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Productive evaluation of slow-growing Mexican turkeys with different diets in confinement

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Open Journal of Animal Sciences 2013年第1期3卷 46-53页

作者： Elizabeth Pérez-Lara Marco Antonio Camacho-Escobar Narciso Ysac ávila-Serrano Jaime Arroyo-Ledezma Edgar Iván Sánchez-Bernal Mabel Rodríguez-dela Torre virginia reyes-borques Chila’s Bajos Mixtepec Oaxaca México Cuerpo Académico Ciencias Agropecuarias Universidad del Mar Campus Puerto Escondido Puerto Escondido México

Were assessed the effect of five traditional diets backyard turkeys in confinement. The experiment lasted 36 weeks, the turkeys were randomized to one of five diets: kitchen waste + fresh forage (T1), kitchen waste (T2), commercial feed + fresh forage (T3), cracked corn + fresh forage (T4) and commercial feed (T5). Food and water were provided ad libitum. Each treatment with birds of both sexes had two repetitions with four birds and each bird was considered as an experimental unit. Were evaluated daily weight gain, total weight gain, final live weight, total length peak-tail, monthly gain peak-tail, total length, total length of wings, monthly gain wings length, and feed cost. The data were analyzed in a completely randomized arrangement with adjusted means and Tukey’s mean comparison, then an evaluation of treatment groups by analyzing clusters for semi quantitative data. The biggest daily gain, total weight gain and final live weight was obtained with treatment T3, while the highest increase in peak-length tail and wings was obtained with treatment T1 (P < 0.05). T2 treatment turned out to be most economical, but the treatment that best scores obtained was T1. We conclude that the use of kitchen waste + fresh forage is a feasible strategy to feed slow-growing turkeys.

关键词： Creole Turkey Cost of Feed Fresh Forage Guajolote Meleagris Gallopavo Traditional Diets

Unique,Persistent,Resolvable:Identifiers as the Foundation of FAIR

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Data Intelligence 2020年第1期2卷 30-39,302页

作者： Nick Juty Sarala M.Wimalaratne Stian Soiland-reyes John Kunze Carole A.Goble Tim Clark Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK European Bioinformatics Institute(EMBL-EBI) HinxtonCambridgeCB101SDUK California Digital Library OaklandCalifornia 94612-2901USA Data Science Institute University of VirginiaCharlottesvilleVA 22903-1738USA

The FAIR principles describe characteristics intended to support access to and reuse of digital artifacts in the scientific research ***,globally unique identifiers,resolvable on the Web,and associated with a set of additional descriptive metadata,are foundational to FAIR *** we describe some basic principles and exemplars for their design,use and orchestration with other system elements to achieve FAIRness for digital research objects.

关键词： Identifiers metadata findability FAIR data data infrastructures

Tsunami of immunotherapy reaches mesothelioma

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World Journal of Clinical Oncology 2022年第4期13卷 267-275页

作者： Xabier Mielgo-Rubio Ana Cardena Gutierrez Veronica Sotelo Pena Maria virginia Sanchez Becerra Andrea Maria Gonzalez Lopez Adriana Rosero Juan Carlos Trujillo-reyes Felipe Counago Department of Medical Oncology Hospital Universitario Fundacion AlcorconAlcorcon 28922MadridSpain Department of Medical Oncology Hospital Universitario Nuestra Senora de CandelariaSanta Cruz de TenerifeCanarias 38010Spain Department of Medical Oncology Hospital Virgen de La LuzCuenca 16002Spain Department of Medical Oncology Hospital Universitario Del HenaresCoslada 28822MadridSpain Department of Thoracic Surgery Hospital Universitari de la Santa Creu i Sant PauUniversitat Autonoma de BarcelonaBarcelona 08029Spain Department of Radiation Oncology Hospital Universitario Quironsalud MadridPozuelo de Alcorcon 28223MadridSpain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department Universidad Europea de MadridVillaviciosa de Odon 28670MadridSpain

Malignant pleural mesothelioma(MPM) is the most common type of malignant mesothelioma. It is a rare tumor linked to asbestos exposure and is associated with a poor prognosis. Until very recently, patients with advanced or unresectable disease had limited treatment options, primarily based on doublet chemotherapy with cisplatin and pemetrexed. In 2020 and 2021, after more than a decade with no major advances or new drugs, two phase Ⅲ clinical trials published results positioning immunotherapy as a promising option for the first-and second-line treatment of MPM. Immunotherapy has revolutionized the treatment of many cancers and is also showing encouraging results in malignant mesothelioma. Both immune checkpoint inhibition and dual cytotoxic T-lymphocyte–associated antigen 4 and programmed death-ligand 1 pathway blockade resulted in significantly improved overall survival in randomized phase Ⅲ trials. In the Check Mate 743 trial, first-line therapy with nivolumab plus ipilimumab outperformed standard chemotherapy, while in the CONFIRM trial, nivolumab outperformed placebo in patients previously treated with chemotherapy. These two trials represent a major milestone in the treatment of MPM and are set to position immunotherapy as a viable alternative for treatment-naive patients and patients with progressive disease after chemotherapy.

