检索结果-南通市图书馆

The delivery of N-myc downstream-regulated gene 2(NDRG2)self-amplifying mRNA via modified lipid nanoparticles as a potential treatment for drug-resistant and metastatic cancers

引用

Medical Review 2024年第3期4卷 235-238页

作者： Sandra E.Reznik Amit K.Tiwari vivek chavda Charles R.Ashby Jr. Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensUSA Departments of Pathology and Obstetrics and Gynecology and Women’s Health Montefiore Medical Center/Albert Einstein College of MedicineBronxUSA Department of Pharmaceutical Sciences College of Pharmacy University of Arkansas for Medical Sciences Little RockUSA Department of Pharmaceutics and Pharmaceutical Technology L.M.College of Pharmacy AhmedabadIndia Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

The protein,N-myc downstream-regulated gene 2(NDRG2),a tumor suppressor,is significantly decreased or absent in many types of *** is a significant negative correlation between the levels of NDRG2 and the development and progression of cancer tumor recurrence and tumor invasion,in different *** contrast,the in vitro and in vivo overexpression of the NDRG2 protein decreases the proliferation,growth,adhesion and migration of many types of cancer *** in vitro overexpression of NDRG2 increases the efficacy of certain anticancer drugs in specific types of cancer *** hypothesize that the delivery of the mRNA of the NDRG2 protein,encapsulated by lipid nanoparticles,could represent a potential treatment of metastatic and drug-resistant *** would be accomplished using a self-amplifying mRNA that encodes the NDRG2 protein and an RNA-dependent-RNA polymerase,obtained from an in vitrotranscribed(IVT)*** IVT mRNA would be encapsulated in a lipid *** efficacy of the nanoformulation would be determined in cultured cancer cells and if the results are positive,nude mice transplanted with either drug-resistant or metastatic drug-resistant cancer cells,would be treated with the nanoformulation and monitored for efficacy and adverse *** the appropriate preclinical studies indicate this formulation is efficacious and safe,it is possible it could be evaluated in clinical trials.

关键词： N-myc downstream-regulated gene 2(NDRG2) cancer self-amplifying mRNA nanoparticle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unveiling resveratrol’s potential:Navigating the landscape of autoimmune diseases

引用

Clinical Traditional Medicine and Pharmacology 2024年第3期5卷 87-95页

作者： Keshava Jetha Arya Vyas Ashutosh Tripathi Jeet Gandhi vivek chavda Department of Pharmaceutics and Pharmaceutical Technology L.M.College of PharmacyAhmedabad380009GujaratIndia Ph.D.Section Gujarat Technological UniversityAhmedabad382424GujaratIndia Ph.D.Section Kadi Sarva VishvavidyalayaGandhinagar382024GujaratIndia

Background:Autoimmune diseases pose a multifaceted challenge in the realm of medical science,warranting in-novative approaches for their ***,a naturally ccurring compound found in various dietary sources,has captured attention for its potential immunomodulatory and anti-inflammatory ***-standing the interplay between autoimmune diseases and resveratrol is crucial for exploring novel therapeutic ***:This review aims to explore the intricate relationship between autoimmune diseases and *** seeks to provide insights into the mechanistic underpinnings of autoimmune diseases,emphasizing the necessity for innovative therapeutic ***,it aims to comprehensively discuss the pharmacological properties of resveratrol and its potential applications in managing autoimmune ***:A structured review approach was employed to organize the content into distinct *** literature searches were conducted to gather information on autoimmune diseases,the pharmacology of resvera-trol,and its effects on immune regulation,inflammation,and oxidative *** and clinical evidence regarding the efficacy of resveratrol in managing specific autoimmune diseases was critically ***:Resveratrol demonstrates immunomodulatory,anti-inflammatory,and antioxidant effects,which are rel-evant to autoimmune disease *** properties impact immune cell regulation,pro-inflammatory cytokines,inflammatory mediators,and oxidative stress,potentially ameliorating autoimmune *** studies present promising evidence for the efficacy of resveratrol in conditions such as rheumatoid arthri-tis,systemic lupus erythematosus,multiple sclerosis,and inflammatory bowel disease,albeit further research is necessary to determine its safety and optimal ***:The review underscores the promising potential of resveratrol in autoimmune disease *** targeting k

