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Anticancer activity of Tephrosia purpurea and Ficus religiosa using MCF 7 cell lines

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Asian Pacific Journal of Tropical Medicine 2011年第7期4卷 526-529页

作者： vishal Gulecha Thangavel Sivakuma Nandha College of Pharmacy ErodeTamilnaduIndia

Objective:To investigate anticancer activity of different fractions of Tephrosia purpurea[TP] （Sharapunkha,Fabaceae） and Ficus religiosa[FR]（Peepal,Moraceae）.Methods:The fractions of TP and FR were prepared and tested for in vitro anticancer activity using human MCF 7 cell line by trypan blue exclusion ***:The result showed that among all these fractions of *** and FRIII showed better anticancer activity compared to other *** IC50 value for TPI（152.4μM）,TPIII（158.71μM）.FRI（160.3μM） and for FRIII（222.7μM） was ***:The present study shows anticancer potential of TP and FR fractions in MCF 7 cell line.

关键词： Tephrosia purpurea Ficus religiosa MCF 7 cell line trypan blue

Genetic Algorithm Based QoS Aware Adaptive Subcarrier Allocation in Cognitive Radio Networks

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Wireless Engineering and Technology 2015年第4期6卷 87-97页

作者： Dipak P. patil vishal A. Wankhede Vijay M. Wadhai Sant Gadge Baba Amravati University Amravat India

In this paper, an adaptive subcarrier allocation scheme with reconfiguration of operating parameters for Cognitive Radio Networks (CRN) is presented. A QoS-conscious spectrum decision frame work is projected, where spectrum bands are determined by considering the application requirements as well as the dynamic nature of the spectrum bands. The novel subcarrier allocation algorithm is developed to fulfill different performance objective as a solution for subcarrier allocation and power allocation problem for Cognitive Radio (CR) users in CRNs. It employs operating frequency parameter modification using Proportional Resource Algorithm and Genetic Algorithm (GA). The multi objective optimization problem with equality and inequality constraint is considered. Moreover, a dynamic subcarrier allocations scheme is developed based on GA to decide on the spectrum bands adaptively dependent on the time-varying CR network capacity. The proposed algorithm targets to achieve maximum data rate for each subcarrier, maximize the overall network throughput and maximize the number of satisfied user under the constraints of bandwidth and guarantee Quality of Service (QoS) requirement from dynamic spectrum management (DSM) perspective. Moreover, it determines the best available channel.

关键词： Cognitive Radio Genetic Algorithm QoS Subcarrier Allocation

Safety and Efficacy of Neoadjuvant DOF [Docetaxel, Oxaliplatin, 5-Fluorouracil] Chemotherapy Regimen in Patients with Locally Advanced Gastric and Gastro-Esophageal Junction Cancers: A Single Center Experience from India

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Journal of Cancer Therapy 2020年第5期11卷 237-250页

作者： vishal Kulkarni Satheesh Chiradoni Thungappa Shekhar patil Vinu Sarathy Kiran Pura Krishnamurthy Rajesh Kumar Radheshyam Naik Department of Medical Oncology Health Care Global Enterprises Ltd. Bangalore India

Background:?The role of chemotherapy in Gastric Cancer is constantly evolving?with various neoadjuvant and adjuvant strategies. Several chemotherapeutic agents are used in the treatment of locally advanced gastric cancer (LAGC) namely Platinum based compounds (Cisplatin, Oxaliplatin), Fluoropyrimidines like 5-Flurouracil [(5-FU), Capecitabine)], Taxanes (Docetaxel) and Anthracyclines (Epirubicin). Various doublet and triplet combination chemotherapy regimens have been used for neo-adjuvant chemotherapy (NACT) in LAGCs. In this study we evaluated the safety and efficacy of docetaxel based triplet regimen DOF [Docetaxel, Oxaliplatin, 5-Fluorouracil] in LAGC. Material and methods:?50 Newly diagnosed patients of Locally Advanced Gastric Cancer (stage II or III) deemed fit to receive chemotherapy were included in our study. After 3 cycles of neoadjuvant chemotherapy, patients were assessed based on radiological and pathological response.?Results: 50 Patients were included in our study of which majority were male (32), median age at presentation was 55 years and 24 patients presented with a history of gastrointestinal reflux disease (GERD). The most common hematological toxicities observed in our study were anemia (61.2%), neutropenia (42.6%, febrile neutropenia constituted 6%) and thrombocytopenia (13.2%). The most common gastro-intestinal [GI] toxicities observed in our study included nausea (69.2%), vomiting (31.2%), diarrhea (34%), oral mucositis (14%) and constipation (6.6%). We found that safety profile of DOF regimen was favorable with majority of patients tolerating the regimen well. The Overall Response Rate (68%), Disease Control Rate (96%) and Resectability Rate (80%) were higher compared to western studies. Pathological CR (17.5%), ypN0?disease status (42.5%) and nodal down staging (52%), all showed positive correlations with survival outcomes. Conclusion:?DOF regimen is an effective and feasible option for neoadjuvant treatment of LAGC in an Indian population

