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肛门直肠畸形或先天性巨结肠成年患者生活质量改变的原因分析

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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 22-22页

作者： Hartman E. E. Oort F.J. visser m.r. 郑世成(译) 王顺涛(校) Academic medical Centre University of Amsterdam Building J4 P.O. Box 22660 1100 DDAmsterdam Netherlands 不详

PUrPOSE: The aim of this study was to examine changes in the quality of life of adult patients with anorectal malformations or Hirschsprung’s disease over a three-year interval and to identify demographic, clinical, and psychosocial variables that explain possible quality-of-life changes. Understanding the factors that affect changes in quality of life over time is particularly important to provide adequate care. mETHODS: Questionnaires were administered to 261 patients (77 percent),with a three-year interval. Background characteristics, including demographic and clinical variables, and psychosocial variables (i.e., self-esteem, mastery, social support, disease cognition) were measured on one occasion. Generic and disease-specific quality of life were measured twice. rESULTS: On average patients indicated no change in quality-of-life level after three years. However, variance in the change scores revealed individual variation, indicating the presence of patients who im.r.ved and patients who deteriorated. Patients who were female, older, have other congenital diseases, or a stoma reported poorer quality of life over time. The psychosocial variable “disease cognition“ most strongly affected the change in quality of life of patients with anorectal malformations or Hirschsprung’s disease. CONCLUSIONS: Our results could alert clinicians to patients who are at risk for quality-of-life deterioration and might therefore be in need for extra care. Our findings illustrate the importance of psychosocial functioning for enhancing the quality of life over time of these patients.

关键词：患者生活质量先天性巨结肠肛门直肠畸形成年患者原因分析社会心理学人口统计学社会心理变量疾病认知老年女性患者

Analysis of the meiosis in the F_1 hybrids of Longiflorum × Asiatic(LA) of lilies(Lilium) using genomic in situ hybridization

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Journal of Genetics and Genomics 2008年第11期35卷 687-695页

作者： Shujun Zhou munikote S. ramanna richard G.E visser Jaap m. van Tuyl Institute of Landscape College of Agriculture ＆ Biotechnology Zhejiang University Hangzhou 310029 China Plant Breeding Lab Wageningen University P.O. Box 386 6700 AJ Wageningen The Netherlands

Longiflorum and Asiatic lilies of the genus Lilium of the family Liliaceae are two important groups of modem lily cultivars. One of the main trends of lily breeding is to realize introgression between these groups. With cut style pollination and em.r.o rescue, distant hybrids between the two groups have been obtained. However, the FI hybrids are highly sterile or some of them could produce a small number of 2n gametes, and their BC1 progenies are usually triploids. Dutch lily breeders have selected many cultivars from these BC1 progenies based on their variation. It is presumably suggested that such variation could be caused by intergenomic recombination and abnormal meiosis during gamete formation in F1 hybrids of Longiflorum × Asiatic （LA） hybrids in Lilium. Therefore, the meiotic process of ten F1 LA hybrids was cytologically investigated using genomic in situ hybridization and traditional cytological methods in the present research. The results showed that： at metaphase I, the homoeologous chromosome pairing among different F1 hybrids ranged from 2.0 to 11.4 bivalents formed by homoeologous chromosomes per pollen mother cell （PmC）, and very few multivalents, and even very few bivalents were formed by two chromosomes within one genome rather than homoeologous chromosomes in some PmCs; at anaphase I, all biva- lents were disjoined and most univalents were divided. Both the disjoined bivalents （half-bivalents） and the divided univalents （sister chromatids） moved to the opposite poles, and then formed two groups of chromosomes; because the two resulting half-bivalents retained their axes in the cell undisturbed, many crossover types, including single crossovers, three strand double crossovers, four strand double crossovers, four strand triple crossovers, and four strand multiple crossovers between the non-sister chromatids in the tetrads of bivalents, were clearly inferred by analyzing the breakpoints on the disjoined bivalents. The present investigation not only ex

关键词： Lilium genomic in situ hybridization abnormal meiosis crossover 2n gamete

microbial starch-binding domains are superior to granule-bound starch synthase I for anchoring luciferase to potato starch granules

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Progress in Natural Science:materials International 2006年第12期16卷 1295-1299页

作者： Jean-Paul VINCKEN Luc C.J.m. SUUrS richard G.F. visser Laboratory of Plant Breeding Department of Plant Sciences Wageningen University Wageningen The Netherlands

microbial starch-binding domains (SBD) and granule-bound starch synthase I (GBSSI) are proteins which are accumulated in potato starch granules. The efficiency of SBD and GBSSI for targeting active luciferase reporter proteins to granules during starch biosynthesis was compared. GBSSI or SBD sequences were fused to the N- or C-terminus of the luciferase (LUC) gene, via an artificial Pro-Thr encoding linker sequence. The genes were introduced into an amylose-free (amf) potato mutant. It appeared that SBD was superior to GBSSI as a targeting sequence, mainly because the luciferase retained higher activity in the SBD-containing fusion proteins than in the GBSSI-containing ones.