关键词： Autoimmune diseases Resveratrol Immunomodulation Anti-inflammatory Antioxidant Clinical trials Translational research

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ayurvedic and Other Herbal Remedies for Dengue: An Update

引用

Clinical Complementary Medicine and Pharmacology 2022年第3期2卷 7-27页

作者： vivek P.chavda Anup Kumar Rittwika Banerjee Nayan Das Department of Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabad380009GujaratIndia Pharmacy Section L.M.College of PharmacyAhmedabad380058GujaratIndia

Dengue fever is a flu-like ailment propagated by female mosquitos of the Aedes aegypti *** is also known as dandaka jwara in *** is most common in the world’s subtropical and tropical climate ***,severe headache,nausea,rashes,joint pain,pain behind the eyes,muscle pain,and swollen glands are all common dengue *** not handled promptly,these symptoms can lead to more severe issues such as exhaustion,blood in the vomit,continuous vomiting,bleeding gums,restlessness,severe abdominal pain,and rapid *** there is no specific medication for dengue fever,the disease is treated by eliminating and managing the ***,there are a variety of ayurvedic remedies(like Carica papaya L.,Cissampelos pareira L.,etc.)that can help to tackle the same by strengthening the immune system and controlling *** review article provides a comprehensive overview of dengue virus infections,clinical symptoms,diagnosis,mitigation,and treatments,focusing on ayurvedic and herbal remedies.

关键词： Dengue Dengue fever Ayurveda Herbal remedy Dengue Virus COVID-19

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

COVAX-19 ■Vaccine:Completely blocks virus transmission to non-immune individuals

引用

Clinical Complementary Medicine and Pharmacology 2021年第1期1卷 28-31页

作者： vivek P.chavda Lalitkumar K.Vora Disha R.Vihol Department of Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabad-380009GujaratIndia School of Pharmacy Queen’s University Belfast97 Lisburn RoadBT97BLUK Pharmacy Section L.M.College of PharmacyAhmedabad-380058GujaratIndia

Various vaccine platforms are geared against COVID-19 vaccine development to produce immunogens in *** design a recombinant protein-based COVID-19 vaccine,Vaxine pty Ltd used computer models of the spike protein and its human receptor,ACE2,to identify how the virus infects human *** on this,the COVAX-19 ■vaccine is *** does reduce not only COVID-19 disease but also blocks virus shedding and *** are optimistic that this vaccine candidate could be clinically available soon with sufficient vaccine efficacy with a considerable amount of reduction in vaccination-related side effects.

关键词： COVAX-19■Vaccine SARS-CoV-2 Pandemic Advax^(TM) SpikoGen■etc

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The potential role of essential oils in boosting immunity and easing COVID-19 symptoms

引用

Clinical Traditional Medicine and Pharmacology 2024年第2期5卷 54-62页

作者： vivek P chavda Pankti C.Balar Gargi Jogi Swati Marwadi Aayushi Patel Avani Doshi Jinal Ajabiya Lalitkumar Vora Department of Pharmaceutics and Pharmaceutical Technology L.M.College of PharmacyAhmedabad 380009GujaratIndia Department of Biotechnology Savitribai Phule University of Pune411041MaharashtraIndia Pharmacy Section Long Island UniversityUniversity PlazaBrooklynNY 11201United States Department of Pharmaceutical Chemistry K B Raval College of PharmacyGandhinagar 382423India Department of Pharmaceutics Analysis National Institute of Pharmaceutical Education and Research(NIPER)Ahmedabad 380009GujaratIndia School of Pharmacy Queen’s University Belfast97 Lisburn RoadBT97BLUK

Background:Several trials have been conducted since the beginning of the COVID-19 pandemic to establish possible clinical treatments for the infected ***,many these approaches have failed to demonstrate positive results in human clinical *** the middle of this investigation,essential oils attracted interest due to their numerous benefits and possible role in management of *** oils have virucidal effects at nontoxic quantities due to their tiny molecular size,high lipophilicity,and quick commencement of ***,the pulmonary exhalation,lower respiratory stimulus,and deep lung transport properties of essential oils increase their potential medicinal ***:The present review aimd to evaluate the potential efficacy of essential oil in management of ***:Following the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA)guidelines,studies published in English up to January 2024 were searched in the PubMed,Scifinder,and Scopus database,using relevant keywords,such as“Essential oil and COVID-19”,“Essential Oil and Viral Infection”,*** non-English articles,abstracts,conference papers,book chapters,and reviews were ***:A total of 108 potentially relevant articles were included for full-text review,with the emphasis is on scrutinizing the probable antiviral action of essential oils to inhibit the replication of *** tried to provide an opinion based on different studies performed using the same concept in different corners of the ***:Various essential oils hold a great potential to work as an adjuvant therapy in management and prevention of COVID-19.

