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Jamun(Syzygium cumini(L.)Skeels)seed bioactives and its biological activities:A review

Food Bioscience 2022年第6期50卷 2035-2050页

作者： Manoj Kumar Muzaffar Hasan Jose M.Lorenzo Sangram Dhumal Jyoti Nishad Nadeem Rais Aman Verma Sushil Changan Mrunal Deepak Barbhai Radha Deepak Chandran Ravi pandiselvam Marisennayya Senapathy Abhijit Dey prakash Chandra pradhan pran Mohankumar vishal p.deshmukh Ryszard Amarowicz Mohamed Mekhemar Baohong Zhang Chemical and Biochemical processing Division ICAR – Central Institute for Research on Cotton TechnologyMumbai400019India Department of Biology East Carolina UniversityGreenvilleNC27858USA Agro produce processing Division ICAR – Central Institute of Agricultural EngineeringBhopal462038India Centro Tecnológico de la Carne de Galicia rúa Galicia n◦4Parque Tecnológico de GaliciaSan Cibrao das Viñas32900OurenseSpain Área de Tecnología de los Alimentos Facultad de Ciencias de OurenseUniversidad de Vigo32004OurenseSpain Division of Horticulture RCSM College of AgricultureKolhapur416004MaharashtraIndia Department of Food Technology Shaheed Rajguru College of Applied Sciences for WomenUniversity of Delhi110096India Department of pharmacy Bhagwant UniversityAjmer305004India Division of plant Improvement and pest Management ICAR – Central Arid Zone Research Institute (CAZRI)JodhpurIndia Division of Crop physiology Biochemistry and Post-Harvest TechnologyICAR – Central Potato Research InstituteShimla171001India School of Biological and Environmental Sciences Shoolini University of Biotechnology and Management SciencesSolan173229India Department of Veterinary Sciences and Animal Husbandry Amrita School of Agricultural SciencesAmrita Vishwa Vidyapeetham UniversityCoimbatore642109Tamil NaduIndia Division of physiology Biochemistry and Post-Harvest TechnologyICAR – Central Plantation Crops Research Institute (CPCRI)Kasaragod671 124KeralaIndia Department of Rural Development and Agricultural Extension College of AgricultureWolaita Sodo UniversityWolaita SodoEthiopia Department of Life Sciences Presidency University86/1 College StreetKolkata700073West BengalIndia Sardarkrushinagar Dantiwada Agricultural University BanaskanthaGujarat385506India School of Agricultural Sciences Karunya Institute of Technology and SciencesCoimbatore641114Tamil NaduIndia Bharati Vidyapeeth (Deemed to be University) Yashwantrao Mohite Institute of ManagementKaradIndia Institute of Animal

Jamun(Syzygium cumini Skeels)is a nutritious fruit and has historically been used as both as an edible and a traditional *** jamun seed is an inedible by-product of the ***,their high concentration of phytochemicals makes them valuable components of *** studies on diverse biological activities of jamun seeds have warranted their application in human health and biomedical *** review paper discusses critically the phytochemical composition of jamun seeds and the bioactivities,including their antioxidant,anti-inflammatory,anti-cancer,antidiabetic,anti-microbial,anti-obesity,hepato-protective,cardio and gastro-protective *** bioactivity of jamun seed is related to the presence of phenols,flavonoids,steroids,alkaloids,triterpenoids,tannins,and *** research in vivo,and in vitro experiments with human and animal cell models support the idea that jamun seed extract can be valuable additions in food and biomedical fields due to the diverse bio-functional ***,in-depth and systematic in vivo clinical trials using human subjects must be conducted to confirm the safe consumption limit and establish other therapeutic roles of jamun seeds for their abundant utilization as a nutraceutical or pharmacological ***,research is required to understand the exact mechanisms of the bioactivities exhibited by jamun seeds.

