2024年第4期15卷 548-553页

作者： Rupak Desai Avilash Mondal vivek Patel Sandeep Singh Shaylika Chauhan Akhil jain Independent Researcher AtlantaGA 30079United States Department of Internal Medicine Nazareth HospitalPhiladelphiaPA 19152United States Department of Clinical Epidemiology Biostatistics and Bio-informaticsAmsterdam UMCAmsterdam 7057Netherlands Department of Internal Medicine Geisinger Health SystemWikes-BarrePA 18702United States Division of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTX 77079United States

BACKGROUND Over the years,strides in colon cancer detection and treatment have boosted survival rates;yet,post-colon cancer survival entails cardiovascular disease(CVD)*** on CVD risks and acute cardiovascular events in colorectal cancer survivors has been *** To compare the CVD risk and adverse cardiovascular outcomes in current colon cancer survivors compared to a decade *** We analyzed 2007 and 2017 hospitalization data from the National Inpatient Sample,studying two colon cancer survivor groups for CVD risk factors,mortality rates,and major adverse events like pulmonary embolism,arrhythmia,cardiac arrest,and stroke,adjusting for confounders via multivariable regression *** Of total colon cancer survivors hospitalized in 2007(n=177542)and 2017(n=178325),the 2017 cohort often consisted of younger(76 vs 77 years),male,African-American,and Hispanic patients admitted non-electively vs the 2007 ***,the 2017 cohort had higher rates of smoking,alcohol abuse,drug abuse,coagulopathy,liver disease,weight loss,and renal *** in the 2017 cohort also had higher rates of cardiovascular comorbidities,including hypertension,hyperlipidemia,diabetes,obesity,peripheral vascular disease,congestive heart failure,and at least one traditional CVD(P<0.001)vs the 2007 *** adjusted multivariable analysis,the 2017 cohort had a significantly higher risk of pulmonary embolism(PE)(OR:1.47,95%CI:1.37-1.48),arrhythmia(OR:1.41,95%CI:1.38-1.43),atrial fibrillation/flutter(OR:1.61,95%CI:1.58-1.64),cardiac arrest including ventricular tachyarrhythmia(OR:1.63,95%CI:1.46-1.82),and stroke(OR:1.28,95%CI:1.22-1.34)with comparable all-cause mortality and fewer routine discharges(48.4%vs 55.0%)(P<0.001)vs the 2007 *** Colon cancer survivors hospitalized 10 years apart in the United States showed an increased CVD risk with an increased risk of acute cardiovascular events(stroke 28%,PE 47%,arrhythmia 41%,and cardiac arres

关键词： Colon cancer Colorectal cancer Cardiovascular diseases Cardiovascular disease risk Cardiac events Stroke

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急性脑卒中患者溶栓治疗后神经功能无改善：预测指标及其与预后的关系

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美国医学会杂志（中文版） 2005年第5期24卷 271-276页

作者： Gustavo Saposnik Bryan Young Brian Silver Silvia Di Legge Fiona Webster Vadim Beletsky vivek jain 孙伟平（译）黄一宁（校） Stroke Program Department of Clinical Neurological Sciences London Health Sciences Centre University of Western Ontario London Department of Neurology Henry Ford Hospital Detroit Mich 不详

背景：急性脑卒中溶栓治疗关注的焦点为3个月时神经功能的改善。很少研究分析24小时结局。早期准确预测不良预后可以影响临床治疗和出院计划。目的：评价重组人组织型纤溶酶原激活物（rt—PA）治疗后24小时神经功能无改善的预测指标及其... 详细信息