关键词： COVID-19 SARS-CoV-2 Sunlight UV radiation Essential oil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reviving Fertility:Phytochemicals as Natural Allies in the Fight against Non-genetic Male Infertility

引用

Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 112-128页

作者： vivek P.chavda Shreya S Sonak Pankti C.Balar Krupa Vyas Pranali Palandurkar Komal Mule Krishna Patel vivek Hala Dixa A.Vaghela Devarshi Acharya Akta Vaishnav Jimil Gandhi Vasso Apostolopoulos Department of Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabadGujarat 380008India Bharati Vidyapeeth University’s Poona College of Pharmacy ErandwaneKothrudPune 411038India Pharmacy section L M College of PharmacyAhmedabadGujarat 380008India University Department of Pharmaceutical Sciences R.T.M Nagpur 440033India Department of Pharmaceutics Khyati College of PharmacyAhmedabad 380009India IICISST Sardar Patel UniversityVallabh Vidyanagar 388120India Institute for Health and Sport Immunology and Translational ResearchVictoria UniversityMelbourneVIC 3030Australia Immunology Program Australian Institute for Musculoskeletal ScienceMelbourneVIC 3021Australia

Background:Male infertility poses a growing challenge to the healthcare system,with its prevalence on the *** lifestyle,food,and addictions such as smoking,alcoholism,*** the *** several approaches are being investigated to prevent and treat this condition,each therapeutic approach has its *** medications continue to play a crucial role in the healthcare *** recent years,there has been a shift towards determining the efficacy of phytochemicals(or,herbal drugs)as ***:To evaluate the effect of various herbs,plant,metabolites,or a part of plant in management of non-genetic male ***:The male infertility-associated keywords were searched in PubMed,excluding those non-English writen papers.A total of 146 pertinent and closely connected records were included for full reading and inclusion in the systemic ***:The manuscript focuses on individual herbal drug components,their active ingredients,their role in improving the condition and quality of life,and decreasing the prevalence of male ***:Herbal medicinal plants show promising outcomes to treat male *** alternatives are appealing and have regained *** future holds promise for some of these herbal treatments to advance with many showing improved outcomes in males with infertility issues.

关键词： Male infertility Plant-based management Phytochemical Herbal drug Traditional Chinese medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nature meets technology:Harnessing nanotechnology to unleash the power of phytochemicals

引用

Clinical Traditional Medicine and Pharmacology 2024年第3期5卷 111-124页

作者： Divya Teli Riyansi Satasia Vishwa Patel Ruchi Nair Rudri Khatri Dhvani Gala Pankti C.Balar Kishan Patel Anu Sharma Palak Vadodariya vivek P.chavda Department of Pharmaceutical Chemistry L.M.college of pharmacyAhmedabadGujarat380009India Department of Chemistry School of ScienceGujarat UniversityAhmedabadGujarat380009India Pharmacy section L.M.college of pharmacyAhmedabadGujarat380009India Department of Chemistry University at BuffaloBuffaloNY 14260United States of America Department Pharmaceutical Sciences University of MassachusettsBostonMA 02125United States of America Faculty of Pharmacy Marwadi UniversityRajkotGujarat360006India Department of Pharmaceuticals and Pharmaceutical Technology L.M.college of pharmacyAhmedabadGujarat380009India

