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Treatment outcome,cognitive function,and psychopathology in methamphetamine users compared to other substance users

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World Journal of Psychiatry 2022年第7期12卷 944-957页

作者： Nina Behle Felicia Kamp Lisa Proebstl Laura Hager Marlies Riebschläger Maik Schacht-Jablonowsky willem Hamdorf Stefanie Neumann Daniela Krause Kirsi Manz Andreas Guenter Franke Gabriele Koller Michael Soyka Department of Psychiatry and Psychotherapy Ludwig Maximilians UniversityMunich 80336Germany MEDIAN Clinic MecklenburgVitense 19217Germany Institute for Medical Information Processing Ludwig Maximilians UniversityMunich 81377Germany University of Applied Labour Studies of the Federal Employment Agency Mannheim 68163Germany Department of Psychiatry Ludwig Maximilians UniversityMunich 80336Germany

BACKGROUND The rising number of people using methamphetamine leads to an increasing need for treatment options for this patient ***-based research on the efficacy of treatment programs for methamphetamine users is *** to specific characteristics of methamphetamine users,the question arises whether established treatment methods for individuals using other substances can be effective for the treatment of methamphetamine dependence as *** hypothesize that there are significant differences between the two groups that may affect the effectiveness of treatment and worsen the prognosis of treatment outcomes for methamphetamine users compared to consumers of other *** To investigate potential differences in cognitive functioning and psychopathology between methamphetamine users and other substance users and possible correlations with treatment *** A total of 110 subjects were recruited for an observational,longitudinal study from a German inpatient addiction treatment center:55 patients with methamphetamine dependence and 55 patients with dependence of other substances(“OS group”).Both groups were examined at beginning(baseline)and end of treatment(after 6 mo)with regard to treatment retention,craving,cognitive functioning,psychosocial resources,personality traits,depression,and other psychiatric *** used were Raven’s IQ test,Mannheimer craving scale,cognitrone cognitive test battery,NEO personality factors inventory,Hamilton depression scale,Becks depression inventory,and a symptom *** statistical methods used were χ^(2)-test,t-test and multiple mixed *** A total drop-out rate of 40%(methamphetamine-group:36.4%;OS-group:43.6%)was observed without significant differences between *** baseline,methamphetamine-group subjects significantly differed from OS-group individuals in terms of a lower intelligence quotient,fewer years of education,slower working speed,and decreased working accura

关键词： Treatment outcome Cognitive function Psychopathology Methamphetamine Substance use Comparison

Severe Weight Loss and Dropped Head Syndrome in MuSK Myasthenia Gravis

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Case Reports in Clinical Medicine 2014年第11期3卷 587-591页

作者： Daniel Yu Bing Tan willem Hendrik Joseph Peter Linssen Boris Liberov Department of Neurology Sint Lucas Andreas Hospital Amsterdam The Netherlands Department of Internal Medicine Zaans Medisch Centrum The Netherlands

Muscle Specific Receptor Thyrosine Kinase (MuSK) Myasthenia Gravis (MG) is a rare auto-immune disorder of the neuromuscular junction. The clinical presentation of MG is dominated by fluctuating weakness of the extra-ocular, orofacial and limb muscles. The clinical presentation of MuSK MG can vary, which may delay diagnostic procedures. We present a patient who initially presented with severe weight loss and slowly progressive developing neck extensor weakness and diplopia. A single fiber EMG led to the diagnosis MG and antibodies directed towards MuSK were detected. He was treated with prednisone and the steroid sparing agent azathioprine after which he made full recovery.

关键词： Myasthenia Gravis Muscle Specific Receptor Thyrosine Kinase Dropped Head Syndrome

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创新发展集群:提升城市竞争力的分析框架

南京社会科学 2010年第9期 6-13页

作者： Leo Van Den Berg Erik Braun willem Van Winden 郑琼洁鹿特丹伊拉斯谟大学比较城市研究所南京市社科院

本文分析和比较了增长集群不同种类的发展,从集群角度看,重点放在本地的互动和创新方面,并且证明是有益的,因为越来越多的经济活动跨越了传统经济部门和创新的范围。为了能够分析和比较不同集群的不同类别,本文构建了一个提升城市竞争... 详细信息

本文分析和比较了增长集群不同种类的发展,从集群角度看,重点放在本地的互动和创新方面,并且证明是有益的,因为越来越多的经济活动跨越了传统经济部门和创新的范围。为了能够分析和比较不同集群的不同类别,本文构建了一个提升城市竞争力的分析框架,从空间经济条件、集群的特定条件及集群的组织能力三大要素出发,在城市范围内对集群进行深入分析,同时详细阐述了三大要素在集群发展中的作用。

