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中华高血压杂志 2020年第11期28卷 1097-1097页

作者：袁源(摘译) 练桂丽(审校) Carrizzo A Moltedo O Damato A Martinello K Di Pietro P Oliveti M Acernese F Giugliano G Izzo R Sommella E Migliarino S Piazza O Izzo C virtuoso n Strianese A Trimarco V Campiglia P Fucile S Puca A Trimarco B Vecchione C 不详

长期以来,高血压被认为是一种对健康构成主要威胁的疾病,尤其是脑卒中、心血管病和终末器官损害的危险因素。因此,需要确定一种控制血压和保护心血管的新型可替代的综合疗法。方法和结果:在2项双盲研究中纳入年龄40~68岁,服用降压药的... 详细信息

长期以来,高血压被认为是一种对健康构成主要威胁的疾病,尤其是脑卒中、心血管病和终末器官损害的危险因素。因此,需要确定一种控制血压和保护心血管的新型可替代的综合疗法。方法和结果:在2项双盲研究中纳入年龄40~68岁,服用降压药的未控制高血压患者69例。45例患者随机服用安慰剂或一种名为AkP05的新型营养合剂,在基线及4周治疗后评估血压、内皮功能和循环一氧化氮水平。

关键词：双盲研究安慰剂营养合剂一氧化氮心血管病控制血压内皮功能高血压患者

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neuroinflammation and glial activation in the central nervous system: a metabolic perspective

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neural Regeneration Research 2023年第5期18卷 1025-1026页

作者： Assunta virtuoso Ciro De Luca Sohaib Ali Korai Michele Papa Giovanni Cirillo Division of Human Anatomy Laboratory of Morphology of Neuronal Networks and Systems BiologyDepartment of Mental and Physical Health and Preventive MedicineUniversity of Campania“Luigi Vanvitelli”NaplesItaly

Decades of research in glial biology have investigated mechanisms of neuro-glial interplay,demonstrating that neurons and glia intimately cooperate for energy metabolism in the central nervous system(CnS)(Magistretti ... 详细信息

关键词： metabolism inflammation system

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Regional brain susceptibility to neurodegeneration: what is the role of glial cells?

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neural Regeneration Research 2020年第5期15卷 838-842页

作者： Andrea Beatriz Cragnolini Giorgia Lampitella Assunta virtuoso Immacolata Viscovo Fivos Panetsos Michele Papa Giovanni Cirillo Facultad de Ciencias Exactas Físicas y NaturalesUniversidad Nacional de CórdobaInstituto de Investigaciones Biológicas y Tecnológicas (IIByT)CONICET-Universidad Nacional de CórdobaCórdobaArgentina Human Anatomy and Laboratory of Morphology of neuronal networks Department of Mental and Physical Health and Preventive MedicineUniversity of Campania “Luigi VanvitelliNaplesItaly neuro-computing & neuro-robotics Research Group Universidad Complutense de MadridNeural Plasticity Research GroupInstituto Investigacion Sanitaria Hospital Clinico San CarlosMadridSpain

The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile *** in the neurodegenerative process,glial cells (including astrocytes,microglial cells,and oligodendrocytes) activate and trigger an insidious neuroinflammatory reaction,metabolic decay,blood brain barrier dysfunction and energy impairment,boosting neuronal *** these mechanisms might induce selective neuronal death in specific brain areas are far from being *** last two decades of neurobiological studies have provided evidence of the main role of glial cells in most of the processes of the central nervous system,from development to synaptogenesis,neuronal homeostasis and integration into,highly specific neuro-glial *** this mini-review,we moved from in vitro and in vivo models of neurodegeneration to analyze the putative role of glial cells in the early mechanisms of *** report changes of transcriptional,genetic,morphological,and metabolic activity in astrocytes and microglial cells in specific brain areas before neuronal degeneration,providing evidence in experimental models of neurodegenerative disorders,including Parkinson’s and Alzheimer’s *** these mechanisms might increase the insight of these processes and pave the way for new specific glia-targeted therapeutic strategies for neurodegenerative disorders.

