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甲烷预混火焰自适应化学理论模拟及其与试验的比较

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中国电机工程学报 2005年第19期25卷 75-79页

作者：乔瑜徐明厚 viriato semi(A|~)o WILLIAM H.GREEN 华中科技大学煤燃烧国家重点实验室湖北省武汉市430074 里斯本高等技术学院麻省理工学院化学工程系

通常实际湍流火焰中不同燃烧区域的化学反应特性大不相同,且辐射在热传递过程中扮演了非常重要的角色。该文采用辐射模型离散坐标Do法来完善自适应化学理论。基于详细化学反应机理,在不同区域使用不同的简化反应模型来进行化学项的求解... 详细信息

通常实际湍流火焰中不同燃烧区域的化学反应特性大不相同,且辐射在热传递过程中扮演了非常重要的角色。该文采用辐射模型离散坐标Do法来完善自适应化学理论。基于详细化学反应机理,在不同区域使用不同的简化反应模型来进行化学项的求解。针对甲烷,空气预混火焰,该文对其燃烧行为进行了合理的重现,考虑辐射模型之后的计算结果与试验结果吻合得更好。

关键词：热能动力工程计算流体力学自适应化学理论辐射传热离散坐标法

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基于自适应化学理论的复杂CH_4燃烧模拟

中国电机工程学报 2004年第2期24卷 181-184页

作者：乔瑜徐明厚徐晓光 Pisi Lu viriato semi■o William H.Green 华中科技大学煤燃烧国家重点实验室湖北武汉430074 麻省理工学院化学工程系里斯本高等技术学院

麻省理工学院化工系的Green教授提出了自适应化学理论AdapChem的概念。这种方法根据反应条件的不同,分别使用多个简化化学反应模型而非复杂的详细基元反应模型进行区域内的数值模拟。该法提供了在保证化学精度条件下,避免效率浪费的一... 详细信息

麻省理工学院化工系的Green教授提出了自适应化学理论AdapChem的概念。这种方法根据反应条件的不同,分别使用多个简化化学反应模型而非复杂的详细基元反应模型进行区域内的数值模拟。该法提供了在保证化学精度条件下,避免效率浪费的一条有效途径。然而,为了完善AdapChem,引入以往没有考虑过的辐射模型是有必要的。为此,该文使用的是离散坐标法并对复杂CH4空气火焰进行了模拟,得到了较为理想的结果。

关键词：燃烧数值模拟 CH4 自适应化学理论化学反应模型离散坐标法

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考虑辐射传热的自适应化学理论数值计算

化工学报 2006年第1期57卷 21-26页

作者：乔瑜徐明厚乌里艾托.塞米艾尔威廉.格林华中科技大学煤燃烧国家重点实验室湖北武汉430074 里斯本高等技术学院麻省理工学院化学工程系

通常实际湍流火焰中不同燃烧区域的化学反应特性大不相同,且辐射在热传递过程中扮演了非常重要的角色.采用辐射模型离散坐标Do法来完善自适应化学理论.基于详细化学反应机理,在不同区域使用不同的简化反应模型来进行化学项的求解.针对甲... 详细信息

通常实际湍流火焰中不同燃烧区域的化学反应特性大不相同,且辐射在热传递过程中扮演了非常重要的角色.采用辐射模型离散坐标Do法来完善自适应化学理论.基于详细化学反应机理,在不同区域使用不同的简化反应模型来进行化学项的求解.针对甲烷/空气预混火焰,对其燃烧行为进行了合理的重现,考虑辐射模型之后的计算结果与试验结果吻合得更好.

关键词：计算流体力学自适应化学理论辐射传热离散坐标法

Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil

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World Journal of Gastroenterology 2015年第4期21卷 1197-1206页

作者： José Miguel Luz Parente Claudio Saddy Rodrigues Coy viriato Campelo Mírian Perpétua Palha Dias Parente Leonardo Araújo Costa Renata Mendes da Silva Celso Stephan José Murilo Robilotta Zeitune Center for Health Sciences Federal University of Piaui (Universidade Federal do Piauí - UFPI)TeresinaPiauí 64049-550Brazil Department of Surgery School of Medical SciencesState University of Campinas (Universidade Estadual de Campinas)CampinasS?o Paulo 13083-970Brazil Center of Health Sciences State University of Piaui (Universidade Estadual do Piauí - UESPI)TeresinaPiauí 64001-280Brazil Federal University of Piaui (Universidade Federal do Piauí - UFPI) TeresinaPiauí 64049-550Brazil Department of Public Health School of Medical SciencesState University of Campinas (Universidade Estadual de Campinas - Unicamp)CampinasS?o Paulo 13083-970Brazil Department of Internal Medicine School of Medical SciencesState University of Campinas (Universidade Estadual de Campinas - Unicamp)CampinasS?o Paulo 13083-970Brazil