关键词： Bioactivity Jamun seeds phytochemicals Health promoting activity

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Fibrinogen’s potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 203-204页

作者： vishal Singh Arnab Choudhury Hyung Jin Ahn Department of pharmacology Physiology and NeurosciencesRutgers-New Jersey Medical SchoolNewarkNJUSA Brain Health Institute Rutgers UniversityPiscatawayNJUSA

Alzheimer’s disease(AD)stands out as the primary manifestation of age-related dementia,portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ)plaques and neurofibrillary tangles of hyperphosphorylated ***,from a clinical standpoint,AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological *** often-overlooked aspect of the disease is the presence of extensive cerebrovascular abnormalities,given that the majority of AD patients experience altered cerebral blood flow,damaged vasculature,increased microinfarcts and *** models of AD further support this observation,showing cerebrovascular dysfunction such as impaired cerebral blood flow and altered cerebrovascular reactivity(Tataryn et al.,2021;Gareau et al.,2023).

关键词： cerebrovascular dysfunction Alzheimer

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Enhanced visible-light photocatalytic activity of samarium-doped zinc oxide nanostructures

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Journal of Rare Earths 2020年第1期38卷 29-38页

作者： Sukriti prakash Chand vishal Singh Department of physics National Institute of TechnologyKurukshetra 136119India Centre for Materials Science&Engineering National Institute of TechnologyHamirpur 177005India

In the present work,we have synthesized samarium doped zinc oxide nanostructures(Zn1-xSmxO;x=0.00,0.02,0.04 and 0.06) via chemical precipitation method and studied their structural,morphological,optical and photocatalytic properties.X-ray diffraction(XRD) patterns,pL and Raman spectra results indicate that the undoped and Sm-doped ZnO nanostructures are crystallized in a hexagonal wurtzite *** images show that the morphology of the sample changes from cubical to hexagonal nanostructures with increase in Sm3+doping *** EDX spectra confirm the incorporation of Sm3+ion in *** influence of Sm3+doping on the structure,morphology,absorption,emission and photocatalytic activity of ZnO nanostructures were investigated *** addition of Sm3+ion leads to a red shift in the optical energy band gap from 3.19 to 2.67 eV and hence,increases the visible light absorption *** presence of E2(H) and E1(LO) modes in microRaman spectra confirms the crystallinity and defects in the *** detailed photocatalytic experiments reveal that Sm-doped ZnO nanostructures show the maximum photodegradation efficiency for Methylene blue(MB) dye for x=0.04,i,e.,94.94%,under visible light *** photocatalytic efficiency improves by 6.98 times when ZnO is doped with rare earth metal ion(Sm3+) and is a potential candidate for practical *** investigation demonstrates that as-synthesized nano-sized photocatalysts act as an efficient photocatalyst for the degradation of MB dye.

关键词： photocatalysis Sm-doped ZnO FESEM Micro-Raman UV-Visible spectroscopy Rare earths

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Are outcomes for emergency index-admission laparoscopic cholecystectomy performed by hepatopancreatobiliary surgeons better compared to non-hepatopancreatobiliary surgeons?A 10-year audit using 1:1 propensity score matching

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Hepatobiliary & pancreatic Diseases International 2024年第6期23卷 586-594页

作者： Kai Siang Chan Samantha Baey vishal G Shelat Sameer p Junnarkar Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore

Background:Emergency index-admission cholecystectomy(EIC)is recommended for acute cholecystitis in most *** surgeons have less exposure in managing“difficult”*** study aimed to compare the outcomes of EIC between hepatopancreatobiliary(HpB)versus non-HpB ***:This is a 10-year retrospective audit on patients who underwent EIC from December 2011 to March *** who underwent open cholecystectomy,had previous cholecystitis,previous endoscopic retrograde cholangiopancreatography or cholecystostomy were excluded.A 1:1 propensity score matching(pSM)was performed to adjust for confounding variables(***≥75 years,history of abdominal surgery,presence of dense adhesions).Results:There were 1409 patients(684 HpB cases,725 non-HpB cases)in the unmatched ***(52.3%)of them were males with a mean age of 59.2±14.9 *** 472(33.5%)patients with EIC performed≥72 hours after presentation,40.1%had dense *** incidence of any morbidity,open conversion,subtotal cholecystectomy and bile duct injury were 12.4%,5.0%,14.6%and 0.1%,*** was one mortality within 30 days from *** resulted in 1166 patients(583 per group).Operative time was shorter when EIC was performed by HpB surgeons(115.5 vs.133.4 min,ppital stay was *** performed by HpB surgeons was independently associated with lower open conversion[odds ratio(OR)=0.24,95%confidence interval(CI):0.12–0.49,pp=0.032),but higher subtotal cholecystectomy(OR=4.19,95%CI:2.24–7.84,pparable between the two ***:EIC performed by HpB surgeons were associated with shorter operative time and reduced risk of open ***,the incidence of subtotal cholecystectomy was higher.