关键词： luciferase GBSS I SBD amf potato.

management of recurrent rectal cancer:A population based study in greater Amsterdam

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World Journal of Gastroenterology 2008年第39期14卷 6018-6023页

作者： roel Bakx Otto visser Judith Josso Sybren meijer J Frederik m Slors J Jan B van Lanschot Department of Surgery Academic Medical CentreAmsterdam AZ 1105Netherlands Com.r.hensive Cancer Centre Amsterdam Amsterdam CX 1066Netherlands Department of Surgery Free University Medical CentreAmsterdam HV 1081Netherlands Presently at the Erasmus medical Center Rotterdam CE 3015Netherlands

AIm： To analyze, retrospectively in a populationbased study, the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision （TmE）. mETHODS： All rectal carcinomas diagnosed during 1998 to 2000 and initially treated with a macroscopically radical resection （632 patients） were selected from the Amsterdam Cancer registry. For patients with recurrent disease, information on treatment of the recurrence was collected from the medical records. rESULTS： Local recurrence with or without clinically apparent distant dissemination occurred in 62 patients （10%）. Thirty-two patients had an isolated local recurrence. Ten of these 32 patients （31%） underwent radical re-resection and experienced the highest survival （three quarters survived for at least 3 years）. Eight patients （25%） underwent non-radical surgery （median survival 24 rno）, seven patients （22%） were treated with radio- and/or chemotherapy without surgery （median survival 15 mo） and seven patients （22%） only received best supportive care （median survival 5 too）. Distant dissemination occurred in 124 patients （20%） of whom 30 patients also had a local recurrence. The majority （54%） of these patients were treated with radio- and/or chemotherapy without surgery （median survival 15 mo）. Twenty-seven percent of these patients only received best supportive care （median survival 6 mo）, while 16% underwent surgery for their recurrence. Survival was best in the latter group （median survival 32 mo）. CONCLUSION： Although treatment options and survival are limited in case of recurrent rectal cancer after radical local resection obtained with TmE, patients can benefit from additional treatment, especially if a radical resection is feasible.

关键词： rectal cancer Total mesorectal excision Local recurrence relative survival

Prior-based Bayesian information criterion

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Statistical Theory and related Fields 2019年第1期3卷 2-13页

作者： m.J.Bayarria James O.Berger Woncheol Jang Surajit ray Luis r.Pericchi Ingm.r.visser Department of Statistics and Operations research University of ValenciaValenciaSpain Department of Statistical Science Duke UniversityDurhamNCUSA Department of Statistics Seoul National UniversitySeoulKorea School of mathematics and Statistics University of GlasgowGlasgowUK Department of mathematics University of Puerto RicoSan JuanPuerto Rico Department of Psychology University of AmsterdamAmsterdamNetherlands

We present a new approach to model selection and Bayes factor determination,based on Laplaceexpansions(as in BIC),which we call Prior-based Bayes Information Criterion(PBIC).In thisapproach,the Laplace expansion is only done with the likelihood function,and then a suitableprior distribution is chosen to allow exact computation of the(approximate)m.r.inal likelihoodarising from the Laplace approximation and the *** result is a closed-form expression similar to BIC,but now involves a term arising from the prior distribution(which BIC ignores)andalso incorporates the idea that different parameters can have different effective sample sizes(whereas BIC only allows one overall sample size n).We also consider a modification of PBIC whichis m.r. favourable to complex models.

关键词： Bayes factors model selection Cauchy priors consistency effective sample size Fisher information Laplace expansions robust priors

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90年代传染病的治疗

药学进展 1992年第3期16卷 173-177页

作者： m.r.zenberg-Arska m.r.visser 玉荣肖霞

虽然抗微生物药已使用50多年了,但仍有许多患者死于感染。在传染病的预防、治疗方面和研制、开发作用更强、更安全、广谱的抗微生物药方面均已取得了显著的进展。在增强和恢复人体对致病性或条件致病性微生物的免疫应答方面也作了大量... 详细信息

虽然抗微生物药已使用50多年了,但仍有许多患者死于感染。在传染病的预防、治疗方面和研制、开发作用更强、更安全、广谱的抗微生物药方面均已取得了显著的进展。在增强和恢复人体对致病性或条件致病性微生物的免疫应答方面也作了大量的工作。那么,为什么某些抗微生物药对严重感染的患者缺乏疗效?对这样一些感染我们该如何进行治疗?