背景：急性脑卒中溶栓治疗关注的焦点为3个月时神经功能的改善。很少研究分析24小时结局。早期准确预测不良预后可以影响临床治疗和出院计划。目的：评价重组人组织型纤溶酶原激活物（rt—PA）治疗后24小时神经功能无改善的预测指标及其与3个月时不良预后的关系。设计、地点和参试者：对一所大学医院1999年1月至2003年3月连续收治的接受rt—PA治疗的急性脑卒中患者进行前瞻性队列研究。参试者来源于安大略省一个主要城市的2个学术中心和7个县的33家附属医院。主要观察指标：神经功能无改善定义为在24小时时国立卫生研究院卒中量表评分较基线水平改善≤3分。3个月时不良预后定义为改良Rankin量表评分3～5分或死亡。结果：216例接受rt—PA治疗的急性卒中患者中，111例（51．4％）在发病24小时神经功能无改善。在校正年龄、性别和卒中严重程度因素后，人院时基线血糖水平（血糖〉144mg／dL[8mmol／L]的优势比[OR]，2．89；95％CI，1．40～5．99）、皮层受累（OR，2．66；95％CI，1．36～5．20）以及治疗开始时间（治疗每延迟1分钟的OR，1．01；95％CI，1．0～1．02）是24小时神经功能无改善的独立预测指标。3个月时，43例患者（20．2％）死亡；在170例幸存者中，75例患者（44％）预后不良。在校正年龄、性别和卒中严重程度因素后，24小时神经功能无改善是不良预后（OR，12．9；95％CI，5．7—29．6）和死亡的独立预测指标（OR，7．5；95％C1，2．9～19．6）。24小时神经功能无改善的患者住院时间延长（14．5天比9．6天，P=0．02）。结论：对于接受溶栓治疗的急性脑卒中患者，24小时神经功能无改善与3个月时预后不良和死亡相关。高血糖、开始溶栓治疗时间和皮层受累是24小时神经功能无改善的预测指标。

关键词：独立预测指标脑卒中患者急性脑卒中神经功能不良预后溶栓治疗治疗后组织型纤溶酶原激活物前瞻性队列研究国立卫生研究院

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Secured ECG Signal Transmission Using Optimized EGC with Chaotic Neural Network in WBSN

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Computer Systems Science & Engineering 2023年第2期44卷 1109-1123页

作者： Ishani Mishra Sanjay jain vivek Maik Department of ECE New Horizon College of EngineeringBengaluru560103India CMR Institute of Technology Bengaluru560037India SRM University Chennai603203India

In wireless body sensor network(WBSN),the set of electrocardiogram(ECG)data which is collected from sensor nodes and transmitted to the server remotely supports the experts to monitor the health of a *** transmit-ting these collected data some adversaries may capture and misuse it due to the compromise of ***,the major aim of this work is to enhance secure trans-mission of ECG signal in *** attain this goal,we present Pity Beetle Swarm Optimization Algorithm(PBOA)based Elliptic Galois Cryptography(EGC)with Chaotic Neural *** optimize the key generation process in Elliptic Curve Cryptography(ECC)over Galoisﬁeld or EGC,private key is chosen optimally using PBOA *** the encryption process is enhanced by presenting chaotic neural network which is used to generate chaotic sequences or cipher *** of this work show that the proposed cryptogra-phy algorithm attains better encryption time,decryption time,throughput and SNR than the conventional cryptography algorithms.

关键词： Wireless body sensor network ECG pity beetle swarm optimization algorithm elliptic galois cryptography and chaotic neural network

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Secure and Optimal LOADng Routing for IoT with Composite RoutingMetric

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Computers, Materials & Continua 2023年第1期74卷 655-669页

作者： Divya Sharma Sanjay jain vivek Maik Department of Electronics and Communication New Horizon College of EngineeringBengaluru560103India CMR Institute of Technology Bengaluru560037India Department of Electronics and Communication SRM Institute of Science and TechnologyKattankulathurChennai603203India

Security is the one of the major challenges for routing the data between the source and destination in an Internet of Things(IoT)*** overcome this challenge,a secure Lightweight On-demand Ad hoc Distancevector—Next Generation(LOADng)Routing Protocol is proposed in this *** the LOADng protocol is the second version of Ad Hoc On-Demand Distance Vector(AODV)protocol,it retains most of the basic functionality and characteristics of *** the route discovery process,the cyclic shift transposition algorithm(CSTA)is used to encrypt the control packets of the LOADng protocol to improve its *** approach only derives transposition and substitution without product cipher with respect to input *** this,for choosing the best probable path between the source and destination,routing metrics such as link quality Indicator(LQI),hop count(HC)and queue length(QL)are included in the control *** data is then securely sent using CSTA using the optimal secure path *** Results depict that the proposed secure and optimal LOADng(SO-LOADng)using CSTA encryption obtains better throughput,delivery ratio encryption time and decryption time than the existing state-ofart approaches.

