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Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice

Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 391-400,I0008-I0291页

作者： swapnil Gavhane Chandrakant Gawli sachin Kumar Biswajit Das Gayatri Marathe vishal s.patil Harun M.Patel Basavaraj Bommanahalli Chanakya Nath Kundu Chandragouda R.patil R.C.Patel Institute of Pharmaceutical Education and Research Karwand NakaShirpurMaharashtra 425405India Department of Pharmacology Delhi Pharmaceutical Sciences and Research UniversityNew Delhi 110017India school of Biotechnology Kalinga Institute of Industrial TechnologyBhubaneshwar 751024India Gadag Institute of Medical sciences GadagKarnataka 582103India

Objective:To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis(IPF)and to explore its underlying mechanisms using network ***:IPF was induced in C57BL/6 mice by a single intratracheal instillation of bleomycin(5 mg/kg).Trigonelline was administered at doses of 25,50,and 100 mg/kg/day orally from the 2nd day post-bleomycin induction up to the 14th *** IPF-induced mice,lung coefficient,immune cell infiltration in bronchoalveolar lavage fluid,and oxidative stress were *** alterations in lung tissues were also ***,network pharmacology approach was conducted to reveal molecular interactions of bleomycin and trigonelline with targets of ***:Trigonelline treatment reduced bleomycin-induced oxidative stress and immune cell infiltration,and mitigated physiological changes in the lung tissues of ***,trigonelline alleviated bleomycin-induced histological alterations in lung *** pharmacology analysis showed that bleomycin and trigonelline interacted with IPF targets,such as NFKB1,HDAC2,HIF1A,and ***:The interaction of trigonelline with key IPF targets and its ameliorative effects on lung damage and oxidative stress highlight its potential in treating *** may be considered an antifibrotic agent for further clinical development.

关键词： Trigonelline Idiopathic pulmonary fibrosis Antifibrotic Bleomycin Network pharmacology

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Decoding bovine coronavirus immune targets:an epitope informatics approach

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Animal Diseases 2024年第2期4卷 138-153页

作者： swati Rani Mehnaj Khatoon Jagadish Hiremath Kuralayanapalya Puttahonnappa suresh Jayashree Anandakumar Nagendra Nath Barman sheethal Manjunath Yamini sri s sharanagouda s.patil spatial Epidemiology Lab ICAR-National Institute of Veterinary Epidemiology and Disease InformaticsYelahankaBengaluruKarnataka 560064India College of Veterinary science Assam Agricultural UniversityGuwahatiAssam 785013India Yuvaraja’s College Mysuru University of MysuruMysuruKarnataka 570005India

Bovine coronavirus(BCoV)poses a significant threat to the global cattle industry,causing both respiratory and gastrointestinal infections in cattle *** necessitates the development of efficacious *** several inactivated and live BCoV vaccines exist,they are predominantly limited to *** immunization of adult cattle is imperative for BCoV infection control,as it curtails viral transmission to calves and ameliorates the impact of enteric and respiratory ailments across all age groups within the *** study presents an in silico methodology for devising a multiepitope vaccine targeting *** spike glycoprotein(s)and nucleocapsid(N)proteins,which are integral elements of the BCoV structure,play pivotal roles in the viral infection cycle and immune *** constructed a remarkably effective multiepitope vaccine candidate specifically designed to combat the BCoV *** immunoinformatics technology,B-cell and T-cell epitopes were predicted and linked together using linkers and adjuvants to efficiently trigger both cellular and humoral immune responses in *** in silico construct was characterized,and assessment of its physicochemical properties revealed the formation of a stable vaccine *** 3D modeling of the vaccine construct,molecular docking revealed a stable interaction with the bovine receptor ***,the viability of the vaccine’s high expression and simple purification was demonstrated by codon optimization and in silico cloning expression into the pET28a(+)*** applying immunoinformatics approaches,researchers aim to better understand the immune response to bovine coronavirus,discover potential targets for intervention,and facilitate the development of diagnostic tools and vaccines to mitigate the impact of this virus on cattle health and the livestock *** anticipate that the design will be useful as a preventive treatment for BCoV sickness in cattle,opening the door for furthe