关键词：发展集群互动创新

基于机器视觉的轻触开关引脚缺陷检测算法研究

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浙江工业大学学报 2015年第1期43卷 30-33,38页

作者：蒋建东陈培余童一珏 willem Hoogmoed 浙江工业大学特种装备制造与先进加工技术教育部重点实验室浙江杭州310014 瓦赫宁根大学农场技术组

针对轻触开关在生产过程中外观检测的要求,进行了基于机器视觉的轻触开关引脚外观图像检测技术研究.通过CCD获取图像,采用滤波、阈值分割等预处理提取了轻触开关的二值图像,并采用轮廓提取,根据最小面积包围法获取图像绕中心旋转角度的... 详细信息

针对轻触开关在生产过程中外观检测的要求,进行了基于机器视觉的轻触开关引脚外观图像检测技术研究.通过CCD获取图像,采用滤波、阈值分割等预处理提取了轻触开关的二值图像,并采用轮廓提取,根据最小面积包围法获取图像绕中心旋转角度的方法对图像进行矫正,对旋转后的图像提取4个引脚区域的ROI区域.对提取引脚区域的黑色像素面积进行统计,并与设定的标准面积阈值进行对比判断进行轻触开关引脚外观缺陷的检测.实验结果表明:引脚歪脚的识别率为98%,引脚合格的误判率为3%,综合准确率大于97%,所提出的检测方法及算法能准确检测轻触开关的引脚缺陷,满足轻触开关外观检测的需求.

关键词：轻触开关机器视觉外观检测缺陷 ROI

Spinal fixation after laminectomy in pigs prevents postoperative spinal cord injury

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Animal Models and Experimental Medicine 2022年第2期5卷 153-160页

作者： Emma M.H.Slot Bart de Boer Saskia Redegeld Sander van Thoor Nizar Moayeri willem-Bart Slooff Irene A.Schaafsma Björn Meij Tristan P.C.van Doormaal Department of Neurology and Neurosurgery University Medical Center UtrechtUtrechtThe Netherlands Department of Neurosurgery Elizabeth TweeSteden HospitalTilburgThe Netherlands Brain Technology Institute UtrechtThe Netherlands Department of Clinical Sciences Faculty of Veterinary MedicineUtrecht UniversityUtrechtThe Netherlands Department of Neurosurgery Clinical Neuroscience CenterUniversity Hospital ZurichZurichSwitzerland

Background:A safe,effective,and ethically sound animal model is essential for preclinical research to investigate spinal medical *** report the initial failure of a porcine spinal survival model and a potential solution by fixating the ***:Eleven female Dutch Landrace pigs underwent a spinal lumbar interlaminar decompression with durotomy and were randomized for implantation of a medical device or control *** resonance imaging(MRI)was performed before ***:Neurological deficits were observed in 6 out of the first 8 *** of these animals were terminated prematurely because they reached the predefined humane *** cord compression and myelopathy was observed on postoperative MRI *** hypothesized postoperative spinal instability with epidural hematoma,inherent to the biology of the model,and subsequent spinal cord injury as a potential *** the subsequent 3 animals,we fixated the spine with Lubra *** these animals recovered without neurological *** extent of spinal cord compression on MRI was variable across animals and did not seem to correspond well with neurological ***:This study shows that in a porcine in vivo model of interlaminar decompression and durotomy,fixation of the spine after lumbar interlaminar decompression is feasible and may improve neurological *** research is necessary to evaluate this hypothesis.

关键词： fixation i nterlaminar decompression medical device model spinal cord injury

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新游戏老规则

经理人 2000年第9期 58-61页

作者： willem Burgers 中欧国际工商学院

吞噬你的市场、视资产为负债,电子商务、互联网只是大现象中的一小部分而已。 willem Burgers教授在电子商务论坛上激情洋溢的讲演,给人以新的警示。

关键词：飞利浦资产负债游戏汽车苹果电脑交易成本交易费用索尼

Have You Considered Eating Your Weeds?

