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Effect of cleavable multi-copy antimicrobial peptide fusion expressed in transgenic Brassica napus

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Effect of cleavable multi-copy antimicrobial peptide fusion ...

Endogenous histamine inhibits the development of morphine-induced conditioned place preference

第十一届全国植物基因组学大会

作者： Renhu Liu,Xiaoyun Chen,Xiaofu Wang,Chunxiu Lang,Fulin Wang,Jinqing Chen~* Institute of virology and Biotechnology,zhejiang academy of agricultural sciences,hangzhou 31002.,china

Antimicrobial peptides(AMPs) are a diverse group of small soluble proteins with broad spectrum antimicrobial *** have been demonstrated to kill Gram negative and Gram positive bacteria,enveloped viruses,fungi pathogen...

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来源： cnki会议评论

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Acta Pharmacologica Sinica 2007年第1期28卷 10-18页

作者： Ying-xia GONG~2 Min LV~(2,3) Yong-ping ZHU~2 Yuan-yuan ZHU~2 Er-qing WEI~2 Hong SHI~3 Qun-li ZENG~2 Zhong CHEN~(2,4)2 department of Pharmacology and Neurobiology,School of Medicine,zhejiang University,hangzhou 310031,china 3 department of Pharmacology,zhejiang academy of Medical sciences,hangzhou 310031,china departmentofPharmacologyandNeurobiology SchoolofMedicineZhejiangUniversityHangzhou310031China departmentofPharmacology ZhejiangAcademyofMedicalSciencesHangzhou310031China

Aim:The conditioned place preference(CPP)paradigm was used to investigatethe effects of endogenous histamine on the processes leading to morphine-induced reward-seeking behavior in Sprague-Dawley ***:The modelof CPP was used to assess the rewarding effect of *** levels of histamine,glutamate,γ-aminobutyric acid(GABA),dopamine(DA)and 3,4-dihydroxyphenyl-acetic acid(DOPAC)in rat brains were measured with high-performance *** technique was used to observe themorphological changes of ***:Intraperitoneal injection of mor-phine(2,5 or 10 mg/kg)induced the development of CPP in a *** addition,morphine administrations(10 mg/kg)decreased the hista-mine content and reduced the number and size of histaminergic neurons in thetuberomammillary nucleus(TM),as well as markedly increasing the DOPAC/DAratios in the ventral tegmental area(VTA)and nucleus accumbens(NAc).Intra-peritoneal injection of histidine(50,100 or 200 mg/kg)dose-dependently inhibitedthe development of morphine-induced *** lesions of the TM,whichdecreased the histamine levels in the VTA and NAc,potentiated the developmentof CPP induced by morphine(1 mg/kg,a dose that produced no appreciable effectwhen given alone)and increased the DOPAC/DA ratios in the VTA and NAc,butdid not change the glutamate or GABA levels in these *** reversedthe effects of the TM ***:These results indicate that endog-enous histamine plays a role in inhibiting the development of morphine-inducedreward-seeking behavior,and the inhibition may involve the modulation of dopa-minergic activity.

关键词： conditioned place preference histamine morphine rat tuberomammillary nucleus

NEWLY RECORDED SPECIES OF FREE-LIVING NEMATODES FROM china (CHROMADORIDA,ENOPLIDA & ARAEOLAIMIDA)

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水生生物学报 1997年第4期21卷 319-321页

作者： Wu Jihua Liang Yanling and Sun Xida (Institute of Hydrobiology, the Chinese academy of sciences, Wuhang 430072) (department of Biology, hangzhou Normal College, hangzhou 310012)

The present paper embodies 11 species belonging to Chromadorida, Enoplida and Araeolaimida. All of these species are recorded from china for the first time. The genera Achromadora, Ironus, Triplina, Cylindrolaimus and... 详细信息

关键词： Free-living nemotodes Chromadorida Enoplida Araeolaimida New records

Bifurcation stabilization of nonlinear systems by dynamic output feedback with application to rotating stall control

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Science china(Information sciences) 2012年第1期55卷 200-213页