关键词： IoT LOADng CSTA link quality indicator queue length

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Effects of cartilaginous rings on airflow and particle transport through simplified and realistic models of human upper respiratory tracts

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Acta Mechanica Sinica 2013年第6期29卷 883-892页

作者： vivek Kumar Srivastav Akshoy Ranjan Paul Anuj jain Department of Applied Mechanics Motilal Nehru National Institute of Technology

In the present study, computational fluid dynamics （CFD） is used to investigate inspiratory and expiratory airflow characteristics in the human upper respiratory tract for the purpose of identifying the probable locations of particle deposition and the wall injury. Computed tomography （CT） scan data was used to reconstruct a three dimensional respiratory tract from trachea to first generation bronchi. To compare, a simplified model of respiratory tract based on Weibel was also used in the study. The steady state results are obtained for an airflow rate of 45 L/min, corresponding to the heavy breathing condition. The velocity distribution, wall shear stress, static pressure and particle deposition are compared for inspiratory flows in simplified and realistic models and expiratory flows in realistic model only. The results show that the location of cartilaginous rings is susceptible to wall injury and local particle deposition.

关键词： Upper respiratory tract Cartilaginous rings Computational fluid dynamics (CFD) Computed tomogra- phy (CT) Wall shear stress Particle deposition.

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ON THE (p,q)-MELLIN TRANSFORM AND ITS APPLICATIONS

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Acta Mathematica Scientia 2021年第5期41卷 1719-1732页

作者： Pankaj jain Chandrani BASU vivek PANWAR Department of Mathematics South Asian University Akbar BhawanChanakya PuriNew Delhi-110021India

In this paper,we introduce and study a(p,q)-Mellin transform and its corresponding convolution and *** terms of applications of the(p,q)-Mellin transform,we solve some integral ***,a(p,q)-analogue of the Titchmarsh th... 详细信息

关键词： q-Mellin transform (p q)-Mellin transform inversion formula convolution integral equation

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Optimized Tuning of LOADng Routing Protocol Parameters for IoT

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Computer Systems Science & Engineering 2023年第8期46卷 1549-1561页

Interconnected devices and intelligent applications have slashed human intervention in the Internet of Things(IoT),making it possible to accomplish tasks with less human ***,it faces many problems,including lower capacity links,energy utilization,enhancement of resources and limited resources due to its openness,heterogeneity,limited resources and *** is challenging to route packets in such a constrained *** an IoT network constrained by limited resources,minimal routing control overhead is required without packet *** constrained environments can be improved through the optimal routing *** is challenging to route packets in such a constrained ***,this work is motivated to present an efficient routing protocol for enhancing the lifetime of the IoT *** On-demand Ad hoc Distance-vector Routing Protocol—Next Generation(LOADng)protocol is an extended version of the Ad Hoc On-Demand Distance Vector(AODV)*** AODV,LOADng is a lighter version that forbids the intermediate nodes on the route to send a route reply(RREP)for the route request(RREQ),which originated from the source.A resource-constrained IoT network demands minimal routing control overhead and faster packet ***,in this paper,the parameters of the LOADng routing protocol are optimized using the black widow optimization(BWO)algorithm to reduce the control overhead and ***,the performance of the proposed model is analyzed with the default LOADng in terms of delay,delivery ratio and *** results show that the LOADng-BWO protocol outperforms the conventional LOADng protocol.