关键词： Mesothelioma Malignant pleural mesothelioma Immunotherapy Immune checkpoint inhibitors Cytotoxic T-lymphocyte–associated antigen 4 Programmed cell death protein 1 Nivolumab Ipilimumab Immunotherapy combo Check Mate 743 CONFIRM

Acute liver failure secondary to acute antibody mediated rejection after compatible liver transplant: A case report

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World Journal of Hepatology 2022年第1期14卷 287-294页

作者： Todd J Robinson James B Hendele Idoia Gimferrer Nicolae Leca Scott W Biggins Jorge D reyes Lena Sibulesky Department of Surgery Virginia MasonSeattleWA 98101United States Department of Surgery University of Washington Medical CenterSeattleWA 98195United States Bloodworks Northwest SeattleWA 98104United States Department of Nephrology University of Washington Medical CenterSeattleWA 98195United States Department of Gastroenterology and Hepatology University of Washington Medical CenterSeattleWA 98195United States

BACKGROUND The liver has traditionally been regarded as resistant to antibody-mediated rejection(AMR).AMR in liver transplants is a field in its infancy compared to kidney and lung *** our case we present a patient with alpha-1-antitrypsin disease who underwent ABO compatible liver transplant complicated by acute liver failure(ALF)with evidence of antibody mediated rejection on allograft biopsy and elevated serum donor-specific antibodies(DSA).This case highlights the need for further investigations and heightened awareness for timely *** SUMMARY A 56 year-old woman with alpha-1-antitrypsin disease underwent ABO compatible liver transplant from a deceased *** recipient MELD at the time of transplant was *** flow cytometric crossmatches were noted to be positive for T and B *** patient had an uneventful recovery *** on postoperative day 5 the patient developed fevers,elevated liver function tests,distributive shock,renal failure,and hepatic *** went into ALF with evidence of antibody mediated rejection with portal inflammation,bile duct injury,endothelitis,and extensive centrizonal necrosis,and C4d staining on allograft biopsy and elevated *** various interventions including plasmapheresis and immunomodulating therapy,she continued to *** was relisted and successfully underwent liver *** This very rare case highlights AMR as the cause of ALF following liver transplant requiring retransplantation.

关键词： Liver transplant Acute antibody mediated rejection Acute liver failure Donor specific antibody Liver rejection Case report

Evaluation of the Marginal Adaptation in Metal Crowns Using CAD/CAM and Manual Wax Patterns

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Microscopy Research 2015年第2期3卷 26-32页

作者： Alan Sepulveda-Rodríguez Felipe Guerrero-Martínez César Gaitan-Fonseca Takashi Komabayashi Enrique reyes-Vela David Masuoka Department of Stomatology Universidad Autónoma de Aguascalientes Aguascalientes Mexico Faculty of Dentistry Universidad Autónoma de San Luis Potosí San Luis Potosí Mexico Department of Endodontics West Virginia University Charleston USA

The aim of this study is to evaluate the maximum and minimum distances between the model and the cast crown of three techniques using Scanning Electron Microscopy (SEM). Three technique groups were used for this study: group A (control), traditional manual wax patterns;group B, dipping wax patterns;group C, resin patterns made with CAD/CAM. For each group, 10 samples were made using the same model, and then metal cast. Marginal accuracies of the samples were evaluated by performing gap measurements using SEM with a magnification of 1200× (minimum distance). The data were statistically analyzed using the one-way analysis of variance (ANOVA) at the 0.05 significance level. The average (standard deviation) of the minimum distance [μm] was 22.5 (12.1), 9.9 (4.3), and 14.7 (6.6), in groups A, B, and C, respectively. The average standard deviation of gap area [μm2] was 21667.2 (3476.4), 9906.4 (1512.1), and 16048.8 (8123). In the minimum distance comparison, groups A and B (p = 0.006) showed statistically significant results. In the gap area comparison, there was no statistical significance among groups A, B, and C (p = 0.174). The marginal adaptations of all three techniques were within a reported clinically acceptable range of margin.

关键词： Marginal Adaptation CAD/CAM Metal Caps Wax Pattern

小胶质细胞在多种实验性癫痫发作模型中发挥有益作用

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神经损伤与功能重建 2023年第6期18卷 F0003-F0003页

作者： Synphane Gibbs-Shelton Jordan Benderoth Ronald P Gaykema Justyna Straub Kenneth A Okojie Joseph O Uweru Dennis H Lentferink Binita Rajbanshi Maureen N Cowan Brij Patel Anthony Brayan Campos-Salazar Edward Perez-reyes Ukpong B Eyo 杜一星(编译) Brain Immunology and Glia Center University of VirginiaCharlottesvilleVirginiaUSA Department of Pharmacology University of VirginiaCharlottesvilleVirginiaUSA Department of Neuroscience University of VirginiaCharlottesvilleVirginiaUSA Neuroscience Graduate Program University of VirginiaCharlottesvilleVirginiaUSA 不详

癫痫发病率高,影响各年龄层次,包括年轻人和老年人。目前临床上使用的抗癫痫药物都是根据已知的以神经元为中心的机制研发,但有约1/3的患者对现有药物的治疗无效。因此,有必要对癫痫产生和持续的其他替代和补充机制进行研究。神经炎症,... 详细信息

癫痫发病率高,影响各年龄层次,包括年轻人和老年人。目前临床上使用的抗癫痫药物都是根据已知的以神经元为中心的机制研发,但有约1/3的患者对现有药物的治疗无效。因此,有必要对癫痫产生和持续的其他替代和补充机制进行研究。神经炎症,广义上定义为中枢神经系统中免疫细胞和分子的激活。研究发现,神经炎症促进癫痫的发生,但参与该病理生理过程的特定细胞尚不清楚。小胶质细胞是大脑的主要炎症细胞。因为既往研究使用的方法对小胶质细胞的特异性较低,或者存在固有的混淆,所以小胶质细胞的作用一直存在争议。使用一种选择性靶向小胶质细胞的方法(以避免上述副作用),我们发现了小胶质细胞在限制化学惊厥、电性和高热性癫痫发作方面有广泛有益作用,并进一步发现小胶质细胞对控制癫痫发作的作用。

关键词： CSF1R PLX3397 炎症小胶质细胞癫痫发作