AIM: To evaluate the demographic characteristics and clinical phenotypes of inflammatory bowel disease(IBD) in a geographic area in Northeastern ***: This retrospective study was conducted at the Hospital of the Federal University of Piauí in Northeastern Brazil. Demographic characteristics and clinical phenotypes of IBD were analyzed in relation to the time of diagnostic confirmation, which was defined as the date of disease onset. Data were collected between January 2011 and December 2012 and included all census patients 18 years of age or older during that period for whom there was diagnostic confirmation of Crohn's disease(CD), ulcerative colitis(UC), or unclassified colitis according to the Montreal criteria. We also analyzed the period of time between the onset of clinical manifestations and the diagnosis of IBD(delay in the diagnosis). Statistical analyses included means and standard deviations for numeric variables and the Pearson χ2 adherence test for nominal variables. The annual index occurrence and overall prevalence of IBD at our institution were also calculated, with P values oved by the Institutional Ethics and Research ***: A total of 252 patients with IBD were included, including 152(60.3%) UC patients and 100(39.7%) CD patients. The clinical and demographic characteristics of all patients with IBD showed a female to male ratio of 1.3:1.0 and a mean age of35.2(SD = 14.5) years. In addition, the majority of patients were miscegenated(171, 67.9%), had received higher education(157, 62.4%), lived in urban areas(217, 86.1%), and were under the age of 40 years(97, 62.5%). For patients with CD, according to the Montreal classification, the predominant features present from the onset of disease were an age between 17 and 40 years(A2); colonic disease location(L2); and nonstricturing, nonfistulizing disease behavior(B1). However, approximately one-quarter of all CD patie

关键词： Inflammatory bowel diseases Crohn’s disease Ulcera

Medicinal properties of Angelica archangelica root extract: Cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development

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Journal of Integrative Medicine 2019年第2期17卷 132-140页

作者： Carlos R.oliveira Daniel G.Spindola Daniel M.Garcia Adolfo Erustes Alexandre Bechara Caroline Palmeira-dos-Santos Soraya S.Smaili Gustavo J.S.Pereira André Hinsberger Ezequiel P.viriato Maria Cristina Marcucci Alexandra C.H.F.Sawaya Samantha L.Tomaz Elaine G.Rodrigues Claudia Bincoletto Departamento de Farmacologia Escola Paulista de Medicina (EPM) Universidade Federal de Sao Paulo (UNIFESP) Grupo de Fitocomplexos e Sinalizacao Celular Escola de Ciências da Saúde Universidade Anhembi Morumbi Faculdade de Ciências Farmacêuticas e Bioquímicas oswaldo Cruz Laboratório de Produtos Naturais e Quimiometria Programa de pós-graduacao em Farmácia e Biotecnologia Universidade Anhanguera de Sao Paulo Faculdade de Ciências Farmacêuticas Universidade Estadual de Campinas (UNICAMP) Unidade de oncologia Experimental EPM Universidade Federal de Sao Paulo (UNIFESP)

objective: Although Angelica archangelica is a medicinal and aromatic plant with a long history of use for both medicinal and food purposes, there are no studies regarding the antineoplastic activity of its *** study aimed to evaluate the cytotoxicity and antitumor effects of the crude extract of A. archangelica root(CEAA) on breast ***: The cytotoxicity of CEAA against breast adenocarcinoma cells(4T1 and MCF-7) was evaluated by a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide(MTT) assay. Morphological and biochemical changes were detected by Hoechst 33342/propidium iodide(PI) and annexin V/PI staining. Cytosolic calcium mobilization was evaluated in cells staining with FURA-4 NW. Immunoblotting was used to determine the effect of CEAA on anti-and pro-apoptotic proteins(Bcl-2 and Bax, respectively).The 4 T1 cell-challenged mice were used for in vivo ***: Using ultra-high-performance liquid chromatography–mass spectrometry analysis, angelicin, a constituent of the roots and leaves of A. archangelica, was found to be the major constituent of the CEAA evaluated in this study(73 mg/mL). The CEAA was cytotoxic for both breast cancer cell lines studied but not for human fibroblasts. Treatment of 4 T1 cells with the CEAA increased Bax protein levels accompanied by decreased Bcl-2 expression, in the presence of cleaved caspase-3 and cytosolic calcium mobilization, suggesting mitochondrial involvement in breast cancer cell death induced by the CEAA in this cell line. No changes on the Bcl-2/Bax ratio were observed in CEAA-treated MCF7 cells. Gavage administration of the CEAA(500 mg/kg) to 4T1 cell-challenged mice significantly decreased tumor growth when compared with untreated ***: Altogether, our data show the antitumor potential of the CEAA against breast cancer cells in vitro and in vivo. Further research is necessary to better elucidate the pharmacological application of the CEAA in breast cancer therapy.

关键词： Angelica archangelica Umbelliferae Apoptosis Cell death Breast cancer Angelicin

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“人类纪”时代迈向托勒密革命

工程研究（跨学科视野中的工程） 2014年第2期6卷 137-140页

作者：维里亚托.索罗梅纽.马奎斯陈晓利里斯本大学哈尔滨学院政法学院哈尔滨150086

解决"人类纪"的复杂性是一项艰巨的智力任务。我们对科学的态度将会经历戏剧性转变,不仅就其与技术的关系而言是如此,而且就其本身的自我理解——作为现代性产生以来的四百年中确立起来的关键社会建制的自我认同——而言也是如此。如果... 详细信息

解决"人类纪"的复杂性是一项艰巨的智力任务。我们对科学的态度将会经历戏剧性转变,不仅就其与技术的关系而言是如此,而且就其本身的自我理解——作为现代性产生以来的四百年中确立起来的关键社会建制的自我认同——而言也是如此。如果我们要真正了解什么是利害攸关的事情,复杂性便成为了一个关键词。本文首先对这个"人类纪"时代中科学复杂性的四个重要特征进行点评,而后重点分析了我们这个"人类纪"时代的挑战性迷宫,进而提出,只有满足两个基本条件,科学才会在当前危险的文明转型中发挥决定性作用。本文的贡献是为有待于"认知共同体"中的众多学者一道进行的理论探索进行思想准备。

关键词： “人类纪” 复杂性托勒密革命环境危机技术哲学