关键词： Bail-out Cholecystectomy Cholecystitis Open conversion Tokyo guidelines

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post-cholecystectomy bile leak is not always synonymous with acute bile duct injury:Need for reclassification

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Hepatobiliary & pancreatic Diseases International 2020年第5期19卷 492-494页

作者： vishal Gupta Department of Surgical Gastroenterology King George’s Medical UniversityLucknowUP 226003India

Bile leak after laparoscopic cholecystectomy remains a significant cause of postoperative *** duct stump is the most common site(~70%)of bile leak after cholecystectomy[1].Incidence of bile leak from the cystic duct stump is 0.5%−3%which is higher(4%−7%)in cases with complicated gallstone disease(*** cholecystitis)[2].Bile leak in postoperative period after cholecystectomy,manifesting as bile in intraoperatively placed drain or as an intrabdominal collection,localized or generalized,is considered a complication secondary to bile duct injury(BDI)that was sustained during the *** to the site of leak,such bile leak is classified as an iatrogenic BDI,and is subsequently categorised depending on the site of leak if that is localized on subsequent investigations.

关键词： bile cholecystectomy acute

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perspicacious Apprehension of HDTbNB Algorithm Opposed to Security Contravention

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Intelligent Automation & Soft Computing 2023年第2期35卷 2431-2447页

作者： Shyla vishal Bhatnagar NSUT East Campus(Formerly Ambedkar Institute of Advanced Communication Technologies and Research) Guru Gobind Singh Indraprastha UniversityNew Delhi110031India NSUT East Campus(Formerly Ambedkar Institute of Advanced Communication Technologies and Research) New Delhi110031India

The exponential pace of the spread of the digital world has served as one of the assisting forces to generate an enormous amount of informationﬂow-ing over the *** data will always remain under the threat of technolo-gical suffering where intruders and hackers consistently try to breach the security systems by gaining personal information *** this paper,the authors pro-posed the HDTbNB(Hybrid Decision Tree-based Naïve Bayes)algorithm toﬁnd the essential features without data scaling to maximize the model’s performance by reducing the false alarm rate and training period to reduce zero frequency with enhanced accuracy of IDS(Intrusion Detection System)and to further analyze the performance execution of distinct machine learning algorithms as Naïve Bayes,Decision Tree,K-Nearest Neighbors and Logistic Regression over KDD 99 *** performance of algorithm is evaluated by making a comparative analysis of computed parameters as accuracy,macro average,and weighted ***ﬁndings were concluded as a percentage increase in accuracy,precision,sensitiv-ity,speciﬁcity,and a decrease in misclassiﬁcation as 9.3%,6.4%,12.5%,5.2%and 81%.

关键词： Naïve bayes decision tree k-nearest neighbors logistic regression neighbors classiﬁer

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Visible light photocatalysis in the synthesis of pharmaceutically relevant heterocyclic scaffolds

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Organic Chemistry Frontiers 2022年第5期9卷 1485-1507页

作者： vishal Srivastava pravin K.Singh Shraddha Tivari praveen p.Singh Department of Chemistry CMP Degree CollegeUniversity of AllahabadPrayagraj 211002India Department of Chemistry United College of Engineering&ResearchNainiPrayagraj 211010India

Visible light and photoredox catalysis have emerged as a powerful and long-lasting tool for organic syn-thesis,demonstrating the importance of a variety of chemical bond formation *** products,physiologically active substances,medicines,and agrochemicals all contain heterocyclic *** impact of visible light-promoted chemistry on the functionalization of heterocycles as well as the syn-thesis and modification of heterocyclic compounds of medicinal importance is summarized in this review.

