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Thinking beyond Opisthorchis viverrini for risk of cholangiocarcinoma in the lower Mekong region:a systematic review and meta-analysis

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Infectious Diseases of Poverty 2018年第1期7卷 427-439页

作者： Jennifer A.Steele Carsten H.Richter Pierre Echaubard Parichat Saenna virginia Stout Paiboon Sithithaworn Bruce A.Wilcox Department of Infectious Disease and Global Health Tufts UniversityCummings School of Veterinary MedicineNorth GraftonMAUSA Global Health Asia Integrative Education and Research ProgrammeFaculty of Public HealthFaculty of Public Health StudiesBangkokThailand Center for Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunmingChina Department of Biology Laurentian UniversityGreater SudburyONCanada Department of Science Education Khon Kaen UniversityFaculty of EducationKhon KaenThailand Department of Parasitology Khon Kaen UniversityFaculty of MedicineKhon KaenThailand

Background:Cholangiocarcinoma(CCA)is a fatal bile duct cancer associated with infection by the liver fluke,Opisthorchis viverrini,in the lower Mekong *** public health interventions have focused on reducing exposure to ***,but incidence of CCA in the region remains *** this may indicate the inefficacy of public health interventions due to complex social and cultural factors,it may further indicate other risk factors or interactions with the parasite are important in pathogenesis of *** systematic review aims to provide a comprehensive analysis of described risk factors for CCA in addition to *** to guide future integrative *** body:We searched five international and seven Thai research databases to identify studies relevant to risk factors for CCA in the lower Mekong *** studies were assessed for risk of bias and quality in terms of study design,population,CCA diagnostic methods,and statistical *** final 18 included studies reported numerous risk factors which were grouped into behaviors,socioeconomics,diet,genetics,gender,immune response,other infections,and treatment for *** risk factors were reported by two or more studies and were assessed with random effects models during *** meta-analysis indicates that the combination of alcohol and smoking(OR=11.1,95%CI:5.63-21.92,P<0.0001)is most significantly associated with increased risk for CCA and is an even greater risk factor than *** *** analysis also suggests that family history of cancer,consumption of raw cyprinoid fish,consumption of high nitrate foods,and praziquantel treatment are associated with significantly increased *** risk factors may have complex relationships with the host,parasite,or pathogenesis of CCA,and many of these risk factors were found to interact with each other in one or more ***:Our findings suggest that a complex variety of risk factors in ad

关键词： Cholangiocarcinoma Risk factors Opisthorchis viverrini Mekong Southeast Asia Thailand Public health

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不当激励机制与学术论文发表的不端行为

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科学通报 2015年第25期60卷 2360-2361页

作者： virginia Barbour 安瑞 Committee on Publication Ethics (COPE) Brisbane Australia 不详

在过去的一些年里,伴随着新期刊和新的期刊运作模式的产生、新的技术、同行评议模式、以及新的研究协作关系及新传播方式的出现,学术出版行业正在变得越来越复杂.与此同时,学者在论文发表方面所承受的压力也日趋强烈.学术论文被认为是... 详细信息

在过去的一些年里,伴随着新期刊和新的期刊运作模式的产生、新的技术、同行评议模式、以及新的研究协作关系及新传播方式的出现,学术出版行业正在变得越来越复杂.与此同时,学者在论文发表方面所承受的压力也日趋强烈.学术论文被认为是学术界的＂通行货币＂——因其一直是获评终身教授、得到持续的资金支持以及职位晋升的关键因素.而且,当今出版物的＂货币价值＂作用愈演愈烈，其价值直接体现在学者的工资、奖金以及就业等各方面．

关键词：学术论文不端行为学术出版终身教授货币价值同行评议审稿人职位晋升撤稿学术不端

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Detail in contemporary timber architecture

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2010年

作者： McLeod virginia.

