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T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets

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World Journal of Gastroenterology 2014年第46期20卷 17416-17425页

作者： Luis A Videla virginia fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesFaculty of MedicineUniversity of ChileIndependencia 1027SantiagoChile School of Medical Technology Faculty of MedicineDiego Portales UniversityEjército 141SantiagoChile

AIM: To investigate the redox dependency and promotion of downstream targets in thyroid hormone (T3)-induced AMP-activated protein kinase (AMPK) signaling as cellular energy sensor to limit metabolic stresses in the l... 详细信息

关键词： Liver Thyroid hormone N-acetylcysteine AMP-activated protein kinase Fatty acid oxidation

Embodying Deeply Held Values in Education:Seeking a More Equitable World for Both Humans and Non-Humans

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ECNU Review of Education 2024年第2期7卷 241-251页

作者：林静 Shue-kei Joanna Mok virginia Gomes Department of Counseling Higher Education and Special EducationCollege of Education3214 Benjamin BuildingUniversity of MarylandCollege ParkMD20742USA

Highlights In this article,we contend that the bedrock of an equitable world lies in the profound recognition of love as the fundamental force permeating the *** believe that love is built into the essence of who we *** posit that genuine progress toward an equitable world is elusive unless we place love,both for one another and for the natural world,at the core of our educational endeavors.

关键词： Embodied practices heart and spirit love and equity love as a cosmic force

Ca-based materials derived from calcined cigarette butts for CO_(2)capture and thermochemical energy storage

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Journal of Environmental Sciences 2024年第6期140卷 230-241页

作者： Nabil Amghar virginia Moreno Pedro E.Sánchez-Jiménez Antonio Perejón Luis A.Pérez-Maqueda Instituto de Ciencia de Materiales de Sevilla C.S.I.C.-Universidad de SevillaC.Américo Vespucio4941092 SevillaSpain Instituto de Tecnología de Materiales(ITM) Universitat Politècnica de València(UPV)Plaza Ferrándiz y Carbonell 1AlcoyAlicante 03801Spain Departamento de Química Inorgánica Facultad de QuímicaUniversidad de Sevilla41012 SevillaSpain

Cigarette butts(CBs)are one of the most common types of litter in the *** to the toxic substances they contain,the waste generated poses a harmful risk to the environment,and therefore there is an urgent need for alternative solutions to landfill ***,this work presents a possible revalorization of this waste material,which implies interesting environmental *** were used as sacrificial templates for the preparation of CaO-based materials by impregnation with calcium and magnesium nitrates followed by flaming *** materials presented enhanced porosity for their use in the Calcium Looping process applied either to thermochemical energy storage or CO_(2)capture *** influence of the concentration of Ca and Mg in the impregnating solutions on the multicycle reactivity of the samples was *** improved multicycle performance was obtained in terms of conversion for both applications.

关键词： Cigarette butts Calcium-Looping CO_(2)Capture Thermochemical energy storage

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False Positive HIV “Combo” Screening Test in a Hemodialysis Patient in Saudi Arabia: A Case Report and Review of the Literature

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Case Reports in Clinical Medicine 2024年第9期13卷 366-374页

作者： Ngozi virginia Aikpokpo Ahmed Yayha Omaysh Diaverum AB Saudi Arabia Riyadh KSA Department of Health University of Bath Claverton Down Bath UK

Introduction: HIV screening tests are routinely conducted on dialysis patients as the constant exposure of their blood during the dialysis process makes them a reasonable risk for blood-borne infections. However, in low prevalence settings, where HIV rates are <0.1% of the population, false positive results are more likely. This results in apprehension in the dialysis unit as breaches in infectious disease protocols could be presumed. This is illustrated in the case report below. Case Summary: A 62-year-old male Saudi end-stage kidney disease patient secondary to DM nephropathy began dialysis a year before presentation in a hemodialysis center in Saudi Arabia. Routine screening tests done at the start of dialysis revealed negative Hepatitis C, HIV 1 and 2 screening but a positive Hepatitis B surface antigen screen. The patient went for holiday dialysis at another facility and had a routine fourth-generation HIV test done which was positive. A confirmatory HIV PCR test was negative. Conclusion: This case highlights the need for caution in interpreting highly sensitive and specific HIV screening tests in a low-prevalence setting. Routine screening beyond the national recommendation may not be necessary in low-prevalence areas.