关键词： astrocytes glial cells microglia neurodegenerative diseases neuroinflammation Parkinson's disease reactive gliosis selective neuronal degeneration

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Dynapenia in all-cause mortality and its relationship with sedentary behavior in community-dwelling older adults

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Sports Medicine and Health Science 2022年第4期4卷 253-259页

作者： Rizia Rocha Silva Lucas Lima Galvão Joilson Meneguci Douglas de Assis Teles Santos Jair Sindra virtuoso Júnior Sheilla Tribess Research Center on Physical Activity Health and AgingDepartment of Sport SciencesInstitute of Health SciencesFederal University of Triângulo MineiroUberabaMinas GeraisBrazil Department of Education University do Estado da BahiaTeixeira de FreitasBahiaBrazil

The aim of the present study was to investigate the relationship of dynapenia combined with sedentary behavior(SB)on the risk of mortality in older adults living in a Brazilian community.A total of 322 participants aged60 years from the ELSIA(Longitudinal Study of Elderly Health in Alcobaça)prospective cohort were *** was diagnosed when the handgrip strength wasn andnsidering the total time spent sitting during one day in the week and one day on the *** combined with dynapenia,we derived the construction of four groups:best behavior(absence of dynapenia and low SB),intermediate behavior(absence of dynapenia and high SB;presence of dynapenia and low SB)and worst behavior(presence of dynapenia and high SB).Mortality was assessed by the follow-up time until death and/or *** the 5-year follow-up of the study,55 participants progressed to *** the adjusted models,the dynapenia and the time spent exposed to SB were analyzed in a combined way,the older adults with worse behavior(high SB and dynapenia)had higher risk ratios for mortality(hazard ratio 2.46;95%confidence interval 1.01–5.97)than the best behavior *** adults with dynapenia are at greater risk for all-cause mortality,which is aggravated by the addition of longer exposure to SB.

关键词： Mortality Muscle strength Aging Sedentary behavior

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Design of Low Power Transmission Gate Based 9T SRAM Cell

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Computers, Materials & Continua 2022年第7期72卷 1309-1321页

作者： S.Rooban Moru Leela Md.Zia Ur Rahman n.Subbulakshmi R.Manimegalai Department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationVaddeswaramGunturAndhra Pradesh522502India Department of Electronics and Communication Engineering Francis Xavier Engineering CollegeTirunelveliTamil Nadu627003India Department of Computer Science and Engineering PSG Institute of Technology and Applied ResearchCoimbatoreTamil Nadu641062India

Considerable research has considered the design of low-power and high-speed *** integrated circuits with low-power consumption is an important issue due to the rapid growth of high-speed *** static random-access memory(SRAM)units are necessary components in fast mobile *** SRAM cells are more energyconsuming and with lower *** major constraints in SRAM cells are their reliability and low *** objectives of the proposed method are to provide a high read stability,low energy consumption,and better writing abilities.A transmission gate-based multi-threshold single-ended Schmitt trigger(ST)9T SRAM cell in a bit-interleaving structure without a write-back scheme is ***,an ST inverter with a single bit-line design is used to attain the high read stability.A negative assist technique is applied to alter the trip voltage of the single-ended ST *** multithreshold complementary metal oxide semiconductor(MTCMOS)technique is adopted to reduce the leakage power in the proposed single-ended TGST 9T SRAM *** proposed system uses a combination of standard and ST inverters,which results in a large read *** with the previous ST 9T,ST 11T,11T,10T,and 7T SRAM cells,the proposed cell is implemented in Cadence virtuoso ADE with 45-nm CMOS technology and consumes 35.80%,42.09%,31.60%,12.54%,and 31.60%less energy for read operations and 73.59%,93.95%,92.76%,89.23%,and 85.78%less energy for write operations,respectively.

关键词： Bit-interleaving low power SRAM cell schmitt trigger transmission gate

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采用130nm工艺技术的2．4Ghz CMOS浮动有源电感LnA的设计

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磁性元件与电源 2018年第11期 141-144,156页

作者： M.Muhamad n.Soin H.Ramiah 马来西亚玛拉工艺大学(UiTM)电气工程学院吉隆坡马来亚大学工程学院

本文介绍了CMOS有源电感集成电路的设计和优化。这种有源电感器采用silterra0．13μm技术，并使用Cadence virtuoso和Spectre RF进行仿真。该有源电感的中心频率为2.4GHz，符合IEEE 802．11b／g／n标准。为了减小硅芯片尺寸，在低噪声... 详细信息

本文介绍了CMOS有源电感集成电路的设计和优化。这种有源电感器采用silterra0．13μm技术，并使用Cadence virtuoso和Spectre RF进行仿真。该有源电感的中心频率为2.4GHz，符合IEEE 802．11b／g／n标准。为了减小硅芯片尺寸，在低噪声放大器LnA电路中使用有源电感代替无源电感。该电感器通过低噪声放大器电路进行测试和分析。并已经进行了基于LnA电路的有源和无源电感之间的比较。结果表明，该有源电感器在不牺牲噪声系数和LnA增益的情况下，芯片尺寸显著缩小，面积为73％，这是LnA中最重要的标准。最佳低噪声放大器提供20．7dB的功率增益（S21），噪声系数（nF）为2.1dB。

关键词：有源电感 CMOS LnA 技术设计低噪声放大器 802.11b/g virtuoso

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