ISBN: (纸本)9781856696418

Detail in Contemporary Timber Architecture provides analysis of both the technical and the aesthetic importance of details in modern timber architecture. Featuring the work of renowned architects from around the world, this book presents 50 of the most recently completed and influential timber designs for both residential and commercial architecture. Each project is presented with color photographs, site plans, and sections and elevations, as well as numerous construction details. There is also a descriptive text, detailed captions, and in-depth information for each project, including the location, client, architectural project team, main consultants, and contractors. The projects are presented in clear and concise layouts over four pages. All of the drawings are styled in the same way and presented at standard architectural scales to allow for easy comparison. There is also a CD-ROM that contains all the drawings as printed in the book, in both EPS and DWG (generic CAD) formats. In addition, the book features an index of architects that includes the name, address, and all contact details for each architect included.

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来源：畅想之星图书光盘版（南... 评论

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Liver Characterization of a Cohort of Alpha-1 Antitrypsin Deficiency Patients with and without Lung Disease

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Journal of Clinical and Translational Hepatology 2024年第10期12卷 845-856页

作者： Naweed Mohammad Regina Oshins Tongjun Gu virginia Clark Jorge Lascano Naziheh Assarzadegan George Marek Mark Brantly Nazli Khodayari Division of Pulmonary Critical Care and Sleep MedicineCollege of MedicineUniversity of FloridaGainesvilleFLUSA Interdisciplinary Center for Biotechnology Research Bioinformatics CoreUniversity of FloridaGainesvilleFLUSA Division of Gastroenterology Hepatology and NutritionCollege of MedicineUniversity of FloridaGainesvilleFLUSA Division of Pathology Immunologyand Laboratory MedicineCollege of MedicineUniversity of FloridaGainesvilleFLUSA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA

Background and Aims:Alpha-1 antitrypsin deficiency(AATD)is a genetic disorder characterized by the misfolding and accumulation of the mutant variant of alpha-1 antitrypsin(AAT)within hepatocytes,which limits its access to the circulation and exposes the lungs to protease-mediated tissue *** results in progressive liver disease secondary to AAT polymerization and accumulation,and chronic obstructive pulmonary disease(COPD)due to deficient levels of AAT within the *** goal was to characterize the unique effects of COPD secondary to AATD on liver disease and gene ***:A subcohort of AATD individuals with COPD(n=33)and AATD individuals without COPD(n=14)were evaluated in this study from our previously reported cross-sectional *** used immunohistochemistry to assess the AATD liver phenotype,and RNA sequencing to explore liver *** observed a distinct transcriptomic profile in liver tissues from AATD individuals with COPD compared to those ***:A total of 339 genes were differentially *** pathways related to fibrosis,extracellular matrix remodeling,collagen deposition,hepatocellular damage,and inflammation were significantly upregulated in the livers of AATD individuals with *** analysis also revealed higher levels of fibrosis and hepatocellular damage in these ***:Our data supports a relationship between the development of COPD and liver disease in AATD and introduces genes and pathways that may play a role in AATD liver disease when COPD is *** believe addressing lung impairment and airway inflammation may be an approach to managing AATD-related liver disease.

关键词： Alpha-1 antitrypsin deficiency Chronic obstructive pulmonary disease Liver fibrosis Liver biopsy Liver histology Transcriptomics

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Systemic treatment of advanced, metastatic, medullary thyroid carcinoma

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 326-344页

作者： Antonio Matrone Carla Gambale Alessandro Prete virginia Cappagli Loredana Lorusso Valeria Bottici Rossella Elisei Department of Clinical and Experimental Medicine Endocrine UnitUniversity Hospital of PisaPisa 56124Italy

