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Glutathione Enzymes and Liver Injury in Acute Dengue Viral Infection

Journal of Biosciences and Medicines 2019年第10期7卷 61-71页

作者： Lal Chandrasena Arjuna De Silva Chandima De Mel Hemantha Peiris visul. abesuriya Sanjay De Mel Suranjith Seneviratne Samantha Bandara Nawaloka Hospitals Research and Education Foundation Nawaloka Hospitals PLC Colombo Sri Lanka Department of Medicine Faculty of Medicine University of Kelaniya Kelaniya Sri Lanka Department of Biochemistry Faculty of Medical Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka Department of Haematology-Oncology National University Cancer Institute National University Health System Singapore Singapore Institute of Immunity and Transplantation Royal Free Hospital and University College London London UK Department of Medical Laboratory Sciences Faculty of Allied Health Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka

Identification of redox markers may be of clinical significance in the management of dengue patients. This study is to identify the association between antioxidant enzymes, hematological parameters and liver transaminases in patients with acute dengue infection. Blood samples were taken from patients on the day of admission, day 05 and 07 from admission for analysis of glutathione peroxidase (GPX), glutathione reductase (GR), aspartate transaminase (AST), alanine transaminase (ALT) and hematological parameters. AST and ALT levels were significantly elevated (p < 0.05) on day 05 in dengue patients. In contrast, GPX and GR showed significantly low levels on day 05 compared to on the day of admission and day 07. Although there was a decline in the trend of platelets towards day 05, values were not significantly different. Dengue associated with liver injury appears to peak around day 05 when the GPX and GR enzymes levels in patients were the lowest suggesting that increased viral load in the acute phase of dengue infection has initiated an antioxidant imbalance. Thus, timely investigation of antioxidant enzymes (GR and GPX) and liver transaminases around day 05 of admission may be of value in the management of patients with dengue infection similar to as seen in platelet counts.

关键词： Aspartate Transaminase Alanine Transaminase Dengue Glutathione Peroxidase Glutathione Reductase

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Glutathione Reductase, Liver Transaminases and Atypical Lymphocytes Count as Early Predictive Biomarkers in Diagnosis of Thrombocytopenia in Dengue Viral Infection

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Journal of Biosciences and Medicines 2021年第1期9卷 119-130页

作者： Samantha Bandara Lal G. Chandrasena Hemantha Peiris visul. abesuriya Arjuna De Silva Chandima De Mel Sanjay De Mel Suranjith L. Seneviratne Department of Medical Laboratory Sciences Faculty of Allied Health Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka Nawaloka Hospitals Research and Education Foundation Nawaloka Hospitals PLC Colombo Sri Lanka Department of Biochemistry Faculty of Medical Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka Department of Medicine Faculty of Medicine University of Kelaniya Ragama Sri Lanka Department of Haematology-Oncology National University Cancer Institute National University Health System Singapore Institute of Immunity and Transplantation Royal Free Hospital and University College London UK

Objective: The aim of the study is to identify whether Atypical Lymphocyte (AL), liver transaminases, and Glutathione Reductase (GR) can be used as potential biomarkers in the assessment of severity and thrombocytopenia in dengue. Methods: A cross-sectional analytical study was carried out on diagnosed dengue patients admitted to Nawaloka Hospital, Sri Lanka. Blood samples were taken from patients (n = 50) on the day of admission, 3rd and 5th day from admission for analysis of GR, aspartate transaminase, alanine transaminase, platelets, white blood cells, and Atypical Lymphocytes (AL). Results: GR level of all three measured stages had a higher area under the curve (>88%), high sensitivity and specificity compared to liver transaminases. A significant regression model represents on admission GR and AL levels as predictive variables to platelet levels in day 03 from admission (Day 3 Platelet level = 127155.3 - 383 * GR - 0.431 * AL). Conclusion: Liver transaminases, GR, and AL% can be considered as a profile of predictive biomarkers in early diagnosis of severity of dengue infection. The degree of thrombocytopenia can be predicted using on admission GR and AL% level in acute dengue viral infection.

关键词： Dengue Liver Transaminases Glutathione Reductase Atypical Lymphocytes

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