关键词： Saudi Arabia False Positive HIV Test Hemodialysis

Characterization of Arroyo Verde Epithermal Deposit:Paragenesis,Mineral Geochemistry,Geochronology and Fluid Inclusions in Lower Chon Aike Volcanism,Argentina

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Journal of Earth Science 2024年第1期35卷 62-84页

作者： Cecilia Pavón Pivetta Leonardo Benedini Paulo Marcos Ma.Agustina Cócola Mercedes virginia Barros Daniel Gregori Leonardo Strazzere Anderson Costa dos Santos Mauro C.Geraldes Instituto Geologico del Sur(INGEOSUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Universidad Nacional de Rio Negro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Universidade do Estado do Rio de Janeiro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Geobiotec Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is located within the Lower Chon Aike volcanism and is developed between 192.6±2.5 Ma(mineralization host rock)and 189.5±2.6 Ma(overlying lava).Marifil volcanic complex is the host rock for these veins,veinlets and *** particular small deposit has developed low to intermediate sulphidation characteristics,with gangue mineral textures associated with several ore *** probe microanalysis determines electrum,silver minerals such as acanthite,and tetrahedrite,related Ag-Cu minerals like jalpaite,mckinstryite,stromeyerite,and base metals like chalcopyrite,sphalerite,galena and *** inclusions in quartz of two out of five events indicate that these Low Jurassic veins were formed due to subtle boiling and dilution mechanisms and by low-salinity(3.4 wt.%to 6.7 wt.%NaCl Eq)magmatic-hydrothermal fluid at 225 to 310℃.The fluid inclusion measurements that indicate boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 *** particular character has not been previously recorded for other sectors of the eastern north Patagonian region.

关键词： epithermal deposit Ag minerals mineral geochemistry fluid inclusions Chon Aike geochronology

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Mathematical Modeling of HIV Investigating the Effect of Inconsistent Treatment

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1063-1078页

作者： Sr Mary Nyambura Mwangi virginia M. Kitetu Isaac O. Okwany Department of Mathematics and Actuarial Science Catholic University of Eastern Africa Nairobi Kenya

HIV is a retrovirus that infects and impairs the cells and functions of the immune system. It has caused a great challenge to global public health systems and leads to Acquired Immunodeficiency Syndrome (AIDS), if not attended to in good time. Antiretroviral therapy is used for managing the virus in a patient’s lifetime. Some of the symptoms of the disease include lean body mass and many opportunistic infections. This study has developed a SIAT mathematical model to investigate the impact of inconsistency in treatment of the disease. The arising non-linear differential equations have been obtained and analyzed. The DFE and its stability have been obtained and the study found that it is locally asymptotically stable when the basic reproduction number is less than unity. The endemic equilibrium has been obtained and found to be globally asymptotically stable when the basic reproduction number is greater than unity. Numerical solutions have been obtained and analyzed to give the trends in the spread dynamics. The inconsistency in treatment uptake has been analyzed through the numerical solutions. The study found that when the treatment rate of those infected increases, it leads to an increase in treatment population, which slows down the spread of HIV and vice versa. An increase in the rate of treatment of those with AIDS leads to a decrease in the AIDS population, the reverse happens when this rate decreases. The study recommends that the community involvement in advocating for consistent treatment of HIV to curb the spread of the disease.