Medullary thyroid carcinoma(MTC)is a rare endocrine tumor,which arises from thyroid parafollicular C *** its ability to metastasize by blood and lymphatic vessels,it can show a more aggressive clinical behavior than differentiated thyroid *** of RET gene is the main molecular alteration involved in MTC *** the case of germline RET mutation,MTC can be inherited in an autosomal dominant way and show three different phenotypes:familial medullary thyroid carcinoma and multiple endocrine neoplasia types IIA and *** addition,in sporadic cases,somatic RET mutation remains the key molecular alteration in most of *** thyroidectomy with prophylactic or therapeutic central compartment lymph nodes dissection is the surgical treatment of *** surgical treatments and local therapies should be used in the case of single or few local or distant ***,in cases with large metastatic spread of the disease,particularly in those with significant tumor progression,additional systemic treatments are *** this review,we discuss the key points of systemic treatment in advanced,metastatic *** provide an update on the main aspects(from biological rationale to clinical experience)of each treatment,focusing our attention on the drugs used in clinical practice in the last ***,we give insights about the emerging treatments from highly selective RET inhibitors to new radionuclide therapy.

关键词： Medullary thyroid carcinoma tyrosine kinase inhibitors targeted therapy immunotherapy radionuclide therapy RET selective inhibitors

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Peptide Variant Detection by a Living Yeast Biosensor via an Epitope-Selective Protease

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BioDesign Research 2023年第1期5卷 1-11页

作者： Tea Crnković Benjamin J.Bokor Mead E.Lockwood virginia W.Cornish Department of Chemistry Columbia UniversityNew YorkNY 10027USA. Department of Biological Sciences Columbia UniversityNew YorkNY 10027USA. School of General Studies Columbia UniversityNew YorkNY 10027USA. Department of Systems Biology Columbia UniversityNew YorkNY 10027USA. Department of Biological Engineering Massachusetts Institute of TechnologyCambridge02139 MAUSA.

We previously demonstrated that we could hijack the fungal pheromone signaling pathway to provide a living yeast biosensor where peptide biomarkers were recognized by G-protein-coupled receptors and engineered to transcribe a ***,we demonstrated that the protease could be reintroduced to the biosensor to provide a simple mechanism for distinguishing single-amino-acid changes in peptide ligands that,otherwise,would likely be difficult to detect using binding-based *** characterized the dose–response curves for five fungal pheromone G-protein-coupled receptors,peptides,and proteases—Saccharomyces cerevisiae,Candida albicans,Schizosaccharomyces pombe,Schizosaccharomyces octosporus,and Schizosaccharomyces *** scanning was carried out for the most selective of these—*** and ***—with and without the *** peptide variants were discovered,which showed diminished cleavage by the protease(CaPep2A and CaPep2A13A).Those peptides were then distinguished by utilizing the biosensor strains with and without the protease,which selectively cleaved and altered the apparent concentration of peptide required for half-maximal activation for 2 peptides—CaPep and CaPep13A,respectively—by more than one order of *** results support the hypothesis that the living yeast biosensor with a sequence-specific protease can translate single-amino-acid changes into more than one order of magnitude apparent shift in the concentration of peptide required for half-maximal *** further engineering by computational modeling and directed evolution,the biosensor could likely distinguish a wide variety of peptide sequences beyond the alanine scanning carried out *** the future,we envision incorporating proteases into our living yeast biosensor for use as a point of care diagnostic,a scalable communication language,and other applications.

关键词： apparent otherwise utilizing

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CRITICAL ISSUES OF POWDER METALLURGY TURBINE DISKS

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Acta Metallurgica Sinica(English Letters) 1996年第6期9卷 467-471页

作者： K.M. Chang(Department of Mechanical and Aerospace Engineering,West virginia University, P.O. Box 6160, Morgantown,WV 26506, USA West virginia Univ Morgantown United States

P/M superalloy disks obtain their final strength by appropriate heat treatments; the maximum attainable strength depends on the rapid cooling rate from the solution annealing. A rapid quench of a large disk forging can cause two problems, surface cracking and shape *** the past,many attempts employ the finite element code to model and to predict temperature evolution and induced stress distribution in a large turbine disk. The major difficulty was the correct description of alloy behavior; particularly the thermomechanical properties and the failure criteria of material during the cooling. High temperature fatigue resistance is always the key requirement for disk materials. New methodology of residual life management emphasizes the initiation as well as the propagation of the cracks developed under the service conditions. One of major challenges to P/M superalloys is the time-dependent behavior of fatigue cracking, which relates to the well-known SAGBO (stress-assisted grain boundary oxidation) phenomenon.A great effort has been done to understand the micro-mechanism of time-dependent fatigue crack propagation resulted in the second generation of P/M superalloys. Further improvement on temperature capability of disk alloys at rim area may lead to the idea of dual-property *** grain structures at different portions of a large disk are possible,as the property requirements for different locations are different. This goal is achievable if the thermal history at specific disk locations can be controlled to develop desirable microstructures and *** suggestions on the future direction of research efforts will be discused.