Background:Phytochemicals encompass a diverse array of bioactive substances originating from plants,exhibit-ing a broad spectrum of possible health-promoting ***,the clinical uses of these compounds are restricted due to their limited solubility,stability,bioavailability,and target ***-based delivery methods present a viable approach to address these problems and enhance the properties and biological activity of *** have the potential to augment the solubility,bioavailability,and pharmacokinetics of phytochemicals by means of several *** potential approach to enhance the surface area and solubility of phytochemicals is by lowering their particle *** process of adsorption of surfactants onto phytochemical particles can lead to the formation of micelles,which exhibit solubility in ***-mulations have the potential to enhance the uptake of phytochemicals across many biological barriers,including the intestinal ***:To study the potential of nanoformulation in enhancing the therapeutic action of phytochemicals Method:Systemic review was performed while considering some aspects of PRISM ***:The nanoparticles have a great potential in delivering the phytochemicals and could of great help in the management of various ***,exhaustive research and clinical trials are yet demanded to provide the evidential proof for the ***:In conclusion,the utilisation of ligand-functionalized nanoparticles enables the precise targeting of phytochemicals to particular cells or *** field of nanotechnology has significant promise in transform-ing the advancement and administration of phytochemicals for medicinal and preventative *** utilisation of nanotechnology holds promise in addressing the obstacles related to the physicochemical charac-teristics of phytochemicals,hence enabling the development of enhanced and precise delivery

关键词： Phytochemicals Nanotechnology Bioactivity Enhancement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phytochemical Loaded Nanovehicles of Biopolymer for Breast Cancer:A Systemic Review

引用

Clinical Complementary Medicine and Pharmacology 2023年第4期3卷 60-78页

作者： vivek P.chavda Suneetha Vuppu Rajashri Bezbaruah Lakshmi Vineela Nalla Siva Nageswara Rao Gajula Pankti C.Balar Toshika Mishra Nikita Sharma Sathvika Kamaraj Thushar Suresh Anand Sairam Bedanta Bhattacharjee Department of Pharmaceutics and Pharmaceutical Technology LM College of PharmacyAhmedabadGujarat 380009India Department of Biotechnology ScienceInnovationand Society Research lab 115Hexagon(SMV)Vellore Institute of TechnologyVelloreTamil Nadu 632014India Institute of Pharmacy Assam Medical College and HospitalDibrugarhAssam 786002India Department of Pharmaceutical Science Faculty of Science and EngineeringDibrugarh UniversityDibrugarhAssam 786004India Department of Pharmacy Koneru Lakshmaiah Education FoundationVaddeswaramAndhra PradeshIndia Department of Pharmaceutical Analysis GITAM School of PharmacyGITAM(Deemed to be University)RushikondaVisakhapatnamAndhra Pradesh 530045India Pharmacy Section LM College of PharmacyAhmedabadGujarat 380009India Departemnt of Pharmacology and Toxicology Girijananda Chowdhury Institute of Pharmaceutical Science-TezpurSonitpurAssam 784501India

Background:Breast cancer is one of the most common malignancies affecting women worldwide,emphasizing the need for effective therapeutic *** derived from plants have gained significant attention due to their potential anticancer ***:This review aims to comprehensively assess the existing literature on using phytochemical-loaded for-mulations as a therapeutic approach for breast *** analyzing the available evidence,we aim to determine the potential benefits and limitations of these formulations in terms of their anticancer activity,bioavailability,and ***:A systematic search of relevant databases was conducted to identify studies investigating phytochemical-loaded formulations in the context of breast cancer *** inclusion criteria encompassed clinical trials,preclinical studies,and in-vitro experiments that reported using phytochemicals in various formulations for breast cancer *** extraction was performed to ensure the reliability and validity of the included ***:The review highlights the diverse range of phytochemicals used in different formulations for breast cancer *** suggest that these formulations exhibit promising anticancer effects by targeting mul-tiple signaling pathways in breast cancer progression,including cell proliferation,apoptosis,angiogenesis,and ***,various delivery systems,such as nanoparticles,liposomes,and micelles,have enhanced phytochemicals’bioavailability and targeted ***:Phytochemical-loaded formulations hold immense potential as a therapeutic approach for breast cancer *** reviewed evidence indicates their ability to inhibit tumor growth,enhance chemotherapy effectiveness,and reduce adverse ***,further research is warranted to optimize the formulation strategies,investigate the long-term safety profiles,and conduct large-scale clinical trials to establish their efficacy and applicabi

关键词： Breast cancer Cancer Phytochemicals Nanocerriers Nanoparticles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：