关键词： heterocyclic Visible synthesis

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Effect of pulse slippage on density transition-based resonant third-harmonic generation of short-pulse laser in plasma

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Frontiers of physics 2016年第4期11卷 163-170页

作者： vishal Thakur Niti Kant Department of physics Lovely Professional University Phagwara-144411 Punjab India

The resonant third-harmonic generation of a tion was investigated. Because of self-focusing self-focusing laser in plasma with a density transi- of the fundamental laser pulse, a transverse intensity gradient was created, which generated a plasma wave at the fundamental wave frequency. phase matching was satisfied by using a Wiggler magnetic field, which provided additional angular too- mentum to the third-harmonic photon to make the process resonant. An enhancement was observed in the resonant third-harmonic generation of an intense short-pulse laser in plasma embedded with a magnetic Wiggler with a density transition. A plasma density ramp played an important role in the self-focusing, enhancing the third-harmonic generation in plasma. We also examined the ef- fect of the Wiggler magnetic field on the pulse slippage of the third-harmonic pulse in plasma. The pulse slippage was due to the group-velocity mismatch between the fundamental and third-harmonic pulses.

关键词： short pulse laser pulse slippage third harmonic generation plasma

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power plant selection in a carbon constrained world the TERA(technoeconomic environmental risk analysis)

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航空动力学报 2009年第4期24卷 896-902页

作者： Stephen Ogaji pericles pilidis vishal Sethi Department of power and propulsion School of Engineering Cranfield University

There is an increasing concern that current trends of consumption of natural resources cannot *** is imperative that major targeted investments are made into economical and reliable environment friendly propulsion and power *** novel and promising concepts are being *** selection of the best candidates to pursue for investment becomes a very difficult choice.A detailed TERA(techno-economic environmental risk analysis) framework is described here to quantify risks and to compare and rank competing schemes on a formal and consistent *** technique is based on detailed and rigorous thermodynamic representations of power plants.A layer of environment,economic,weather and other models to describe the appropriate local conditions is superimposed to *** outcome is a techno-economic environmental risk analysis framework with appropriate detail of each power plant as applied to the appropriate *** results for each concept can then be compared and contrasted to make appropriate selections.

关键词： TERA(techno-economic environmental risk analysis) techno-economic risk analysis gas turbine multi-disciplinary optimisation(MDO)

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Withania somnifera (Ashwagandha):a Novel Source of L-asparaginase

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Journal of Integrative plant Biology 2009年第2期51卷 201-206页

作者： vishal p.Oza Shraddha D.Trivedi pritesh p.parmar R.B.Subramanian B.R.D.School of Biosciences Sardar Patel UniversityV.V.Nagar 388 120 (Gujarat)India B.R.D.School of Biosciences Sardar Patel UniversityV.V.Nagar 388120 (Gujarat)India

Different parts of plant species belonging to Solanaceae and Fabaceae families were screened for L-asparaginase enzyme （E.C.3.***.1.1.）. Among 34 plant species screened for L-asparaginase enzyme. Withania somnifera L. was identified as a potential source of the enzyme on the basis of high specific activity of the enzyme. The enzyme was purified and characterized from W. somnifera, a popular medicinal plant in South East Asia and Southern Europe. purification was carried out by a combination of protein precipitation with ammonium sulfate as well as Sephadex-gel filtration. The purified enzyme is a homodimer, with a molecular mass of 72 ± 0.5 kDa as estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresisand size exclusion chromatography. The enzyme has a pH optimum of 8.5 and an optimum temperature of 37 ℃. The Km value for the enzyme is 6.1 × 10^-2 mmol/L. This is the first report for L-asparaginase from W. somnifera, a traditionally used Indian medicinal plant.

关键词： Fabaceae L-asparaginase purification Sotanaceae Withania somnifera.

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