关键词： superalloy disk,powder metallurgy (P/M) quench cracking,fatigue crack propagation SAGBO (stress-assisted grain boundary oxidation),dual-property disk grain size

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THE LEGACY

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英语学习 2000年第7期 20-24页

作者： virginia WOOLF 君泽

Angela死了,而她的丈夫可能是最后一个知道她是自杀的。英国小说家沃尔芙笔下的这一家庭悲剧揭示的远非情感问题。

关键词： Miller THE LEGACY

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3D additive-manufactured nanocomposite magnetic scaffolds: Effect of the application mode of a time-dependent magnetic field on hMSCs behavior

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Bioactive Materials 2017年第3期2卷 138-145页

作者： Ugo D'Amora Teresa Russo Antonio Gloria virginia Rivieccio Vincenzo D'Anto Giacomo Negri Luigi Ambrosio Roberto De Santis Institute of Polymers Composites and BiomaterialsNational Research CouncilNaplesItaly Villa Betania Evangelical Hospital NaplesItaly Department of Neuroscience Reproductive Sciences and Oral SciencesUniversity of Naples Federico IINaplesItaly Unit of Dentistry Bambino GesùChildren's HospitalIRCCSRomeItaly

Over the past few years,the influence of static or dynamic magnetic fields on biological systems has become a topic of considerable *** has recently been implicated to play significant roles in the regulation of cell responses and,for this reason,it is revolutionizing many aspects of healthcare,also suggesting new opportunities in tissue *** aim of the present study was to analyze the effect of the application mode of a time-dependent magnetic field on the behavior of human mesenchymal stem cells(hMSCs)seeded on 3D additivemanufactured poly(3-caprolactone)/iron-doped hydroxyapatite(PCL/FeHA)nanocomposite scaffolds.

关键词： Additive manufacturing Scaffold Magnetic field Cell-material interaction

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Immune strategies of phagoctytic cells stimulated in vitro with live and heat-inactivated Streptococcus pyogenes

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BIOCELL 2013年第3期37卷 63-69页

作者： Agustín César MÖHLINGER virginia Paula SIFFREDI Serenela CHULIBERT Adriana PONESSA Rodolfo David NOTARIO Diana Graciela DLUGOVITZKY Inmunology Section Microbiology DepartmentFaculty of Medical SciencesRosario National UniversityArgentina Microbiology Department Faculty of Medical SciencesRosario National UniversityArgentina

Streptococcus pyogenes(group A Streptococcus)is frequently involved in a wide range of human *** we evaluated polymorphonuclear neutrophils and mononuclear cells from healthy subjects for their bactericidal function after stimulation with live and inactivated Streptococcus pyogenes(Streptococcus Group A).Mononuclear cells and Neutrophils were isolated from heparinized blood samples(n=18)using a Ficoll-Hypaque gradient and cultured in RPMI 1640 for 18 hours with a suspension of either live or inactivated Streptococcus *** the respiratory burst(flow cytometry)and nitrite,TNF and IL17 production(ELISA)were measured in the cell culture *** increased respiratory burst(expressed as R index)was induced by both live and inactivated ***,increased nitrite,TNF and IL17 concentrations were found in cell culture supernatants in both *** findings may provide some explanation as to the roles played by neutrophils and mononuclear cells in Streptococcus pyogenes immunopathogenicity。

关键词： Respiratory burst nitrites TNFa IL17

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