关键词： HIV Modeling Mathematical Modeling Reproduction Number Inconsistent Treatment

Mathematical Modeling of the Co-Infection Dynamics of HIV and Tuberculosis Incorporating Inconsistency in HIV Treatment

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Journal of Applied Mathematics and Physics 2024年第5期12卷 1744-1768页

作者： Sr Mary Nyambura Mwangi virginia M. Kitetu Isaac O. Okwany Department of Mathematics and Actuarial Science Catholic University of Eastern Africa Nairobi Kenya

A non-linear HIV-TB co-infection has been formulated and analyzed. The positivity and invariant region has been established. The disease free equilibrium and its stability has been determined. The local stability was determined and found to be stable under given conditions. The basic reproduction number was obtained and according to findings, co-infection diminishes when this number is less than unity, and persists when the number is greater than unity. The global stability of the endemic equilibrium was calculated. The impact of HIV on TB was established as well as the impact of TB on HIV. Numerical solution was also done and the findings indicate that when the rate of HIV treatment increases the latent TB increases while the co-infected population decreases. When the rate of HIV treatment decreases the latent TB population decreases and the co-infected population increases. Encouraging communities to prioritize the consistent treatment of HIV infected individuals must be emphasized in order to reduce the scourge of HIV-TB co-infection.

关键词： Co-Infection Modeling HIV-TB Co-Infection Mathematical Modeling Reproduction Number Inconsistent Treatment

Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation

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Neural Regeneration Research 2020年第3期15卷 407-415页

作者： Heather R.Lucas Ricardo D.fernández Department of Chemistry Virginia Commonwealth University

N-acetylatedα-synuclein(αSyn)has long been established as an intrinsically disordered protein associated with a dysfunctional role in Parkinson’s *** recent years,a physiologically relevant,higher order conformation has been identified as a helical tetramer that is tailored by buried hydrophobic interactions and is distinctively aggregation *** canonical mechanism by which the tetramer assembles remains *** novel biochemical approaches,computational methods,pioneering purification platforms,and powerful imaging techniques continue to develop,puzzling information that once sparked debate as to the veracity of the tetramer has now shed light upon this new counterpart inαSyn *** magnetic resonance and computational studies on multimericαSyn structure have revealed that the protein folding propensity is controlled by small energy barriers that enable large scale ***,familial mutations ablate tetramerization and reconfigure polymorphic *** this review,we will discuss the dynamic landscape ofαSyn quaternary structure with a focus on the tetrameric conformation.

关键词： alpha-synuclein amyloid fibrils intrinsically disordered protein multimer N-acetylation oligomer Parkinson’s disease protein folding protein structure tetramer

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Evaluating methods to quantify sediment volumes trapped behind check dams,Saldana badlands(Spain)

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International Journal of Sediment Research 2017年第1期32卷 1-11页

作者： Iván Ramos-Diez Joaquín Navarro-Hevia Roberto San Martín fernández virginia Díaz-Gutiérrez Jorge Mongil-Manso Department of Agricultural and Forestry Engineering University of Valladolid Sustainable Forest Management Research Institute Department of Statistics and Operations Research.University of Valladolid Hydrology and Conservation Research Group.Catholic University of vila

The determination of sediment yield in catchments based on the sediment trapped by check dams is becoming a subject of *** fact,several methods have been developed in recent years to estimate the sediment retained by check *** complexity,precision and accuracy of each method vary *** this study,we evaluate the sediment trapped by check dams comparing the Sections method respect to the Prism,Pyramid,DTMs and Trapezoid *** analyzed a sample of 25 check dams(α-1=90%;ε=10%) in the Saldana badlands(Spain).The results showed that the Sections method offered a volume of retained sediment between the others,which gave an absolute variation from 22%to40%.The high variability of the check dam and sediment wedge sizes made necessary to compare methods in groups combining both *** significant differences in sediment volumes could be found between the methods for very small(height(h):1.8-2.3 m;trapped volume(V):6-102 m3) or large check dams(h > 2.3 m;V:165-387 m3),while significant differences are found for small(h < 1.5 m;V:1-229 m3) or middle-sized check dams(h:2.2-3.2 m;V:65-235 m3).Nevertheless,volume differences between groups ranged up to + 25%.For these reason,the size of the check dam,the shape of the sediment wedge and the accuracy of the measure methods must considered when selecting an appropriate method to obtain the volume of retained sediment by check dams.A correct estimation of the sediment retention is needed to evaluate the role and efficiency of check dams in restoration projects or to estimate sediment yields.

关键词： Erosion Gullies Check dam construction Sediment retention Erosion models Topographic survey