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American Journal of Plant Sciences 2014年第8期5卷 1110-1116页

作者： willem Sternberg Jansen van Rensburg Michele Cloete Abe Shegro Gerrano Patrick Olusanmi Adebola Agricultural Research Council—Vegetable and Ornamental Plant Institute Pretoria South Africa

In most parts of the developed world, Pigweed, Spider plant, Lambs amongst others are regarded as weeds. But in Africa and other developing countries, these plants form part of the daily diets of many rural households. The oldest inhabitants of South Africa have harvested leaves from wild plants to supplement the meat from hunted animals. Over 100 different species of plants are cooked as a potherb/relish with corn meal. These species include indigenous species as well as indigenized, mostly weedy, species. These species became part of the African culture and heritage and were collectively known as morogo or imifino. The popularity of specific species is a function of many factors, including availability, ease of preparation, taste, consistency and appearance. Some popular genera are Amaranthus, Cleome, Solanum and Corchorus. Micronutrient malnutrition is widespread in South Africa with vitamin A and iron as the major concern for micronutrient deficiency. Morogo can contribute to alleviating these micronutrient deficiencies. It was found that for the species tested, that morogo are low in energy and that leaves of nightshade, pigweed and spider flower provided more than 50% of the RDA for vitamin A.

关键词： Imifino Morogo Pigweed Spider Flower Food Security

Wintering Swan Geese maximize energy intake through substrate foraging depth when feeding on buried Vallisneria natans tubers

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Avian Research 2019年第2期10卷 163-170页

作者： Yan Chen Yong Zhang Lei Cao willem F.de Boer Anthony D.Fox School of Life Sciences University of Science and Technology of ChinaHefei 230027China Co-Innovation Center for Sustainable Forestry in Southern China College of Biology and the EnvironmentNanjing Forestry UniversityNanjing 210037China Research Center for Eco-Environmental Science Chinese Academic of Sciences18 Shuangqing RoadBeijing 100085China University of Chinese Academy of Sciences 19 Yuquan RoadShijingshan DistrictBeijing 100049China Resource Ecology Group Wageningen UniversityDroevendaalsesteeg3a6708 PB WageningenThe Netherlands Department of Bioscience Aarhus UniversityKalφGrenavej 148410 RφndeDenmark

Background: Foraging theory predicts that animals select patches that offer the highest net rate of energy gain. Hence, prey distribution patterns and spatiotemporal heterogeneity play important roles in determining animal feeding patch selection. For waterfowl foraging on buried aquatic plant tubers, the distribution and biomass of these plant organs vary with depth in the substrate. Since excavation costs also increase with depth, the energy intake of the animals foraging on these plants is highly sediment depth dependent. Methods: Here, using observations of Swan Geese (Anser cygnoides) foraging on Vallisneria natans tubers, we test our hypothesis that geese feeding on tubers buried at intermediate sediment depth maximize their daily energy intake because of the interaction between tuber size and abundance with depth. To do this, we measured the distribution patterns of buried Vallisneria tubers under both undisturbed conditions and post-exploitation by geese (i.e. giving-up conditions). We investigated the relationship between tuber size and burial depth, and total tuber biomass within each sediment layer in undisturbed and exploited plots. Finally, we compared modelled Swan Goose daily energy intake feeding on Vallisneria tubers buried at different sediment layers (1–10, 11–20 and 21–30 cm below the surface). Results: Dry weight of Vallisneria tubers linearly increased with burial depth, while average total dry weight density of tubers showed a unimodal relationship, peaking at intermediate levels. Not surprisingly, Swan Geese foraged most intensively on tubers buried at intermediate sediment depths, where they maximize their daily energy intake. Our results support our hypothesis that Swan Geese feeding on tubers at intermediate depths maximize their daily energy intake. Conclusions: Our study is the first to quantify foraging strategies of Swan Geese during the wintering period, emphasizing the importance of plant traits on foraging selection of belowground f

关键词： Energetic trade-off Optimal foraging Shengjin Lake Substrate Tuber burial depth Yangtze River

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创新型处理高污染废水的低温常压蒸发技术

世界农药 2014年第3期36卷 56-58页

作者： willem Vriesendorp 刘琴创源科瑞环保科技(北京)有限公司北京100102

农药废水对环境造成严重污染。农药废水处理旨在降低农药生产废水中污染物浓度,提高回收利用率,从而尽量达到无害化。创源环保(CWT)公司开发的低温常压蒸发工艺能在处理废水时实现大幅地低能耗运行和低维护成本,同时也提高了回收废水中... 详细信息

农药废水对环境造成严重污染。农药废水处理旨在降低农药生产废水中污染物浓度,提高回收利用率,从而尽量达到无害化。创源环保(CWT)公司开发的低温常压蒸发工艺能在处理废水时实现大幅地低能耗运行和低维护成本,同时也提高了回收废水中有价值的物质的可能性。

关键词：农药废水回收低温常压蒸发技术