关键词：传染病抗微生物疗法免疫疗法

科学严谨的患者信息登记是高质量胃癌外科研究的基石——荷兰上消化道癌症审计数据库11年经验分享

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中华胃肠外科杂志 2023年第2期26卷 148-153页

作者：王敬普 Eline m de Groot maurits r visser misha D.P Luyer Jelle P ruurda richard van Hillegersberg 荷兰乌特勒支大学医学中心外科部荷兰乌特勒支3584CX 荷兰临床审计研究所科学局荷兰莱顿2333AA 凯瑟琳那医院外科部荷兰埃因霍温5623EJ

随着过去数十年微创技术、围手术期康复干预和集中化医疗制度的逐步应用,胃癌术后30 d病死率和并发症发生率有了显著改善。然而,当前阶段的胃癌术后短期预后依然不容乐观,可能对胃癌手术治疗的疗效产生严重的负面影响,仍有很大的改善空... 详细信息

随着过去数十年微创技术、围手术期康复干预和集中化医疗制度的逐步应用,胃癌术后30 d病死率和并发症发生率有了显著改善。然而,当前阶段的胃癌术后短期预后依然不容乐观,可能对胃癌手术治疗的疗效产生严重的负面影响,仍有很大的改善空间。高质量的临床研究是分析治疗结果和评估新治疗策略的重要工具。因此,严谨的胃癌患者信息登记作为高质量外科研究的基础应受到足够重视。在过去的11年里,荷兰上消化道癌症审计(DUCA)数据库在上消化道肿瘤患者的数据登记和维护方面拥有丰富的经验,它在数据登记、数据质量控制、数据申请和使用以及数据安全等方面采取的有效措施,使得该数据库中患者数据的质量保持在较高水平。这些数据已被广泛用于医疗质量监测和科学研究,对改善上消化道癌症患者的术后短期预后产生了非常积极的影响。DUCA的工作可能对建立基于人群的临床数据库具有一定的参考价值。

关键词：胃肿瘤并发症荷兰上消化道癌症审计,数据库

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DB2通用数据库自学教程 1

Blood Volume Status in Patients with Chronic Fatigue Syndrome: relation to Complaints

1999年

作者：（美）Susan m.visser 王晓冬译

本书全面地讲述了DB2通用数据库5.0版所讨论如何满足从Web访问安装、配置、日常管理、命令、性能调整和错误诊断及解决方法，到深入讨论如何满足从Web访问数据库中的并行处理，并且通过一些实例和专家提供的技巧教你如何在最短的时间内... 详细信息

ISBN: (纸本)7900617922

本书全面地讲述了DB2通用数据库5.0版所讨论如何满足从Web访问安装、配置、日常管理、命令、性能调整和错误诊断及解决方法，到深入讨论如何满足从Web访问数据库中的并行处理，并且通过一些实例和专家提供的技巧教你如何在最短的时间内了DB2技术，创建、管理和优化DB2数据库。

关键词：关系型数据库数据库管理系统,DB2

来源：畅想之星图书光盘版（南... 评论

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International Journal of Clinical medicine 2018年第11期9卷 809-819页

作者： C. (Linda) m. C. van Campen Frans C. visser Stichting CardioZorg Hoofddorp The Netherlands

Four studies have compared a possible decrease in circulating blood volume in myalgic encephalomyelitis/chronic fatigue syndrome (mE/CFS) patients when compared to a healthy population. A m.r. recent study has proven a correlation between rBC volume and OI in chronic OI patients without being diagnosed mE/CFS. The aim of the present study was to relate measured blood, rBC and plasma volumes (absolute and percent normalized) with the orthostatic intolerance complaints in mE/CFS patients. In the included 11 female mE/CFS patients, percentage decrease in normalized blood, rBC and plasma volume was similar for all three components: 83% ±12%, 83% ±12% and 83% ±11%, respectively. In patients with a clinical suspicion of OI (n = 7) all 3 volume components were significantly lower compared to patients without clinical suspicion of OI (n = 4). The difference percentage to normalized Blood volume was 77(7) vs 94(10) (p-value rence percentage to normalized rBC volume was 76(7) vs 96(10) (p-value rence percentage to normalized plasma volume was 77(7) vs 93(10) (p-value resent versus absent. Plasma volumes were plotted against rBC volumes: the relation found was rBC volume = 0.99* Plasma volume + 1.55;p r = 0.90. In line with literature data, this pilot study shows that total blood volume and its components: rBC and plasma volume may be reduced in mE/CFS patients, especially in the presence of a clinical suspicion of OI.

关键词： Blood Volume Chronic Fatigue Syndrome Orthostatic Intolerance red Blood Cell Volume