关键词： Internet of things optimization algorithm routing protocol LOADng

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Bipolar clavicular dislocation treated with biological anatomical repair and reconstruction:A case report with a literature review of management options

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Chinese Journal of Traumatology 2022年第4期25卷 245-248页

作者： Hemant Bansal Aditya jain Samarth Mittal vivek Trikha Department of Orthopedics Jai Prakash Narayan Apex Trauma CenterAll India Institute of Medical SciencesNew Delhi110029India

Bipolar clavicular dislocation is rare,and therefore its management is *** an increase of patient’s physical demand and a near-normal shoulder function,there has been a shift in the paradigm of its management from a conservative one to a stabilized one of anatomical open *** methods of fixation have also evolved with the advent of more biological fixation devices,which elude implant or fixation related *** case report highlights the salient features of this rare case and details the management options along with the benefits of biological anatomical repair and reconstruction.

关键词： Bipolar clavicular dislocation Traumatic floating clavicle Pan-clavicular dislocation Biological repair Surgical management

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Intracapsular fracture of the proximal femur in a bilateral above-knee amputee: A case report with technical tips for intraoperative positioning and literature review

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Chinese Journal of Traumatology 2022年第5期25卷 306-310页

作者： Aditya jain Hemant Bansal Samarth Mittal Arvind Kumar vivek Trikha Primus Super Specialy Hospital New DelhiIndia Department of orthopaedics Jay Prakash Narayan Apex Trauma Center All India Institute of Medical SciencesNew DelhiIndia Department of Orthopaedis Hamdard Institute of Medical Sciences&ResearchNew DelhiIndia

Intracapsular fractures of the proximal femur are one of the most common fractures of the lower limbs. Most cases require osteosynthesis with suitable implants, and intraoperative positioning of the patient on the fracture table is a prerequisite to facilitate fracture manipulation, traction, reduction and fluoroscopy assessment. However, positioning the limbs of bilateral above-knee amputees for internal fixation of related proximal femoral fractures is a difficult task, which requires customized inventory for effective limb positioning and fracture manipulation. This study reported a rare case following a crush injury of bilateral lower limb in a road traffic accident, and described some technical tips of acute femoral neck fractures in bilateral above-knee amputation. The patient was managed with immediate guillotine amputation and later secondary wound closure followed by internal fixation of the right-sided femoral neck fracture with multiple cancellous cannulated screws.

关键词： Femoral neck fractures Bilateral amputee Above-knee amputation Intraoperative positioning Surgical management

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Surgical treatment of proximal humerus fractures using PHILOS plate

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Chinese Journal of Traumatology 2014年第5期17卷 279-284页

作者： GN Kiran Kumar Gaurav Sharma Vijay Sharma Vaibhav jain Kamran Farooque vivek Morey Department of Orthopaedics All India Institute of Medical Sciences New Delhi 110029 India

Objective：To evaluate functional outcome and complications of open reduction and internal fixation with proximal humeral internal locking system （PHILOS） plate for proximal humerus ***：We reviewed 51 patients who underwent open reduction and internal fixation with PHILOS plate between the years 2007 to *** were 35 men and 16 women with a mean age of 38 years （range 24-68）.There were 41 patients in the age group of ＜60 years and 10 patients in the age group of ＞60 *** to Neer classification system,8,15 and 23 patients had 2-part,3-part,and 4-part fractures,respectively and 5 patients had 4-part fracture *** surgeries were carried out at our tertiary care trauma *** evaluation of the shoulder at final follow-up was done using Constant-Murley ***：The mean follow-up period was 30 months （range 12-44 months）.Two patients were lost to *** the remaining 49 patients,all fractures were united clinically and *** mean time for radiological union was 12 weeks （range 8-20 weeks）.At the final follow-up the mean Constant-Murley score was 79 （range 50-100）.The results were excellent in 25 patients,good in 13 patients,fair in 6 patients and poor in 5 *** the follow-up,four cases of varus malunion,one case of subacromial impingement,one case of deep infection,one case of intraarticular screw penetration and one case of failure of fixation were *** cases of avascular necrosis,hardware failure,locking screw loosening or nonunion were ***：PHILOS provides stable fixation in proximal humerus *** prevent potential complications like avascular necrosis,meticulous surgical dissection to preserve vascularity of humeral head is necessary.

关键词： Proximal humerus fracture Fracture fixation, internal Proximal humeral internal locking system

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