关键词： Locally Advanced Gastric Cancer (LAGC) Neoadjuvant Chemotherapy DOF (Docetaxel Oxaliplatin 5-Fluorouracil) Safety Toxicity

Erratum to:Chinia ***.—the second diatom genus simonsenioid raphe from mangroves in Fujian,China

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Journal of Oceanology and Limnology 2022年第3期40卷 1286-1286页

作者： Huina LIN Weiwei WU Lin SUN Andrzej WITKOWSKI Xiaoye LI vishal patil Junrong LIANG Xuesong LI Yahui GAO Changping CHEN School of Life Sciences and Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems Xiamen UniversityXiamen 361102China State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361102China Institute of Marine and Environmental Sciences University of SzczecinMickiewicza 16aPL-70-383 SzczecinPoland

Erratum to:https://***/10.1007/s00343-021-1067-0 The title of this article contains a few *** correct one is given below:Chinia ***.—a second diatom genus with the simonsenioid raphe type from mangroves in Fujian Pro... 详细信息

关键词： gen.nov Fujian Chi

Prospective Analysis of Patients Treated with Chemotherapy in Metastatic Adenocarcinoma of Lung—Single Centre Experience

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Journal of Cancer Therapy 2017年第9期8卷 838-844页

作者： B. J. Srinivasa L. P. Bhanu Girish Badarke Mohammad Nasiruddin Sulav Sapkota D. Tousif vishal Kulkarni P. K. Kiran Vinu Sarathy G. S. Deepika Amritanshu Ram Raghavendra Rao Shekar patil Radheshyam Naik Department of Medical Oncology HCG SC Bangalore India

Background: Lung cancer is the leading cause of cancer-related death worldwide with an estimated 1.6 million new cases diagnosed each year. According to standard guidelines in NSCLC, the effectiveness of combined chemotherapy regimen comprises of pemetrexed and platinum, and very few reports are available in Indian population. This study shows the experience with pemetrexed and platinum combination chemotherapy in metastatic NSCLC in first line setting. Methods: Total 61 patients with following inclusion criteria were recruited such as: 1) PS of 1 and 2;2) NSCLC of non-squamous histology;3) locally advanced or metastatic disease at diagnosis;4) should have received minimum 3 cycles of pemetrexed and platinum as first line treatment and or continued for 6 cycles;5) EGFR/ALK mutated or EGFR/ALK unknown patients but must have received upfront chemo. Primary endpoint of the present study is to assess Disease Control Rate (DCR) (CR + PR + SD). Progression Free Survival, OS and Toxicity assessment were secondary endpoints. Results: The mean number of average chemotherapy cycles was found to be 4.38. The range of chemotherapy was 2 - 6 cycles. Disease control rate, defined as (CR + PR + SD), was seen in 44 (72.1%) patients. (PR in 26 (42.62%), SD 18 (29.5%)), Progressive disease (PD) was observed in 17 (27.9%) patients. Overall study showed that patients had PFS of 9.414 months (95% CI 6.709 - 12.120) and OS of 13.437 months (95% CI 10.721 - 16.153). Conclusion: Pemetrexed and platinum combination is effective and well-tolerated chemotherapy regimen in patients with metastatic adenocarcinoma lung cancer patients. Pemetrexed and cisplatin may be more effective in particular. Early switch over to TKIs is preferred immediately after obtaining molecular subtype result.

关键词： Pemetrexed Carboplatin NSCLC Cisplatin EGFR