作者： CHEN PengNian1,QIN HuaShu2,WANG Yong3&HONG YiGuang2 1department of Mathematics,china Jiliang University,hangzhou 310018,china 2Institute of Systems Science,The Chinese academy of sciences,Beijing 100080,china 3department of Mechanics,Peking University,Beijing 100871,china 1. department of Mathematics China Jiliang University Hangzhou 310018 China2. Institute of Systems Science The Chinese Academy of Sciences Beijing 100080 China3. Department of Mechanics Peking University Beijing 100871 China

The paper deals with the problem of stabilization of stationary bifurcation solutions of nonlinear systems via dynamic output *** is emphasized that the parameter of the system is not directly *** introduce the concepts of uniform observability of the inverse of a function of state and input and N-order-input-to-state bifurcation *** on the concepts,we propose a new method for designing dynamic compensators that guarantee bifurcation stability for the closed-loop *** an example,we apply the general theory to active control of rotating stall in axial flow compressors by designing a stabilizing dynamic compensator for the three-state Moore-Greitzer model with a class of cubic compressor characteristics.

关键词： bifurcation control uniform observability dynamic output feedback rotating stall

Inelastic Scattering of Antiproton From ^(18)O

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Chinese journal of nuclear physics 1997年第2期19卷 73-76页

作者： Hu Sufen~1 Yang Chaoyun~2 Zhang Yushun~(3,4)1 department of Physics,zhejiang University,hangzhou 31002.2 department of Physics,The School of zhejiang Light Industry,Hanzhou 3100153 Institute of High Energy Physics,the Chinese academy of sciences,Beijing 1000394 CCAST(World Lab.),Beijing 100080, 浙江大学物理系浙江杭州浙江轻工业学校物理系浙江杭州 310015 中科院高能物理所北京

The differential cross sections of the inelastic scattering of antiproton leading to the2+ excited stae of 18O are calculated at 178.4 MeV by the Eikonal approximation and thecollective model of *** may be concluded t... 详细信息

关键词： Inelastic scattering Antiproton Eikonal approximation Collective model

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侵染人参果的马铃薯M病毒基因组全序列分析

微生物学报 2003年第3期43卷 336-341页

作者：郑红英陈炯陈剑平浙江省农业科学院病毒学与生物技术研究所

测定了侵染人参果的马铃薯M病毒 (PVM Ch)基因组全序列。线状、单链正义RNA全长 852 6bp ,含 6个开读框 (ORF) ,具麝香石竹潜隐病毒属 (GenusCarlavirus)典型结构特征。序列比较表明它与其他PVM分离物各基因核苷酸和编码蛋白氨基酸序列... 详细信息

测定了侵染人参果的马铃薯M病毒 (PVM Ch)基因组全序列。线状、单链正义RNA全长 852 6bp ,含 6个开读框 (ORF) ,具麝香石竹潜隐病毒属 (GenusCarlavirus)典型结构特征。序列比较表明它与其他PVM分离物各基因核苷酸和编码蛋白氨基酸序列同源性分别为62 5 %～ 97 2 %和 60 9%～ 97 4% ,其中CP基因最保守 ,而TGB3基因变异最大。系统进化树分析表明美国爱达荷州马铃薯分离物 (PVM Id) (AF0 2 3877)为PVM的一个远缘株系 ,而其他 4个PVM分离物的成簇在外壳蛋白 (Coatprotein ,CP)和核酸结合蛋白 (Nucleicacidbindingpro tein ,NABP)区域略有差异。这是PVM在人参果上侵染的首次报道。

关键词：侵染人参果序列分析马铃薯M病毒基因系统进化树基因组结构

Facile Synthesis of Amidines via Intermolecular Reductive Coupling of Nitriles with Azobenzene Promoted by Samarium Diiodide

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Chinese Chemical Letters 2000年第6期11卷 495-498页

作者： Zhi Fang LI Ping LU Yong Min ZHANG(department of Chemistry, zhejiang University (Xixi campus), hangzhou 31002.Laboratory of Organometallic Chemistry, Institute of Organic Chemistry Chinese academy of sciences, Shanghai 200032) zhejiang Univ Dept Chem Hangzhou 310028 Peoples R China Chinese Acad Sci Inst Organ Chem Organomet Chem Lab Shanghai 200032 Peoples R China

The intermolecular reductive coupling of nitrites with azobenzene induced by SmI2 was studied. Amidine derivatives were prepared in good yields under neutral and mild conditions.