关键词： Immunoinformatics Bovine coronavirus Multiepitope vaccine Molecular docking In silico cloning

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Assessing the Viability of Gandhar Field in India’s Cambay Basin for CO_(2) storage

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哈尔滨工程大学学报（英文版） 2024年第3期23卷 529-543页

作者： Vikram vishal somali Roy Yashvardhan Verma Bharath shekar Department of Earth sciences Indian Institute of Technology BombayMumbai 400076India National Centre of Excellence in Carbon Capture and Utilization Indian Institute of Technology BombayMumbai 400076India

Our research is centered on the Gandhar oil field, which was discovered in 1983, where daily oil production has declined significantly over the years. The primary objective was to evaluate the feasibility of carbon dioxide(CO_(2)) storage through its injection into the siliciclastic reservoirs of Ankleshwar Formation. We aimed to obtain high-resolution acoustic impedance data to estimate porosity employing model-based poststack seismic inversion. We conducted an analysis of the density and effective porosity in the target zone through geostatistical techniques and probabilistic neural networks. simultaneously, the work also involved geomechanical analysis through the computation of pore pressure and fracture gradient using well-log data, geological information, and drilling events in the Gandhar field. Our investigation unveiled spatial variations in effective porosity within the Hazad Member of the Ankleshwar Formation, with an effective porosity exceeding 25% observed in several areas, which indicates the presence of well-connected pore spaces conducive to efficient CO_(2) migration. Geomechanical analysis showed that the vertical stress(sv) ranged from 55 MPa to 57 MPa in Telwa and from 63.7 MPa to 67.7 MPa in Hazad Member. The pore pressure profile displayed variations along the stratigraphic sequence, with the shale zone, particularly in the Kanwa Formation, attaining the maximum pressure gradient(approximately 36 MPa). However, consistently low pore pressure values(30-34 MPa) considerably below the fracture gradient curves were observed in Hazad Member due to depletion. The results from our analysis provide valuable insights into shaping future field development strategies and exploration of the feasibility of CO_(2) sequestration in Gandhar Field.

关键词： Carbon capture and storage Reservoir characterization seismic inversion Geomechanics CO_(2)storage CO_(2)enhancing oil recovery

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Progress in metal oxide-based electrocatalysts for sustainable water splitting

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Materials Reports(Energy) 2024年第3期4卷 19-34页

作者： Aasiya s.Jamadar Rohit sutar susmita patil Reshma Khandekar Jyotiprakash B.Yadav Vacuum Techniques and Thin Film Laboratory USICShivaji UniversityKolhapur416004MaharashtraIndia

Metal oxide-based electrocatalysts are promising alternatives to platinum group metals for water splitting due to their low cost,abundant raw materials,and impressive *** review covers recent progress in various metal oxides tailored for hydrogen and oxygen evolution reactions,discussing their crystal structure,composition,and surface modification influence on *** like surface engineering,doping,and nanostructuring are evaluated for enhancing catalytic activity and *** key considerations for commercialization are highlighted,emphasizing ongoing research,innovation,and future scope to drive widespread adoption of water-splitting technology for a cleaner and sustainable future.

关键词： Metal oxide HER OER Electrocatalyst Overall water spilling

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Fibrinogen’s potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 203-204页

作者： vishal singh Arnab Choudhury Hyung Jin Ahn Department of Pharmacology Physiology and NeurosciencesRutgers-New Jersey Medical SchoolNewarkNJUSA Brain Health Institute Rutgers UniversityPiscatawayNJUSA

Alzheimer’s disease(AD)stands out as the primary manifestation of age-related dementia,portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ)plaques and neurofibrillary tangles of hyperphosphorylated ***,from a clinical standpoint,AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological *** often-overlooked aspect of the disease is the presence of extensive cerebrovascular abnormalities,given that the majority of AD patients experience altered cerebral blood flow,damaged vasculature,increased microinfarcts and *** models of AD further support this observation,showing cerebrovascular dysfunction such as impaired cerebral blood flow and altered cerebrovascular reactivity(Tataryn et al.,2021;Gareau et al.,2023).

