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Low red blood cell levels of deglycating enzymes in colorectal cancer patients

World Journal of Gastroenterology 2011年第3期17卷 329-333页

作者： Maria Notarnicola Maria Gabriella Caruso Valeria Tutino vito guerra Giovanni Misciagna Laboratory of Biochemistry National Institute for Digestive Diseases Laboratory of Epidemiology and Biostatistics National Institute for Digestive Diseases

AIM: To investigate Glyoxalase Ⅰ and fructosamine-3-kinase (FN3K) activity in red blood cells from patients with colorectal adenomas and cancer. METHODS: Thirty three consecutive subjects with one or more histologically confirmed colorectal adenomatous polyps, 16 colorectal cancer patients and a group of 11 control subjects with normal colonoscopy were included in the study. Glyoxalase Ⅰ and FN3K activities were measured in red blood cells using a spectrophotometric and radiometric assay, respectively. RESULTS: A significant reduction in both Glyoxalase Ⅰ and FN3K activity was detected in patients with tumors compared to patients with adenomas and the controls. Erythrocyte Glyoxalase Ⅰ activity in colorectal cancer was approximately 6 times lower than that detected in patients with adenoma (0.022 ± 0.01 mmol/min per milliliter vs 0.128 ± 0.19 mmol/min per milliliter of red blood cells, P = 0.003, Tukey's test). FN3K activity in red blood cells from patients with colon cancer was approximately 2 times lower than that detected in adenoma patients (19.55 ± 6.4 pmol/min per milliliter vs 38.6 ± 31.7 pmol/min per milliliter of red blood cells, P = 0.04, Tukey's test). CONCLUSION: These findings suggest that deglycating enzymes may be involved in the malignant transformation of colon mucosa.

关键词： Colorectal cancer Enzymatic activity Fructosamine-3-kinase Glycation Glyoxalase Ⅰ

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Analysis of aggressiveness factors in hepatocellular carcinoma patients undergoing transarterial chemoembolization

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World Journal of Gastroenterology 2018年第15期24卷 1641-1649页

作者： Yossi Ventura Brian I Carr Issac Kori vito guerra Oren Shibolet Liver Unit Department of Gastroenterology and Hepatology Tel-Aviv Medical Center Sackler faculty of Medicine Tel-Aviv University Izmir Biomedicine and Genome Center Dokuz Eylul University Interventional Radiology Division of Imaging TelAviv Medical Center Department of Clinical Trials and Epidemiology IRCCS de Bellis

AIM To investigate novel predictors of survival in hepatocellular carcinoma(HCC) patients following transarterial chemoembolization(TACE).METHODS One hundred sixty seven patients with un-resectable HCC were retrospectively analyzed to identify factors that might contribute to their HCC biology and aggressiveness. We correlated routine laboratory results(total bilirubin, AST, ALKP, GGTP, albumin etc.) to maximum tumor diameter, number of tumor nodules, portal vein thrombosis and blood alpha-fetoprotein levels. These 4 parameters were previously combined to form an aggressiveness index(AgI). We used The Wilcoxon ranksum(Mann-Whitney), to test the correlation between the AgI categories and liver function parameters. The Cox proportional hazards model was applied to evaluate the categories of AgI associated with overall survival. RESULTS The AgI was strongly correlated with survival in this novel patient population. Three year survival probability for AgI > or 4 had HR for mortality of 2.18(95%CI: 1.108-4.310, P 4 had a HR for mortality of 2.26(95%CI: 1.184-4.327, P < 0.016). GGTP had a HR of 1.003(95%CI: 1.001-1.004, P < 0.001).CONCLUSION Our study validates the AgI in a new population with un-

关键词： Hepatocellular carcinoma Aggressiveness index Liver function Transarterial chemoembolization survival

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Discordance among aggressiveness characteristics of hepatocellular carcinoma:Portal vein thrombosis and multifocality,related to tumor size,but not to serum alpha-fetoprotein level

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Liver Research 2023年第3期7卷 256-262页

作者： Brian I.Carr vito guerra Volkan Ince Burak Isik Sezai Yilmaz Liver Transplant Institute Inonu University Faculty of MedicineMalatyaTurkey National Institute of Gastroenterology S.de Bellis Research HospitalBariItaly Department of Surgery Inonu University Faculty of MedicineMalatyaTurkey

Background and aims:Hepatocellular carcinoma(HCC)is characterized by several clinically important prognostic parameters,including portal vein thrombosis(PVT),tumor multifocality,and serum alphafetoprotein(AFP)levels,in addition to maximum tumor diameter(MTD).However,associations among these parameters have not been thoroughly ***,the study aimed to investigate the correlations among these HCC characteristics in a prospectively collected ***:An 8080 HCC patient database derived from our weekly HCC council meeting was examined with respect to the correlations at baseline patient presentation between increases in MTD and changes in the percentage of patients with PVT,multifocality,or AFP ***:The percentage of patients with PVT and with multifocality(tumor nodule numbers≥3)significantly increased with enlarging MTD,regardless of the serum AFP level,showing the independence of PVT and multifocality on *** percentage of patients with multifocality increased with enlarging MTD,in the presence or absence of PVT,showing the independence of multifocality from ***,discordance was found between different tumor ***:A statistically significant association was found between PVT and MTD and between multifocality and MTD,all three of which are independent of *** and multifocality appeared to be independent of each *** PVT and multifocality were independent of AFP,they were also augmented with high serum AFP *** results suggest the possibility of multiple pathways of tumor progression in the later stages of HCC development.

关键词： Hepatocellular carcinoma(HCC) Portal vein thrombosis(PVT) Multifocality Alpha-fetoprotein(AFP) Heterogeneity

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