关键词： synthesis samarium amidines nitriles azobenzene

Interactive Effects of Lead and Bensulfuron-Methyl on Decomposition of ^(14)C-Glucose in Paddy Soils

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Pedosphere 2009年第5期19卷 577-587页

作者： HOU Xian-Wen WU Jian-Jun XU Jian-Ming TANG Cai-Xian Institute of Soil and Water Resources and Environmental Science Zhejiang Provincial Key Laboratory of SubtropicalSoil and Plant Nutrition Zhejiang University Hangzhou 310029 （China） Institute of Environmental and Plant Protection Chinese Academy of Tropical Agricultural Sciences Danzhou 571737（China） department of agricultural sciences La Trobe University Victoria 3086 （Australia）

Little information is available on the interactive effects of inorganic and organic pollutants on carbon utilization by soil *** study examined the effects of two common soil pollutants,lead(Pb) and bensulfuron-methyl herbicide(BSM),on decomposition of an adscititious carbon source(14C-glucose).Two contrasting paddy soils,a silty clay soil and a clay loam soil,were incubated with different concentrations and combinations of pollutants for 60 *** rotatable central composite design was adopted to design the combinations of the pollutant concentrations so that rate response curves could be *** decomposition of 14C-glucose occurred in the first three days for both soils where no Pb or BSM was added(control).Overall,63%-64% of the added 14C-glucose was decomposed in the control over the 60-day *** addition of Pb or BSM significantly decreased the decomposition of 14C-glucose during the first week but increased the decomposition thereafter;as a result,the percentages of 14C-glucose decomposed(57%-77%) over the 60-day period were similar to or higher than those of the *** of the pollutants in combination did not further inhibit decomposition compared with the ***,decomposition rates were lower in the silty clay soil than in the clay loam soil,which was related to the soil texture,cation exchange capacity,and *** relationship between the decomposition rates and the pollutants could be well characterized by the quadratic regression orthogonal rotation *** initial antagonistic effects of the pollutants followed by the synergistic effects on microbial activity might result from changes of the concentrations of the pollutants.

关键词： carbon source compound pollution herbicide microbial activity

Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro

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Acta Pharmacologica Sinica 2007年第3期28卷 417-422页

作者： Hao-shu WU~(2,4) Juan-hong YU~(3,4) Ying-yin LI~2 Yu-she YANG~3 Qiao-jun HE~2 Yi-jia LOU~(2,5) Ru-yun JI~3 ~2department of Pharmacology and Toxicology,College of Pharmaceutical sciences,zhejiang University,hangzhou 310058,china ~3State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological sciences,Graduate School of the Chinese academy of sciences,Shanghai 201203,china department of Pharmacology and Toxicology College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China department of State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Graduate School of the Chinese Academy of Sciences Shanghai 201203 China

Aim:To examine the insulin sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative YY20 in insulin-sensitive cell ***:Theperoxisome proliferator-activated receptor γ（PPARγ）agonist bioactivities of YY20were detected by a preadipocyte differentiation ***-PCR and Westernblotting analysis were used to detect the expression of the target gene or *** effects of YY20 on insulin-mediated glucose consumption were determined inthe HepG2 human hepatocellular carcinoma ***:YY20 could enhancethe differentiation of preadipocytes to adipocytes and upregulate the gene ex-pression of PPARγ2,as well as the protein expression of insulin receptor sub-strate-1（IRS-1）,glucose transporter-4（GLUT4）,and adiponectin（ACRP30）.Theeffects on GLUT4 and ACRP30 could be reversed by the PPARγ inhibitor ***,YY20 efficiently reduced glucose consumptions in HepG2 cells after24 h culture,and the effects were related to insulin and YY20 ***:YY20,a potential insulin-sensitizing agent like rosiglitazone,couldenhance glucose consumption in HepG2 cells in a concentration-and insulin-dependent *** may improve the insulin resistance associated with type 2diabetes.

关键词： YY20 peroxisome proliferator-activated receptor y insulin sensitivity glucose consumption