关键词： cerebrovascular dysfunction Alzheimer

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Clinical use of donor-derived cell-free DNA in kidney transplantation

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World Journal of Transplantation 2024年第4期14卷 61-66页

作者： vishal Jaikaransingh Bhaktidevi Makadia Hafiz s Khan Irtiza Hasan Department of Medicine Divison of NephrologyUniversity of Florida College of Medicine-JacksonvilleJacksonvilleFL 32209United States

Traditional monitoring of kidney transplant recipients for allograft dysfunction caused by rejection involves serial checks of serum creatinine with biopsy of the renal allograft if dysfunction is *** approach is labor-intensive,invasive and *** addition,because this approach relies on a rise in serum creatinine above historical baselines,injury to the allograft can be extensive before this rise *** an effort to address this,donor-derived cell-free DNA(dd-cf DNA)is being used with increasing frequency in the clinical setting as a means of diagnosing a rejection of the renal allograft early in the *** can poten-tially allow for early intervention to minimize not only injury,but the intensity of antirejection therapy needed and the avoidance of side ***,we will review the available methodology for the determination and quantification of dd-cf DNA,the data supporting its use in clinical practice and the limitations of this technology.

关键词： Kidney Transplant Donor-derived cell-free DNA Transplant rejection Biomarker

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Improved region growing segmentation for breast cancer detection:progression of optimized fuzzy classifier

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International Journal of Intelligent Computing and Cybernetics 2020年第2期13卷 181-205页

作者： Rajeshwari s.patil Nagashettappa Biradar Department of Electronics and Communication BLDEA’s V P Dr PG Halakatti College of Engineering and TechnologyBijapurIndia Department of Electronics and Communication Bheemanna Khandre Institute of TechnologyBidarIndia

Purpose-Breast cancer is one of the most common malignant tumors in women,which badly have an effect on women’s physical and psychological health and even danger to ***,mammography is considered as a fundamental criterion for medical practitioners to recognize breast ***,due to the intricate formation of mammogram images,it is reasonably hard for practitioners to spot breast cancer ***/methodology/approach-Breast cancer is one of the most common malignant tumors in women,which badly have an effect on women’s physical and psychological health and even danger to ***,mammography is considered as a fundamental criterion for medical practitioners to recognize breast ***,due to the intricate formation of mammogram images,it is reasonably hard for practitioners to spot breast cancer ***-The performance analysis was done for both segmentation and *** the analysis,the accuracy of the proposed IAP-CsA-based fuzzy was 41.9%improved than the fuzzy classifier,2.80%improved than PsO,WOA,and CsA,and 2.32%improved than GWO-based fuzzy ***,the accuracy of the developed IAP-CsA-fuzzy was 9.54%better than NN,35.8%better than sVM,and 41.9%better than the existing fuzzy ***,it is concluded that the implemented breast cancer detection model was efficient in determining the normal,benign and malignant ***/value-This paper adopts the latest Improved Awareness Probability-based Crow search Algorithm(IAP-CsA)-based Region growing and fuzzy classifier for enhancing the breast cancer detection of mammogram images,and this is the first work that utilizes this method.

关键词： Mammogram Breast cancer detection Optimized region growing Membership optimized-fuzzy classifier Improved crow search algorithm

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Characterization of early maturing elite genotypes based on MTsI and MGIDI indexes: an illustration in upland cotton(Gossypium hirsutum L.)

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Journal of Cotton Research 2024年第3期 253-265页

作者： D s RAJ supritha patil Rajesh s. patil Bhuvaneshwara R. NAYAK spurthi N. PAWAR Kasu N. Department of Genetics and Plant Breeding College of Agriculture University of Agricultural Sciences Agricultural Research station Department of Biotechnology College of Agriculture University of Agricultural Sciences Department of Crop Physiology College of Agriculture University of Agricultural Sciences

Background Globally, the cultivation of cotton is constrained by its tendency for extended periods of growth. Early maturity plays a potential role in rainfed-based multiple cropping system especially in the current era of climate change. In the current study, a set of 20 diverse Gossypium hirsutum genotypes were evaluated in two crop seasons with three planting densities and assessed for 11 morphological traits related to early maturity. The study aimed to identify genotype(s) that mature rapidly and accomplish well under diverse environmental conditions based on the two robust multivariate techniques called multi-trait stability index(MTsI) and multi-trait genotype-ideotype distance index(MGIDI).Results MTsI analysis revealed that out of the 20 genotypes, three genotypes, viz., NNDC-30, A-2, and s-32 accomplished well in terms of early maturity traits in two seasons. Furthermore, three genotypes were selected using MGIDI method for each planting densities with a selection intensity of 15%. The strengths and weaknesses of the genotypes selected based on MGIDI method highlighted that the breeders could focus on developing early-maturing genotypes with specific traits such as days to first flower and boll opening. The selected genotypes exhibited positive genetic gains for traits related to earliness and a successful harvest during the first and second pickings. However, there were negative gains for traits related to flowering and boll *** The study identified three genotypes exhibiting early maturity and accomplished well under different planting densities. The multivariate methods(MTsI and MGIDI) serve as novel approaches for selecting desired genotypes in plant breeding programs, especially across various growing environments. These methods offer exclusive benefits and can easily construe and minimize multicollinearity issues.

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some new results on time-varying stratonovich and Itô bilinear stochastic systems

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Journal of Control and Decision 2014年第4期1卷 283-298页

作者： Nanasaheb s.patil shambhu N.sharma Department of Electrical Engineering S.V.National Institute of TechnologySuratIndia

The bilinear stochasticity of dynamical systems is attributed to the input–output coupling term,where the input is a random input and the state is the output of dynamical *** influenced bilinear systems are described via bilinear stochastic differential *** this paper,first we construct a mathematical method for the closed-form solution to a scalar stratonovich time-varying bilinear stochastic differential equation driven by a vector random input as well as the Itô***,the analytic results of the paper are applied to an electrical circuit that assumes the structure of a bilinear stochastic dynamic *** noise analysis of the bilinear dynamic circuit is achieved by deriving the mean and variance equations as *** theory of this paper hinges on the‘stratonovich calculus’,conversion of the stratonovich integral into the Itôintegral and characteristic function of the vector Brownian *** results of this paper will be useful for research communities looking for estimation and control of bilinear stochastic differential systems.

关键词： bilinear stochasticity Itôcalculus stratonovich calculus characteristic function bilinear stochastic dynamic circuits

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Health Monitoring of Milling Tool Inserts Using CNN Architectures Trained by Vibration spectrograms

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Computer Modeling in Engineering & sciences 2023年第7期136卷 177-199页

作者： sonali s.patil sujit s.Pardeshi Abhishek D.Patange Department of Mechanical Engineering College of Engineering PunePune411005India

In-process damage to a cutting tool degrades the surface􀀀nish of the job shaped by machining and causes a signi􀀀cant􀀀nancial *** stimulates the need for Tool Condition Monitoring(TCM)to assist detection of failure before it extends to the worse *** Learning(ML)based TCM has been extensively explored in the last ***,most of the research is now directed toward Deep Learning(DL).The“Deep”formulation,hierarchical compositionality,distributed representation and end-to-end learning of Neural Nets need to be explored to create a generalized TCM framework to perform eciently in a high-noise environment of cross-domain *** this motivation,the design of dierent CNN(Convolutional Neural Network)architectures such as AlexNet,ResNet-50,LeNet-5,and VGG-16 is presented in this ***-time spindle vibrations corresponding to healthy and various faulty con􀀀gurations of milling cutter were *** data was transformed into the time-frequency domain and further processed by proposed architectures in graphical form,i.e.,*** model is trained,tested,and validated considering dierent datasets and showcased promising results.

关键词： Milling tool inserts health monitoring vibration spectrograms deep learning convolutional neural network

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